Holy shit?????

Trastuzumab deruxtecan slashes mortality in HER2-low metastatic breast cancer, establishing it as the new standard post-chemotherapy. by Modi S, Jacot W (...) Cameron D et 22 al. in Nat Med #MedSky 👉 get more here 📖 read the article:

This is a big advance, folks. We've never had a disease-modifying drug for this devastating inherited disease www.science.org/content/arti... www.washingtonpost.com/health/2025/... www.economist.com/science-and-...

The projected rise in global cancer deaths 1990 —5.9 million 2023—10.4 million 2050—18.8 million is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done www.thelancet.com/journals/lan...

The path to preventing rheumatoid arthritis Identification of precursor immune system features and the beginning of clinical trials with this objective www.science.org/doi/10.1126/...

A simple way to help reduce obesity and stroke? Stop the shifts in our clocks twice a year www.pnas.org/doi/abs/10.1...

Ikmen book 27 The Wooden Library published in paperback on 11th September. I’m giving away 2 copies to celebrate. RT and follow to enter. Winners announced Wednesday 10 September.

One more diabolical trick of cancer cells: transferring their mitochondria to fibroblasts to promote their growth nature.com/articles/s43...

Severe, refractory lupus successfully treated with engineered T cells derived from a healthy donor nature.com/articles/s41...

How does Epstein- Barr virus induce multiple sclerosis? The infection leads to B cells that get into the brain, attracting pro-inflammatory T cells (mouse model) www.nature.com/articles/s41...

New @nature.com The possibility that lithium deficiency is a driver of Alzheimer's disease. Experimental model shows Li depletion impedes amyloid clearance, and repletion in humans could be achieved with low doses nature.com/articles/s41...

Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general @nejm.org www.nejm.org/doi/pdf/10.1...

One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system erictopol.substack.com/p/our-braini...

Dendritic copolymer-drug conjugates dramatically improved triple-negative breast cancer treatment, achieving 95% tumor suppression with reduced side effects. by Liu G, Wang B (...) Luo K et 4 al. in Acta Biomater #MedSky 👉 get more here 📖 read the article:

A single CD137 antibody-drug conjugate dose effectively prevents acute GVHD in primates, paving the way for new transplant therapies. by Gerdemann U, Kimler K (...) Tkachev V et 22 al. in Blood #MedSky 👉 get more here 📖 read the article:

How microplastics can induce a leaky gut www.nature.com/articles/s41...

Flavonoid food and beverage intake—quantity and diversity— is linked to reduced all-cause mortality, cancer, cardiovascular disease, Type 2 diabetes, and neurodegenerative disease www.nature.com/articles/s43...

Wow. I read anecdotes in early Jan that suggested if we wanted this vaccine we should get it ASAP. I did. Novavax. I cannot believe this terrible idea is hatched.

This is very cool! www.nytimes.com/2025/05/09/w...

BioPharmCatalyst Weekly #Watchlist Key Catalysts Due Near Term $KROS $PYPD $VERA $NKTR $LYRA $BHVN $TOVX $MLYS $ASND $ACTU $PBM www.biopharmcatalyst.com/news/2025/ke...

New evidence @nejm.org today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....

GLP-1RA and SGLT2i Medications may have protective effects against the development of Alzheimer’s disease and related dementias in patients with Type 2 diabetes. jamanetwork.com/journals/jam...

Incredibly sobering piece in @bostonglobe.com, the latest in a series of recent articles arguing that US biotech (and more specifically, Boston/Cambridge biotech) is being preempted by *innovative* biotech from China (long underestimated/viewed as me-too): www.bostonglobe.com/2025/04/14/b... .

𝐂𝐨𝐦𝐩𝐚𝐧𝐲 𝐍𝐞𝐰𝐬: After switching to a new GalNAc-LNP delivery vehicle a year ago, Verve Therapeutics today announced the initial safety and efficacy data from its VERVE-102 PCSK9 based editor. Full video: www.biotechtv.com/post/verve-t...

