Bacterial genomes encode a rich repertoire of antiphage systems, but we still know surprisingly little about when these systems are actually expressed. In this preprint, Lucas Paoli et al, ask what shapes antiphage systems expression in native contexts. www.biorxiv.org/content/10.6...

Really excited to say that we have been awarded a BBSRC sLola! Really looking forward to kick off this project with such a fantastic team! @webberma.bsky.social @overtonlab.bsky.social @bugsinblood.bsky.social Sara Jabbari, Dong-Hyun Kim @imibirmingham.bsky.social www.ukri.org/news/powerin...

Interesting CRISPRi screening in Smeg to identify factors modulating resistance to antimicrobials (new insights into the role of the cell envelope)

Many congratulations one more time for an excellent viva! @tosinorababa.bsky.social Fantastic work!!

Very happy to have been involved in the discovery of “pre-methylenomycin C lactone”, a promising new antibiotic from Streptomyces bacteria - #JACS warwick.ac.uk/news/pressre...

#PhDone! Congratulations to Dr @tosinorababa.bsky.social, who passed his viva today 🎉

Fantastic paper by James Bean and colleagues on phage Bas63 - this has been one of the first phages I ever isolated just for fun as a PhD student (in 2012!). It's #2 on this plate of Rhine river water on an E.coli K-12 lawn.... How it started /// How it's going

#microsky #phagesky #phage defence Novel bacterial ubiquitination-like pathway! www.nature.com/articles/s41...

Really interesting interview. @timcoulson.bsky.social and I were also fortunate to chat with David Baker on our podcast which you can catch here: Science Of The Times EP7 Pt2 - Interview with 2024 Nobel Prize winner for Chemistry David Baker youtu.be/jShxgJ3XrWA

R.I.P Hamilton Smith, 1978 Nobel Laureate for the discovery of type II restriction-modification systems (HindII).

Day 26, Give. This virus of bacteriophage Zamilon virophage, might benefit the bacteria (or not). Virophage infect viruses, in particular the giant DNA virus family Mimiviridae. #Drawtober #PhageSky #SciArt

Looking for a PhD? 🚀 MIBTP projects are out lots to explore! 🔬 #Bacteria • #AMR • #Interdisciplinary • FUN! My projects explore how Gram-negative bacteria build and maintain their three-layered cell envelope, using cryo-EM, fluorescence microscopy and biochemistry. warwick.ac.uk/fac/cross_fa...

In a break from recent themes & in honor of World Phage Week (Oct 22-28), some reflections on the world of bacteria and phage, part of a short series explaining the rationale for why we have invested so much time in exploring when microbes get sick too. joshuasweitz.substack.com/p/happy-worl...

www.nature.com/articles/s41... #microsky but kinda #phagesky too

Interesting paper on bacteriophage genomics and bioinformatics 'Phage quest: a beginner’s guide to explore viral diversity in the prokaryotic world' by @sebwielgoss.bsky.social and colleagues academic.oup.com/bib/article/...

Our new paper out on influence of chronic pancreatitis on the gut microbiome. What makes this more special is it is Ryan Marsh’s 1st as corresponding author. doi.org/10.1186/s128...

www.pnas.org/doi/10.1073/... #phagesky #phage defence #synbio #microsky

Very excited to share the latest work from our lab, which was published today in Nature! nature.com/articles/s41... PhD graduate and now post-doc Sofia Dahlman, along with co-senior author Sam Forster from The Hudson and other researchers from our lab and others.

Day 15, Comfort. Phages are safe and protected away from UV light, heat and denaturing chemicals. Maybe they just need comfort of blankets and hot drinks to survive the autumn. #Drawtober #SciArt #PhageSky

Three Bicentenary research fellowships on offer at @officialuom.bsky.social @fbmh-uom.bsky.social for exceptional ECRs with <3y postdoc experience 3yrs salary + £30k pa research expenses Do you have a great idea & want to join @mermanchester.bsky.social? www.bmh.manchester.ac.uk/research/sup...

Our latest work reveals that arbitrium phages cross-communicate across species! These tiny viruses “listen” to signals from others, coordinating lysis-lysogeny decisions across species. Original idea from @albertomarina.bsky.social and, as usual, he was right. www.biorxiv.org/content/10.1...

