Susan Lee
@susanleeo.bsky.social
📤 626
📥 645
📝 113
Reader, not big commentor. Politics junkie. My likes are my bookmarks.
reposted by
Susan Lee
Redshift
14 days ago
Holy shit?????
add a skeleton here at some point
4
59
22
reposted by
Susan Lee
STITCHES Medicine - the Best of Medical Research
21 days ago
Trastuzumab deruxtecan slashes mortality in HER2-low metastatic breast cancer, establishing it as the new standard post-chemotherapy. by Modi S, Jacot W (...) Cameron D et 22 al. in Nat Med
#MedSky
👉 get more
here
📖 read the article:
loading . . .
Trastuzumab deruxtecan in HER2-low metastatic breast cancer: long-term survival analysis of the randomized, phase 3 DESTINY-Breast04 trial - Nature Medicine
This prespecified updated survival and exploratory subgroup efficacy analysis of the phase 3 DESTINY-Breast04 trial shows that trastuzumab deruxtecan treatment in patients with HER2-low metastatic breast cancer leads to continuous survival benefit irrespective of estrogen receptor or hormone receptor status.
https://www.nature.com/articles/s41591-025-03981-4
0
8
3
reposted by
Susan Lee
Eric Topol
about 1 month ago
This is a big advance, folks. We've never had a disease-modifying drug for this devastating inherited disease
www.science.org/content/arti...
www.washingtonpost.com/health/2025/...
www.economist.com/science-and-...
11
782
159
reposted by
Susan Lee
Eric Topol
about 1 month ago
The projected rise in global cancer deaths 1990 —5.9 million 2023—10.4 million 2050—18.8 million is yet another reason we need to get primary prevention into high gear, which is now possible but not getting done
www.thelancet.com/journals/lan...
25
484
152
reposted by
Susan Lee
Eric Topol
about 1 month ago
The path to preventing rheumatoid arthritis Identification of precursor immune system features and the beginning of clinical trials with this objective
www.science.org/doi/10.1126/...
loading . . .
Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation
Individuals at risk for rheumatoid arthritis exhibit inflammation and immune dysregulation before and during transition to active disease.
https://www.science.org/doi/10.1126/scitranslmed.adt7214
1
111
22
reposted by
Susan Lee
Adrian Woolfson
about 1 month ago
www.nature.com/articles/s41...
loading . . .
RNA-stabilized coat proteins for sensitive and simultaneous imaging of distinct single mRNAs in live cells - Nature Methods
Destabilized variants of MS2 and PP7 coat proteins enable improved live-cell imaging of tagged RNAs in mammalian cells by decreasing background signal caused by unbound coat protein–fluorescent protein fusions.
https://www.nature.com/articles/s41592-025-02782-4
0
1
1
reposted by
Susan Lee
Eric Topol
about 2 months ago
A simple way to help reduce obesity and stroke? Stop the shifts in our clocks twice a year
www.pnas.org/doi/abs/10.1...
loading . . .
Circadian-informed modeling predicts regional variation in obesity and stroke outcomes under different permanent US time policies | PNAS
Seasonal changes in time policy, such as switching between Standard Time (SDT) and Daylight Saving Time (DST), have been adopted by many countries,...
https://www.pnas.org/doi/abs/10.1073/pnas.2508293122
7
294
110
reposted by
Susan Lee
Barbara Nadel
2 months ago
Ikmen book 27 The Wooden Library published in paperback on 11th September. I’m giving away 2 copies to celebrate. RT and follow to enter. Winners announced Wednesday 10 September.
0
13
9
reposted by
Susan Lee
Eric Topol
2 months ago
One more diabolical trick of cancer cells: transferring their mitochondria to fibroblasts to promote their growth
nature.com/articles/s43...
loading . . .
Cancer-derived mitochondria fuel fibroblasts to become pro-tumorigenic - Nature Cancer
Cancer-associated fibroblasts represent a functionally diverse and heterogeneous entity within the solid tumor microenvironment. Mitochondrial transfer from cancer cells to fibroblasts is now shown to...
https://nature.com/articles/s43018-025-01005-1
6
129
44
reposted by
Susan Lee
Eric Topol
2 months ago
Severe, refractory lupus successfully treated with engineered T cells derived from a healthy donor
nature.com/articles/s41...
loading . . .
