Matt Cieslak
@cieslakmatt.bsky.social
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Director of Informatics at PennLINC. Diffusion MRI, open science, computation and statistics
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Matt Cieslak
Joëlle Bagautdinova
14 days ago
Ever wondered how white matter tracts actually map onto the cortical hierarchy and cognition—beyond the usual “projection vs association” labels? Our new preprint tackles exactly that! 🧠✨
doi.org/10.64898/202...
Thread below 🧵
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Anatomical White Matter Tracts Span the Cortical Hierarchy to Support Cognitive Diversity
Long-range white matter (WM) tracts support cognition by enabling communication between distant cortical regions, which are organized along a hierarchy defined by the sensorimotor-to-association (S-A)...
https://doi.org/10.64898/2025.12.20.695692
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Matt Cieslak
Baller Lab
about 2 months ago
Excited to share that our new review, "Depression as a disease of white matter network disruption: Learning from Multiple Sclerosis," is out now in Biological Psychiatry! We propose MS as a powerful model for studying how white matter network changes contribute to depression.
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Depression as a disease of white matter network disruption: Learning from Multiple Sclerosis
Depression is a common and debilitating psychiatric disorder that is associated with substantial morbidity and mortality. For nearly 40 years, scientists have attempted to localize depression in the b...
https://www.biologicalpsychiatryjournal.com/article/S0006-3223(25)01638-5/fulltext
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Matt Cieslak
Ted Satterthwaite
2 months ago
BEYOND delighted to see two brilliant
#PennLINC
alumni --
@valeriejsydnor.bsky.social
+
@lindenmp.bsky.social
-- named by The Transmitter as "Rising Stars of Neuroscience 2025". Super well deserved -- CONGRATS!!!
www.thetransmitter.org/early-career...
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The Transmitter’s Rising Stars of Neuroscience 2025
We recognize the outstanding achievements of 25 neuroscientists who stand to shape the field for years to come.
https://www.thetransmitter.org/early-career-researchers/rising-stars-neuroscience-2025/
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Matt Cieslak
Brooke Sevchik
2 months ago
🧠I am excited to announce that our manuscript introducing a new data resource – PennLEAD (Penn Longitudinal Executive functioning in Adolescent Development) – is now available on bioRxiv. Below are some details highlighting our data resource🧵funded by NIMH R01MH113550
www.biorxiv.org/content/10.1...
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After years of development and testing, we are happy to present our work in "Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications"!
www.biorxiv.org/content/10.1...
. A thread:
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Diffusion MRI Processing in the HEALthy Brain and Child Development Study: Innovations and Applications
The landmark ongoing HEALthy Brain and Cognitive Development (HBCD) study will longitudinally chart brain development in a large sample (projected n=7,200) of infants through age 10 years with multimo...
https://www.biorxiv.org/content/10.1101/2025.11.10.687672v2
2 months ago
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Matt Cieslak
Ariel Rokem
3 months ago
Join us for the
#NeuroHackademy
Neuroimaging and Data Science networking event at this year's
@sfn.org
meeting. Tues. Nov. 18th from 7–9pm at the Marriott Marquis, Grand Ballroom 4. The event is free; food and drink will be available for purchase from the hotel.
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Matt Cieslak
Jonah Padawer-Curry, PhD
3 months ago
🚨 New science alert! Our cross-species study, now in Nature Neuroscience, demonstrates psychedelics distort how we should interpret functional brain imaging. 👇🧵
nature.com/articles/s41...
#Neuroscience
#Psychedelics
#BrainImaging
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Psychedelic 5-HT2A receptor agonism alters neurovascular coupling and differentially affects neuronal and hemodynamic measures of brain function
Nature Neuroscience - Padawer-Curry et al. show that the hallucinogenic 5-HT2A receptor agonist DOI alters neurovascular coupling in mice, with implications for the interpretation of human fMRI...
https://nature.com/articles/s41593-025-02069-z.epdf?sharing_token=EKC7s4NLKHXzwF
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Matt Cieslak
Golia Shafiei
4 months ago
Excited to share that our work introducing the Reproducible Brain Charts (RBC) data resource is now published in Neuron!! 🎉 📚 Read the paper:
authors.elsevier.com/c/1lpaF3BtfH...