I have various PhD projects to offer via Midland Integrative Biosciences Training Partnership for candidates that they wish to come to @warwicklifesci.bsky.social. Please check lnkd.in/gQTPnk6W for more info, under the Microbiology section!

www.microbiologyresearch.org/content/jour... #microsky #microbiome from the @gavinhthomas.bsky.social lab in York in collab with Hull

Day 7, Share. Inoviruses are filamentous single stranded DNA phages that can be produced continuously and exported by their host without lysis and killing their host. They have a single repeating major coat protein that covers their length and specialised spike proteins. #Drawtober #SciArt #Phagesky

Day 5, Moon. The physical structures of phages are often compared to the shape and landing action of a lunar lander, with tail fibres reminiscent of the landing struts, to gently settle on the surface of its host. #Drawtober #SciArt #Phagesky

Check it out! A proper team effort from past and present group members and a great collaboration with @sergemostowylab.bsky.social

New preprint! Ever wondered why only a fraction of genomes encode CRISPR immunity? 🧬 🦠 Turns out CRISPR is rarely beneficial against virulent phages, being most beneficial against those for which resistance mutations are rare! An epic effort by Rosanna Wright www.biorxiv.org/content/10.1...

www.cell.com/current-biol... #phagesky #phage

Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols. Thread 1/n

Now peer-reviewed, improved and published in @microbiologysociety.org Microbiology - thanks to editor and reviewers! www.microbiologyresearch.org/content/jour...

Recent paper from the lab studying predictors of phage cocktail efficacy against complex clinical Pseudomonas populations royalsocietypublishing.org/doi/epdf/10.... Led by Rosanna Wright with extraordinary MSc (PhD) student Maisie Czernuska

www.biorxiv.org/content/10.1... #phagesky #phage defence

Excited to annouce the latest research published by our lab, which is led by Dinesh Subedi and is out today in Nature Microbiology. www.nature.com/articles/s41...

Thrilled to share our two latest papers with the @tcostalab.bsky.social lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species. @imperialcollegeldn.bsky.social www.cell.com/cell/fulltex...

Incredibly proud of Dr Revathy who is inspiring the next generation of scientists around the world. And even though we can't see them through a foldscope, bacteriophages are still our favourite microbes 🤩 quadram.ac.uk/blogs/inspir...

So proud of my MBio student Kieran and my team for this exciting work @DrShannonGreer @warwicklifesci.bsky.social #phage #Pseudomonas #biocontrol doi.org/10.1111/1751...

www.nature.com/articles/s41... #phagesky #phage

On #WorldSepsisDay, huge thanks to all the clinicians, nurses, lab professionals & researchers working to detect, treat & prevent #Sepsis. Your advances in diagnostics & therapies save lives every day. 💙 #PatientSafety #GlobalHealth #Infection #CriticalCare #MedTwitter

It begins the 4th annual BSVoM conference with Karen Northshield a survivor of major infection of K. pneumoniae that occurred due to the #Brussles bombings. Thanks to the group @jeanpaulpirnay.bsky.social and her doctor Anaïs Eskenazi she received life-saving #phage therapy. Amazing story!

📣 New preprint alert! Happy to share the first results from our effort to reannotate Pseudomonas #phage proteins of unknown function, using structural bioinformatics. 📄 doi.org/10.1101/2025...

www.biorxiv.org/content/10.1... #phagesky #phage

www.nature.com/articles/s41... #microsky

Phages on the big screen! 🎬 Premiere of a brilliant film about phage therapy by our friend Thomas Häusler - powerful story, a great panel discussion, and inspiring conversations over the apero. 🧬🥂 #PhageTherapy

Hello new phage phollowers! I am shamelessly self-promoting mine and Angus Buckling's relatively new review "Critically evaluating the relative importance of phage in shaping microbial community composition" www.cell.com/trends/micro...

Very honoured to be invited speaker in this fantastic conference! Looking forward to it!

Hello BSVoM Blueskyers, Are you in need of some #phage, #phage therapy and other viruses of microbes conferences?!! 👁️👇🏽 🦠 BSVoM Symposium (Sept 12): Keynotes from @jeanpaulpirnay.bsky.social and @antoniasagona.bsky.social and more!! 🗓️ Abstracts: Aug 8 | Reg: Sept 1 www.bsvom.be/en/abstract-...

Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription. www.cell.com/cell/fulltex... Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.

Because of the forces they have to withstand being whizzed around on #flagellae, flagellotropic #phages are super stable. It turns out that the same super-stability remains long after you adapt to a host bacterium without a #flagellum rdcu.be/ewnzT

How did we get here? Senior scientists should now apply for grant funding to second scientists into admin positions because these scientists could then apply for grant funding … www.nature.com/articles/d41...

Check out our latest preprint! We show that the same antibacterial toxin requires different immunity proteins depending whether it’s intra or extracellular