Antibody-lectin chimeras for glyco-immune checkpoint blockade - @jcstark.bsky.social @carolynbertozzi.bskyverified.social go.nature.com/4aRDpk8

I believe that we are about to see a major scientific conflict play out here on BlueSky, for better or for worse. I'll weigh in on this on the blog once I'm sure that I understand everyone's positions:

Just an absolutely gutting essay by Tatiana Schlossberg, a writer, mother of two young children, and cousin of RFK Jr who is dying of leukemia. www.newyorker.com/culture/the-...

Scientific journals: we don’t want you using generative AI because it makes shit up. Same journal: here is an AI summary or evaluation of this paper. This might be more useful than the actual abstract or paper that the authors freaking wrote Same journal: AI cover art which makes no sense? Oooh!

Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp

Biological Chemistry's position is still taking applications. UM is a great place to be a PI, I'd love to see a new membrane biology or lipids expert join our community. This is open for new and established investigators.

Computrs usd a rstrictd alphabt to dsign protins that fold & “mak sns.”

Excited to share our new review on our current understanding of small cell lung cancer (SCLC) heterogeneity and plasticity, led by Gina Duronio in the lab: www.tandfonline.com/doi/full/10....

We are hiring an immunologist. This is a hard money position. We have a very robust research infrastructure. Rowan is rapidly growing, with 20,000+ undergrads, two med schools, and a vet school. Contact me for more details. jobs.rowan.edu/en-us/job/50...

Excited to share our latest work on a new cilia disassembly pathway and a link between this pathway and the neurological disorder focal cortical dysplasia: www.science.org/doi/10.1126/... Brief summary: we used a genome-wide CRISPRa GOF screen to identify negative regulators of ciliary signaling...

ATTN: Two faculty positions are available in my department (neuroscience) at the University of Minnesota. This is a general search with no topic focus. November 20th application deadline. Apply here: hr.umn.edu/jobs/Find-Job Assistant Prof job code: 364920 Associate/Full Prof job code: 364921

This year’s Merck-Banyu Lectureship Award winner is Professor Koji Kubota from Hokkaido University. We are thrilled to welcome him to Stanford Chemistry on Thursday, October 23rd where he will give an exciting lecture on "Exploring Synthetic Mechanochemistry." chemistry.stanford.edu/events/merck...

For the #lovers of #TCRs -we are looking for #postdocs with interest in #functional and #mutational studies -dare to express 700 #self #antigen #specific #TCRs and #study them in #depth!!!!

Why does the naked mole rat have the longest lifespan of any rodent, nearly 40 years? A 30-year long mystery unraveled @ScienceMagazine today! Its cGAS enzyme in cells has 4 missense mutations that upends its function, promoting DNA repair and suppressing inflammation www.science.org/doi/10.1126/...

If you’re around at the #NotchMeetingXIII poster session today, come by to check out Poster #9! 🧬✨ @anna_frontino will be there presenting our shared work on how Jagged1 variants shape liver vascular and biliary development. Stop by to say hi and chat Notch!

CAR T therapy has seen great effectiveness in liquid tumors, but little in solid tumors (e.g. ovarian cancer). Here we developed hyper-migratory CAR TV cells to infiltrate en masse ovarian tumors. (Left: control CAR T cells; right CAR TV cells). Read this here: www.biorxiv.org/content/10.1...

I've been watching as NIGMS works their tails off to get R35 awards out the door before the end of the FY on 30 Sept. They all look great but this one really grabbed my attention. It's about long "noncoding" (lnc) RNA's. Only, this one *does* encode peptides… reporter.nih.gov/project-deta...

Dear scientific community, I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford. my.corehr.com/pls/uoxrecru... my.corehr.com/pls/uoxrecru...

University efficiency drives may have opposite effect, study finds. The administrative burden in Australian universities is most keenly felt by teaching and research staff, according to a study from the University of Melbourne’s faculty of education. www.researchprofessionalnews.com/rr-news-aust...

Bindcraft is awesome! If you haven’t already seen the preprint check out the final pub here. We’ve had nearly 100% success using it for the targets we’ve attempted.

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

Am I crazy or did we just have a convo about how we can't fund cancer research?

Donald Trump cut funding for cancer research by 31% in the first three months of his term. This is an attack on every American family who has loved someone with cancer.

