Zoe Hall
@zoehall-icl.bsky.social
đ€ 63
đ„ 98
đ 9
Associate Professor in Biomedical Mass Spectrometry, Imperial College London
pinned post!
In our new paper with
@louisefets.bsky.social
we show with
#MSI
that drugs can accumulate heterogeneously in
#ovarian
#cancer
and may explain why treatments work well in some patients and not others. Huge congrats to Carmen Ramirez Moncayo, Louise and all authors!
bit.ly/4byaY9W
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Hidden drug reservoirs in cancer cells could explain treatment resistance
Cancer drugs can accumulate in hidden âstorage hubsâ inside tumour cells, creating uneven drug exposure across tumours, according to new...
https://bit.ly/4byaY9W
4 months ago
1
5
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reposted by
Zoe Hall
Nature
5 days ago
Nature research paper: Dietâmicrobiome synergy underlies obesity-associated immunotherapy efficacy
go.nature.com/4vNurMw
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Dietâmicrobiome synergy underlies obesity-associated immunotherapy efficacy - Nature
Diet shapes obesity-associated therapeutic responses to immune checkpoint inhibitors through gut microbial metabolism and host anti-tumour immunity, demonstrated in mouse custom-diet models and human-to-mouse fecal microbiota transplantation experiments.
https://go.nature.com/4vNurMw
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reposted by
Zoe Hall
Nature Metabolism
about 1 month ago
RESEARCH | T Budden, A VirĂłs et al (UoM, UK) Fibroblast lipid metabolism influences squamous cell carcinoma invasion, with distinct pathways affecting oral and lung cancer aggressivenessđ§Ș
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Tissue-specific fibroblast lipid cues impose the rate of epithelial cancer invasion - Nature Metabolism
Tissue-specific fibroblast lipid cues are shown to significantly influence the invasion rate of squamous cell carcinomas (SCCs), with oral and lung fibroblasts promoting aggressive cancer behaviour through distinct lipid metabolic pathways, while dermal fibroblasts, being lipid poor, limit cutaneous SCC invasion.
http://dlvr.it/TT1nsj
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reposted by
Zoe Hall
Cell Metabolism
2 months ago
Online now: Microbial phosphoketolase promotes histone lactylation to improve anti-TNF therapy efficacy in inflammatory bowel disease
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Microbial phosphoketolase promotes histone lactylation to improve anti-TNF therapy efficacy in inflammatory bowel disease
Jiang et al. show that microbial phosphoketolase (PKT) enhances anti-TNF efficacy in inflammatory bowel disease by rewiring macrophage glucose metabolism. Through a lactate-driven H4K12 lactylation-SERT axis, PKT promotes 5-HIAA production to expand Tregs. A prospective clinical trial further demonstrates that PKT-producing Bifidobacterium improves therapeutic outcomes.
http://dlvr.it/TSWjqw
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reposted by
Zoe Hall
Nature Metabolism
2 months ago
RESEARCH | Guo, Li, Wu et al.(Soochow U) A signaling axis promoting glycolysis in colorectal cancer cells, driving extracellular lactylation of CD44 & impairing T cell anti-tumor actionđ§Ș
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Extracellular CD44 lactylation impairs CD8+ T cell function in KRAS-mutant colorectal cancer - Nature Metabolism
TRIP6 phosphorylation triggers a signalling cascade that promotes glycolysis in KRAS-mutant colorectal cancer cells. The resulting lactate accumulation drives extracellular lactylation of CD44 on CD8âș T cells, thereby compromising their anti-tumour activity.
http://dlvr.it/TSSz3J
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reposted by
Zoe Hall
Nature Metabolism
2 months ago
RESEARCH | M Hennequart, KH Vousden et al. (Crick Institute): Loss of ALDH1L2 expression elevates ROS and drives early stages of pancreatic ductal adenocarcinoma development đ§Ș
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ALDH1L2 regulates reactive oxygen species and acinar-to-ductal metaplasia in the pancreas - Nature Metabolism
In the early stages of pancreatic ductal adenocarcinoma (PDAC) development, loss of ALDH1L2 expression elevates reactive oxygen species levels, driving accelerated acinar-to-ductal metaplasia. Decreased ALDH1L2 expression is accompanied by formate overflow, which can be used to monitor PDAC progression.
