And here is your accompanying editorial: Leveraging Single-Cell Profiling in Early-Phase Trials to Guide Rational Therapy Development url: academic.oup.com/neuro-oncolo...

Darwin's regrets: "If I had to live my life again I would have made a rule to read some poetry and listen to some music at least once every week.. The loss of these tastes is a loss of happiness, and may possibly be injurious to the intellect and more probably to the moral character"

Read this inspiring perspectives coauthored by the Worm Resource directors and worm Nobel Laureates! 4 Nobel Prizes and how they were enabled by major NIH-supported research resources (the Caenorhabditis Genetics Center, WormBase, and WormAtlas) www.pnas.org/doi/10.1073/...

The promise of TIL therapy for glioblastoma www.cell.com/trends/cance... authors.elsevier.com/a/1m5yH8Z12y... @dukeneurosurgery.bsky.social @neurosurgucsf.bsky.social

Yet another great reason to live in Europe!! Multilingualism protects against accelerated aging 😀 An analysis of aging in >86,000 participants across 27 European countries Amoruso et al, Nature Aging 🧪⏳ www.nature.com/articles/s43...

Conrad Hal Waddington was born OTD in 1905. His “epigenetic landscape” is a diagrammatic representation of the constraints influencing embryonic development. On his 50th birthday, his colleagues gave him a pinball machine on the model of the epigenetic landscape. 🧪 🦫🦋 🌱🐋 #HistSTM #philsci #evobio

Even chimpanzees think rationally and weigh the evidence when making a choice ;-) @science.org www.science.org/doi/10.1126/...

Back then, it took almost 40 years for his work to be discovered, and even today science communication remains flawed. We must get better at finding and evaluating science and remember that major discoveries may emerge from non-prestigious institutes and appear in non-glamorous journals.

Senior Research Tech (Duke) – tumor immunobiology lab. Work with tumor/blood/CSF samples, culture patient-derived cell lines, assist single-cell assays, and support & lead research. Bio degree + research exp required. No visa sponsorship. Title may vary. Apply → careers.duke.edu/job-invite/2...

Paul Mischel is championing the importance of odd rings of DNA in tumors—and their promise as targets for cancer therapy @science.org www.science.org/content/arti...

We need to do more to find effective treatments for leptomeningeal metastasis from solid tumors but this commentary from our team shows we are making some progress as a field! @dukemets.bsky.social @dukecancer.bsky.social rdcu.be/eySK8

Are you a top US-based scientist wanting to relocate to Australia? We are now calling for formal applications from both Australian and non-Australian citizens based in the US whose work is internationally recognised as exceptional. 📅 Applications close: Aug 29, 2025 🔗 science.org.au/gtap/?utm_so...

'Using a genome-wide in vivo CRISPR screen, we identified phosphodiesterase 5 & its substrate cGMP as key modulators of DC migration. Advanced tumours disrupted cGMP synthesis in DCs to decrease their motility, while PDE5 perturbation preserved the cGMP pool to restore DC migration' #TumorImmunology

A study has found a promising new way to attack high-grade gliomas (HGG), by targeting the cells surrounding a tumour. The brilliant findings, led by Pofessor Misty Jenkins, Zoe Day and Dr Ryan Cross are now published in Nature’s npj Precision Oncology. www.nature.com/articles/s41...

It seems that only the science community is noticing that NIH and NSF budgets are cut 40% and 55% in the budget bill, respectively. If you live in Maine, West Va, Pennsylvania, Alabama, or Louisiana, CALL YOUR SENATOR as they could make a difference. See below. prospect.org/politics/202...

This would be a great time for everyone to be cool when reviewing manuscripts and *not* request $25,000 worth of new experiments that don’t substantially advance or validate the study...

Delighted to be back in Melbourne to speak at the BCC symposium, listen to exciting scientific presentations and to be with friends @wehi-research.bsky.social @saskiafreytag.bsky.social

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1/3 PLEASE READ, LIKE, REPOST this "1/3" post There is a Senate Hearing May 14th with RFK Jr to discuss Trump's proposed HHS budget. Please find call/email the members of the committee every day until then (I have compiled contact info for the members in post 2/3)

Can an LLM system become conscious? This question has generated significant debate and too much hype. Here's a paper from @cp-trendsneuro.bsky.social on what neuroscience has to say about that shine-lab.org/wp-content/u...

JCI - IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma models www.jci.org/articles/vie...

A Spatial Multi-Omic Framework Identifies Gliomas Permissive to TIL Expansion www.biorxiv.org/content/10.1...

Integrated Proteogenomic Characterization of Glioblastoma Evolution: Overcoming Barriers to Develop Personalized Treatment Strategies dailynews.ascopubs.org/do/integrate...

This #science exciting! Collaborate, #clincaltrials, nurses, scientists - my co-lead H Rizos🤩. #immunotherapy 4 #GBM #glioblastoma Handed draft trial design+drugs to @jimwhittle.bsky.social @braincancercentre.bsky.social @sydneyuni.bsky.social @melanomaau.bsky.social www.nature.com/articles/s41...

Outstanding lecture by Martin van den Bent, receiving the Victor Levin award! #SNO2024 @martinvandenbent.bsky.social @neuroonc.bsky.social @eanoassociation.bsky.social

Congratulations to Mitchel Berger for receiving the Lifetime Achievement Award. #SNO2024 #ScientificMeeting

Great presentations and discussions on serial biopsies and biologically driven designs at the #SNO2024 Biospecimen Workshop @roelverhaak.bsky.social

Small group scholar mentorship #SNO2024

Editorial Scholars Training Session at SNO

Dear new #science #STEM community- @abireland.bsky.social and I are thrilled to share our latest. The basal cell changes everything for #SCLC #plasticity! Despite prevailing dogma, we now believe the basal cell is the most plausible origin for SCLC because:

My first post on Bluesky to celebrate 2 full days of science on #glioblastoma (No stone left unturned) with great discussions with outstanding friends and scientists and many new ideas. Many thanks to the Mark and Sontag Foundations.

Huge resource of MSK-IMPACT "genomes", what a treasure trove! Automated real-world data integration improves cancer outcome prediction www.nature.com/articles/s41...