🚨 New paper alert! Sex and smoking bias in the selection of somatic mutations in human bladder www.nature.com/articles/s41... by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

🚨 new glioblastoma preprint alert! we present the first spatially resolved single cell atlas comparing radionecrotic changes (RN) and recurrent IDH-wildtype glioblastoma (GB) –– shedding light on a long-standing diagnostic challenge. 🧵 1/

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

Don’t miss the YO4YO Virtual Session with Ranjit Bindra & @ekocakavuk.bsky.social How to move from bedside to bench to biotech 📅 8 July 2025 🕒 15:00–16:00 CEST 🔗 buff.ly/Qgnebwk

I am deeply saddened by the passing of Prof. Gazi Yaşargil (1925–2025), the father of microneurosurgery. What an inspirational career devoted to the betterment of medicine and humankind, a legacy that will be carried onward. Rest in peace, Gazi Hocam.

🧵 Ahmed’s @genomedatalab.bsky.social paper on evolution of chemotherapy resistance is out @natcomms.nature.com! We developed DiffInvex - a method tracking how #cancer driver genes change under therapy using ~10k whole-genomes. Key insight: drug resistance often emerges through existing pathways 1/5

🧪 We’re Hiring: Lab Technician 🧪 I’m happy to share that our newly established Emmy Noether Group in Essen is looking for a Lab Technician to join our team! 🔗 Apply here: karriere.ume.de/job-finder/?... 📅 Start: At the earliest possible date 💻 Homepage: kocakavuklab.vercel.app/overview

Evolutionary fingerprints of epithelial-to-mesenchymal transition | @nature.com www.nature.com/articles/s41...

📣 Open computational PhD & Postdoc positions! Excited about the open positions as part of our newly funded Emmy Noether Group are online now under kocakavuklab.vercel.app/joinus 📢 Please RT (what's the bsky equivalent here?) and distribute ! 👇A quick instruction on how to apply

New preprint from the lab - Selective depletion of cancer cells with extrachromosomal DNA via lentiviral infection www.biorxiv.org/content/10.1...

🚀 Fully Funded PhD – AI & Neurodevelopment @ KCL! 🧠💡 Come join us in the IMAGINE lab to develop AI tools for imaging and genetics in neurodevelopmental disorders! Apply here: shorturl.at/Zb4GX For more info, get in touch: [email protected]

Programs, origins and immunomodulatory functions of myeloid cells in glioma | @nature.com www.nature.com/articles/s41...

📣 Open computational PhD & Postdoc positions! Excited about the open positions as part of our newly funded Emmy Noether Group are online now under kocakavuklab.vercel.app/joinus 📢 Please RT (what's the bsky equivalent here?) and distribute ! 👇A quick instruction on how to apply

Assessing the functionality of over 4,000 genome variants for their role in cancer, with prominence of impact for those related to the immune system and chronic inflammation www.nature.com/articles/s41...

📢ONLINE @naturegenet.bsky.social 📰Quantifying cell divisions along evolutionary lineages in #cancer. By Martin Blohmer, Kamila Naxerova and colleagues. ⬇️ www.nature.com/articles/s41...

Wir suchen 2 Oberärzt:Innen (Akute Leukämien und Allo-TX). Wir bieten das gesamte Spektrum der univ. Hämatologie von mol. Diagnostik bis ICU mit einem fantastischen Team. karriere.ume.de/job-finder/?... karriere.ume.de/job-finder/?... Bei Interesse melden Sie sich bitte sehr gerne bei uns!

(1/3) Excited to share our latest work using @depmap.org to uncover a new synthetic lethality in two distinct patient populations! We found that SKI complex inactivation through two independent genomic alterations creates a dependency on PELO #CancerResearch #SyntheticLethality #Genomics #DepMap

What an absolute pleasure to host my mentor @roelverhaak.bsky.social at our West German Cancer Center in Essen today. Fantastic talk in a packed room on #WorldCancerDay2025.

Excited to see Moscot (moscot-tools.org) published in @Nature! We scaled Optimal Transport (OT) in single-cell genomics & added multimodality together with spatiotemporal trajectory inference, finding exciting new biology in the pancreas! 🚀 Read at www.nature.com/articles/s41...

Conventional chemotherapy has successfully cured millions of cancers, yet its mechanism of action remains unclear. In this #Perspective, Letai & de The assess the proposed existing mechanisms, identify gaps in our understanding & suggest principles to improve chemotherapy utility. 📖👉 bit.ly/3C53w8g

Here's our latest, led by Drs. Riaz Gillani & Ryan Collins - we studied a type of inherited genetic event (structural variants) + risk of developing certain cancers in kids: @danafarber.bsky.social @bostonchildrens.bsky.social @broadinstitute.org @science.org www.science.org/doi/10.1126/...

We recently announced a dual new release of intOGen and boostDM Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations ➡️ Compendium of Cancer Driver Genes - www.intogen.org ➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm

1/23 Big news for the #ObenaufLab! So excited to finally share our new study providing another puzzle piece, why immunotherapy fails in many tumors, now out in @Nature 🧵👇 www.nature.com/articles/s41...

🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov

Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...

👉 One click to follow many of the most inspiring researchers around in precision oncology go.bsky.app/xg4Y26 Comment if you want to join the evolving list

Too often we spend only two weeks choosing a problem and then many years trying solving it, but this limits our potential impact. A must read for PhD students: Problem choice and decision trees in science and engineering. pubmed.ncbi.nlm.nih.gov/38608651/

Genomics, evolution, and more starter pack! Help build community with this starter pack. This list is currently incomplete. Want to be included? Reply and I will remedy that! go.bsky.app/JjvzkWU

I created a genomics+bioinformatics starter pack. If I left you off, *please* reply and I'll add you! go.bsky.app/B5YYBfq

Another starter pack of fine fine folks - New PIs! We're all figuring it out together! Please do (self-)nominate go.bsky.app/KJXNgfZ

go.bsky.app/KxWyLE4 Trying to put together a starter pack for journals!

Inspired by the other amazing starter packs - here's one for cancer researchers! I tried to make this broad - from immunology to genomics to cell biology and so much more.. This list also includes organizations & institutes supporting cancer researchers 🧪🔬⚕️🩺 Hope its useful! go.bsky.app/FEoaJMc