http://dlvr.it/TSNj3Q
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reposted by
Zoe Hall
The Lancet
3 months ago
Nearly 780 people die every day in Europe from liver diseaseâa largely preventable crisis. A new report from the EASLâLancet Commission calls for urgent policy action to tackle Europeâs rising liver disease burden:
spkl.io/63326AfOqr
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Zoe Hall
Nature Metabolism
3 months ago
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FXRâs double life in bile ducts
Nature Metabolism, Published online: 28 April 2026; doi:10.1038/s42255-026-01528-6Biliary epithelial cells have long been viewed as passive conduits for bile transport. A study in mice now reveals that FXR signalling in these cells maintains a protective barrier, with implications for liver fibrosis therapy.
http://dlvr.it/TSGvGs
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Congratulations to the whole team - happy that
@gruevska.bsky.social
and I could play a small part in this exciting study!
add a skeleton here at some point
3 months ago
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4
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reposted by
Zoe Hall
Nature Reviews Cancer
3 months ago
#Review
đš Metabolic dysfunction associated steatotic liver disease
#MASLD
and alcoholic liver disease
#ALD
drive liver cancer. HeikenwĂ€lder&Co review mechanisms of disease progression and therapeutic advances to reduce cancer risk. đđ
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The versatile interplay between steatotic liver disease and liver cancer - Nature Reviews Cancer
Metabolic dysfunction-associated steatotic liver disease (MASLD) and alcoholic liver disease (ALD) are drivers of liver cancer, promoting its development through chronic liver injury and inflammation. In this Review, Rahbari et al. highlight the distinct pathophysiological mechanisms of progression and therapeutic advancements for MASLD and ALD, emphasizing the need for more tailored approaches to manage these complex diseases and their cancer risks.
http://dlvr.it/TSBQNJ
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Find out how
#lipid
#metabolism
plays a role in
#drugresistance
in
#lungcancer
in our new study from the PhD work of Julia Babuta and collaboration with AstraZeneca!
pubs.acs.org/doi/full/10....
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Altered Sphingolipid Metabolism is Associated with Osimertinib Resistance in Nonsmall-Cell Lung Cancer
Nonsmall-cell lung cancer (NSCLC) accounts for more than 80% of lung cancer cases. Epidermal growth factor receptor mutations (EGFRm) occur in 15 and 40% of NSCLC in Western and Asian populations, res...
https://pubs.acs.org/doi/full/10.1021/acs.jproteome.6c00216?trk=feed-detail_main-feed-card_reshare_feed-article-content
3 months ago
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reposted by
Zoe Hall
Nature Cancer
3 months ago
New REVIEW published
@natcancer.nature.com
! 'Single-cell and spatial profiling in cancer biology and clinical oncology' âïžBy Benjamin Izar, Elham Azizi and co-authors đ
www.nature.com/articles/s43...
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Single-cell and spatial profiling in cancer biology and clinical oncology - Nature Cancer
Izar and colleagues review the insights into cancer biology gained via single-cell analyses and spatial profiling and overview the challenges and opportunities associated with the implementation of th...
https://www.nature.com/articles/s43018-026-01142-1?utm_source=bluesky&utm_medium=social&utm_campaign=natcancer
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8
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reposted by
Zoe Hall
Trends in Endocrinology and Metabolism
3 months ago
Online Now: Lipid signaling networks in pancreatic cancer progression and therapeutic perspectives
#trends
#endocrinology
#metabolism
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Lipid signaling networks in pancreatic cancer progression and therapeutic perspectives
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers, driven by aggressive biology, profound therapy resistance, and scarce treatment options. Beyond classical metabolic rewiring, recent discoveries reveal that lipid metabolism plays a central and previously underappreciated role in PDAC progression. Emerging evidence shows that fatty acids, cholesterol, lysophospholipids, sphingolipids, and oxidized lipid species actively shape oncogenic signaling, influence stromal and immune interactions, and contribute to metastasis and treatment evasion. In this review, we highlight these recent advances and discuss how lipid-driven circuits intersect with major oncogenic pathways, including KRAS effectors and phosphoinositide 3-kinaseâAKT. By integrating mechanistic insights with therapeutic perspectives, we outline new opportunities to exploit lipid-based vulnerabilities in pancreatic cancer.
http://dlvr.it/TRrL6n
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reposted by
Zoe Hall
Nature
4 months ago
Nature research paper: Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion
go.nature.com/4rTbG7w
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Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion - Nature
Insights into the mechanism by which phosphatidylserine functions as a non-classical inhibitory molecule during T cell exhaustion, and how phosphatidylserine-targeting antibodies enhance T cell responses are explored.
https://go.nature.com/4rTbG7w
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9
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reposted by
Zoe Hall
The Lancet
4 months ago
Alcohol-related liver disease could be nearly three times higher than previous estimates, new US study suggests. Find out more in @lancetgastrohep.bsky.social:
spkl.io/63322A0liA
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reposted by
Zoe Hall
Healthcare in Europe
4 months ago
Why do some
#cancer
cells develop treatment
#resistance
? The answer may lie in hidden âstorage hubsâ inside
#tumour
cells, which create uneven drug exposure across tumours, according to new
#research
led by
@louisefets.bsky.social
from đŹđ§
@mrc-lms.bsky.social
.
