Another red alert for American science | Science www.science.org/doi/10.1126/...

Can eating less help us age better? Research has long shown that cutting calories can improve lifespan in some species, but it’s not always practical or healthy for people. Now, a study from immunobiologist Vishwa Deep Dixit is exploring how we might get those same benefits without the risks.

Excited to announce our new study (w/ @maxkrummel.bsky.social) published today @nature.com: Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells. www.nature.com/articles/s41... #immunology #cellbiology @immunox.bsky.social

Thank you to the incredible panel of researchers who presented at the Immune Development in Early Life Hot Topic Symposium at @pasmeeting.bsky.social #PAS2026 L to R: Dr. Xiaobin Wang, Dr. Ofer Levy, Dr. Oluwabunmi Olaloye, Dr. Octavio Ramilo, Dr. Paolo Palma. #vaccines #IDEAL #EarlyLifeImmunity

We focus on human immunology to understand the effects of #aging. Great science being shared at @hipcproject.bsky.social annual meeting by @adamtanguay.bsky.social from @yalemed.bsky.social

After the HIPC Symposium, meet some of our researchers and speakers at our Immunology Superbooth in the exhibition center! At booths #736 #738 @aai.org

@skleinstein.bsky.social presenting on @immportdb.bsky.social and @hipcproject.bsky.social work at #AAI2026 💡

We have age-associated macrophages in visceral fat making C3a and increasing inflammation. C'mon macrophages, we need your help here. Wonderful new paper from Dixit lab @yalemed.bsky.social #SenNet www.nature.com/articles/s43...

#AAI2026: Besides our #HIPC Guest Symposium, we will have two presentations from members of our #ImmuneSpace team ( @skleinstein.bsky.social & Jian Xing) on Saturday, April 18th! Hope to see you there at @aai.org 💬💡🙂

Members of our Data Management and Analysis team had a great time at NextGenOmics, Spatial & Data US! Joann Diray Arce, PhD gave a talk on ImmuneVISTA and MultiOMICs in #vaccine research #NGOUS2026 #OGPREMED #vaccines

Congratulations to my wonderful Yale colleagues!

Working together to advance understanding of human immunology. Well said Holden! @hipcproject.bsky.social

FACT OF THE DAY. 26 March 1953. In a huge medical breakthrough, US medical researcher Dr Jonas Salk announced that he had created the first polio vaccine. Polio cases fell from 58,000 per year in 1952 to 6,000 by 1958. Salk’s vaccine was replaced by a new one developed by Albert Sabin in 1962.

🎉 Congrats to #AGE2026 Early Career Scholar Awardee Piper Wilburn- #IndianaUniversitySchoolOfMedicine. Recognized by the #AmericanAgingAssociation, her research studies how the bone marrow niche shapes stem cell function and transplant outcomes in aging. #Geroscience #AgingResearch

Good discussion of the disappearing NIH Notices of Funding Opportunity (NOFOs). elizabethginexi.substack.com/p/the-nofo-g...

I love phagocytosis- the most ancient form of immunity (estimated at 1 billion yrs old!). Lucky to geek out with all the other macrophage and neutrophil geeks at beautiful Keble college, Oxford.

New clues to understand #HealthyAging from @yalemed.bsky.social studying longevity in nature. #SenNet www.science.org/doi/epdf/10....

Sharing on behalf of Dr. Florian Krammer for those interested - his podcast is great! Episode 0 of my new podcast viroLOGICAL is online. This first episode is a little longer and gives a general overview of viruses and viral diseases. Find it on Apple, Spotify, and Podigee: virological.podigee.io

Learning lots about #lung autoimmunity as a contributor to severe #asthma from Dr Manali Mukherjee from #TheFirestone. Great reminder that blood is not always the right place to sample for autoimmunity -sputum can be a much more informative marker.

Both chambers of Congress have now passed the FY26 minibus with NIH provisions. The President will sign. (1) $48.7 billion for NIH (2) Full IDC recovery (3) No more multi-year funding (4) No NIH reorganization, maintaining the current IC structure.

Thank you to Bob McDonald for hosting me on @CBCRadioCanada to discuss our work @yaleschoolofmed.bsky.social on what leads to variation in common cold virus infections and how we tackled this using nasal organoids. Listen here: www.cbc.ca/listen/live-...

Glad to join today in teaching #CyTOF for Yale's Computational Proteomics course directed by Dr. Maria Rodriguez Martinez. Multidimensional single cell immune profiling for #HIPC takes a team including Dr. Adam Tanguay and Dr. Ashish Shelar.

My most recent manuscript is available from @pnas.org . We describe a population of inflammatory cytokine MIF responsive T cells and their importance in Rheumatoid Arthritis pathogenesis.

