Excited to share our cross-disorder GWAS analysis of neurological and psychiatric disorders (~1 M cases), now out in @natneuro.nature.com! We show more extensive genetic pleiotropy than previously recognized, supporting a more unified view of these disorders rdcu.be/ePmwD

From big to small: Emerging methods for enhancing precision psychiatry through transfer learning www.sciencedirect.com/science/arti...

I’m seriously intrigued by this. How are brains set up such that 4 lbs of wonderful in 2 hours doesn’t spiral into mania? That’s robust & highly nontrivial integration!

Overall social media use is declining. Between 2020 and 2024, more Americans — especially the youngest (18–24) and oldest (65+) — report using no social media at all. A small group of heavy users remains, but the middle is thinning out.

Interested in using the PCL-5 to measure PTSD symptoms in your EMA study? We conducted item analysis to examine item thresholds & discrimination parameters & examined DIF across daily surveys www.sciencedirect.com/science/arti...

@matthiasmichel.bsky.social and I are beavering away reading and responding to all the excellent commentaries on our BBS paper outlining an evolutionary account of visual consciousness. In the meantime, if you missed our target article, it's available here: www.cambridge.org/core/journal...

PCI Psychology! psych.peercommunityin.org

We're a month further into the job market - how are things looking? The good news is that the market does seem to have been delayed: ~150 new listings have appeared since my last post. The bad news is that the total is still substantially lower than what it was during the covid dip.

Intervening on a central node in a network likely does little given that its connected neighbors will "flip it back" immediately. Happy to see this position supported now. "Change is most likely [..] if it spreads first among relatively poorly connected nodes." www.nature.com/articles/s41...

Super proud of this collaboration with rockstar Ryan Raut - born out of playing in the sandbox in our last year of grad school! Multi-scale brain activity can be predicted from a simple measure of arousal like pupil diameter. Out with linear causality, in with dynamic systems to explain neurobiology

In this video, Andy Jahn discusses the latest developments in #SPM, the latest release #SPM25 and our recent #SPM Homecoming with the wonderful @corticalpete.bsky.social, @liviasimela.bsky.social and @johmedr.bsky.social. youtu.be/VqzvUPV7pk8?...

Our new paper is out now in Neuron! 🎉 With @vaibhavtripathi.bsky.social @maxwellelliott.bsky.social Joanna Ladopoulou, Wendy Sun, Mark Eldaief, and Randy Buckner Paper link: www.sciencedirect.com/science/arti...

Lab’s latest is out in Imaging Neuroscience, led by Kirsten Peterson: “Regularized partial correlation provides reliable functional connectivity estimates while correcting for widespread confounding”, where we demonstrate a major improvement to standard fMRI functional connectivity (correlation) 1/n

8/ In contrast to standard power calculations, our results suggest that jointly optimizing sample size and scan time can boost prediction accuracy while cutting costs. For more complex study design, you can check out our calculator: thomasyeolab.github.io/OptimalScanT...

1/11 Excited to share our @Naturestudy led by @leonooi.bsky.social @csabaorban.bsky.social @shaoshiz.bsky.social AI performance is known to scale with logarithm of sample size (Kaplan 2020), but in many domains, sample size can be # participants or # measurements... doi.org/10.1038/s415...

Dreaming of a dataset that tracks mood, sleep & activity to better understand affective instability (AI)…AND paired with advanced MRI? 🤯 Check out our new bioRxiv preprint for a 13–23 y/o community sample (n=10 and growing!) with multi-echo fMRI, EMA & actigraphy: www.biorxiv.org/content/10.1...

A putative neural correlate of mood! One big (scandalous?) idea, simple analyses, and the STRONGEST brain/behavior correlation I've EVER seen (which is shocking, given that it's mood). Work with: You-Ping Yang, @catrinahacker.bsky.social and Veit Stuphorn. www.biorxiv.org/content/10.1...