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âHidden drug storehousesâ could explain treatment resistance in cancer
One of oncologyâs biggest challenges is that the same treatment can work well for some patients but fail completely in others.
https://healthcare-in-europe.com/en/news/hidden-drug-treatment-resistance-in-cancer.html
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7
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In our new paper with
@louisefets.bsky.social
we show with
#MSI
that drugs can accumulate heterogeneously in
#ovarian
#cancer
and may explain why treatments work well in some patients and not others. Huge congrats to Carmen Ramirez Moncayo, Louise and all authors!
bit.ly/4byaY9W
loading . . .
Hidden drug reservoirs in cancer cells could explain treatment resistance
Cancer drugs can accumulate in hidden âstorage hubsâ inside tumour cells, creating uneven drug exposure across tumours, according to new...
https://bit.ly/4byaY9W
4 months ago
1
5
2
reposted by
Zoe Hall
MRC Laboratory of Medical Sciences
4 months ago
New research shows cancer drugs can accumulate in hidden âstorage hubsâ inside tumour cells, creating uneven drug exposure across tumours. This could help explain why some patients respond better to treatment than others & may open avenues towards more personalised therapy approaches in the future.
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Hidden drug reservoirs in cancer cells could explain treatment resistance
Cancer drugs can accumulate in hidden âstorage hubsâ inside tumour cells, creating uneven drug exposure across tumours, according to new research from the MRC Laboratory of Medical Sciences (LMS) and ...
https://lms.mrc.ac.uk/hidden-drug-reservoirs-in-cancer-cells-could-explain-treatment-resistance/
1
5
1
reposted by
Zoe Hall
The Francis Crick Institute
4 months ago
New research from the Crick and
@viblifesciences.bsky.social
has shown how secondary breast cancer tumour cells can reprogram lung cells to supply them with fats for energy and other key functions.
www.crick.ac.uk/news/2026-03...
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Taking advantage of metastatic cancerâs need for fats
Secondary breast cancer tumours reprogram lung cells to feed them energy-rich fats. Could this dependency be their downfall?
https://www.crick.ac.uk/news/2026-03-18_taking-advantage-of-metastatic-cancers-need-for-fats
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7
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reposted by
Zoe Hall
Nature Metabolism
4 months ago
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Lipid-dependent accrual of a subset of monocyte-derived macrophages is essential for tissue regeneration
Nature Metabolism, Published online: 11 March 2026; doi:10.1038/s42255-026-01480-5A distinct lipid-laden subset of monocyte-derived macrophages regulates hepatocyte proliferation and liver regeneration in injured livers, via CD36-mediated signalling.
http://dlvr.it/TRRVDV
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1
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reposted by
Zoe Hall
Nature Reviews Gastroenterology & Hepatology
4 months ago
New online! Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut
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Metabotherapy for intestinal disease: using metabolites to prevent and treat disorders of the gut
Nature Reviews Gastroenterology & Hepatology, Published online: 02 March 2026; doi:10.1038/s41575-026-01178-9Metabolites are important mediators of metabolism at the cellular and organismal levels. This Review explores the concept of metabotherapy, harnessing metabolites to prevent and treat gastrointestinal disorders, providing insights into metabolite classifications and their pathophysiological mechanisms in health and disease and mapping their potential as therapeutic targets.
http://dlvr.it/TRFmL3
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5
3
reposted by
Zoe Hall
Nature Reviews Gastroenterology & Hepatology
5 months ago
New online! Lessons learned from viral hepatitis testing that inform law and policy responses to steatotic liver disease
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Lessons learned from viral hepatitis testing that inform law and policy responses to steatotic liver disease
Nature Reviews Gastroenterology & Hepatology, Published online: 30 January 2026; doi:10.1038/s41575-026-01174-zSteatotic liver disease (SLD), which might lead to cirrhosis and hepatocellular carcinoma, is on the rise worldwide. This Expert Recommendation draws on lessons learned to tackle viral hepatitis and proposes a framework for SLD screening and testing policies.
