Camino de Valencia. Mañana participo en una jornada muy chula sobre comunicación y divulgación científica: #CuentaCienciaIISLaFe. Con gente 🔝: @conchilillo.bsky.social. Kristin Suleng. Carlos Romá. @sergioefe.bsky.social. @bayesana.bsky.social. @raticosdeciencia.bsky.social. Qué ganas.

The outer ear is a mammalian innovation but where did it come from? In our study in Nature, Mathi Thiruppathy and colleagues find that the outer ear arose from modification of an ancestral gill program first originating in marine invertebrates. www.nature.com/articles/s41... 1/n

Evo-devo aficionados, don't miss this really cool paper by @mathithiru.bsky.social, @crumplab.bsky.social et al. Development of the mammalian outer ear and fish gills share regulatory programs (with cross-compatible enhancers!), suggesting a common evolutionary origin of these structures.

📣 Hiring, please forward widely!! Two postdoc openings to work on genomics of diabetes 1. Computational regulatory genomics/statistical genetics. 2. Experimental cell-based modeling DM if interested @crg.eu shorturl.at/O3wMi shorturl.at/ieyZy

How to test the functional impact of non-coding variants in vivo? We developed a new method called dual-enSERT, which can quantitatively compare the effects of enhancer variants in live mouse embryos in under two weeks. www.nature.com/articles/s41... 1/n

Con relación a este nuevo proyecto 2025-2028 nuestro laboratorio del CNB del @csic.es busca candidatos/as graduados/as con máster para realizar una tesis doctoral con una contrato de cuatro años. Interesados/as escribidme por email con vuestro CV y expediente académico.

How do 250k regulatory sequences coordinate 15k genes in mammalian development? Just out: A genomic evidence board to decode the chaos by mapping enhancer-gene interactions across embryonic mouse tissues New resource with Miao Yu, Ming Hu, Bing Ren, and more. www.nature.com/articles/s41...

How can some vertebrates naturally recover from deafness? In work in PNAS, Tuo Shi finds that enhancers for sensory genes remain open but silent in sister cells of zebrafish and lizards, allowing these to make new inner ear sensory hair cells upon damage. www.pnas.org/doi/10.1073/...

Announcing new free ESHG webinar series! 🗓️ Last Wednesday of each month 📅 First episode: Feb 26, 2025 (16:00 CET) 🎤 Speaker: Malte Spielmann 💡 Topic: "The Dark Side of the #Genome: Challenges & Opportunities in the Post-Genomic Era" 🔗 Register now: wma.eventsair.com/eshg-webinar...

A dozen experts on computational biology to bioengineering to AI have been confirmed for the Eighth Annual Mutational Scanning Symposium, May 21st through 23rd in Barcelona, Spain. Registration opens January 20. Learn more: brotmanbaty.org/news/mss-202... @varianteffect.bsky.social

Please check out our new paper showing that the supposed looping factor ZNF143 has no role in chromatin looping: www.cell.com/molecular-ce... And also check out the companion paper from @andersshansen.bsky.social: www.cell.com/molecular-ce...

We have an opening for a PhD student, for a cryo-EM/biochemistry project at the interface of ubiquitin and DNA repair. Enthousiasm and experience with protein biochemistry and/or structural biology really important. Recruitment will fall under the the NKI PhD program, please see below

jobs.exeter.ac.uk/hrpr_webrecr... Interested in data management? Want a permanent position working in beautiful Devon and work collaboratively to support the work of lots of genomics team? Apply!!

🔺🔺🔺RED TRIANGLE ALERT 🔺🔺🔺 Ever wonder how #TADs compare across the tree of life?Look no further & read our Review!!! Find out what genes & 3D chromatin can & can't do in Bacteria! Archeae! Yeast! Plants! Animals! SMCs & RNA-Pol are the only thing they have in common www.nature.com/articles/s41...

By definition, enhancers can activate from a distance. But with increased distance between enhancer and promoter, the activation drops. To study this systematically, we build a synthetic locus: www.cell.com/molecular-ce... 1/12

Very excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)

Honoured to be recognised by @gensocuk.bsky.social and humbled to be named alongside so many incredible geneticists 🤯🧬 But science is a team sport: this is really down to, and for, my absolutely incredible team who inspire, drive, and motivate me every day 🌟 #teamWork #youGuysRock 1/2

The final countdown 😀

Droplet Hi-C enables scalable, single-cell profiling of chromatin architecture in heterogeneous tissues www.nature.com/articles/s41...

🚀 Ready to immerse yourself in a world-class research environment? ✨Take the first step towards your dream career with the #IRBTarget #PhD program. Your future in science starts here! Apply now! ➡️bit.ly/4fPW5Rj @batllelab.bsky.social @milanlab.bsky.social @alejofraticelli.bsky.social

My group's work dissecting the contribution of common variants to rare neurodevelopmental conditions is now out at nature.com/articles/s41..., led by co-first authors Qinqin Huang (not yet on blue sky) and @emiliewigdor.bsky.social . See below for Emilie's tweetorial.