I've been watching as NIGMS works their tails off to get R35 awards out the door before the end of the FY on 30 Sept. They all look great but this one really grabbed my attention. It's about long "noncoding" (lnc) RNA's. Only, this one *does* encode peptides… reporter.nih.gov/project-deta...

Dear scientific community, I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford. my.corehr.com/pls/uoxrecru... my.corehr.com/pls/uoxrecru...

University efficiency drives may have opposite effect, study finds. The administrative burden in Australian universities is most keenly felt by teaching and research staff, according to a study from the University of Melbourne’s faculty of education. www.researchprofessionalnews.com/rr-news-aust...

Bindcraft is awesome! If you haven’t already seen the preprint check out the final pub here. We’ve had nearly 100% success using it for the targets we’ve attempted.

Exciting to see our protein binder design pipeline BindCraft published in its final form in @Nature ! This has been an amazing collaborative effort with Lennart, Christian, @sokrypton.org, Bruno and many other amazing lab members and collaborators. www.nature.com/articles/s41...

Am I crazy or did we just have a convo about how we can't fund cancer research?

Donald Trump cut funding for cancer research by 31% in the first three months of his term. This is an attack on every American family who has loved someone with cancer.

My dept in London at Imperial (Bioengineering) is recruiting a group leader at Professor level 🧑‍🎓 Please RT. It's a great place with world-class expertise in all sorts of biomedical & biological engineering topics like synthetic biology. It's also not in the USA. www.imperial.ac.uk/jobs/search-...

"I would not have dared to dream that metastatic melanoma would become a treatable disease in my lifetime. Yet here we are today, with 43% of people diagnosed with metastatic melanoma living 10 years or more, due to treatments that we broadly refer to as cancer immunotherapy." Barry P. Sleckman, UAB

Hello Community! Are you a postdoc/grad student preparing to launch a faculty search? Do you have a track record of excellence in research, leadership, mentorship & community engagement? Apply to the 2025 Next Generation Faculty Symposium: www.berkeleystanfordnextgensymposium.com! Pls repost! (1/3)

Huge opportunity for postdocs gearing up for an academic job search, hosted by @stanford-chemh.bsky.social @berkeleymcb.bsky.social and UCSF!

Actually, flip the headline. It's really "How the Federal Government Became so Dependent on Universities." These competitively awarded, peer reviewed research grants produce tremendous returns on investment. New tech, health, science that benefit all people & businesses in the USA & world.

Congratulations to Iva Greenwald and Gary Struhl for the Gairdner Award for their work on Notch!! It’s so lovely to have some good news in these difficult times. zuckermaninstitute.columbia.edu/columbia-gai...

New preprint, very proud of this one www.biorxiv.org/content/10.1...

There is still time to apply for this funded postdoc position! 👇🏾Applicants must apply using the link in the original post below to be considered. Please apply if interested!

Excited to share this work from the Garcia Lab out today in @naturecomms.bsky.social! We engineer "cytokine adaptors", molecular immune switches that simultaneously block a target cytokine while inducing local activation of alternative cytokine receptors. rdcu.be/ec7GS

New lab tradition alert🚨 Elliot poses with his honorary PhD sword! We got the idea when I was a thesis opponent in Finland, and it was too cool not to implement it here… Congrats again, Elliot!

"NIH" is still "working" on this. They are either just plain stalling or developing "guidance" for the councils to align with administration priorities.

My first PhD student, Elliot Medina, successfully defended his thesis today! And as an added bonus, he got a job offer during his Q&A session! Elliot is an absolute wizard of a structural biologist & protein engineer. I could not have been more fortunate to have him as employee #1 in my lab.

This quote is all I have to go on: "CSR can now begin sending forward Federal Register notices (FRNs) incrementally to begin the resumption of SRG meetings." No idea about council meetings. In any case, sending you courage (and trying to figure out how to be courageous myself!).

Last day to register and submit your abstract for the West Coast Structural Biology Workshop. Don't miss out!! wcsbw2025.macromolecules.xyz

I wrote an opinion piece for my hometown newspaper in Central NY about attacks on NIH/NSF/research and why this harms not just US science but local jobs and economies. Thanks @sciencehomecoming.bsky.social for sparking these efforts! I encourage others to join in! www.syracuse.com/opinion/2025...