🧠 Explore the RBC dataset:
reprobrainchart.github.io
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Matt Cieslak
Ted Satterthwaite
4 months ago
New preprint from stellar IRTG PhD student Amelie Rauland + team on white matter bundle reconstruction! Shows that WM bundles can be reliably extracted from simple 32-direction dMRI & features predict cognition - huge potential for legacy and clinical data. Thread 👇
www.biorxiv.org/cgi/content/...
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Matt Cieslak
Ariel Rokem
5 months ago
New paper alert! This paper describes the work that we have been doing in the last few years to create a software ecosystem for tractometry that is extensible, interoperable, and generally useful.
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Matt Cieslak
Lucina Uddin
6 months ago
Looking for
@theabcdstudy.bsky.social
fMRI timeseries data?It's all in the 6.0 data release, thanks to
@drdamienfair.bsky.social
and team at ABCC 🧠:
docs.abcdstudy.org/latest/docum...
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ABCD-BIDS community collection
https://docs.abcdstudy.org/latest/documentation/imaging/abcc_start_page.html
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Matt Cieslak
Microstructure & Connectivity Lab
6 months ago
(1/4) Our recent work shows DTI-ALPS is confounded by white matter geometry (crossing fibers, undulation, dispersion), ALPS-asymmetry signature (ALPS measures asymmetry of diffusion) occurs throughout all WM, and ALPS-WM is not always orthogonal to PVS
onlinelibrary.wiley.com/share/TPCABU...
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SO COOL
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6 months ago
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Matt Cieslak
Damien Fair
7 months ago
Alert! ... for the child development world!
@fluxsociety.bsky.social
@fitngin.bsky.social
The Healthy Brain and Child Development (HBCD) Study has released its first data wave - it’s massive. Check here:
docs.hbcdstudy.org
and here:
nbdc-datahub.org
Here’s why it matters 🧠🍼
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Matt Cieslak
Golia Shafiei
11 months ago
(1/18) Now out on BioRxiv‼️ Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health |
doi.org/10.1101/2025...
Funded by National Institute of Mental Health (NIMH)
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Reproducible Brain Charts: An open data resource for mapping brain development and its associations with mental health
Major mental disorders are increasingly understood as disorders of brain development. Large and heterogeneous samples are required to define generalizable links between brain development and psychopat...
https://doi.org/10.1101/2025.02.24.639850
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I'm a huge fan of this project
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7 months ago
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Matt Cieslak
Ted Satterthwaite
7 months ago
@kevin-y-sun.bsky.social
will be presenting his work on "Copy Number Variant Risk Scores Are Associated with Personalized Functional Brain Network Topography" Wed, June 25, 13:15 - 15:15 & Thus, June 26, 13:45 - 15:45
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Matt Cieslak
Ted Satterthwaite
7 months ago
@audreycluo.bsky.social
will be presenting her fab work on "Two Axes of White Matter Development" on Wed, June 25, 13:15 -15:15 & Thurs, June 26, 13:45 -15:45; Poster #1010.
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Matt Cieslak
Ted Satterthwaite
7 months ago
@goliashf.bsky.social
is ALSO presenting "Systematic dynamical profiling to discover and manipulate the dynamical regime of the primate brain" Thursday, Jun 26: 9:00 AM – 10:15 AM during the computational dynamics symposium in Room M2.
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Matt Cieslak
Ted Satterthwaite
7 months ago
@goliashf.bsky.social
is presenting (via video, 🥲) "Reproducible Brain Charts: An Open Data Resource for Mapping the Developing Brain and Mental Health" on Friday, Jun 27: 11:30 AM – 12:45 PM. This talk is part the Neuroinformatics and Data Sharing session in Room M3 (Mezzanine Level).
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Matt Cieslak
Ted Satterthwaite
7 months ago
@stevenmeisler.com
is presenting "A quality-rated, analysis-ready release of 26,174 dMRI sessions from the ABCD Study" Friday / Saturday 1810. Wooo!!!!
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reposted by
Matt Cieslak
Baller Lab
8 months ago
The Baller Lab is thrilled to announce that
@elenaccooper.bsky.social
just had her first first-author publication! “Investigating mood and cognition in people with multiple sclerosis: a prospective cross-sectional study protocol” is now published on BMJ Open:
bmjopen.bmj.com/content/15/5/e094733
! 🧠
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Investigating mood and cognition in people with multiple sclerosis: a prospective cross-sectional study protocol
Introduction Multiple sclerosis (MS) is an immune-mediated neurological disorder that affects one million people in the USA. Up to 50% of patients with MS experience depression, yet the mechanisms of ...
https://bmjopen.bmj.com/content/15/5/e094733
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Some very cool imaging sequences in this one
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9 months ago
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10 months ago
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Matt Cieslak
Emily G. Jacobs
11 months ago
THRILLED to see this SI now out addressing the power and potential of focusing our lens on women. H/t to Tali for making space for these ideas to flourish and for a dream team of investigators to contribute!! Advancing the science of women’s health | Science Advances
www.science.org/doi/10.1126/...