Allogeneic CD19-targeting T cells for treatment-refractory systemic lupus erythematosus: a phase 1 trial - Nature Medicine
In a small trial of patients with severe systemic lupus erythematosus and nephritis, treatment with allogeneic T cells with a CD19 chimeric antigen receptor inserted into the T cell receptor locus and...
https://nature.com/articles/s41591-025-03899-x
3
199
52
reposted by
Susan Lee
Eric Topol
3 months ago
How does Epstein- Barr virus induce multiple sclerosis? The infection leads to B cells that get into the brain, attracting pro-inflammatory T cells (mouse model)
www.nature.com/articles/s41...
loading . . .
EBV induces CNS homing of B cells attracting inflammatory T cells - Nature
Epstein–Barr virus infection generates a neuroinvasive B cell subset, which recruits activated T cells to the central nervous system, promoting multiple sclerosis.
https://www.nature.com/articles/s41586-025-09378-0
9
250
93
reposted by
Susan Lee
Eric Topol
3 months ago
New
@nature.com
The possibility that lithium deficiency is a driver of Alzheimer's disease. Experimental model shows Li depletion impedes amyloid clearance, and repletion in humans could be achieved with low doses
nature.com/articles/s41...
loading . . .
Lithium deficiency and the onset of Alzheimer’s disease - Nature
Lithium has an essential role in the brain and is deficient early in Alzheimer’s disease, which can be recapitulated in mice and treated with a novel lithium salt that restores the physiological level.
https://nature.com/articles/s41586-025-09335-x
21
458
180
reposted by
Susan Lee
Eric Topol
3 months ago
Important first-in-human report today for donor pancreatic islet beta-cell transplant to an individual w/Type 1 diabetes. With genome editing, there was no immune response induced or need for immunosuppression. Major implications for transplantation in general
@nejm.org
www.nejm.org/doi/pdf/10.1...
loading . . .
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2503822
12
301
85
reposted by
Susan Lee
Eric Topol
3 months ago
One in 4 people carry one copy of the APOE4 allele, the strongest known genetic risk factor for Alzheimer's disease. We've just learned how that risk is mediated—the immune system
erictopol.substack.com/p/our-braini...
5
269
88
reposted by
Susan Lee
Adrian Woolfson
4 months ago
www.cell.com/trends/immun...
loading . . .
Using TCR-CAR dual signaling for precise cancer targeting
Recently, Kondo et al. engineered the coexpression of a T cell receptor (TCR) and a chimeric antigen receptor (CAR) and developed an antagonism-enforced braking system where TCR signals both enhance a...
https://www.cell.com/trends/immunology/abstract/S1471-4906(25)00120-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1471490625001206%3Fshowall%3Dtrue
0
2
1
reposted by
Susan Lee
STITCHES Medicine - the Best of Medical Research
4 months ago
Dendritic copolymer-drug conjugates dramatically improved triple-negative breast cancer treatment, achieving 95% tumor suppression with reduced side effects. by Liu G, Wang B (...) Luo K et 4 al. in Acta Biomater
#MedSky
👉 get more
here
📖 read the article:
loading . . .
Redox-responsive dendritic copolymer-drug conjugates enhance therapeutic mitophagy through coordinated microtubule destabilization for synergistic triple-negative breast cancer therapy
Application of microtubule-targeting agents (MTAs) for triple-negative breast cancer (TNBC) is hampered by their limited efficacy and strong systemic …
https://www.sciencedirect.com/science/article/pii/S174270612500457X?via%3Dihub
1
11
5
reposted by
Susan Lee
STITCHES Medicine - the Best of Medical Research
5 months ago
A single CD137 antibody-drug conjugate dose effectively prevents acute GVHD in primates, paving the way for new transplant therapies. by Gerdemann U, Kimler K (...) Tkachev V et 22 al. in Blood
#MedSky
👉 get more
here
📖 read the article:
loading . . .
A single dose of a CD137 antibody-drug conjugate protects nonhuman primate allogeneic HCT recipients against acute GVHD
Key Points. In NHPs, a single CD137-ADC dose post-HCT eliminates PD-1+ effector T-cells, enabling reconstitution of non-pathogenic T-cell subsets.The CD137
https://ashpublications.org/blood/article-abstract/doi/10.1182/blood.2024027239/537754/A-single-dose-of-a-CD137-antibody-drug-conjugate?redirectedFrom=fulltext
0
6
2
reposted by
Susan Lee
Eric Topol
5 months ago
How microplastics can induce a leaky gut
www.nature.com/articles/s41...
