Is the #Parkinsons-associated protein TMEM175 a proton channel: Yay or nay? Spencer Freeman and Sergio Grinstein @sickkidsto.bsky.social discuss new study from Riederer et al. (rupress.org/jcb/article/...) in Spotlight: rupress.org/jcb/article/...

An integrated analysis that combines electrophysiological and transcriptomic profiling, along with machine learning, of #islet cells from #T1D donors highlights the importance of α cell dysfunction @albertadiabetes.bsky.social @jci.org @bcellorg.bsky.social www.jci.org/articles/vie...

Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment url: academic.oup.com/endo/article...

New from us! Had a question about mitophagy but were afraid to ask? 😂 Excited to review the latest advances in beta cell mitophagy research as a key adaptive response in all forms of diabetes in @cp-trendsendomet.bsky.social. We'd be honored if you have it a read! #T1D #T2D

🧵(1/7)We are now out of September🍁! From the last two weeks we have had publications from the CIRTN labs of Drs Jenny Bruin, Mourad Ferdaoussi, Peter Light, Patrick MacDonald, James Shapiro and Bruce Verchere!

Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...

Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics | Science www.science.org/doi/10.1126/...

Save the date for the 2026 A-BC Islet Biology meeting! Looking forward to many fantastic presentations by trainees in islet biology from all over Canada as well as great keynote lectures. Please share widely! isletmeeting.weebly.com

Hello! Welcome to the CIRTN-R2FIC BlueSky account! Our group focuses on researching pancreatic islet biology and pathology related to islets such as type 1 and type 2 diabetes. Here you will find bi-weekly updates from the scientists from across Canada that make up CIRTN-R2FIC.

This is awesome. (& who remembers mouth pipetting ✋😱)

I learned that no need to be perfect to move on. Just keep pushing towards the final goal. Working on the details after getting the big picture...

We’re hiring a Postdoctoral Fellow! Exciting opportunity to join our research program @uhn.ca leading community-engaged, equity-driven type 2 diabetes research using qualitative and mixed-methods approaches.🔗: jobs.smartrecruiters.com/UniversityHe... @kristalamb.bsky.social @nhp-uoft.bsky.social

Imeglimin suppresses glucagon secretion and induces a loss of α cell identity: Cell Reports Medicine www.cell.com/cell-reports...

The antigen presentation landscape of cytokine-stressed human pancreatic islets: Cell Reports www.cell.com/cell-reports...

CRISPR activation screen uncovers MARCKSL1 as a gauge for extracellular vesicle secretion. https://www.biorxiv.org/content/10.1101/2025.07.24.665424v1

The official post: apps.ualberta.ca/careers/post...

Official posting coming soon, but here's a heads-up: #Postdoc Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and #diabetes. Diverse backgrounds, skill sets and experiences are welcome! www.bcell.org

Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n

Early-career researchers looking to gain experience within peer reviewing are invited to apply for the JAMA Network Peer Review Academy. Applications are due Monday, July 21. https://ja.ma/3TgYmv5

Our University Research Fellowships are now open for applications. These fellowships are for outstanding early career scientists to pursue cutting-edge scientific research and build an independent research career. Find out more: #RSGrants royalsociety.org/grants/unive...

ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science www.science.org/doi/10.1126/...

Up front & free to read in our July issue #editorspicks: TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion link.springer.com/article/10.1...

We are launching a new initiative to support experimental design, data management/analysis and bioinformatics. Early days yet, but check it out here. www.bcell.org/adi-datasci....

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages. ki.se/en/about-ki/...

Review on metabolism in stem cell derived beta cells from former PhD student with us, Frank Lin. Cell Reports @cp-cellreports.bsky.social www.sciencedirect.com/science/arti...

Great advice here. The palettes with up to 8 colours look excellent for graphs and objects. (I'm a colourblind reader)

Stem cell islets for those living with T1D! www.nejm.org/doi/full/10....

Mark Huising from University of California, Davis, presents research on how dynamic crosstalk within the islet shapes insulin release. 🗣️ Don’t miss today's debate “Are alpha cells and glucagon needed for islet function and glucose homoeostasis?”, chaired by Mark @huisinglab.bsky.social #EISG2025.

Our home-brewed PI3P and PI4P probes in neurons feels like blowing bubbles as a kid: fleeting, a little magical. I’m a Doubting Thomas at ❤️ & why I spend so much time learning to image & build probes. I need to see it to believe it. Too late for #fluorescencefriday but in time for #microscopymonday

🤣🤣🤣🤣🤣

Exciting news, although I guess the logic here seems to be that if you can buy genius, why train your own🤔.

Like this sentence:" If I received this review, would I view it as fair?"😀

Important changes on @erc.europa.eu grants‼️Grant structure & most importantly eligibility timeframes (10 years for starting, 15 years for consolidator post PhD-but you can have them only once) changes: erc.europa.eu/news-events/...

Well, I'm gonna hold my nose, cover my eyes and published this. A longer form story in two parts, first up glucagon antagonist drugs and briefly why they failed today. And then next week, glucagon agonists and why they look to succeed. Hope y'all like it!

Got the job without having any CNS papers

New study on novel translation factor EIF2A led by Panzhinskiy as a collaboration between @jimjohnsonsci.bsky.social lab, Jan lab & @bruceverchere.bsky.social lab UBC Life Sciences Institute. Thanks Breakthrough T1D Canada for funding this project #DiabetesResearch link.springer.com/article/10.1...

Interrogation of Proglucagon-derived peptide secretion using human stem cell-derived alpha (SC-α) cells www.cell.com/stem-cell-re...

This is one of the best ads I have ever seen and I can’t believe I missed it

EIF2A is a novel target for beta cell protection and the circumvention of EIF2S1-mediated translational repression #islets #diabetes @jimjohnsonsci.bsky.social @diabetologiajnl.bsky.social link.springer.com/article/10.1...

Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this! www.biorxiv.org/content/10.1...

Thrilled to share our latest work, which was the outstanding doctoral work of @samanthajsyoon.bsky.social academic.oup.com/endo/advance... 1/12

Molecular Correlates of Glycine Receptor Activity in Human β Cells https://www.sciencedirect.com/science/article/pii/S2212877825000638

“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is” https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y

When failed at the fellowship, I got this... Never stop, keep trying!!!

The Lim Lab at the @crchum.bsky.social is recruiting PhD students or Postdoctoral Fellows to study the roles of 14-3-3zeta in #adipocytes or pancreatic #betacells. Projects are supported by CIHR, NSERC, or Diabetes Canada. Please share with people who might be interested! Thanks!

#hiring. Opportunité de financement pour un MSc ou PHD @ualberta.bsky.social pour les talents #marocains 🇲🇦. Nous recherchons un(e) candidat(e) motivé(e) pour étudier les mécanismes de régulation de la sécrétion d’insuline et leurs implications dans le diabète. shorturl.at/KCPNQ

If you want to understand how cells function, you have to work out what proteins interact with — and where https://go.nature.com/3RgNXOZ