We were trying to confirm the precens of DMT in the brain and in particularly in serotonin neurons. But to our surprice, DMT is neither in the brain or taken up by serotonin nerve terminals! www.sciencedirect.com/science/arti...

Was interviewed by Double Blind Magazine about the mushrooms extend lifespan hype. They wrote a delightful piece about how much mushroom was given. To quote them "That’s a fuckton of mushrooms for 95% of people". I wonder about how the last 5% are doing? doubleblindmag.com/was-the-life...

Psilocybin as an longevity drug? Not really! I wrote a piece in @theconversation.com about why this claim is way out of proportions. theconversation.com/why-the-magi...

What shifts in our brain when our consciousness shifts? On Sept 8-9, we will explore this question at ESI-SyNC 2025 - with exciting talks, posters and discussions on the neural dynamics of altered consciousness, from psychedelics to breathwork, near-death experiences and meditation. (1/2)

We worked so well as a team for the #GRCPsychedelics @vyazovskiy.bsky.social @viditavaidya.bsky.social @melissaherman.bsky.social and congrats to @theborislab.bsky.social and @mikaelpalner.bsky.social, who will be the future vice-chairs!

Science together climb together - sneaked out with fellow #GRCPsychedelics attendees for a quick session 💪

One more clip from my interview with @mikaelpalner.bsky.social. In this one, he outlines a neurological definition for a psychedelic "microdose" according to binding occupancy at the serotonin receptor. And, of course, what that means. youtu.be/gG3JmDo_liU

Microdosing research is being polluted by a lack of specificity, says Dr. @mikaelpalner.bsky.social youtu.be/0MZy1eLQUxY

I love my new office hallway mates, DEI 💪

@mikaelpalner.bsky.social and I debate the value of removing the psychedelic effect from psychedelic drugs. youtu.be/Qokk8MGkeHY

"The very fact that I am having to publish this anonymously in a country that has the right to free speech written into our Constitution is an indictment of what is happening." www.bmj.com/content/388/...

Visited @jameswjesso.bsky.social **Adventures Through The Mind** podcast to talk about microdosing, psilocybin and translation of psychedelic science from rats to humans. #microdosing #psilocybin

I talk with Dr. Mikael Palner from Southern Denmark University about his research on the effects of chronic low dose (microdose) psilocybin on stress resiliency and compulsive behaviours. www.jameswjesso.com/microdosing-... #psychedelics #microdosing #psychedelicscience

Really feeling the #wcbr, if you are around join us for the panel on micodosing tomorrow afternoon. New research will be presented 🏂🏻

@lizs1.bsky.social I'm happy to comment, I did a scientific study above on microdosing psilocybin in rat. www.nature.com/articles/s41...

With president Trump hitting hard on science in the US, I want to let all my fellow US researchers know that Danish foundation provides quite a lot of postdoctoral and sabattical funding for visiting US citizens. Reach out if you want to know more or collaborate while this goes down.

Are you thinking of measuring synaptic plasticity in the living rat brain? Maybe after psychedelic-induced neuroplasticity, as David E Olson suggests in his recent commentary in the American Journal of Psychiatry Check out our SV2A images using [18F]SynVest-1 #psychedelic #neuroplasticity #invivo

This is a great review of novel measurements of functional connectivity. But how would you explain "structurally informed functional connectivity" to a lay person? Give me your best shot 😀 www.nature.com/articles/s41...

A #ScienceReview from last year highlights the growing recognition of the complex cognitive capacities of #rats and its implications for how they are treated in scientific contexts.

Do serotonergic psychedelics (like LSD, psilocybin, and 2C-B) all induce the same acute changes in brain activity? Our research in rats says they have some common features but also some distinctly different ones. The images below are from our newest preprint.

Klemens Egger analyzed the effects of pharmahuasca on whole-brain metabolism in rats. Interestingly, while the combination of harmine and DMT increased the levels of DMT in the brain significantly, we could measure 5-HT2A occupancy. Additionally, all conditions increased thalamic activity. #dmt

Last year, we used 5-HT2A PET (see my previous post) to establish science-backed psilocybin microdosing in rats based on human occupancy data from Madsen et al. (2019). We proved that microdosing of psilocybin induces behavioral and neurobiological changes in rats! www.nature.com/articles/s41...

Moving to a new lab is fantastic. 🐀 Reconnecting the cables, installing the machines and taking photos through a plastic bag is challenging 🤔

In 2008, Matthias Herth produced [18F]MHMZ, a PET tracer I love. My lab uses it extensively to map the 5-HT2A receptors in living rat brain and measure occupancy of psychedelics, like psilocybin below. Don't tell me 1mg/kg is not enough ;)

How will the world look in 25 years if my research turns out to be a breakthrough? That question was posed to me by Third Ear Studio and Denis Rivin 🔹🔺🔸. In their latest series "2049". We're talking about mental illnesses and psychedelic substances. thirdear.studio/da/pods/2049