Things that help calm the nervous system, quickly: - Box breathing (in for 4, hold for 4, out for 4, hold for 4, repeat) - Immerse your face in cold water (activates mammalian dive reflex) - Humming (stimulates vagus nerve) - Exercise (anything helps, outside even better) - Impeachment and removal

Wow! This is so cool

*Neuroscience and philosophy* Given the philosophical/conceptual naivete of all of neuroscience I will be retiring from my faculty position. I'm now looking for positions at philosophy departments and am happy to start at any level. I went from faculty to postdoc before and am ready again.

Lovely work on autoimmunity and its link to psychosis. I wonder what effect this modulation of NMDA receptors has on HALIPs? Less PPI would seem to be the opposite of a strong prior?

Overall, I am very grateful to EIC Dost Ongur for letting me write the paper I wanted to write! Feedback very welcome—I submitted a medium size personalize grant on this topic in the Netherlands now to do this 'HPCing' in large-scale data.

Hey friends, my new paper was just published in JAMA Psychiatry. I draw on biological species classification to sketch a new framework for psychiatric nosology. Brief summary follows below. Full text link: jamanetwork.com/journals/jam... 🧪 #PsychSciSky #MentalHealth

𝗛𝗼𝘄 𝗱𝗼 𝗯𝗿𝗮𝗶𝗻 𝗮𝗿𝗲𝗮𝘀 𝗿𝗲𝗹𝗮𝘁𝗲𝗱 𝘁𝗼 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻? "High-resolution activity maps of PFC did NOT align with cytoarchitecturally defined subregions." Key tenet in neuroscience is that cytoarchitectonic boundaries correspond to functional ones. NB: study in the mouse #neuroskyence doi.org/10.1038/s415...

Please use full factorial designs in preclinical psychedelic research! I'm guilty of not doing so in the past, but it will be critical for understanding their MOA going forward. We need to be able to directly compare effects in pathology to those healthy organisms

Excellent interview... VERY interesting insights on stress vs mitochodrial energy balance. I wonder how much impact on stress adaptation can be gained by increasing mitochondrial resilience w keto/low carb/ Fasting and the right amount of Exercise stress (hiit, resistance trng)

I had a fantastic discussion about our Allostatic Triage Model of Psychopathology (ATP Model) and the potential mitochondrial and metabolic effects of psychedelics with @metabolicmind.bsky.social Thanks so much for having me on! Check er out: youtu.be/-e49-DwCZ9A?...

Congrats @carmensandi10.bsky.social !!

Metabolism is an energetic circuitry that transcends cellular and organellar boundaries www.nature.com/articles/s42...

Wait so midazolam is an antidepressant? Wut?

Hot off the press!

The way we feel and the psychiatric symptoms some of us end up experiencing could emerge from the way energy flows, or fails to flow smoothly, in mitochondria. The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social www.sciencedirect.com/science/arti...

🚨Publication alert! 🚨 Why does stress drive psychopathology & transdiagnostic disease? We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens. www.sciencedirect.com/science/arti...

Pα+ Psychedelic Bulletin #207 - Lykos Rebrands to Resilient - Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision - AbbVie-Gilgamesh Deal Viewed as Validation - Psilocybin Rescheduling Petition Heads to HHS - Much, much more... psychedelicalpha.com/news/p%ce%b1...

I'm near certain sLFOs are big for psychedelics.

Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!

It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit. You all have my sympathies. Unfair doesn’t even begin to describe it.

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵 www.medrxiv.org/content/10.1...

Such a beautiful project! This is the exact sort of framework we need to advance progress going forward.

Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2) Reporting by @jasteralaina.bsky.social. The entire Dispatch is now free to read. psychedelicalpha.com/news/dispatc...

Since its founding in 2021 by myself and Zarmeen Zahid as Your Brain on Science, it's expanded into Psychedelic Brain Science, to encompass the larger goal of including all things psychedelic including research, policy and culture. Now we’re expanding further to provide services! Check it out!

I’m elated to share our latest publication - out now in @natmentalhealth.nature.com! www.nature.com/articles/s44... - tour de force by @leahbanellis.bsky.social @brainandstomach.bsky.social and the rest of the VMP team!

Check out my keynote & Day 1 dispatch of #GRCPsychedelics 🧠 via @psychedelicalpha.bsky.social psychedelicalpha.com/news/dispatc...

