Xiong Liu
@xiongliu.bsky.social
📤 188
📥 551
📝 60
Postdoc; islets; diabetes; ion channel; amateur patch-clamper @university of Alberta
reposted by
Xiong Liu
Journal of Cell Biology
5 days ago
Is the
#Parkinsons-associated
protein TMEM175 a proton channel: Yay or nay? Spencer Freeman and Sergio Grinstein
@sickkidsto.bsky.social
discuss new study from Riederer et al. (
rupress.org/jcb/article/...
) in Spotlight:
rupress.org/jcb/article/...
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Xiong Liu
Daniel Drucker
7 days ago
An integrated analysis that combines electrophysiological and transcriptomic profiling, along with machine learning, of
#islet
cells from
#T1D
donors highlights the importance of α cell dysfunction
@albertadiabetes.bsky.social
@jci.org
@bcellorg.bsky.social
www.jci.org/articles/vie...
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Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment url:
academic.oup.com/endo/article...
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Glucagon, the Alpha Cell, and Potential Targets for Diabetes Treatment
Abstract. Glucagon is a 29-amino acid hormone synthesized and secreted by the pancreatic alpha cell in the islets of Langerhans. It is the primary glucose
https://academic.oup.com/endo/article-abstract/doi/10.1210/endocr/bqaf162/8314792
about 1 month ago
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Xiong Liu
Scott Soleimanpour
about 2 months ago
New from us! Had a question about mitophagy but were afraid to ask? 😂 Excited to review the latest advances in beta cell mitophagy research as a key adaptive response in all forms of diabetes in
@cp-trendsendomet.bsky.social
. We'd be honored if you have it a read!
#T1D
#T2D
add a skeleton here at some point
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Xiong Liu
CIRTN-R2FIC
2 months ago
🧵(1/7)We are now out of September🍁! From the last two weeks we have had publications from the CIRTN labs of Drs Jenny Bruin, Mourad Ferdaoussi, Peter Light, Patrick MacDonald, James Shapiro and Bruce Verchere!
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Xiong Liu
Daniel Drucker
2 months ago
Novel insights into the molecular underpinnings of islet cell dysfunction in
#T1D
highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity
@bcellorg.bsky.social
www.jci.org/articles/vie...
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Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics | Science
www.science.org/doi/10.1126/...
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Mapping early human blood cell differentiation using single-cell proteomics and transcriptomics
Single-cell transcriptomics (scRNA-seq) has facilitated the characterization of cell state heterogeneity and recapitulation of differentiation trajectories. However, the exclusive use of mRNA measurem...
https://www.science.org/doi/10.1126/science.adr8785
3 months ago
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#FluorescencFriday
3 months ago
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Xiong Liu
Rebecca Hull-Meichle
3 months ago
Save the date for the 2026 A-BC Islet Biology meeting! Looking forward to many fantastic presentations by trainees in islet biology from all over Canada as well as great keynote lectures. Please share widely!
isletmeeting.weebly.com
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Xiong Liu
CIRTN-R2FIC
3 months ago
Hello! Welcome to the CIRTN-R2FIC BlueSky account! Our group focuses on researching pancreatic islet biology and pathology related to islets such as type 1 and type 2 diabetes. Here you will find bi-weekly updates from the scientists from across Canada that make up CIRTN-R2FIC.
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Xiong Liu
BCCHR ResDev (DM)
3 months ago
This is awesome. (& who remembers mouth pipetting ✋😱)
add a skeleton here at some point
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www.science.org/doi/full/10....
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Heparan sulfate fine-tuned interleukin-1 (IL-1) signaling inhibits insulin secretion of grafted pancreatic islets
The binding of heparan sulfate to IL-1α potentiates the inhibitory action of IL-1α on insulin release.
https://www.science.org/doi/full/10.1126/sciadv.ady8566
4 months ago
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I learned that no need to be perfect to move on. Just keep pushing towards the final goal. Working on the details after getting the big picture...
add a skeleton here at some point
4 months ago
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Xiong Liu
EARLY Diabetes
4 months ago
We’re hiring a Postdoctoral Fellow! Exciting opportunity to join our research program
@uhn.ca
leading community-engaged, equity-driven type 2 diabetes research using qualitative and mixed-methods approaches.🔗:
jobs.smartrecruiters.com/UniversityHe...
