The Kim Lab (sskimlab.org) at UC Irvine is recruiting motivated grad students interested in uncovering how transcriptional regulators direct cell fates. We accept students through the CMB (cmb.uci.edu) and MCSB (ccbs.uci.edu/education/mcsb/) PhD programs. Please share with prospective grad students!

Less than 70% of science Nobel prize winners awarded this century hail from the country in which they were awarded their prize. “Mobility benefits everyone. Each newcomer brings fresh ideas, new techniques & different ways of looking at old problems” 🧪 #academicSky www.nature.com/articles/d41...

Very happy that the review article by @magnushaughey.bsky.social and Imran Noorani on the evolutionary role of extra-chromosomal DNA in cancers just came out. authors.elsevier.com/sd/article/S...

🚨The formation of 3D chromatin hubs is a poorly understood phenomenon. I wrote a N&V about the excellent work Karpinska, Zhu and colleagues, from @mariekeoudelaar.bsky.social lab, who shed new light on the formation and function of these structures. rdcu.be/elPt3

Excited to share our latest manuscript www.biorxiv.org/content/10.1... This was a great collaboration with Drs. Huse, Lang, @jesserdixon.bsky.social

Incoming - new preprint alert from the Parkes lab led by @brunobeernaert.bsky.social Full bluetutorial follows! 1/ 11 www.biorxiv.org/content/10.1...

🧪 We’re Hiring: Lab Technician 🧪 I’m happy to share that our newly established Emmy Noether Group in Essen is looking for a Lab Technician to join our team! 🔗 Apply here: karriere.ume.de/job-finder/?... 📅 Start: At the earliest possible date 💻 Homepage: kocakavuklab.vercel.app/overview

that’s right

Huge opportunity for postdocs gearing up for an academic job search, hosted by @stanford-chemh.bsky.social @berkeleymcb.bsky.social and UCSF!

Nature Genetics is looking to hire a new editor! Come join our team and help publish the most exciting research in genetics and genomics! Deadline is April 25th. springernature.wd3.myworkdayjobs.com/en-US/Spring...

Earnshaw, Goloborodko, Dekker & Mirny labs are excited to present our latest work, "Rules of engagement for condensins and cohesins guide mitotic chromosome formation" - now accepted!! www.science.org/doi/10.1126/... A short clip describing the key results: www.youtube.com/watch?v=pmvO...

Lookin for a good read in between experiments? Check out the commentary article in @neuroonc.bsky.social @dbayik.bsky.social and I wrote on an insightful study on myeloid cells in gliomas 🙂‍↔️ link here: academic.oup.com/neuro-oncolo...

This is truly heartbreaking! I don’t understand the “logic” behind all this. Hurting the US science will only make scientific enterprises of other countries stronger. Why an administration would want that?

Cancer knows no borders, and setbacks in one part of the world can have lasting consequences for #patients everywhere The #EACR, and all co-signing national #cancer societies & foundations, stand in solidarity and offer our full support to our friends and colleagues in the US #StandUpForScience 🧪

Happy to share our review with @akispapantonis.bsky.social in which we summarise and discuss our current understanding of enhancer-mediated gene activation in the context of the 3D genome: www.annualreviews.org/content/jour...

Review alert - "Modelling and design of transcriptional enhancers" by Seppe and Vasilis 👇

Really excited to share our lab's first manuscript! I cant be more proud of our team, especially @nora-mae.bsky.social who diligently worked on this project. It will be a long thread but I promise it's worth it! #Oncology #BrainMets

Timothy A. Yap, MBBS, PhD, has been appointed editor-in-chief of the AACR journal Clinical Cancer Research. Dr. Yap is co-director for the AACR/ASCO Methods in Clinical Cancer Research Workshop and a past cochair of the AACR Annual Meeting Clinical Trials Committee. www.aacr.org/about-the-aa...

Here is how random things affect your career: in Oct, I applied for my 1st R01. For study sections I recommended CG first and then GRIC. My grant was assigned to GRIC. It seems CG met last week but GRIC was cancelled today. Where should I put this information on my CV/biosketch?!

For all the gains AI affords in compound design and discovery, experimental validation still remains a bottleneck. But we're making that part easy for the cancer target TBXT with a suite of biophysical, in vitro and in vivo assay capabilities—plus prizes for potent binders: tbxtchallenge.org

Multiscale footprints reveal the organization of cis-regulatory elements www.nature.com/articles/s41... ▶️Footprints of DNA–protein interactions from bulk & single-cell ATAC-seq ⤵️ ▶️Deep learning to infer transcription factor and nucleosome binding ▶️Age-associated reduction of nucleosome footprints

All NIH study sections canceled indefinitely. This will halt science and devastate research budgets in universities.

Snow day at the Zoo! ❄️ Lisa our Amur Leopard is choosing to explore the snow this morning. All animals are healthy and doing well. During the wintery weather, our animals have access to their heated barns prepped with extra hay. 📸: John R., Hoofstock & Carnivore Curator

Thrilled to welcome Ziya Gokaslan, M.D., from Brown University to deliver the 29th Annual Leavens Lecture at @mdanderson.bsky.social today! Dr. Gokaslan spoke on spinal surgery and #chordoma.

Hopefully 2025 will be as fun/interesting as it’s mathematically. Happy New Year!!! (Credit: Moshe Verdi - I couldn’t find him here)

🔥We’re hiring! 🌟Positions available: Postdocs, Data Scientists, Software Engineers 🎯 Focus: Spatial Omics—Data Analysis, Pipeline & Method Development ⚙️ Expertise: Bioinformatics, Computational Biology & Pathology, Imaging Data Analysis, AI & ML ✉️ [email protected] 🙏 Please help spread the word

new out in Nature www.nature.com/articles/s41...

www.nature.com/articles/s41... #instability #evolution #cancer

Leonid Mirny and I wrote this for all interested in chromosomes: "The chromosome folding problem and how cells solve it" www.cell.com/action/showP...

Confirmed our recent observation of synergism between gemcitabine and ATR inhibition in two additional cell lines, latest data now on Figshare figshare.com/articles/fig...

Assembloids have emerged as a powerful tool for studying previously inaccessible processes of development and tissue homeostasis. In our article in Cell Stem Cell, we summarize advances in the generation & application of neural and non-neural #assembloids to explore complex cell-cell interactions.