5
118
50
reposted by
Susan Lee
Eric Topol
5 months ago
Flavonoid food and beverage intake—quantity and diversity— is linked to reduced all-cause mortality, cancer, cardiovascular disease, Type 2 diabetes, and neurodegenerative disease
www.nature.com/articles/s43...
11
218
72
Wow. I read anecdotes in early Jan that suggested if we wanted this vaccine we should get it ASAP. I did. Novavax. I cannot believe this terrible idea is hatched.
add a skeleton here at some point
6 months ago
0
3
0
This is very cool!
www.nytimes.com/2025/05/09/w...
loading . . .
F.D.A. Approves First At-Home Alternative to the Pap Smear
https://www.nytimes.com/2025/05/09/well/pap-smear-at-home-alternative-cervical.html?smid=nytcore-android-share
6 months ago
0
2
0
reposted by
Susan Lee
BioPharmCatalyst
7 months ago
BioPharmCatalyst Weekly
#Watchlist
Key Catalysts Due Near Term $KROS $PYPD $VERA $NKTR $LYRA $BHVN $TOVX $MLYS $ASND $ACTU $PBM
www.biopharmcatalyst.com/news/2025/ke...
0
0
1
reposted by
Susan Lee
Eric Topol
7 months ago
New evidence
@nejm.org
today that age-related clonal hematopoiesis (CHIP) has a driver role in evolution of solid cancers
www.nejm.org/doi/full/10....
www.nejm.org/doi/full/10....
loading . . .
Clonal Hematopoiesis as a Driver of Solid Tumors | NEJM
Clonal hematopoiesis is the expansion of a genetically related population of hematopoietic stem and progenitor cells that disproportionately contribute to blood-cell production.1 Clonal hematopoies...
https://www.nejm.org/doi/full/10.1056/NEJMe2504775
3
143
36
reposted by
Susan Lee
Science News
7 months ago
GLP-1RA and SGLT2i Medications may have protective effects against the development of Alzheimer’s disease and related dementias in patients with Type 2 diabetes.
jamanetwork.com/journals/jam...
loading . . .
GLP-1RAs and SGLT2is for Type 2 Diabetes and Alzheimer Disease
This population-based cohort study examines the association of glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter-2 inhibitors with the risk of Alzheimer disease and related de...
https://jamanetwork.com/journals/jamaneurology/article-abstract/2831976
0
14
1
reposted by
Susan Lee
David Shaywitz
7 months ago
Incredibly sobering piece in
@bostonglobe.com
, the latest in a series of recent articles arguing that US biotech (and more specifically, Boston/Cambridge biotech) is being preempted by *innovative* biotech from China (long underestimated/viewed as me-too):
www.bostonglobe.com/2025/04/14/b...
.
loading . . .
‘I think it is actively happening’: Is Boston’s biotech industry doomed? - The Boston Globe
With a "terrible" job market, empty labs, and mounting competition from China, the lifeblood of Kendall Square is under massive threat.
https://www.bostonglobe.com/2025/04/14/business/biotech-boston-kendall-square-jobs-drugs-labs/
0
2
3
reposted by
Susan Lee
BiotechTV
7 months ago
𝐂𝐨𝐦𝐩𝐚𝐧𝐲 𝐍𝐞𝐰𝐬: After switching to a new GalNAc-LNP delivery vehicle a year ago, Verve Therapeutics today announced the initial safety and efficacy data from its VERVE-102 PCSK9 based editor. Full video:
www.biotechtv.com/post/verve-t...
loading . . .
0
3
1
reposted by
Susan Lee
Taniel
7 months ago
If you’re a North Carolinian, you can check whether your name or the names of anyone you know is on the list of the 65K voters whose votes may be tossed. You could have an opportunity to fix it if so.
thegriffinlist.com
50
4704
3278
reposted by
Susan Lee
Reiner
over 1 year ago
Vitamin D appears to promote the immune response to cancer and the success of immunotherapy. Now a mechanism is identified involving the gut microbiome interactions
www.science.org/doi/10.1126/...
Vitamin D regulates microbiome-dependent cancer immunity
loading . . .
