Zoe Hall
@zoehall-icl.bsky.social
📤 54
📥 98
📝 4
Associate Professor in Biomedical Mass Spectrometry, Imperial College London
pinned post!
Excited to share our latest study in Metabolism, exploring how dysregulated
#sphingolipid
#metabolism
contributes to
#liver
#fibrosis
using
#spatial
#lipidomics
! A huge thank you to
@gruevska.bsky.social
and all the collaborators who made this possible!
www.metabolismjournal.com/article/S002...
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Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver
Steatotic liver disease (SLD), which encompasses various causes of fat accumulation in the liver, is a major cause of liver fibrosis. Understanding th…
https://www.sciencedirect.com/science/article/pii/S0026049525001064
7 months ago
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5
3
reposted by
Zoe Hall
Mike Lange
20 days ago
Excited to share my postdoc work
@olzmannlab.bsky.social
! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!
shorturl.at/B5XYD
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FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology
Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.
https://www.nature.com/articles/s41556-025-01790-y
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reposted by
Zoe Hall
Nature
about 2 months ago
Nature research paper: Reprogramming neuroblastoma by diet-enhanced polyamine depletion
go.nature.com/4nLY0to
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Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature
Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.
https://go.nature.com/4nLY0to
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reposted by
Zoe Hall
Waggoner Lab
2 months ago
TREM2 macrophages are associated with enhanced response to PD-1 blockade in human hepatocellular carcinoma
@miriammerad.bsky.social
www.biorxiv.org/content/10.1...
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8
4
reposted by
Zoe Hall
Nature Metabolism
4 months ago
ICYMI:
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The source of dietary fat influences anti-tumour immunity in obese mice
Nature Metabolism, Published online: 25 July 2025; doi:10.1038/s42255-025-01330-wThis study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.
https://bit.ly/4ogH27J
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3
2
reposted by
Zoe Hall
Nature Reviews Gastroenterology & Hepatology
4 months ago
ICYMI: New online! Gut microbiome in metabolic dysfunction-associated steatotic liver disease and associated hepatocellular carcinoma
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Gut microbiome in metabolic dysfunction-associated steatotic liver disease and associated hepatocellular carcinoma
Nature Reviews Gastroenterology & Hepatology, Published online: 07 July 2025; doi:10.1038/s41575-025-01089-1In this Review, Yu and colleagues describe the role of the gut microbiome and the gut–liver axis in metabolic dysfunction-associated steatotic liver disease (MASLD) and MASLD-related hepatocellular carcinoma (HCC). They discuss clinical implications for the diagnosis and treatment of MASLD and MASLD-related HCC.
https://www.nature.com/articles/s41575-025-01089-1?utm_source=bluesky&utm_medium=social&utm_campaign=nrgastro
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reposted by
Zoe Hall
MRC Laboratory of Medical Sciences
4 months ago
A new study, published today in Nature, reveals the hidden benefits of weight loss on fat tissue. A better understanding of how weight loss leads to health improvements at a molecular level could help inform the development of therapies for diseases such as type 2 diabetes in the future.
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Study reveals the hidden benefits of weight loss on fat tissue
Scientists from the MRC Laboratory of Medical Sciences (LMS) and Imperial College London have produced the first detailed characterisation of the changes that weight loss causes in human fat tissue by...
https://lms.mrc.ac.uk/study-reveals-the-hidden-benefits-of-weight-loss-on-fat-tissue/
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Enjoying
#metabolomics2025
in Prague! Just presented some of our work on
#massspec
imaging of
#liver
fibrosis!
@gruevska.bsky.social
5 months ago
0
13
5
reposted by
Zoe Hall
Agostinis Lab
5 months ago
🚨 Where does
#lipid
peroxidation kick off in
#ferroptosis
? 🔥Excited to reveal
#ER
-
#mitochondria
#contactsites
as the ignition point of the lipid peroxidation cascade! Huge kudos to our Maria Livia Sassano
@mariamls.bsky.social
& our amazing collaborators who made this breakthrough possible!
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Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis - Nature Cell Biology
Sassano et al. identify endoplasmic reticulum–mitochondria contact sites as the intracellular location where phospholipid peroxidation first occurs to promote ferroptosis. Manipulating these contact s...
https://doi.org/10.1038/s41556-025-01668-z
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Great collaboration with
@louisefets.bsky.social
- check out the pre-print and thread below!!
add a skeleton here at some point
5 months ago
1
5
0
reposted by
Zoe Hall
Pieter Dorrestein
5 months ago
This is such an incredible paper. Must read if you care about metabolites and cores organ interactions. For me most interesting finding is that the liver is NOT the only organ that converts cholesterol to bile acids. But ther are so many cool onserbwtions
www.cell.com/cell/abstrac...
