If any1 wants to try my very unpolished and unfinished TUI plasmid editor in its very pre-alpha form, I reserved a slot on the ol pip bandwagon. Just type in: pip install splicecraft and I recommend runnin this often to update: pip install --upgrade splicecraft It's a WIP 💚

Absolutely amazing. When I started grad school there, Scripps hadn't conferred a single PhD and wasn't accredited. My son is graduating college this year, which makes me positive: my folks must have thought I was insane.

Researchers invented a fake disease to test the spread of misinformation, and it worked a little too well. ChatGPT gave medical advice for 'bixonimania,' found in bogus preprints that thanked Starfleet Academy. They were only preprints, but it does highlight a significant area of concern. #MedSky

I *really* like the Artemis II crew. At a moment when our nation is ruled by our worst it is inspiring to see some of our best at work. They chose the name Integrity for their spacecraft. That speaks volumes.

CSR to continue the one-third triage cutoff for NIH grant review drugmonkey.wordpress.com/2026/04/06/c...

apple.news/A7pRmoOMpT72... Sharing w/feedback to illustrate that there’s no ‘normal’ grief. My take is different. I ignored calls after finding my spouse’s corpse. I’m stoic & taciturn, calls felt too demanding. I appreciated texts, but what made me most grateful was any invitations to share a meal.

For sure, there is no normal grief. I appreciated texts, and meals, and calls, and generally any kind of help (w 2 kids) after losing a spouse. Initially the outpouring of support was significant, but after ~10 mos that started to fizzle. But grief doesn’t fizzle, it may just change its form.

Written by a multiple myeloma patient, who dug into the history behind revlimid’s discovery, and remarkable pricing history.

“ Rather than cutting or barely restoring funds, Congressional and administration leaders should commit to 10 years of steady increases in overall science funding of at least 6% per year. Over a dozen years, this would double the nominal dollar investment in science…” 🧪

Do you want cancer treatment improvements to continue: support fundamental research at NIH and NSF and its translational follow-up! Write Congress! 🧪

Written by a multiple myeloma patient, who dug into the history behind revlimid’s discovery, and remarkable pricing history.

Revlimid has its origin in a pill that cost patients $7.50 each. Decades later, the cancer drug costs more than $18,000 for a month’s supply — even though it still only costs about 25 cents to manufacture. (Published May 2025)

I’m amazed. It’s really true: BA.3.2 (new COVID lineage) is infecting children at a much higher rate than previous lineages. I’m late to this party, but I couldn’t really believe it was true until I did the analysis for myself. 1/

“ Rather than cutting or barely restoring funds, Congressional and administration leaders should commit to 10 years of steady increases in overall science funding of at least 6% per year. Over a dozen years, this would double the nominal dollar investment in science…” 🧪

New York Times article exploring the scientific brain drain to Europe. [Gift link] www.nytimes.com/2026/04/04/b...

This type of valuation in biotech would typically require one or more drugs deep in human clinical trials.

Proof that a scientist who actually remembers what lab was like during the "first one in lab picks the music" era... InPrep still has only 224 followers after publishing all these absolute bangers. (or maybe it's the youngs who haven't bothered with Bluesky 🤷)

Massive budget cuts for US science proposed again by Trump administration www.nature.com/articles/d41...

The President's fiscal year 2027 Budget was released today. Important---Important---Important The President's Budget is always fundamentally a political document that Congress may or may not (usually not) take very seriously. www.whitehouse.gov/wp-content/u... 1/9

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

Very cool 🧪🧵re mitochondrial genome partitioning

Here's the full Trump-Vought FY27 budget proposal. www.whitehouse.gov/wp-content/u... It lists NIH as "-$5 billion" with a top line budget of $41B. The math doesn't math tho bc FY26 budget was $48.7, making $41B a $7.7B (not $5B) cut. Also calls to eliminate NIMHD, FIC & NCCIH.