Vitamin D regulates microbiome-dependent cancer immunity
A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to tr...
https://www.science.org/doi/10.1126/science.adh7954
1
24
16
reposted by
Susan Lee
Eric Topol
7 months ago
There are so many ways to rev up our immune response against cancer. Here, the oncolytic viruses
www.cell.com/cancer-cell/...
6
215
45
reposted by
Susan Lee
The Guardian
8 months ago
Researchers develop AI tool that could speed up coeliac disease diagnosis
loading . . .
Researchers develop AI tool that could speed up coeliac disease diagnosis
Cambridge study finds algorithm is as effective as a pathologist in detecting disease – and much quicker AI could speed up the diagnosis of coeliac disease, according to research. Coeliac disease is an autoimmune condition affecting just under 700,000 people in the UK, but getting an accurate diagnosis can take years. Continue reading...
https://www.theguardian.com/science/2025/mar/27/coeliac-disease-diagnosis-ai-tool?utm_source=dlvr.it&utm_medium=bluesky&CMP=bsky_gu
2
90
23
reposted by
Susan Lee
Nature Biotechnology
8 months ago
Tumor-reactive T cell receptors are predicted based on single-cell RNA sequencing and single-cell T cell receptor sequencing
go.nature.com/4b8aN3p
rdcu.be/efeUq
loading . . .
Identification of clinically relevant T cell receptors for personalized T cell therapy using combinatorial algorithms - Nature Biotechnology
Tumor-reactive T cell receptors are predicted based on single-cell RNA sequencing and single-cell T cell receptor sequencing.
https://go.nature.com/4b8aN3p
0
12
5
reposted by
Susan Lee
BioPharmCatalyst
8 months ago
$REVB reported that its Gemini priming significantly reduced proinflammatory cytokines and increased anti-inflammatory cytokines in human PBMCs exposed to inflammation triggers.. See More Pre-market Movers 👇
www.biopharmcatalyst.com/news/2025/re...
$INCY $DYN $DTIL $STRO $ZNTL
0
2
1
reposted by
Susan Lee
Sherrilyn Ifill
8 months ago
Science, folks. Science. This is wonderful news.
add a skeleton here at some point
246
9588
1933
reposted by
Susan Lee
Daphne Zohar
8 months ago
Nice balanced piece in the @WSJ on the tremendous promise and also the challenges in neuropsychiatry
www.wsj.com/tech/biotech...
loading . . .
Big Pharma Walked Away From Mental Health. Why Some Are Coming Back.
Psychiatry was once big business for pharma, with drugs like Prozac making billions. Now a few breakthroughs are reviving interest.
https://www.wsj.com/tech/biotech/big-pharma-walked-away-from-mental-health-why-some-are-coming-back-e2f1ec15
0
11
3
reposted by
Susan Lee
Science Friday
8 months ago
Today on
#SciFri
📻
15
1257
175
reposted by
Susan Lee
Scott Gottlieb, MD
8 months ago
Measles outbreak in the U.S. continues to expand with 39 new cases in Texas (198 total) and 20 new cases in New Mexico (30 total) h/t BNO News
18
463
121
reposted by
Susan Lee
Science News
8 months ago
A phenotype-independent 'label-capture-release' process for isolating viable circulating tumor cells in real-time drug susceptibility testing
www.sciencedirect.com/science/arti...
loading . . .
A phenotype-independent “label-capture-release” process for isolating viable circulating tumor cells in real-time drug susceptibility testing
Although various strategies have been proposed for enrichment of circulating tumor cells (CTCs), the clinical outcomes of CTC detection are far from s…
https://www.sciencedirect.com/science/article/pii/S2666675825000086
0
9
2
reposted by
Susan Lee
Science Friday
8 months ago
Pancreatic cancer is notoriously hard to treat, with a mortality rate of about 90%. In today’s episode, we talk with a scientist who is fighting the cancer with an mRNA vaccine. Listen here 🎧:
https://buff.ly/3ES4ndw
263
11728
2516
reposted by
Susan Lee
Science Friday
9 months ago
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine had no signs of relapse after three years. Dr. Vinod Balachandran from
@mskcancercenter.bsky.social
joins us to discuss the results and what they could mean for cancer treatment.
loading . . .
A Vaccine For Pancreatic Cancer Continues To Show Promise
In a small trial, nearly half of pancreatic cancer patients who received an mRNA vaccine for the disease had no relapse three years later.
https://buff.ly/3X8O2re
697
24285
6394
reposted by
Susan Lee
Science News
9 months ago
Duration of frozen days show a strong decline in the Northern Hemisphere mainly driven by autumn temperature increase
www.the-innovation.org/article/doi/...
