Mathi Thiruppathy
@mathithiru.bsky.social
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Mathi Thiruppathy
Katie Mack
4 months ago
I think for me the most compelling answer for "why fund basic research?" (and the one most relevant to the people doing the work) is that humans are curious and finding stuff out makes us happy and fulfilled. Science is a thing humans like. Life would be more dull and sad if we didn't do it. end/🧵
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add a skeleton here at some point
5 months ago
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Mathi Thiruppathy
Evgeny Kvon
7 months ago
Our paper describing the Range Extender element which is required and sufficient for long-range enhancer activation at the Shh locus is now available at
@nature.com
. Congrats to
@gracebower.bsky.social
who led the study. Below is a brief summary of the main findings
www.nature.com/articles/s41...
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Range extender mediates long-distance enhancer activity - Nature
The REX element is associated with long-range enhancer–promoter interactions.
https://www.nature.com/articles/s41586-025-09221-6
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Evgeny Kvon
7 months ago
How do non-coding variants in enhancers lead to disease? Happy to share our recent work, led by
@ewholling.bsky.social
, in which we discovered that poised chromatin sensitizes enhancers to aberrant activation by non-coding mutations, contributing to disease.
www.biorxiv.org/content/10.1...
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😍 So much fascinating development in this system. These images and movies do justice to how beautiful and complex fish gills are.
add a skeleton here at some point
7 months ago
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Mathi Thiruppathy
Mathieu Preußner
9 months ago
-A Gill's Secret Sidekick - A small, often-overlooked organ tucked behind the eye. In zebrafish, the pseudobranch arises from mandibular arch mesenchyme — the same region that forms jaws — and shares gene expression and developmental programs with true gills. 🔬
#FluorescenceFriday
#zebrafish
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Mathi Thiruppathy
Mathieu Preußner
10 months ago
Gills just wanna have
#FluorescenceFriday
🎵 Phalloidin reveals the beauty of the filament's distal tip in cleared gills of adult 🦓🐟
#microscopy
#devbio
#sciart
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Gorgeous gills. 😍
add a skeleton here at some point
11 months ago
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Really appreciated this opportunity from
@the-node.bsky.social
to write about the amazing journey I got to be on for 6 years and the people I met on the way. Every day I feel fortunate to live in and work for a society that chooses to be curious. Now more than ever I hope it continues to do so. ✨
add a skeleton here at some point
11 months ago
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Mathi Thiruppathy
Rita Strack
12 months ago
"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here:
www.nature.com/articles/s41...
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Mathi Thiruppathy
Development
about 1 year ago
Sox10 is required for systemic initiation of bone mineralization Read this
#OpenAccess
Research Article by Stefani Gjorcheska, Lindsey Barske & co.
@cincyresearch.bsky.social
:
https://journals.biologists.com/dev/article/152/2/dev204357/365396/Sox10-is-required-for-systemic-initiation-of-bone
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Mathi Thiruppathy
Nadav Ahituv
about 1 year ago
Massively parallel reporter assays (MPRAs) testing >680,000 sequences combined with machine learning to improve regulatory element & variant effect prediction. Amazing work by
@vagar.bsky.social
, Fumitaka Inoue,
@jshendure.bsky.social
and many others as part of ENCODE.
www.nature.com/articles/s41...
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Massively parallel characterization of transcriptional regulatory elements - Nature
Lentivirus-based reporter assays for 680,000 regulatory sequences from three cell lines coupled to machine-learning models lead to insights into the grammar of cis-regulatory elements.
https://www.nature.com/articles/s41586-024-08430-9
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Excited to share this story from my PhD revealing the surprising legacy of our gill-bearing ancestry in the form of our cartilaginous outer ears, summarized in this series of Tweets.
add a skeleton here at some point
about 1 year ago
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