Pα+ Psychedelic Bulletin #207 - Lykos Rebrands to Resilient - Pharma Pushes Back on Norway’s Ketamine Reimbursement Decision - AbbVie-Gilgamesh Deal Viewed as Validation - Psilocybin Rescheduling Petition Heads to HHS - Much, much more... psychedelicalpha.com/news/p%ce%b1...

I'm near certain sLFOs are big for psychedelics.

Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!

It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit. You all have my sympathies. Unfair doesn’t even begin to describe it.

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵 www.medrxiv.org/content/10.1...

Such a beautiful project! This is the exact sort of framework we need to advance progress going forward.

Dispatch: The Neurobiology of Psychedelics Gordon Research Conference — Circuitry, Consciousness, and Clinical Horizons (Part 2) Reporting by @jasteralaina.bsky.social. The entire Dispatch is now free to read. psychedelicalpha.com/news/dispatc...

Since its founding in 2021 by myself and Zarmeen Zahid as Your Brain on Science, it's expanded into Psychedelic Brain Science, to encompass the larger goal of including all things psychedelic including research, policy and culture. Now we’re expanding further to provide services! Check it out!

I’m elated to share our latest publication - out now in @natmentalhealth.nature.com! www.nature.com/articles/s44... - tour de force by @leahbanellis.bsky.social @brainandstomach.bsky.social and the rest of the VMP team!

Check out my keynote & Day 1 dispatch of #GRCPsychedelics 🧠 via @psychedelicalpha.bsky.social psychedelicalpha.com/news/dispatc...

Had a blast at the first ever #GRCPsychedelics - thanks so much to Chairs @alexkwan.bsky.social @vyazovskiy.bsky.social & Vice Chairs @melissaherman.bsky.social @viditavaidya.bsky.social for bringing our community together 🫶 Per usual, I took no pics - but luckily Missy had it covered for me 😂

Attending the first psychedelic GRC organized by @alexkwan.bsky.social & @vyazovskiy.bsky.social was surreal. The internationally representative panels ensure we are collectively/efficiently advancing our understanding of psychedelics. Special thanks to @mayoonthebrain.bsky.social for bringing me ❤️

Bring out the dancing lobsters 🦞🕺 #GRCPsychedelics @sequencemyneuro.bsky.social @fredbarrettphd.bsky.social @tanner-anderson.bsky.social

Everyone approves of the dinner to end the #GRCPsychedelics 🦞 @deffinger.bsky.social @jasteralaina.bsky.social @sequencemyneuro.bsky.social @veronicachelu.bsky.social and Erin Neyhart

Obviously the mitochondria is the best organelle. 1 can leave cell, but stays 2 own genome 3 regulates nuclear gene expression 4 can kill whole cell 5 makes energy, distributes it to orchestrate cellular processes 6 controls whole organisms behavior 7 makes (sex, growth, stress, etc) steroids

Science together climb together - sneaked out with fellow #GRCPsychedelics attendees for a quick session 💪

Great panel this morning on the human and clinical studies of psychedelics - my impression is we have come a long way in the last few years in terms of design and quantification #GRCPsychedelics

@sofiyahupalo.bsky.social @cllantz.bsky.social @sequencemyneuro.bsky.social @oliverk28.bsky.social @christineliu.art @matt-spec.bsky.social @svmahler.bsky.social @callimcflurry.bsky.social @torbenott.bsky.social @mikaelpalner.bsky.social @ramosneuro.bsky.social

🌈🧠 The Trip Between Bedside and Bench 🌈🧠 Join us at #SfN2025 for a deep dive into cross-species research in psychedelic neuroscience! 🧬 Posters, 🎤 panels, 🔑 keynotes, 🍸 cocktails, and 🥟 tasty apps await. RSVP, explore speaker profiles, and help spread the word: 👉 hopkinspsychedelic.org/sfn2025

I had a great time at #GCRpsychedelics, discussing our data on the non-hallucinogenic derivative of LSD, alongside a stellar panel of researchers! Very grateful to @alexkwan.bsky.social and @vladvysotsky.bsky.social for inviting me and putting together a very exciting program!

Thank you #NIMH #NIDA and #BrainInitiative for an informal panel at the #GRCPsychedelics to answer questions regarding grant funding. 🙏

Poster session in full swing. Lots of exciting unpublished work. #GRCPsychedelics

Going to open an escape room where hippocampus researchers have to solve riddles without using space as an explanation for everything

Psilocybin only enhances fear extinction when its hippocampus-dependent (trace/context), and only in a sub-population of mice. Anybody have an explanation? I’ve got ideas, but curious what other are thinking about this ? www.nature.com/articles/s41...