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Cross-organ metabolite production and consumption in healthy and atherogenic conditions
An atlas mapping organ-specific metabolite production and consumption across various pathophysiological states in pigs shows impaired metabolic activity across organs by a Western diet or hypercholest...
https://www.cell.com/cell/abstract/S0092-8674(25)00512-4
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reposted by
Zoe Hall
Evangelos Triantafyllou
5 months ago
Very excited to participate 😁
@imperialcollegeldn.bsky.social
Great Exhibition Road Festival: we are exhibiting "Your Liver: The Inside Story", Future Medicine Zone 🧫🧪🔬🩺 |
@triantafylloulab.bsky.social
&
@zoehall-icl.bsky.social
labs |
@imperialmdr.bsky.social
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Great Exhibition Road Festival is nearly here! We will be exhibiting "Your Liver: The Inside Story" in the Future Medicine Zone.
@gruevska.bsky.social
@triantafylloulab.bsky.social
@imperialmdr.bsky.social
@imperialbrc.bsky.social
See you there!
greatexhibitionroadfestival.co.uk
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Home - The Great Exhibition Road Festival
The Great Exhibition Road Festival is an annual celebration of science and the arts in South Kensington, London.
https://greatexhibitionroadfestival.co.uk
6 months ago
0
2
2
reposted by
Zoe Hall
Aleksandra Gruevska
6 months ago
Excited to present our work at
#EASLCongress
2025 (THU-036-YI). See you tomorrow at 1pm on the Track Hub 2 - Basic science to check how we use
#massspecimaging
and IMC for metabolic profiling of
#liver
fibrosis. Special thanks to our collaborators and funders
@zoehall-icl.bsky.social
0
10
4
reposted by
Zoe Hall
BioMassSpec
7 months ago
Maximizing Data Coverage through Eight Sequential Mass Spectrometry Images of a Single Tissue Section
#JASMS
pubs.acs.org/doi/10.1021/...
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Maximizing Data Coverage through Eight Sequential Mass Spectrometry Images of a Single Tissue Section
Typical mass spectrometry imaging (MSI) experiments involve the collection of data from only one class of molecules per section. However, it is often necessary to collect data from different classes o...
https://pubs.acs.org/doi/10.1021/jasms.5c00032
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2
reposted by
Zoe Hall
Aleksandra Gruevska
7 months ago
Very happy and proud to see our work published in Metabolism!
www.metabolismjournal.com/article/S002...
We thank all our collaborators and especially all the patients who contributed to the study. Thank you
@zoehall-icl.bsky.social
for all the support since day one!
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Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver
Steatotic liver disease (SLD), which encompasses various causes of fat accumulation in the liver, is a major cause of liver fibrosis. Understanding the specific mechanisms of lipotoxicity, dysregulate...
https://www.metabolismjournal.com/article/S0026-0495(25)00106-4/fulltext
1
2
2
Excited to share our latest study in Metabolism, exploring how dysregulated
#sphingolipid
#metabolism
contributes to
#liver
#fibrosis
using
#spatial
#lipidomics
! A huge thank you to
@gruevska.bsky.social
and all the collaborators who made this possible!
www.metabolismjournal.com/article/S002...
loading . . .
Spatial lipidomics reveals sphingolipid metabolism as anti-fibrotic target in the liver
Steatotic liver disease (SLD), which encompasses various causes of fat accumulation in the liver, is a major cause of liver fibrosis. Understanding th…
https://www.sciencedirect.com/science/article/pii/S0026049525001064
7 months ago
0
5
3
reposted by
Zoe Hall
BioMassSpec
7 months ago
Spatial Metabolomics in Acute Kidney Injury
#SeminNephrol
#MassSpec
www.seminarsinnephrology.org/article/S027...
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Spatial Metabolomics in Acute Kidney Injury
Acute kidney injury (AKI) is a common condition linked to increased morbidity, mortality, and substantial health care costs both in the United States and globally. Early diagnosis, prompt intervention...
https://www.seminarsinnephrology.org/article/S0270-9295(25)00017-8/abstract
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3
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reposted by
Zoe Hall
Christian Frezza
7 months ago
www.nature.com/articles/s42...
Metabolites are not genes. repeat, please!
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Metabolites are not genes — avoiding the misuse of pathway analysis in metabolomics - Nature Metabolism
Pathway analysis, originally developed for gene expression data, has been adapted for metabolomics. However, owing to the unique characteristics and constraints of metabolites compared with genes, pat...
https://www.nature.com/articles/s42255-025-01283-0
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reposted by
Zoe Hall
BioMassSpec
8 months ago
Development of a Single-Cell Spatial Metabolomics Method for the Characterization of Cell–Cell Metabolic Interactions
#AC
#MassSpec
pubs.acs.org/doi/10.1021/...
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Development of a Single-Cell Spatial Metabolomics Method for the Characterization of Cell–Cell Metabolic Interactions
Tumor microenvironment (TME) is characterized by complex cellular composition and high molecular heterogeneity. Characterizing the metabolic interactions between different cells in the TME is importan...
https://pubs.acs.org/doi/10.1021/acs.analchem.5c00384
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