@biorxivpreprint.bsky.social A tonsil organoid model reveals Epstein-Barr virus infected germinal center B cell states during primary infection www.biorxiv.org/content/10.6... @bgewurz.bsky.social @harvardmed.bsky.social @ucirvine.bsky.social

3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis cell.com/cell/fulltex... cell.com/cell/fulltex... www.cell.com/cell/fulltex...

What drives pathogenic B-cell activation in autoimmunity & certain cancers? @bgewurz.bsky.social & team show stimulation of B cells with pathogenic triggers strongly induces BCAT1, which localized to lysosomal membranes to support metabolic needs: www.jci.org/articles/vie...

#NewResearch Lysine-specific histone demethylase complex restricts Epstein–Barr virus lytic reactivation @bgewurz.bsky.social #microsky www.nature.com/articles/s41...

Interesting that ebv oncogene lmp1 is suggested to be related to multiple sclerosis in the study. among other things, the CD40 mimic LMP1 upregulates b cell antigen presentation to and activation of T cells.

The cancers with the highest cure rates are actually childhood cancers, partly because most of these kids are in clinical trials, which is how we advance science

This is taken for granted, but very literally change the world

More than 2 million people in the U.S. will be diagnosed with cancer this year. Now is not the time to pull back on discovering new cancer treatments, screening methods, and cures. Join us and urge Congress to continue to invest in #CancerResearch. Every moment counts. ⬇️

Yo-we can't buy your products if you don't labor to reverse the funding freeze, and you'll have to close your plant in Mebane NC @milliporesigma.bsky.social @thermofishersci.bsky.social @sigmaaldrich.bsky.social

This is for study, but raises the question of whether EBV is driving this as well. The relative risk between EBV and multiple sclerosis is higher than that between smoking and lung cancer, based on a study of military members who were EBV negative at time of recruitment.

"Cuts to the HHS workforce have the potential to dismantle the critical government infrastructure that has played a pivotal role in cancer survivorship for 18 million individuals who are alive today in the U.S. resulting in more suffering from cancer nationwide." - @llacasseacscan.bsky.social

Can you explain your doctoral research through interpretive dance? The 17th annual #DanceYourPhD competition is open! Submit by 28 March for a chance to win $2000: https://scim.ag/4gKMnz9

Cool title for a review on bacterial subversion of host cell pathways

Are you travelling abroad soon? Open the Uber app. Click Account. Click Wallet. Click Preferred Currency. Select No Preferred Currency - always pay in the local currency of your ride. If you don't select this, Uber will add a 1.5% conversion fee to your trip fare.

CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach https://go.nature.com/42XLYpK

It was wonderful to have Italo Tempera join us in Boston today for a seminar and visit

NIH freeze on grants, indirect-cost research cuts lead young scientists to look at opportunities abroad. "A fire sale on American academics right now."

This is outstanding. All academic scientists should be required to watch this.

JUST IN: A federal judge in Massachusetts has blocked the Trump administration's rate change to NIH grants. storage.courtlistener.com/recap/gov.us...

CRISPR-Cas, cheap genomic sequencing, mRNA vaccines and other products, paired with AI protein folding prediction technology (eg Alphafold) are the likely core of the next big thing. and it's where a big chunk of 2 decades of US R&D have gone. Cumulative US R&D by top spenders / by sector, 2004-2023

This Sunday, students who live in Boston and their families have free access to nine of the City’s world-class cultural institutions through #BostonFamilyDays. Before heading out tomorrow, please check the institutions’ websites for closures and schedule changes.

Your Action Is Needed! Congress needs to hear from scientists. Call your representatives to oppose funding freezes and restrictions on research. Find contact info at govtrack.us and make your voice heard today! #SciencePolicy www.ascb.org/science-poli...