@kristalamb.bsky.social
@nhp-uoft.bsky.social
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Postdoctoral Fellow, Qualitative Type 2 Diabetes Research
Company Description: UHN is Canada’s #1 hospital and the world’s #1 publicly funded hospital. With 10 sites and more than 44,000 TeamUHN members, UHN consists of Toronto General Hospital, Toronto West...
https://jobs.smartrecruiters.com/UniversityHealthNetwork/744000073617796-postdoctoral-fellow-qualitative-type-2-diabetes-research
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Imeglimin suppresses glucagon secretion and induces a loss of α cell identity: Cell Reports Medicine
www.cell.com/cell-reports...
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Imeglimin suppresses glucagon secretion and induces a loss of α cell identity
In type 2 diabetes, glucagon dysregulation persists. Tsuno et al. demonstrate that imeglimin suppresses glucagon secretion and induces α cell dedifferentiation via inhibition of Gsα and MafB, respecti...
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791%2825%2900327-1
4 months ago
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The antigen presentation landscape of cytokine-stressed human pancreatic islets: Cell Reports
www.cell.com/cell-reports...
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The antigen presentation landscape of cytokine-stressed human pancreatic islets
Nanaware et al. characterize peptides presented by MHC proteins in inflamed human pancreatic islets and test them for reactivity with CD4 and CD8 T cells from patients with T1D. These results identify...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2825%2900698-9
4 months ago
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Xiong Liu
bioRxiv Cell Biology
5 months ago
CRISPR activation screen uncovers MARCKSL1 as a gauge for extracellular vesicle secretion.
https://www.biorxiv.org/content/10.1101/2025.07.24.665424v1
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Xiong Liu
Patrick MacDonald🇨🇦
5 months ago
The official post:
apps.ualberta.ca/careers/post...
add a skeleton here at some point
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reposted by
Xiong Liu
Patrick MacDonald🇨🇦
5 months ago
Official posting coming soon, but here's a heads-up:
#Postdoc
Opportunity for individuals with an interest in advancing the understanding of pancreatic islet hormones in health and
#diabetes
. Diverse backgrounds, skill sets and experiences are welcome!
www.bcell.org
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Xiong Liu
Scott Soleimanpour
5 months ago
Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔 🚨In new work out today in
@natmetabolism.nature.com
, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨
nature.com/articles/s42...
1/n
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LONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes - Nature Metabolism
LONP1, whose expression is downregulated in islets from donors with type 2 diabetes, is vital to mediate efficient mitochondrial protein folding, thus preventing proteotoxicity and promoting islet β c...
https://nature.com/articles/s42255-025-01333-7
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reposted by
Xiong Liu
JAMA
5 months ago
Early-career researchers looking to gain experience within peer reviewing are invited to apply for the JAMA Network Peer Review Academy. Applications are due Monday, July 21.
https://ja.ma/3TgYmv5
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Xiong Liu
The Royal Society
5 months ago
Our University Research Fellowships are now open for applications. These fellowships are for outstanding early career scientists to pursue cutting-edge scientific research and build an independent research career. Find out more:
#RSGrants
royalsociety.org/grants/unive...
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ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox | Science
www.science.org/doi/10.1126/...
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ROS transfer at peroxisome-mitochondria contact regulates mitochondrial redox
Maintenance of mitochondrial redox homeostasis is of fundamental importance to cellular health. Mitochondria harbor a host of intrinsic antioxidant defenses, but the contribution of extrinsic, nonmito...
https://www.science.org/doi/10.1126/science.adn2804
5 months ago
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Xiong Liu
Diabetologia
5 months ago
Up front & free to read in our July issue
#editorspicks
: TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion
link.springer.com/article/10.1...
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TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion - Diabetologia
Aims/hypothesis Diabetes is associated with the dysfunction of glucagon-producing pancreatic islet alpha cells, although the underlying mechanisms regulating glucagon secretion and alpha cell dysfunct...
https://link.springer.com/article/10.1007/s00125-025-06411-9
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reposted by
Xiong Liu
Patrick MacDonald🇨🇦
5 months ago
We are launching a new initiative to support experimental design, data management/analysis and bioinformatics. Early days yet, but check it out here.
www.bcell.org/adi-datasci....
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Xiong Liu
Mathew Kiang
6 months ago
Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.
ki.se/en/about-ki/...
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Call for 20 Assistant Professor positions
Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...
https://ki.se/en/about-ki/jobs-at-ki/join-a-global-community-of-excellence
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reposted by
Xiong Liu
Patrick MacDonald🇨🇦
6 months ago
Review on metabolism in stem cell derived beta cells from former PhD student with us, Frank Lin. Cell Reports
@cp-cellreports.bsky.social
www.sciencedirect.com/science/arti...