This is from The Tonight Show with Johnny Carson aired on May 20th, 1977. Carl Sagan says something very important, a strong message that didn't lose any validity since then.

Wowzers, a peripheral mitokine,GDF-15 mediates anxiety behavior caused by restraint stress through the GFRAL receptor in the brain stem! “Anxiety-like behaviour elicited by adrenaline or restraint stress is eliminated in mice lacking the GDF15 receptor GFRAL” www.nature.com/articles/s42...

Incredibly grateful to have had the opportunity to visit the Shulgin lab last weekend. Sasha Shulgin discovered the empathogenic properties of MDMA and first synthesized DOI, an important tool for psychedelic research, among myriad other important compounds.

' this study provides evidence of a dementia-preventing or dementia-delaying effect from zoster vaccination ' www.nature.com/articles/s41...

Fascinating! Do we think this vaccine is cross reacting with another virus that contributes to dementia, or that this is explained by other off target effects unrelated to viral pathogens?

Yuge paper! Long awaited CryoEM structures for seven psychedelics.

I'm not sure that our study necessarily implies that one should not average trials - averaging will always have its place. However, our results do show that there is substantial and meaningful variability across trials that is lost when averaging. #neuroscience #neuroskyence

We’ve launched a new clinical trial exploring the efficacy of psilocybin therapy for anorexia nervosa in young adults (age 18 to 25)! Learn more at tiny.ucsf.edu/HTkr9L or take our pre-screen survey to see if you’re a good fit tiny.ucsf.edu/gmvCA3.

This is so cool! Love to see it

Super cool work showing that pleiotropic genes increase trans-diagnostic risk for multiple categories of psychiatric disorders! www.cell.com/cell/abstrac...

Of all known technologies, I am most excited about Raman Spectroscopy. Its the closest thing to the Star Treck Tricorder that I'm aware of. Lasers wiggle molecules, and you measure the wiggles to know what it is. Imagine a world where we can scan just about anything and determine its composition?

Reminder: You can always submit a grant late and include a cover letter saying why. NIH receipt and referral may take it. Or not. If you end up missing deadline because of these Commons access issues, there is this potential save move.

I’ll be speaking at the upcoming International Society of Research on Psychedelics (ISRP) virtual conference on March 7, 2025! 🌐 ✨ 24 presentations from psychedelic researchers. ✨ Cutting-edge insights in psychedelic science. ✨ Register here today! #Psychedelics #PsychedelicResearch #ISRP2025

Open to all interested in psychedelics, the upcoming virtual ISRP meeting! Register now and catch up on the latest breakthroughs!

Today is the last day for early bird registration for @ISRPsychedelics! Are psychedelics anti-inflammatory? Come to my talk to find out what we know.

Are psychedelics anti-inflammatory? A systematic review and meta-analysis of studies examining the immunomodulatory effects of serotonergic psychedelics Come see me present at the International Society for Research on Psychedelics on March 7th! (online) www.isrpsych.org/conferences

Would love to chat about this with some bioethicists sometime! It’s a very interesting and unfortunately touchy topic that we really need to discuss out in the open! #bioethics @trpr-ucsf.bsky.social

Home of the?

The (concise) core of my critique of MAPS/Lykos' MDMA-assisted therapy model is now published as a bioethics commentary in AJOB, titled "Focused Bodywork as Facilitated Communication: Cautionary Perspectives on Touch in Psychedelic Therapy": www.tandfonline.com/doi/full/10....

🚨 Save the Date! 🚨 I'm speaking about 4-HO-MiPT analogs at the upcoming International Society of Research on Psychedelics (ISRP) virtual conference on March 7, 2025! 🌐 ✨ 24 presentations ✨ Register here today - www.isrpsych.org/store #Psychedelics #PsychedelicResearch #ISRP2025

How the brain gets rid of its chemical waste through the glymphatics during sleep, via blood vessel oscillations, regulated by norepinephrine. Impeded by Ambien! www.cell.com/cell/abstrac... www.science.org/content/arti...

Big co-1st/corresponding author paper just published in @JAMAPsychiatry! I just can't thank our team enough for their unwavering support on this project. Modifying Informed Consent to Help Address Functional Unmasking in Psychedelic Clinical Trials jamanetwork.com/journals/jam...

Effects of psilocybin in mice depend on context of administration! Psilocybin [5 mg/kg (> 5-10x higher than human dose)] has anxiolytic effects in male and female mice, which were ameliorated (m) or attenuated (f) by concurrent restraint stress. www.sciencedirect.com/science/arti...

Woah.. surprised to see this, but obviously it should be addressed in our public health policies.. my understanding is that topical fluoride on the teeth is highly effective at reducing cavities, but systemic fluoride is less useful in that way.. so keep it in toothpaste, but not water?

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