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Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at @nature.com. Congrats to @gracebower.bsky.social who led the study. Below is a brief summary of the main findings www.nature.com/articles/s41... 1/

How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by @ewholling.bsky.social, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease. www.biorxiv.org/content/10.1... 1/

😍 So much fascinating development in this system. These images and movies do justice to how beautiful and complex fish gills are.

-A Gill's Secret Sidekick - A small, often-overlooked organ tucked behind the eye. In zebrafish, the pseudobranch arises from mandibular arch mesenchyme — the same region that forms jaws — and shares gene expression and developmental programs with true gills. 🔬 #FluorescenceFriday #zebrafish

Gills just wanna have #FluorescenceFriday 🎵 Phalloidin reveals the beauty of the filament's distal tip in cleared gills of adult 🦓🐟 #microscopy #devbio #sciart

Gorgeous gills. 😍

Really appreciated this opportunity from @the-node.bsky.social to write about the amazing journey I got to be on for 6 years and the people I met on the way. Every day I feel fortunate to live in and work for a society that chooses to be curious. Now more than ever I hope it continues to do so. ✨

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...

Sox10 is required for systemic initiation of bone mineralization Read this #OpenAccess Research Article by Stefani Gjorcheska, Lindsey Barske & co. @cincyresearch.bsky.social : https://journals.biologists.com/dev/article/152/2/dev204357/365396/Sox10-is-required-for-systemic-initiation-of-bone

Massively parallel reporter assays (MPRAs) testing >680,000 sequences combined with machine learning to improve regulatory element & variant effect prediction. Amazing work by @vagar.bsky.social, Fumitaka Inoue, @jshendure.bsky.social and many others as part of ENCODE. www.nature.com/articles/s41...

Excited to share this story from my PhD revealing the surprising legacy of our gill-bearing ancestry in the form of our cartilaginous outer ears, summarized in this series of Tweets.