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Glucose metabolism and regulation in establishing human stem cell-derived β cell maturation
Efforts to generate mature stem cell-derived β (SC-β) cells have been ongoing for decades, yet their functional performance still falls short of prima…
https://www.sciencedirect.com/science/article/pii/S2211124725006631
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Xiong Liu
Cahir O'Kane
6 months ago
Great advice here. The palettes with up to 8 colours look excellent for graphs and objects. (I'm a colourblind reader)
add a skeleton here at some point
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Xiong Liu
Francis Lynn 🇨🇦
6 months ago
Stem cell islets for those living with T1D!
www.nejm.org/doi/full/10....
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Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes | NEJM
Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimisle...
https://www.nejm.org/doi/full/10.1056/NEJMoa2506549?utm_source=conf&utm_medium=qr&utm_campaign=ADA2025
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Xiong Liu
EISG 2025
6 months ago
Mark Huising from University of California, Davis, presents research on how dynamic crosstalk within the islet shapes insulin release. 🗣️ Don’t miss today's debate “Are alpha cells and glucagon needed for islet function and glucose homoeostasis?”, chaired by Mark
@huisinglab.bsky.social
#EISG2025
.
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Xiong Liu
David Solecki
6 months ago
Our home-brewed PI3P and PI4P probes in neurons feels like blowing bubbles as a kid: fleeting, a little magical. I’m a Doubting Thomas at ❤️ & why I spend so much time learning to image & build probes. I need to see it to believe it. Too late for
#fluorescencefriday
but in time for
#microscopymonday
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🤣🤣🤣🤣🤣
add a skeleton here at some point
6 months ago
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Xiong Liu
Dr Peter Senior
6 months ago
edmonton.citynews.ca/2025/06/05/u...
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U of A celebrates 25th anniversary of the Edmonton Protocol, advancing diabetes treatment | CityNews Edmonton
Verlyn Olsen has experienced terrifying moments since being diagnosed with type 1 diabetes in the 80s.
https://edmonton.citynews.ca/2025/06/05/u-of-a-celebrates-25th-anniversary-of-the-edmonton-protocol-advancing-diabetes-treatment/
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Exciting news, although I guess the logic here seems to be that if you can buy genius, why train your own🤔.
add a skeleton here at some point
6 months ago
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Like this sentence:" If I received this review, would I view it as fair?"😀
add a skeleton here at some point
6 months ago
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Xiong Liu
Yasin Dagdas
6 months ago
Important changes on
@erc.europa.eu
grants‼️Grant structure & most importantly eligibility timeframes (10 years for starting, 15 years for consolidator post PhD-but you can have them only once) changes:
erc.europa.eu/news-events/...
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Changes to the 2026 and 2027 Work Programmes
With the launch of the competitions for grants under ERC Work Programme 2026 in July of this year, several changes to the submission of applications and the evaluation of proposals will apply. The mai...
https://erc.europa.eu/news-events/news/changes-2026-and-2027-work-programmes
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Xiong Liu
FlexNP
6 months ago
Well, I'm gonna hold my nose, cover my eyes and published this. A longer form story in two parts, first up glucagon antagonist drugs and briefly why they failed today. And then next week, glucagon agonists and why they look to succeed. Hope y'all like it!
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Glucagon antagonists, a story of failure
(Ant)agonizing over glucose, and the next medical revolution
https://the-incretins.beehiiv.com/p/glucagon-antagonists-a-story-of-failure
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Xiong Liu
Oded Rechavi
7 months ago
Got the job without having any CNS papers
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Xiong Liu
Diabetologia
7 months ago
New study on novel translation factor EIF2A led by Panzhinskiy as a collaboration between
@jimjohnsonsci.bsky.social
lab, Jan lab &
@bruceverchere.bsky.social
lab UBC Life Sciences Institute. Thanks Breakthrough T1D Canada for funding this project
#DiabetesResearch
link.springer.com/article/10.1...
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Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition - Diabetologia
Aims/hypothesis The endoplasmic reticulum (ER) stress-induced unfolded protein response helps determine beta cell survival rate in diabetes. The alternative eukaryotic translation initiation factor 2A...
https://link.springer.com/article/10.1007/s00125-025-06431-5
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Xiong Liu
Daniel Drucker
7 months ago
Interrogation of Proglucagon-derived peptide secretion using human stem cell-derived alpha (SC-α) cells
www.cell.com/stem-cell-re...