Trump wants $200B of our taxpayer $ to fund his war with Iran, without a plan, which bombed an all girl’s school. He wants a 20% cut to the #NIH budget. Screw scientists & the future of next gen innovators. The war is way more important to this administration. 🧪 rollcall.com/2026/03/27/s...

New awards These are still lagging well below the curves for other years. 3/5

IRES elements are real but also have been a locus of scientific dispute for decades. Craig's terrific thread discusses a new paper that reports real progress on the thorny underlying technical issues. This 2005 review from M. Kozak provides a sense of how heated the discussion has been.

gift link www.nytimes.com/2026/03/31/h...

If FDA does this, which is likely succumbing to pressure from RFK Jr, it crosses a new red line and, as far as I know, unprecedented. Lifting a ban on drugs that are injected into the bloodstream without data for safety or efficacy, so they can be compounded and further promoted to Americans.

New paper from Stefano Piccolo and colleagues. "3D morphogenetic blueprint for metastatic outgrowth in breast cancer" We contributed the 3D reconstructions using CODA. More here: www.sciencedirect.com/science/arti...

Intensity of exercise vs volume of physical activity made a difference for lower risk of 8 diseases and all-cause mortality among 96,000 UK Biobank participants, especially notable for immune-mediated (IMID). VPA-vigorous physical activity academic.oup.com/eurheartj/ad...

Just saw a post shared on the other site saying that NASA isn't inspiring because it does science... And you can either be inspiring by launching random junk into space or you can do science ... I really hope the majority of people still see the beauty and inspiration in understanding the universe.

The hardest part of science is posing the right question, not answering it.

#NIH awards K99 to post doctoral researchers to help them become independent scientists. These are the next gen scientists that propel research forward. Early career scientists feel the brunt. For ongoing studies, data goes unanalyzed when funding was terminated abruptly. 🧪 archive.today/hr4uJ

Last night, the ISS captured a stunning aurora between Antarctica and Australia. Check out the incredible timelapse created by our astronaut photographer!

As I prepare for yet another NIH study section with low pay lines & a non-scientific political review post council meeting it is hard not to wonder - WTF But we cannot quit. We must hold the line & our integrity at every opportunity 💙 @princess-vimentin.bsky.social spklr.io/6043EyVh7?fb...

A nicely structured and lucid analysis of the state of therapeutic development for Huntington's Disease and why there's so much cool stuff happening now. By Eric Green of Trace Neuroscience on the @lifescivc.bsky.social blog.

Dr. Jonas Salk March 29, 1954

In case you were wondering—yes, we do still have to keep fighting. rollcall.com/2026/03/27/s...

Exciting News! Grant-witness.us now has dynamic funding curves like mine for NIH available. grant-witness.us/funding_curv... 1/2

Can’t resist pointing out that line comes from a Supreme Court decision about patenting Vitamin D. And yes, I wrote about it. www.cincinnatimagazine.com/features/the...

Amanda Peet’s essay on her breast cancer diagnosis. apple.news/AnjX68rlZQ-i...

Title: "The United States is Driving a Public Heath Emergency of International Concern" www.bmj.com/content/392/...

Breaking: Dr. Robert Malone, vice chair of the federal committee that recommends vaccines to Americans, angrily resigned his position on Tuesday. www.nytimes.com/2026/03/24/h...

An important read 🧪 theconversation.com/how-the-nih-...

As we self-destruct, China moves ahead. Fewer grants were awarded this year. A recent survey of #NIH funded scientists revealed that they had to close their labs, reduce work. Fewer grants = fewer grad students = slow innovation This is on Jay Bhattacharya et al. 🧪 www.nature.com/articles/d41...

Fellow scientists, go into the light!

A very well produced story from NBC in San Diego about disruptions to can cancer research. www.nbcsandiego.com/news/investi...

Good story in C&E News about damage to the scientific enterprise and loss of confidence from researchers about having a trusted partner in the federal government. nam12.safelinks.protection.outlook.com?url=https%3A...