If you’re a North Carolinian, you can check whether your name or the names of anyone you know is on the list of the 65K voters whose votes may be tossed. You could have an opportunity to fix it if so. thegriffinlist.com

Vitamin D appears to promote the immune response to cancer and the success of immunotherapy. Now a mechanism is identified involving the gut microbiome interactions www.science.org/doi/10.1126/... Vitamin D regulates microbiome-dependent cancer immunity

There are so many ways to rev up our immune response against cancer. Here, the oncolytic viruses www.cell.com/cancer-cell/...

Researchers develop AI tool that could speed up coeliac disease diagnosis

Tumor-reactive T cell receptors are predicted based on single-cell RNA sequencing and single-cell T cell receptor sequencing go.nature.com/4b8aN3p rdcu.be/efeUq

$REVB reported that its Gemini priming significantly reduced proinflammatory cytokines and increased anti-inflammatory cytokines in human PBMCs exposed to inflammation triggers.. See More Pre-market Movers 👇 www.biopharmcatalyst.com/news/2025/re... $INCY $DYN $DTIL $STRO $ZNTL

Science, folks. Science. This is wonderful news.

Nice balanced piece in the @WSJ on the tremendous promise and also the challenges in neuropsychiatry www.wsj.com/tech/biotech...

Today on #SciFri 📻

Measles outbreak in the U.S. continues to expand with 39 new cases in Texas (198 total) and 20 new cases in New Mexico (30 total) h/t BNO News

A phenotype-independent 'label-capture-release' process for isolating viable circulating tumor cells in real-time drug susceptibility testing www.sciencedirect.com/science/arti...

Pancreatic cancer is notoriously hard to treat, with a mortality rate of about 90%. In today’s episode,  we talk with a scientist  who is fighting the cancer with an mRNA vaccine. Listen here 🎧: https://buff.ly/3ES4ndw

In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years. Dr. Vinod Balachandran from @mskcancercenter.bsky.social joins us to discuss the results and what they could mean for cancer treatment.

Duration of frozen days show a strong decline in the Northern Hemisphere mainly driven by autumn temperature increase www.the-innovation.org/article/doi/...

The use of a reduced-sodium, added-potassium salt substitute significantly reduced the risks of stroke recurrence and death and is a novel and practical therapeutic option for patients with stroke. jamanetwork.com/journals/jam...

Cone snail toxin inspires new method for studying molecular interactions In the hunt for the target of a cone snail toxin, researchers established a new pipeline that can help identify molecular interactions and may assist with drug discovery www.eurekalert.org/news-release...

Three keys to unlocking successful manuscripts "A full understanding of the points of scientific papers is necessary and important for students and young researchers to prepare high-quality manuscripts." PDF Download www.cell.com/matter/pdf/S...

Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay. "The assay was optimized to detect all stages of PDAC with better performance than the clinical biomarker CA 19-9." www.science.org/doi/10.1126/...

How do GLP-1 drugs affect cognitive and mental health disorders? A comprehensive review www.nature.com/articles/s44...

Supine hypertension with or without seated hypertension was associated with increased risk of adverse cardiovascular disease events compared with seated hypertension alone. jamanetwork.com/journals/jam...

Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures. www.washingtonpost.com/health/2025/...

Researchers discover the brain cells that tell you to stop eating “How does the brain know when the body has had enough--and how does it act on that information to stop eating?” www.cell.com/cell/abstrac...

New in the February 6, 2025, issue of NEJM: Iptacopan in IgA Nephropathy (APPLAUSE-IgAN phase 3 trial) nej.md/3UmrOkh Atrasentan in Patients with IgA Nephropathy (ALIGN phase 3 trial) nej.md/3NzvISW Liraglutide for Children with Obesity (SCALE Kids phase 3a trial) nej.md/3MBP1uc #MedSky

Recursion Pharmaceuticals $RXRX says it has begun a “ClinTech” effort that applies AI beyond drug design and discovery, toward the way it approaches clinical trials. www.genengnews.com/topics/artif...