Solo markers were interesting but combining gene SNPs and plasma metabolite data showed predictions for severe #COVID. That's why we study the whole #SystemsImmunology #BigScience #Teamwork

Dr. Leila Denmark co-developed the pertussis (whooping cough) vaccine. World's oldest practicing pediatrician until she retired at age 103 (after 73 yrs). At the time of her death at age 114 & 60 days, she was the 5th-oldest validated living person in the world & 3rd-oldest in the US. #WomenInSTEM

I am excited to share our new paper @JExpMed led by our one and only #Alejandra_Aroca

Representative Betty McCollum (D-MN, 4th) met with AAI Councilors Gwendalyn Randolph, Steve Jameson, and CPA Chair Lauren Ehrlich! They had a great conversation about how crucial robust funding is for NIH. Thank you for the support! #AAIadvocacy

AAI Councilors Donna Farber, Avery August, and Laurie Harrington had a wonderful meeting with staff from Rep. Josh Riley’s (D-NY, 19th) office, discussing the importance of NIH funding and science-based policy. #AAIadvocacy

The NIH grant cuts in 2025 www.nytimes.com/interactive/...

Super excited for the upcoming #cellbio2025 @ascbiology.bsky.social @embo.org meeting in Philadelphia! Check out the Special President's session on "The Rising Tide of Science Denial" on Saturday at 1pm!

We are proud to feature 2025 RCCN Pilot Awardees Lauren Ferrante and Kathryn Callahan in this Pilot Awardee Spotlight! Learn more about their Inter-NIA Center pilot project here: bit.ly/4izqwNF #Frailty #AgingResearch

Honored to be recognized as one of 25 Best Leaders by @usnews.com including 5 in the Health category. I look forward to meeting some extraordinary colleagues at an upcoming event in Wash DC www.usnews.com/news/leaders...

The Trump admin has been targeting whistleblowers, from the #FEMA36 to the countless other patriotic public servants and scientists across NIH, CDC, NASA, and more who spoke out about the danger posed by the chaos in our federal agencies. This is an concerted, autocratic effort to silence dissent.

New research from Dixit lab @yalemed.bsky.social showing nerve-associated macrophages (NAMs) decline in aging which impairs the breakdown of fat and increases inflammaging. Dixit addresses the biology of aging and intercommunication between nerves and macrophages. www.nature.com/articles/s43...

Taliban Bans Books by Women in Afghanistan’s Universities www.nytimes.com/2025/09/19/w...

Congratulations to our outstanding @yalemed.bsky.social colleague @virusesimmunity.bsky.social

Count on #macrophages to promote health! Congratulations to my @yalemed.bsky.social colleagues for this very novel paper.

mRNA technologies: Unlimited potential to improve human health. I spoke with the fantastic Erin Shumaker at POLITICO to discuss this topic and its applications to cancer, autoimmunity and beyond. @erinlschumaker.bsky.social @politico.com @cornertx #mRNA #Cancer politi.co/3VjfRvu

#Resource Proteomic characterization of varicella-zoster virus–host protein interactions and infection-induced changes in a neuronal cell line identifies potential targets for drug discovery and molecular insights into severe disease. #MicroSky www.nature.com/articles/s41...

Come get your curated #immune #assays from 1,000s of human subjects at our website immunespace.org 🧪 #immunology #IDSky #ImmuneSky immunespace.org/query/filters giphy.com/gifs/Giflyti...

On Aug. 1, ASM & partner societies filed an expanded amicus brief with SCOTUS to defend scientific integrity & protect early-career researchers. The brief highlights the harm caused by NIH grant terminations, including canceling the MOSAIC program. asm.org/press-releas...

The NIH budget will INCREASE by $400 million — not slashed by 40%, as Trump proposed — according to a proposal by Senate appropriators, says Sen Murray. "Some have asked if there will even be an NIH by [2029]. The commmittee's resounding message is yes—Congress has your back", she says.

More insights from #IMPACC studies, including polymorphism that might protect in #covid19 in online publication. Authors include: @skleinstein.bsky.social @bjoernpeters.bsky.social @sesmalab.bsky.social @vivianasimonlab.bsky.social @joanndarce.bsky.social ++ others insight.jci.org/articles/vie...

Our collaborators identify chief predictor of #covid19 severity + death. Many authors include members of #IMPACC network: @rrmsky.bsky.social @bjoernpeters.bsky.social @skleinstein.bsky.social @sesmalab.bsky.social @joanndarce.bsky.social @droferlevy.bsky.social www.frontiersin.org/journals/med...

Welp. www.wsj.com/health/healt...

Three members of the NIH council of councils publish a letter to the editor, coming out against proposed budget cuts and recent grant terminations “The NIH is not just a national treasure — it is a global beacon of biomedical excellence. … We must not weaken it.” www.nature.com/articles/d41...

Really cool stuff! @dremilygoldberg.bsky.social @astratman.bsky.social @bbparis1984.bsky.social @balynzaro.bsky.social