http://dlvr.it/TQg36r
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1
1
reposted by
Zoe Hall
Nature Metabolism
7 months ago
RESEARCH | JF Feng, W Cheng, JT Yu et al. (Fudan Univ): Using data from the UK Biobank, the authors develop a human metabolome-phenome atlas, including a browsable web tool. đ§Ș
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Mapping the plasma metabolome to human health and disease in 274,241 adults - Nature Metabolism
Using data from the UK Biobank, the authors develop a comprehensive human metabolomeâphenome atlas, including a browsable web tool, to uncover unique metaboliteâtrait and metaboliteâdisease associations with time, and discuss potential causal relationships.
https://bit.ly/4rKPi1C
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reposted by
Zoe Hall
Mike Lange
9 months ago
Excited to share my postdoc work
@olzmannlab.bsky.social
! We found lipid droplets, the cellâs lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
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FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
https://www.nature.com/articles/s41556-025-01790-y
5
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reposted by
Zoe Hall
Nature
10 months ago
Nature research paper: Reprogramming neuroblastoma by diet-enhanced polyamine depletion
go.nature.com/4nLY0to
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Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
https://go.nature.com/4nLY0to
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reposted by
Zoe Hall
Waggoner Lab
10 months ago
TREM2 macrophages are associated with enhanced response to PD-1 blockade in human hepatocellular carcinoma
@miriammerad.bsky.social
www.biorxiv.org/content/10.1...
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8
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reposted by
Zoe Hall
Nature Metabolism
12 months ago
ICYMI:
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The source of dietary fat influences anti-tumour immunity in obese mice
Nature Metabolism, Published online: 25 July 2025; doi:10.1038/s42255-025-01330-wThis study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
https://bit.ly/4ogH27J
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3
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reposted by
Zoe Hall
Nature Reviews Gastroenterology & Hepatology
about 1 year ago
ICYMI: New online! Gut microbiome in metabolic dysfunction-associated steatotic liver disease and associated hepatocellular carcinoma
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Gut microbiome in metabolic dysfunction-associated steatotic liver disease and associated hepatocellular carcinoma
Nature Reviews Gastroenterology & Hepatology, Published online: 07 July 2025; doi:10.1038/s41575-025-01089-1In this Review, Yu and colleagues describe the role of the gut microbiome and the gutâliver axis in metabolic dysfunction-associated steatotic liver disease (MASLD) and MASLD-related hepatocellular carcinoma (HCC). They discuss clinical implications for the diagnosis and treatment of MASLD and MASLD-related HCC.
https://www.nature.com/articles/s41575-025-01089-1?utm_source=bluesky&utm_medium=social&utm_campaign=nrgastro
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reposted by
Zoe Hall
MRC Laboratory of Medical Sciences
about 1 year ago
A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue. A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
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Study reveals the hidden benefits of weight loss on fat tissue
Scientists from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have produced the first detailed characterisation of the changes that weight loss causes in human fat tissue by...
https://lms.mrc.ac.uk/study-reveals-the-hidden-benefits-of-weight-loss-on-fat-tissue/
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Enjoying
#metabolomics2025
in Prague! Just presented some of our work on
#massspec
imaging of
#liver
fibrosis!
@gruevska.bsky.social
about 1 year ago
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12
5
reposted by
Zoe Hall
Agostinis Lab
about 1 year ago
đš Where does
#lipid
peroxidation kick off in
#ferroptosis
? đ„Excited to reveal
#ER
-
#mitochondria
#contactsites
as the ignition point of the lipid peroxidation cascade! Huge kudos to our Maria Livia Sassano
@mariamls.bsky.social
& our amazing collaborators who made this breakthrough possible!
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Endoplasmic reticulumâmitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology
Sassano et al. identify endoplasmic reticulumâmitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...
https://doi.org/10.1038/s41556-025-01668-z
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Great collaboration with
@louisefets.bsky.social
- check out the pre-print and thread below!!
add a skeleton here at some point
about 1 year ago
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5
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reposted by
Zoe Hall
Pieter Dorrestein
about 1 year ago
This is such an incredible paper. Must read if you care about metabolites and cores organ interactions. For me most interesting finding is that the liver is NOT the only organ that converts cholesterol to bile acids. But ther are so many cool onserbwtions
www.cell.com/cell/abstrac...