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Advancing the science of women’s health
https://www.science.org/doi/10.1126/sciadv.adw5514
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Big update to CuBIDS! Now with even more precise descriptions of protocol variations in your BIDS data.
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11 months ago
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I've been involved with this project since the very beginning and am very happy with how it ultimately turned out. The curation and processing was absolutely painstaking. Congratulations
@goliashf.bsky.social
on an excellent paper!!
add a skeleton here at some point
11 months ago
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Matt Cieslak
Jayson Jeganathan
11 months ago
Do you work on surface MRI such as HCP data? Our paper is finally out in Imaging Neuroscience, showing biases in surface fMRI. The revised ms has many new insights! TLDR: Vertices are much closer to each other in sulci, resulting in (fake) high spatial autocorrelation. (1/5)
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It's hard to overstate what a big deal this paper is:
onlinelibrary.wiley.com/doi/10.1002/...
. Head motion in dMRI is NOT like head motion in BOLD.
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Head Motion in Diffusion Magnetic Resonance Imaging: Quantification, Mitigation, and Structural Associations in Large, Cross‐Sectional Datasets Across the Lifespan
We characterized motion during diffusion MRI scans across 16,995 image sessions and find that (1) modern preprocessing pipelines effectively mitigate motion to the point where biases are not detectab....
https://onlinelibrary.wiley.com/doi/10.1002/hbm.70143
11 months ago
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reposted by
Matt Cieslak
Valerie Jill Sydnor
12 months ago
Cortical maturation unfolds hierarchically, endowing the PFC with extended plasticity. But do timeframes of plasticity vary across PFC layers? With 7T quantitative myelin imaging, EEG, and cognitive data, we uncover heterochronous laminar maturation in the PFC 1/n.
www.biorxiv.org/content/10.1...
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reposted by
Matt Cieslak
Julia Moser
about 1 year ago
Finally out in its polished form 🤩 New methodological avenues that help facilitate looking at individual brain functional organization in developmental populations 👶🧠
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reposted by
Matt Cieslak
Ariel Rokem
about 1 year ago
The scipy conference is one of the most welcoming and most inspiring conferences I have ever attended. It's at the center of a network of collaborators that work together across many different disciplines and sectors to improve scientific computing openly and broadly.
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Matt Cieslak
Ted Satterthwaite
about 1 year ago
We are super excited about this -- the SYPRES initiative for living systematic reviews on clinical trials of psychedelics in psychiatry. All credit to
@parkersingleton.bsky.social
and the team at
#PennLINC
+
#ACTTION
.
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reposted by
Matt Cieslak
Parker Singleton
about 1 year ago
Psychedelic mental health research is booming—but how do we keep up with rapidly evolving evidence? 🌱 Our team proposes a living evidence synthesis approach to ensure clinicians, policymakers, and the public have access to the latest, most reliable data. 🔗
www.nature.com/articles/s44...
🧪🧵
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An initiative for living evidence synthesis in clinical psychedelic research - Nature Mental Health
Renewed interest in psychedelics as treatments for mental disorders has recently emerged, but substantial challenges remain in obtaining evidence from available data to inform clinical decision-making...
https://www.nature.com/articles/s44220-024-00373-4
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reposted by
Matt Cieslak
Jamie Hanson
about 1 year ago
Weak and unstable prediction of personality from the structural connectome
direct.mit.edu/imag/article...
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Matt Cieslak
Steven Strogatz
about 1 year ago
Hi Adam, I take your point that the quadratic formula can be presented in a way that does not inspire understanding or affection. And it sounds like that's how it was taught to you. So let me try to make a better case for it. Here's how I discussed it in my book The Joy of x. (1/9)
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Matt Cieslak
Simon Eickhoff
about 1 year ago
The limiting factor for MRI based prediction of behavioral traits may be neither the imaging nor the pipeline or learning algorith but rather the reliability of the target phenotypes Thought provoking work my Martin Gell et al:
www.nature.com/articles/s41...