Had a blast at the first ever #GRCPsychedelics - thanks so much to Chairs @alexkwan.bsky.social @vyazovskiy.bsky.social & Vice Chairs @melissaherman.bsky.social @viditavaidya.bsky.social for bringing our community together 🫶 Per usual, I took no pics - but luckily Missy had it covered for me 😂

Attending the first psychedelic GRC organized by @alexkwan.bsky.social & @vyazovskiy.bsky.social was surreal. The internationally representative panels ensure we are collectively/efficiently advancing our understanding of psychedelics. Special thanks to @mayoonthebrain.bsky.social for bringing me ❤️

Bring out the dancing lobsters 🦞🕺 #GRCPsychedelics @sequencemyneuro.bsky.social @fredbarrettphd.bsky.social @tanner-anderson.bsky.social

Everyone approves of the dinner to end the #GRCPsychedelics 🦞 @deffinger.bsky.social @jasteralaina.bsky.social @sequencemyneuro.bsky.social @veronicachelu.bsky.social and Erin Neyhart

Obviously the mitochondria is the best organelle. 1 can leave cell, but stays 2 own genome 3 regulates nuclear gene expression 4 can kill whole cell 5 makes energy, distributes it to orchestrate cellular processes 6 controls whole organisms behavior 7 makes (sex, growth, stress, etc) steroids

Science together climb together - sneaked out with fellow #GRCPsychedelics attendees for a quick session 💪

Great panel this morning on the human and clinical studies of psychedelics - my impression is we have come a long way in the last few years in terms of design and quantification #GRCPsychedelics

@sofiyahupalo.bsky.social @cllantz.bsky.social @sequencemyneuro.bsky.social @oliverk28.bsky.social @christineliu.art @matt-spec.bsky.social @svmahler.bsky.social @callimcflurry.bsky.social @torbenott.bsky.social @mikaelpalner.bsky.social @ramosneuro.bsky.social

🌈🧠 The Trip Between Bedside and Bench 🌈🧠 Join us at #SfN2025 for a deep dive into cross-species research in psychedelic neuroscience! 🧬 Posters, 🎤 panels, 🔑 keynotes, 🍸 cocktails, and 🥟 tasty apps await. RSVP, explore speaker profiles, and help spread the word: 👉 hopkinspsychedelic.org/sfn2025

I had a great time at #GCRpsychedelics, discussing our data on the non-hallucinogenic derivative of LSD, alongside a stellar panel of researchers! Very grateful to @alexkwan.bsky.social and @vladvysotsky.bsky.social for inviting me and putting together a very exciting program!

Thank you #NIMH #NIDA and #BrainInitiative for an informal panel at the #GRCPsychedelics to answer questions regarding grant funding. 🙏

Poster session in full swing. Lots of exciting unpublished work. #GRCPsychedelics

Going to open an escape room where hippocampus researchers have to solve riddles without using space as an explanation for everything

Psilocybin only enhances fear extinction when its hippocampus-dependent (trace/context), and only in a sub-population of mice. Anybody have an explanation? I’ve got ideas, but curious what other are thinking about this ? www.nature.com/articles/s41...

This is from The Tonight Show with Johnny Carson aired on May 20th, 1977. Carl Sagan says something very important, a strong message that didn't lose any validity since then.

Wowzers, a peripheral mitokine,GDF-15 mediates anxiety behavior caused by restraint stress through the GFRAL receptor in the brain stem! “Anxiety-like behaviour elicited by adrenaline or restraint stress is eliminated in mice lacking the GDF15 receptor GFRAL” www.nature.com/articles/s42...

Incredibly grateful to have had the opportunity to visit the Shulgin lab last weekend. Sasha Shulgin discovered the empathogenic properties of MDMA and first synthesized DOI, an important tool for psychedelic research, among myriad other important compounds.

' this study provides evidence of a dementia-preventing or dementia-delaying effect from zoster vaccination ' www.nature.com/articles/s41...

Fascinating! Do we think this vaccine is cross reacting with another virus that contributes to dementia, or that this is explained by other off target effects unrelated to viral pathogens?

Yuge paper! Long awaited CryoEM structures for seven psychedelics.

I'm not sure that our study necessarily implies that one should not average trials - averaging will always have its place. However, our results do show that there is substantial and meaningful variability across trials that is lost when averaging. #neuroscience #neuroskyence

We’ve launched a new clinical trial exploring the efficacy of psilocybin therapy for anorexia nervosa in young adults (age 18 to 25)! Learn more at tiny.ucsf.edu/HTkr9L or take our pre-screen survey to see if you’re a good fit tiny.ucsf.edu/gmvCA3.

This is so cool! Love to see it

Super cool work showing that pleiotropic genes increase trans-diagnostic risk for multiple categories of psychiatric disorders! www.cell.com/cell/abstrac...