My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑‍🎓 Please RT. It's a great place with world-class expertise in all sorts of biomedical & biological engineering topics like synthetic biology. It's also not in the USA. www.imperial.ac.uk/jobs/search-...

"I would not have dared to dream that metastatic melanoma would become a treatable disease in my lifetime. Yet here we are today, with 43% of people diagnosed with metastatic melanoma living 10 years or more, due to treatments that we broadly refer to as cancer immunotherapy." Barry P. Sleckman, UAB

Hello Community! Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)

Huge opportunity for postdocs gearing up for an academic job search, hosted by @stanford-chemh.bsky.social @berkeleymcb.bsky.social and UCSF!

Actually, flip the headline. It's really "How the Federal Government Became so Dependent on Universities." These competitively awarded, peer reviewed research grants produce tremendous returns on investment. New tech, health, science that benefit all people & businesses in the USA & world.

Congratulations to Iva Greenwald and Gary Struhl for the Gairdner Award for their work on Notch!! It’s so lovely to have some good news in these difficult times. zuckermaninstitute.columbia.edu/columbia-gai...

New preprint, very proud of this one www.biorxiv.org/content/10.1...

There is still time to apply for this funded postdoc position! 👇🏾Applicants must apply using the link in the original post below to be considered. Please apply if interested!

Excited to share this work from the Garcia Lab out today in @naturecomms.bsky.social! We engineer "cytokine adaptors", molecular immune switches that simultaneously block a target cytokine while inducing local activation of alternative cytokine receptors. rdcu.be/ec7GS

New lab tradition alert🚨 Elliot poses with his honorary PhD sword! We got the idea when I was a thesis opponent in Finland, and it was too cool not to implement it here… Congrats again, Elliot!

"NIH" is still "working" on this. They are either just plain stalling or developing "guidance" for the councils to align with administration priorities.

My first PhD student, Elliot Medina, successfully defended his thesis today! And as an added bonus, he got a job offer during his Q&A session! Elliot is an absolute wizard of a structural biologist & protein engineer. I could not have been more fortunate to have him as employee #1 in my lab.

This quote is all I have to go on: "CSR can now begin sending forward Federal Register notices (FRNs) incrementally to begin the resumption of SRG meetings." No idea about council meetings. In any case, sending you courage (and trying to figure out how to be courageous myself!).

Last day to register and submit your abstract for the West Coast Structural Biology Workshop. Don't miss out!! wcsbw2025.macromolecules.xyz

I wrote an opinion piece for my hometown newspaper in Central NY about attacks on NIH/NSF/research and why this harms not just US science but local jobs and economies. Thanks @sciencehomecoming.bsky.social for sparking these efforts! I encourage others to join in! www.syracuse.com/opinion/2025...

What happens when we gut federal science funding?

By crushing cancer research, what are Elon & Trump making more efficient? Their NIH funding cuts are illegal—so instead, they're suffocating the grant approval process for cancer researchers with so much red tape that labs & clinical trials will be forced to shut down.

For readers interested in extracellular targeted protein degradation, here's a comprehensive review of the various strategies that are being explored tinyurl.com/3sef94dx rdcu.be/d9twH

My editorial on the indirect cuts. This is an opportunity for campuses to come together to make the case for higher education. Leaders need to step up and ask for support and lead. www.science.org/doi/10.1126/...

Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/

This is such an important point…

In Florida: NIH Awards Funding: $914 M Jobs Supported: 14,688❗️ Economic Activity Supported: $2.78 B❗️ www.unitedformedicalresearch.org/nih-in-your-...

Can’t believe I’m typing this but… FUCK IT IM PLANNING A STAND UP FOR SCIENCE PROTEST IN DC. If you want to be involved, be dm me. I’m nervous, I’ve never done this before, but we gotta be the change we want to see in the world.

This blue place is picking up speed! With new followers, I think it’s a good time to (re)introduce myself. I’m an assistant professor and a cell biologist at UCSF, where my team explores the function and dynamic regulation of the nuclear lamina. (1/n)

I'm not sure anyone is reading papers during the NIH chaos, but I had a lot of fun writing this review on LAG3! This highlights several recent breakthroughs related to the LAG3 immunosuppression mechanism & provides perspectives on therapeutic targeting. onlinelibrary.wiley.com/doi/full/10....