After years of development and testing, we are happy to present our work in "Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications"! www.biorxiv.org/content/10.1.... A thread:

Strongest data yet suggesting that repeated MDMA use causes deficits in declarative memory (e.g., memory for new information, words, etc). #psychedelicscience #MDMA 10.1093/brain/awaf391

Hot off the press!

🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵 nature.com/articles/s41... #Neuroscience #Psychedelics #BrainImaging

If you agree to review a paper, you should send it in on time. You're holding a spot and slowing up the whole process if you don't.

I just saw someone use the abbreviation “AI;DR” and I’ll be laughing for a while.

Amazing stuff here from @goliashf.bsky.social and the RBC team! Harmonized and curated imaging and phenotype data from over 6,000 youth easily accessible without any DUA. Check it out.

New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread 👇 www.biorxiv.org/cgi/content/...

I'm near certain sLFOs are big for psychedelics.

Since July 21st, we have a good reason to celebrate the summa cum laude Defense of the newly minted Dr. Hettwer who received her PhD from @hhu.de under the supervision of Prof. Simon Eickhoff @sbe.bsky.social with strongest support of Dr. Sofie Valk! Congratulations Meike!!!🥂👏🏻🥁🎊

"Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity" www.researchsquare.com/article/rs-7...

✨ New paper ✨ in JAMA Pediatrics! We discuss how understanding the timing ⏰ of stressful events relative to neurodevelopment can help us better identify risk factors (looking backward) and predict future psychopathology (looking forward) at the individual level #neuroskyence #devpsych #PsychSciSky

Is it possible to manipulate a high-level visual property while holding ~all low-level visual properties constant? “No!”, you say. Allow @talboger.bsky.social to show you otherwise! Now in press @currentbiology.bsky.social 🐇🐘

Just delighted to see this out in the world !! This is the first installment of SYPRES -- our living meta-analysis + open data resource focused on psychedelics. Led by the incomparable @parkersingleton.bsky.social and @bsevchik.bsky.social. Check it out + and give us your feedback!!!

🍄 Our new living systematic review and meta-analysis on psilocybin for depression is out. Here's what we found and the open science infrastructure we built to support it 🧪🧵 www.medrxiv.org/content/10.1...

@audreycluo.bsky.social has had one of the most impressive graduate careers I've ever seen. Kudos!!!!

Somehow we got almost all the students and postdocs in one photo!! Until next time #GRCPsychedelics 🫡

So happy the first #GRCPsychedelics was such a success. It was great to see everyone and share all the amazing science and community. Thank you to all the speakers and congratulations to the travel awardees!!

Great panel this morning on the human and clinical studies of psychedelics - my impression is we have come a long way in the last few years in terms of design and quantification #GRCPsychedelics

#GRCPsychedelics 🔥🔥🔥🔥poster session and our first ever Honorary Best PI poster award to @zenbrainest.bsky.social 🤣🤣🤣

Science together climb together - sneaked out with fellow #GRCPsychedelics attendees for a quick session 💪

Good morning! An excellent panel today on the evolving theory for explaining psychedelic drug action #GRCPsychedelics

We systematically reviewed 23 in vitro and 26 in vivo electrophysiological studies on psychedelic compounds, with an emphasis on layer 5 pyramidal neurons. Our results challenge the simplified view that psychedelics uniformly increase cortical excitability www.biorxiv.org/content/10.1...

Amazing work by @valeriejsydnor.bsky.social !!!!

yea, that random structure with a hypervalent nitrogen is definitely 5-meo-dmt

I'm both glad and jealous to see that it looks like @ohbmofficial.bsky.social booked a proper club dj this year. #FOMO

#OHBM2025 is here and the champs from @pennlinc.bsky.social have brought their freshest work express from Philly to Brisbane. Thread below . . .please reach out + come say hi -- always looking to talk science + make new friends!!!

