Let's get negative about scholarly publishing – a new paper (first in a long time for me!) on proposals to tackle the problem of publication bias that emerged from a NINDS workshop held in May last year. occamstypewriter.org/scurry/2025/... [Direct link to paper: journals.plos.org/plosbiology/...

The job posting for the RA position described below is live: uiowa.referrals.selectminds.com/jobs/researc... Please share with anyone who might be interested!

One of our UF faculty appealed the abrupt termination of a prestigious NIH grant. She learned this week was reinstated. Lesson: Be persistent, be bold!

How do motivational disturbances (apathy and ICD) and cognitive effort-based decision-making affect Parkinson's? What if you are slow motorically is there a way to truly assess motivation? YEP. You might be surprised as Bonnie Scott and Robert Eisinger at Fixel delight us in their new PRD journal.

Congratulations to all on clinical psychology internship match day 2025! Including our 7 UF neuropsychology grad students! From New York to California and places in between. 👏👏👏

Contact your POs as well as your government reps www.thetransmitter.org/funding/fede...

“At the National Institutes of Health, the nation’s premier biomedical research agency, an estimated 1,200 employees — including promising young investigators slated for larger roles — have been dismissed.” Yes. Breaking cancer research. @sherylnyt.bsky.social

The white house tried and failed to do this 2017, and will fail again. Also, a good exploration of real ways to increase efficiency and reduce waste in NIH grant funding open.substack.com/pub/goodscie...

Importantly, these are *civil* actions under the Privacy Act of 1974, i.e. individuals can file suit and Trump can’t pardon defendants.

RIP any human subjects methods section: women, gender, female, excluded RIP math/stats: biases, marginalise, equality, inequality, group, inclusive RIP social sciences: status, systemic, political, group, socioeconomic, institutional, cultural This is not just evil it is also SO VERY DUMB

Does Parkinson's affect the eyes? YEP. Does the optic disc fade in Parkinson's? Apparently YES according to Samuel Gibbon and colleagues in a brand new article in the Journal Movement Disorders. Parkinson's is a disease of the brain and body, and YES that includes the eyes.

Alpha synulcien targeting NPT100-18A rescues mitochondrial oxidative stress & neuronal degeneration in human iPSC-based #Parkinsons; First mechanistic insights into how a compartment-specific antioxidant effect in mitochondria might be involved in MoA bmcneurosci.biomedcentral.com/articles/10....

Join researchers across the country in fighting restrictions on the NIH form.jotform.com/250226137228...

If you would like to see how much economic activity and grants and how many people are employed through NIH in your state, just use this handy website. And then contact your Congressional Rep and tell them to prioritize NIH. www.unitedformedicalresearch.org/nih-in-your-...

What happened to the pursuit of truth? rupress.org/jgp/article/... - Eve Marder, on point...

Fantastic lecture. Highly recommended!

We need to understand why and which cells are affected in Parkinson's, and when the process actually starts. Will multiomic studies answer all the questions on neuronal vulnerability? No. Help prioritize disease modifying therapy. Likely. Help to unravel upstream pieces to the puzzle. Definitely.

The body of work in this issue of JAMA is a call for all to adapt to the dynamic shifts in the biomedical landscape while implementing the ethical principles outlined in the newly revised Declaration of Helsinki. Read the Editorial. https://ja.ma/4a9pTWR

Check this out - hats off to Rachel Schade who finds that use of highly prescribed SSRI’s is linked to increase in apathy in individuals with Parkinson disease. Take away- consider other antidepressants

We are excited to announce a new special issue for The Journal of Gerontology: Psychological Sciences focused on Social Determinants of Health! See the Call for Papers here!: academic.oup.com/psychsocgero... #GSA #SDOH #psychology #aging

What about 'inflammasome inhibitors' as a treatment for Parkinson's? There is a lot of interest in new drugs like NT-0796, Selnoflast, Dapansutrile, VTX 3232 and ZYIL1. Bina Patel and colleagues summarize this and more in a new study in Journal of Parkinson's Disease.

A 4-week, double-blind pilot study focuses on promoting physical activity in people with #Parkinsons through a smartphone (STEPWISE) app; Step counts per day⬆️ journals.lww.com/jnpt/fulltex...

70 may be the new 60 years of age Older adults in England had much higher levels of levels of cognitive, physical function and vitality than prior generations at the same age www.nature.com/articles/s43...

Had a fantastic conversation with Roxanne Lofredi on human (invasive) striatal recordings & her new @naturecomms.bsky.social paper, confirming & extending @russpoldrack.bsky.social's 'Stopping Triangle' using DBS stimulation mapping – tune in here: stimulatingbrains.org/66-roxanne-l...