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Cross-organ metabolite production and consumption in healthy and atherogenic conditions
An atlas mapping organ-specific metabolite production and consumption across various pathophysiological states in pigs shows impaired metabolic activity across organs by a Western diet or hypercholest...
https://www.cell.com/cell/abstract/S0092-8674(25)00512-4
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reposted by
Zoe Hall
Evangelos Triantafyllou
about 1 year ago
Very excited to participate đ
@imperialcollegeldn.bsky.social
Great Exhibition Road Festival: we are exhibiting "Your Liver: The Inside Story", Future Medicine Zone đ§«đ§ȘđŹđ©ș |
@triantafylloulab.bsky.social
&
@zoehall-icl.bsky.social
labs |
@imperialmdr.bsky.social
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5
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Great Exhibition Road Festival is nearly here! We will be exhibiting "Your Liver: The Inside Story" in the Future Medicine Zone.
@gruevska.bsky.social
@triantafylloulab.bsky.social
@imperialmdr.bsky.social
@imperialbrc.bsky.social
See you there!
greatexhibitionroadfestival.co.uk
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Home - The Great Exhibition Road Festival
The Great Exhibition Road Festival is an annual celebration of science and the arts in South Kensington, London.
https://greatexhibitionroadfestival.co.uk
about 1 year ago
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2
2
reposted by
Zoe Hall
Aleksandra Gruevska
about 1 year ago
Excited to present our work at
#EASLCongress
2025 (THU-036-YI). See you tomorrow at 1pm on the Track Hub 2 - Basic science to check how we use
#massspecimaging
and IMC for metabolic profiling of
#liver
fibrosis. Special thanks to our collaborators and funders
@zoehall-icl.bsky.social
0
10
4
reposted by
Zoe Hall
BioMassSpec
about 1 year ago
Maximizing Data Coverage through Eight Sequential Mass Spectrometry Images of a Single Tissue Section
#JASMS
pubs.acs.org/doi/10.1021/...
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Maximizing Data Coverage through Eight Sequential Mass Spectrometry Images of a Single Tissue Section
Typical mass spectrometry imaging (MSI) experiments involve the collection of data from only one class of molecules per section. However, it is often necessary to collect data from different classes o...
https://pubs.acs.org/doi/10.1021/jasms.5c00032
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reposted by
Zoe Hall
Aleksandra Gruevska
about 1 year ago
Very happy and proud to see our work published in Metabolism!
www.metabolismjournal.com/article/S002...
We thank all our collaborators and especially all the patients who contributed to the study. Thank you
@zoehall-icl.bsky.social
for all the support since day one!
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Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver
Steatotic liver disease (SLD), which encompasses various causes of fat accumulation in the liver, is a major cause of liver fibrosis. Understanding the specific mechanisms of lipotoxicity, dysregulate...
https://www.metabolismjournal.com/article/S0026-0495(25)00106-4/fulltext
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2
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Excited to share our latest study in Metabolism, exploring how dysregulated
#sphingolipid
#metabolism
contributes to
#liver
#fibrosis
using
#spatial
#lipidomics
! A huge thank you to
@gruevska.bsky.social
and all the collaborators who made this possible!
www.metabolismjournal.com/article/S002...
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Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver
Steatotic liver disease (SLD), which encompasses various causes of fat accumulation in the liver, is a major cause of liver fibrosis. Understanding thâŠ
https://www.sciencedirect.com/science/article/pii/S0026049525001064
about 1 year ago
0
5
3
reposted by
Zoe Hall
BioMassSpec
over 1 year ago
Spatial Metabolomics in Acute Kidney Injury
#SeminNephrol
#MassSpec
www.seminarsinnephrology.org/article/S027...
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Spatial Metabolomics in Acute Kidney Injury
Acute kidney injury (AKI) is a common condition linked to increased morbidity, mortality, and substantial health care costs both in the United States and globally. Early diagnosis, prompt intervention...
https://www.seminarsinnephrology.org/article/S0270-9295(25)00017-8/abstract
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3
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reposted by
Zoe Hall
Christian Frezza
over 1 year ago
www.nature.com/articles/s42...
Metabolites are not genes. repeat, please!
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Metabolites are not genes â avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism
Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...
https://www.nature.com/articles/s42255-025-01283-0
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reposted by
Zoe Hall
BioMassSpec
over 1 year ago
Development of a Single-Cell Spatial Metabolomics Method for the Characterization of CellâCell Metabolic Interactions
#AC
#MassSpec
pubs.acs.org/doi/10.1021/...
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Development of a Single-Cell Spatial Metabolomics Method for the Characterization of CellâCell Metabolic Interactions
Tumor microenvironment (TME) is characterized by complex cellular composition and high molecular heterogeneity. Characterizing the metabolic interactions between different cells in the TME is importan...
https://pubs.acs.org/doi/10.1021/acs.analchem.5c00384
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