It's shocking how little is known about the brainstem red nucleus. In our new paper “The human brainstem’s red nucleus was upgraded to support goal-directed action” out now in @naturecomms.bsky.social we show that current thinking on the red nucleus is in need of a serious upgrade. rdcu.be/ehbOy

Comment: "Can a single brain cell be surprised?" www.nature.com/articles/s41...

It's finally here! Use the Network Correspondence Toolbox to help contextualize your neuroimaging findings 🧠

Thanks to everyone's feedback, we have updated our calculator to optimize sample size N & scan time T for fMRI studies: leonoqr.github.io/ORSP_Calcula... The first new feature is that users can explore how different N & T leads to different accuracy, e.g., N=1000 & T=30min => 81% max accuracy. 🧵

#gFC - scholar.google.com/citations?vi...

ManyShortT1s - direct.mit.edu/imag/article...

Beyond Mechanism—Extending Our Concepts of Causation in Neuroscience onlinelibrary.wiley.com/doi/10.1111/... - really pleased that this paper with Henry Potter is now published in the European Journal of Neuroscience 😊

Nature Neuroscience The architecture of the human default mode network explored through cytoarchitecture, wiring and signal flow www.nature.com/articles/s41...

Can we use brain scans to identify biologically distinct "autisms"? And If so, how? In our latest cross-species study 🐭👨 with @iitalk.bsky.social we dive into these questions! Find out more here 👇👇 www.biorxiv.org/content/10.1... Thread below 🧵 1/n

Excited to see this now out in the world! We identify a computational basis for how persistent underconfidence is maintained in the face of intact performance, finding that it is grounded in impaired updating of global self-beliefs from local metacognition www.nature.com/articles/s41... 1/N

I don’t know how I missed this. A group in Beijing have developed an effective brain-inspired vision chip for autonomous machines, robotics, and AI that was inspired by our perception/action account of ventral-dorsal visual processing in primate cerebral cortex.🧪🧠 www.nature.com/articles/s41...

The FDA recently approved a novel pain medication developed by Vertex, Journavx (suzetrigine) www.fda.gov/news-events/... 1/n

The white house tried and failed to do this 2017, and will fail again. Also, a good exploration of real ways to increase efficiency and reduce waste in NIH grant funding open.substack.com/pub/goodscie...

An Idiographic Network Approach to Posttraumatic Stress Disorder: Symptom Heterogeneity and Implications for Treatment link.springer.com/article/10.1...

Are we still promoting science in these days of woe? Here's a gift link to a fantastic new paper from @mattmattoni.bsky.social and @olinotom.bsky.social. www.sciencedirect.com/science/arti...

The Unbearable Incoherence of Heritability: Interview with Eric Turkheimer ( @ent3c.bsky.social ) “The empirical end to the Galtonian project is more whimper than bang.” www.psychiatrymargins.com/p/the-unbear...

Confessions of an Ambivalent Psychiatrist A guest essay by the psychiatrist Susan Mahler on her experience of depression (including treatments with ECT) and how she finds herself in a position where both lived and professional experience are failing her www.psychiatrymargins.com/p/confession...

New preprint! 🚨 osf.io/preprints/ps... Traditional categorial frameworks, like the DSM and the ICD, have several key limitations, including heterogeneity within diagnoses, comorbidity issues, arbitrary categorical boundaries, and limited clinical application and utility. 1/

To learn more about the imaging data see the following paper: www.biorxiv.org/content/10.1... For more information about the study and how to download the data see: a2cps.org More data coming soon!

TRANSMITTER Newly characterized striatal circuits add twist to ‘go/no-go’ model of movement control www.thetransmitter.org/basal-gangli...

Trends in Cognitive Sciences The Thermodynamics of Mind id.elsevier.com/as/authoriza...

Article: "SPM 25: open source neuroimaging analysis software" arxiv.org/abs/2501.12081

The brain’s action-mode network — a Perspective by Nico U. F. Dosenbach, Marcus E. Raichle & Evan M. Gordon @ndosenbach.bsky.social @gordonneuro.bsky.social www.nature.com/articles/s41...