A new study finds ants best humans at tests of collective intelligence. Learn more: scim.ag/4h2K0ID

This looks like amazing new work from my colleagues at Stanford demonstrating the opponent interactions of DA and 5HT in reinforcement learning.

To all board-eligible clinical neuropsychologists, apply for the AACN-APPCN Scholarship for Board Certification in Clinical #Neuropsychology. Special consideration for those from underrepresented groups. Submissions due 1/1/2025 #NeuropsychSky #NeuroSkyence #Psychology #PsychSky #BlackMenInPsych

Different stages of idiopathic Parkinson’s disease (iPD) can be distinguished by the inflammatory & immunometabolic responses of blood cells, suggesting that immune & metabolic dysregulation may drive PD & help identify novel biomarkers for patient stratification. @malutansey.bsky.social

Our book is now taking pre-orders and it is a great holiday gift to look forward to. We introduce the “Parkinson’s 25,” the most detailed checklist ever created to allow anyone to lower their risk of Parkinson’s. www.hachettebookgroup.com/titles/ray-d... #parkinson

Beautiful work! Not only dies the neighborhood matter but it’s beneficial to live near younger neighbors 😍😎🧠💪🏼

We had the great privilege of hosting Professor Simon Cox of The University of Edinburgh, Director of The Lothian Birth Cohort Study, at @uscpsychology.bsky.social last week when he gave a great colloquium and met with faculty and students. Thanks for coming Simon! #cognitiveaging

Why is the EPA banning TCE for Parkinson's? The odds ratio for the dry cleaning chemical TCE and association with later Parkinson's is ridiculously high. and the community should thank the EPA and embrace this decision as a huge WIN for Parkinson's. This is a BIG DEAL.

The promised efficiency in research spending looks to be up for a strong start

I love the figures and the discussion in this paper. The most important thing in my mind is to move past the peak of inflated expectations, and even past the trough of disillusionment. What will the plateau look like and for whom? academic.oup.com/braincomms/a...

If you see a Christmas garland on MRI (ventricle), will you know what disease it represents? Alexander's of course. Remember, a garland is a circular or spiral arrangement of intertwined material such as flowers or leaves. These have Rosenthal fibers interweaved. Long shows us in Green journal.

👇🏾👇🏾👇🏾

Oligodendrocytes again! Weighted gene co-expression network analysis (WGCNA) analysis suggests that abnormal oligodendrocyte function may play a key role in early #Parkinsons; Suggests 5 potential biomarkers: AGPAT4, DNM3, PPP1R12B, PPP2R2B, & LINC00486 www.frontiersin.org/journals/agi...

Great to be interviewed by KCBS news radio about our recent study linking financial vulnerability and the entorhinal cortex. Check it out here (after 2 min of commercials😉)👇 #alzheimers #dementia #finance #cognition #decisionmaking www.audacy.com/podcast/kcbs...

What if we could take that MRI everyone gets and use AI to detect Parkinson, MSA and PSP? David Vaillancourt tackles this and discussed his work in the Lancet Digital journal and also his NIH U01 large ongoing study. Nice work presented at the Parkinson's Foundation panel in Nashville today.

Now made a better version (nicer colours, other minor tweaks). I am OBSESSED with these!

The skin test for separating Parkinson's vs. MSA. Chris Gibbons presented some data and engaged the audience a great discussion today. Check out this paper on the topic. Also his favorite movie is Monty Python, Holy Grail. Great Parkinson's Foundation panel today in Nashville.

Why is there a crisis approaching for Parkinson's disease? Well, have a look at the formula. The number of cases is exploding and the costs are skyrocketing. Pair that with a decreasing number of available specialists. Key note this morning for the combined Parkinson Foundation/PSG meeting,

Do white matter lesions on brain MRI portend more complications after DBS? Nope according to Jarksji and colleagues in Movement Disorders Clinical Practice. There were 135 people and guess what? Surgical complications and long term motor function not affected.

New paper in Imaging Neuroscience by Mira Erhart, Victor I. Spoormaker, et al: Capturing inter-individual variability in stress dynamics with heart rate traces reveals activity in the bilateral hippocampus, amygdala, and insula doi.org/10.1162/imag...

Can you explain your doctoral research through interpretive dance? The 17th annual #DanceYourPhD competition is open! Submit by 28 March for a chance to win $2000: scim.ag/3BcKi0e

Join Dr Jess Wade on 10 December for the Rosalind Franklin Award Lecture as she explores the technologies of the future, how the most exciting science happens at the intersection between disciplines, and why we need to overhaul research culture to bring the most benefit to society and the economy.

Showed a glimpse of a new atlas that we're building in Paris yesterday. Pretty excited about it and implications for network modeling.