What happens when we gut federal science funding?

By crushing cancer research, what are Elon & Trump making more efficient? Their NIH funding cuts are illegal—so instead, they're suffocating the grant approval process for cancer researchers with so much red tape that labs & clinical trials will be forced to shut down.

For readers interested in extracellular targeted protein degradation, here's a comprehensive review of the various strategies that are being explored tinyurl.com/3sef94dx rdcu.be/d9twH

Helpful table to determine how much your University or health system is set to lose if the NIH indirect cap is suddenly lowered to 15%. For SJSU it is $374k which is on the smaller end but devastating considering our other budget issues. datawrapper.dwcdn.net/l0ZqA/8/

This is such an important point…

In Florida: NIH Awards Funding: $914 M Jobs Supported: 14,688❗️ Economic Activity Supported: $2.78 B❗️ www.unitedformedicalresearch.org/nih-in-your-...

Can’t believe I’m typing this but… FUCK IT IM PLANNING A STAND UP FOR SCIENCE PROTEST IN DC. If you want to be involved, be dm me. I’m nervous, I’ve never done this before, but we gotta be the change we want to see in the world.

This blue place is picking up speed! With new followers, I think it’s a good time to (re)introduce myself. I’m an assistant professor and a cell biologist at UCSF, where my team explores the function and dynamic regulation of the nuclear lamina. (1/n)

I'm not sure anyone is reading papers during the NIH chaos, but I had a lot of fun writing this review on LAG3! This highlights several recent breakthroughs related to the LAG3 immunosuppression mechanism & provides perspectives on therapeutic targeting. onlinelibrary.wiley.com/doi/full/10....

Ah yes, I see it's the time of year when the Philanthropy Industrial Complex (Big P for short) seeds negative stories about Mackenzie Scott because everything about the way she gives money undercuts their entire model... fortune.com/article/mack...

nudging a figure by 1 millimeter within an MS Word version of your grant

In one year, I genetically engineered the boring Arabidopsis into a beautiful ornamental flower 🧬🌹 Here is how and why I gave this model organism a visual upgrade 🧵(1/7)

The real threat to basic science comes from within science itself - from self-dealing academic medical centers who have hijacked biomedical research funding over the past three decades to build empires of soft-money faculty doing translational research of often dubious value.

🫣 @wendygordon.bsky.social @johntngo.bsky.social

First post on bsky to highlight our latest work on smell receptors (www.nature.com/articles/s41...). Odorant receptors are notoriously challenging to work with - we used a classic strategy from protein engineering to get a peek into how these receptors recognize such a diversity of smells.

Super excited to see our Notch agonists highlighted in Nature @natureportfolio.bsky.social! This protein engineering project was carried out by postdoc David Perez @dhperez.bsky.social and many talented collaborators at Moffitt Cancer Center. www.nature.com/articles/d41...

Cool preprint by ⁦Dustin and coworkers on how various T cell engager formats, w/varying geometries/rigidities, impact synapse structure and potency www.biorxiv.org/content/10.1...

We're looking to recruit a postdoc with expertise in RNA biology to join our glyco-RNA team. Please share. moffitt-cancer-center-careers.hctsportals.com/jobs/1808511...

If you're a postdoc looking for opportunities, we are recruiting another *19* new assistant professors with outstanding startup conditions, as part of the Data-Driven Life Science initiative In Sweden! Check out the people who started a year ago, and apply here: www.scilifelab.se/news/second-...

Announcing the 8th Molecular Perspectives in Protein Protein Interactions Conference, Oct 2025 on the island of Crete! Last year all trainees who gave a talk or a poster received a travel award. Sessions range from protein design to infection and immunity. www.aegeanconferences.org/src/App/conf...

Here’s my spreadsheet of starter packs (>80!) related to broadly ‘mechanistic biology’ plus some intriguing extras Complete with collective nouns I’ve been tracking these but now can’t keep up Hope it’s helpful 2/2 docs.google.com/spreadsheets...

@johntngo.bsky.social @wrgordonlab.bsky.social

Started creating a synthetic biology starter pack. Still missing many so reply here if I forgot you or someone else. go.bsky.app/SjfpxTK #synbio