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Modeling diabetic alpha cell dysfunction using stem cell-derived alpha cells
Shrestha et al. report the development of an in vitro human model of pancreatic alpha cells using pluripotent stem cells (SC-alpha cells). SC-alpha cells recapitulate the gene expression, proglucagon ...
https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(25)00108-0
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Xiong Liu
Adam Parkhomenko
7 months ago
This is one of the best ads I have ever seen and I can’t believe I missed it
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21296
5139
reposted by
Xiong Liu
Daniel Drucker
7 months ago
EIF2A is a novel target for beta cell protection and the circumvention of EIF2S1-mediated translational repression
#islets
#diabetes
@jimjohnsonsci.bsky.social
@diabetologiajnl.bsky.social
link.springer.com/article/10.1...
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Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition - Diabetologia
Aims/hypothesis The endoplasmic reticulum (ER) stress-induced unfolded protein response helps determine beta cell survival rate in diabetes. The alternative eukaryotic translation initiation factor 2A...
https://link.springer.com/article/10.1007/s00125-025-06431-5
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Xiong Liu
Richard Benninger
7 months ago
Check out this pre-print from Vira Kravets, Andraz Stozer and myself, for the influence of alpha cells on heterogenous islet Ca2+ responses, including first-responders and first phase timing/amplitude. Was great to be part of this!
www.biorxiv.org/content/10.1...
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Role of GLP1-receptor-mediated α-β-cell communication in functional β-cell heterogeneity.
While the islet β-cells were traditionally viewed as a singular functional entity, findings of 1970s and up until recent years, reveal that individual β-cells differ in their calcium dynamics and insu...
https://www.biorxiv.org/content/10.1101/2025.04.25.650736v1
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Xiong Liu
Francis Lynn 🇨🇦
7 months ago
Thrilled to share our latest work, which was the outstanding doctoral work of
@samanthajsyoon.bsky.social
academic.oup.com/endo/advance...
1/12
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NPAS4 depletion in POMC neurons protects from obesity and alters the feeding-regulated transcriptome in male mice
Abstract. Immediate Early Genes (IEGs), such as Neuronal PAS domain protein 4 (Npas4), are induced as part of the response to environmental stimuli. In the
https://academic.oup.com/endo/advance-article/doi/10.1210/endocr/bqaf083/8121611?utm_source=authortollfreelink&utm_campaign=endo&utm_medium=email&guestAccessKey=5f7be493-2871-45d6-bc3d-5195230c2d09&login=false
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reposted by
Xiong Liu
Patrick MacDonald🇨🇦
8 months ago
Molecular Correlates of Glycine Receptor Activity in Human β Cells
https://www.sciencedirect.com/science/article/pii/S2212877825000638
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Xiong Liu
Patrick MacDonald🇨🇦
8 months ago
“Recruiting U.S. scientists is a fine idea – except we’re barely supporting Canadian scientists as it is”
https://www.theglobeandmail.com/gift/aaa9fec50b2b595cc0291494fc97e4bd10e7d6945d5c457e0bfa75d42846a705/4FRDBEKLNFESVJ3ZILAS36KR7Y
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When failed at the fellowship, I got this... Never stop, keep trying!!!
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8 months ago
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Xiong Liu
Gareth Lim
8 months ago
The Lim Lab at the
@crchum.bsky.social
is recruiting PhD students or Postdoctoral Fellows to study the roles of 14-3-3zeta in
#adipocytes
or pancreatic
#betacells
. Projects are supported by CIHR, NSERC, or Diabetes Canada. Please share with people who might be interested! Thanks!
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Xiong Liu
Mourad Ferdaoussi
8 months ago
#hiring
. Opportunité de financement pour un MSc ou PHD
@ualberta.bsky.social
pour les talents
#marocains
🇲🇦. Nous recherchons un(e) candidat(e) motivé(e) pour étudier les mécanismes de régulation de la sécrétion d’insuline et leurs implications dans le diabète.
shorturl.at/KCPNQ
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Xiong Liu
Nature
8 months ago
If you want to understand how cells function, you have to work out what proteins interact with — and where
https://go.nature.com/3RgNXOZ
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Where do proteins go in cells? Next-generation methods map the molecules’ hidden lives
Nature - Spatial proteomics is helping biologists to uncover how cells work by mapping where proteins operate.
https://go.nature.com/3RgNXOZ
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