📚✨ ~500 Papers. ~30 Researchers & Experts. One Annotated Psychedelics Bibliography... Very excited to share the 2024 edition of Psychedelic Alpha's Interdisciplinary Annotated Psychedelic Research Bibliography, by @michaelhaichin.bsky.social. psychedelicalpha.com/news/the-int...

Dreaming of a dataset that tracks mood, sleep & activity to better understand affective instability (AI)…AND paired with advanced MRI? 🤯 Check out our new bioRxiv preprint for a 13–23 y/o community sample (n=10 and growing!) with multi-echo fMRI, EMA & actigraphy: www.biorxiv.org/content/10.1...

YES!

If you are at #SOBP2025 stop by poster S110 tomorrow evening to see our latest update on SYPRES presented by Brooke Sevchik!

We were Symposium panel at the ASSC Amsterdam 2022. Since, we worked on this paper on #MindBlanking, which we think is a comprehensive coverage of the various questions around the hows of MB. Thank you @cp-trendscognsci.bsky.social for the invitation. Thread🧵 by @thomasandrillon.bsky.social 👇

"Network control energy reductions under DMT relate to serotonin receptors, signal diversity, and subjective experience" 🧪 w/ @christimmermann.bsky.social @andrealuppi.bsky.social Emma E. @leorroseman.bsky.social @robincarhartharris.bsky.social @amykooz.bsky.social www.nature.com/articles/s42...

Finally out! Happy bicycle day.

A much-needed joint effort from five labs to see which behavioral effects of psilocybin in mice are reliable, and which may be spurious 🐁🍄 @theborislab.bsky.social @mazenkheirbek.bsky.social @indigenerd.bsky.social Vikaas Sohal and Stephan Lammel 👏 www.biorxiv.org/content/10.1...

Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🧪 Led by Ling-Xiao Shao and @ItsClaraLiao Funded by @NIH @NIMHgov 📄 Read in @nature.com - www.nature.com/articles/s41... 1/12

Cerebral blood perfusion across biological systems and the human lifespan | doi.org/10.1101/2025... How does blood perfusion map onto canonical features of brain structure and function? @asafarahani.bsky.social investigates ⤵️

It was super fun to contribute to this!

(1/18) Now out on BioRxiv‼️ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health | doi.org/10.1101/2025... Funded by National Institute of Mental Health (NIMH)

Without US academia, you wouldn’t have Google, Apple, Meta, NVidia, Open AI, Tesla, Amazon… and that’s just the tip of the iceberg. In my my mind, the single most powerful engine of economic growth and technological progress in the US and world is our universities.

Can whole-brain imaging of cellular c-Fos signals be used to classify #psychedelics? 🧠🔬💊 Our study by @aboharbf.bsky.social and @pashadavoudian.bsky.social, developing an imaging and machine learning pipeline to test a panel of psychoactive drugs. Paper here 👇 www.nature.com/articles/s41...

Highly recommend!!!

A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it. www.science.org/content/blog...

For my first-ever bluesky post, I'm really excited to share our new preprint "Geometric influences on the regional organization of the mammalian brain" with @alexfornito.bsky.social and a superstar 17-person team! (1/n) www.biorxiv.org/content/10.1...

The river barrel chase scene in that Hobbit film should have gone on longer.

That proud yet mournful feeling when you manage to make it all the way to the end of a Burt's Bees without losing it is what I imagine it to be like watching your kid leave for college.

OK If we are moving to Bluesky I am rescuing my favourite ever twitter thread (Jan 2019). The renamed: Bluesky-sized history of neuroscience (biased by my interests)

New preprint: Insights on Psychedelics: A Systematic Review of Therapeutic Effects In this first systematic review on psychedelic-catalysed insight, we review its prevalence, relationship to dose and time-course, and its link to therapeutic efficacy. osf.io/preprints/os...

Accurate.

We are super excited about this -- the SYPRES initiative for living systematic reviews on clinical trials of psychedelics in psychiatry. All credit to @parkersingleton.bsky.social and the team at #PennLINC + #ACTTION.