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How measurement noise limits the accuracy of brain-behaviour predictions - Nature Communications
Our ability to identify associations between behaviour and brain imaging is important for uncovering markers of cognition and disease. Here, the authors illustrate the importance of the reliability of...
https://www.nature.com/articles/s41467-024-54022-6
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Matt Cieslak
Earl K. Miller
about 1 year ago
Spoiler alert: Yes Can ephapticity contribute to brain complexity?
journals.plos.org/plosone/arti...
#neuroscience
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Can ephapticity contribute to brain complexity?
The inquiry into the origin of brain complexity remains a pivotal question in neuroscience. While synaptic stimuli are acknowledged as significant, their efficacy often falls short in elucidating the ...
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0310640
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Matt Cieslak
Rick Betzel
about 1 year ago
hey -- i'm hiring a postdoc! the ad will be up shortly, but looking for someone with network neuroscience experience (very broadly). the position isn't tied to any specific project/grant, so lots of flexibility in terms of what you'd actually *do*. hmu if you might be interested/want to learn more!
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Matt Cieslak
Tiago Peixoto
about 1 year ago
Good news everyone! A new version of graph-tool is just out!
@graph-tool.skewed.de
graph-tool.skewed.de
Graph-tool is a comprehensive and efficient Python library to work with networks, including structural, dynamical, and statistical algorithms, as well as visualization. 1/N
#networkscience
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Matt Cieslak
Ariel Rokem
about 1 year ago
Grateful to the OHBM communications committee (curiously not yet here?) and particularly to
@audreycluo.bsky.social
for putting together this interview with yours truly:
www.ohbm-com.com/blog/intervi...
, in which I had the opportunity to hold forth on my educational motivations and philosophy
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Interview with Prof. Ariel Rokem, 2024 Winner of the Education Award — OHBM Communications
Dr. Ariel Rokem received the Organization for Human Brain Mapping (OHBM) Education in Neuroimaging Award at the 2024 annual meeting in Seoul, South Korea. Dr. Rokem is a Research Associate Profe...
https://www.ohbm-com.com/blog/interview-with-prof-ariel-rokem-2024-winner-of-the-education-award-1
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Matt Cieslak
Neurosynth
about 1 year ago
Check it out! The future of Neurosynth. We launched Neurosynth Compose: A free and open platform for neuroimaging meta-analysis. NS-Compose makes it easy to perform custom neuroimaging meta-analyses without leaving the browser. It's live, check it out!
compose.neurosynth.org
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neurosynth compose
Neurosynth-Compose App
https://compose.neurosynth.org
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@tsalo.bsky.social
relevant
add a skeleton here at some point
about 1 year ago
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Matt Cieslak
PennLINC
about 1 year ago
Finally, we want to thank the users who have provided feedback and opened bug reports, especially
@erikglee.bsky.social
and Janice Hau, who have provided invaluable feedback on these recent developments. 10/10
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Matt Cieslak
PennLINC
about 1 year ago
Special thanks to
@cieslakmatt.bsky.social
@tsalo.bsky.social
@stevenmeisler.com
@adamraikes.bsky.social
@arokem.bsky.social
@cookni1.bsky.social
for their work getting things over the finish line these last few months. 9/10
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reposted by
Matt Cieslak
PennLINC
about 1 year ago
These are prereleases and we hope users will try them out and let us know about any bugs. We don't plan to add any major features for a little while and are going to focus on fixing any bugs that crop up in the next month or so before releasing 1.0.0. 8/10
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reposted by
Matt Cieslak
PennLINC
about 1 year ago
QSIRecon’s model outputs (e.g., FA, RTOP, etc) are now named according to BEP016. It’s also easy to transform and resample them to template space. 7/10
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reposted by
Matt Cieslak
PennLINC
about 1 year ago
Custom atlases have been difficult to incorporate in the past. QSIRecon now supports external atlases organized as atlas datasets organized according to the Atlas BEP (BEP038). 6/10
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Matt Cieslak
PennLINC
about 1 year ago
QSIRecon is now its own BIDS App, designed to ingress derivatives from QSIPrep, UK Biobank, and HCP-YA. 5/10
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QSIRecon: Reconstruction of preprocessed q-space images (dMRI) — qsirecon 1.0.0rc2 documentation
https://qsirecon.readthedocs.io/en/1.0.0rc2/
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Matt Cieslak
PennLINC
about 1 year ago
Outputs are also more in line with the DWI Derivatives BIDS Extension Proposal (BEP016). 4/10
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