0
14
3
reposted by
Susan Lee
Science News
9 months ago
The use of a reduced-sodium, added-potassium salt substitute significantly reduced the risks of stroke recurrence and death and is a novel and practical therapeutic option for patients with stroke.
jamanetwork.com/journals/jam...
loading . . .
Salt Substitution and Recurrent Stroke and Death
This cluster randomized clinical trial evaluated if a reduced-sodium, added-potassium salt substitute compared with regular salt decreases the risk of stroke recurrence and death in patients with a hi...
https://jamanetwork.com/journals/jamacardiology/article-abstract/2829790?widget=personalizedcontent&previousarticle=2829794
0
26
7
reposted by
Susan Lee
Science News
9 months ago
Cone snail toxin inspires new method for studying molecular interactions In the hunt for the target of a cone snail toxin, researchers established a new pipeline that can help identify molecular interactions and may assist with drug discovery
www.eurekalert.org/news-release...
0
19
2
reposted by
Susan Lee
Science News
9 months ago
Three keys to unlocking successful manuscripts "A full understanding of the points of scientific papers is necessary and important for students and young researchers to prepare high-quality manuscripts." PDF Download
www.cell.com/matter/pdf/S...
0
37
10
reposted by
Susan Lee
Science News
9 months ago
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay. "The assay was optimized to detect all stages of PDAC with better performance than the clinical biomarker CA 19-9."
www.science.org/doi/10.1126/...
loading . . .
Early detection of pancreatic cancer by a high-throughput protease-activated nanosensor assay
A high-throughput, noninvasive, rapid protease-activated nanosensor identifies patients with pancreatic cancer in a small volume of blood.
https://www.science.org/doi/10.1126/scitranslmed.adq3110
0
65
18
reposted by
Susan Lee
Eric Topol
9 months ago
How do GLP-1 drugs affect cognitive and mental health disorders? A comprehensive review
www.nature.com/articles/s44...
13
205
48
reposted by
Susan Lee
Science News
9 months ago
Supine hypertension with or without seated hypertension was associated with increased risk of adverse cardiovascular disease events compared with seated hypertension alone.
jamanetwork.com/journals/jam...
0
21
3
reposted by
Susan Lee
Carolyn Bertozzi
9 months ago
Another assault on US competitiveness at a time when biomedicine is roaring with innovation, an own-goal in a high-stakes international tournament. Of course the real losers are American people needing medicines and cures.
www.washingtonpost.com/health/2025/...
loading . . .
NIH cuts billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.
https://www.washingtonpost.com/health/2025/02/08/nih-cuts-billions-dollars-biomedical-funding-effective-immediately/
57
1682
559
reposted by
Susan Lee
Science News
9 months ago
Researchers discover the brain cells that tell you to stop eating “How does the brain know when the body has had enough--and how does it act on that information to stop eating?”
www.cell.com/cell/abstrac...
loading . . .
Brainstem neuropeptidergic neurons link a neurohumoral axis to satiation
Use of spatially resolved molecular profiling identifies CCK neurons in the brainstem’s dorsal raphe nucleus. These neurons track ingestion to promote satiation through a sustained signaling mechanism...
https://www.cell.com/cell/abstract/S0092-8674(25)00047-9?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867425000479%3Fshowall%3Dtrue
2
37
8
reposted by
Susan Lee
NEJM.org
9 months ago
New in the February 6, 2025, issue of NEJM: Iptacopan in IgA Nephropathy (APPLAUSE-IgAN phase 3 trial)
nej.md/3UmrOkh
Atrasentan in Patients with IgA Nephropathy (ALIGN phase 3 trial)
nej.md/3NzvISW
Liraglutide for Children with Obesity (SCALE Kids phase 3a trial)
nej.md/3MBP1uc
#MedSky
1
13
6
reposted by
Susan Lee
Albert Vilella, PhD.
9 months ago
Recursion Pharmaceuticals $RXRX says it has begun a “ClinTech” effort that applies AI beyond drug design and discovery, toward the way it approaches clinical trials.
www.genengnews.com/topics/artif...
add a skeleton here at some point
2
6
3
Load more
feeds!
log in