The human UDP-Gal-4-epimerase is important for cellular biosynthesis of UDP-Gal and UDP-GalNAc. Both are important precursors for glycosylation. GALE KO abrogates cellular levels of these metabolites. GALE plays a role in cancer (pubmed.ncbi.nlm.nih.gov/31908526/) - so we decided to drug it!

Video compilation from our #türenauf mit der Maus Tag today! #outreach #chemsky @hhu.de @sophieguti.bsky.social @joguti.bsky.social @markussuta.bsky.social @chemiehhu.bsky.social

What can HaloTag do for you? Triggered fluorogenic labelling? Molecular recording? Photo-Chemically Induced Dimerisation? Philipp Mauker's CHalo motif lets reagents do all three, and more. Read the preprint here - doi.org/10.1101/2025... #chembio #fluorescence #cellbio #SLP

Molecular Recording with HaloTag? H2O2, GSH, Trx, LAP? → multiplexable reagents record diverse enzyme activities ratiometrically, without signal loss @biorxivpreprint.bsky.social preprint: doi.org/10.1101/2025... CHalo Crew again programming with HaloTag! #chembio #fluorescence #wednesday

Photocaged HaloTag Ligation with red fluorogenic SiR labels: → on-demand HaloTag visualisation and tracking @biorxivpreprint.bsky.social preprint: doi.org/10.1101/2025... Congrats Philipp Mauker, Joyce Meiring, & the CHalo Crew for again programming with HaloTag! #chembio #fluorescence #wednesday

Chemically Induced Dimerisation, modular & on-demand: => Fast, stepwise reagents for HaloTag-to-SNAP-tag heterodimerisation without a hook effect Now preprinted: doi.org/10.1101/2025... Congratulations to Philipp Mauker & the CHalo Crew for programming with HaloTag! #chembio #fluorescence #friday

We boosted tumour-selective delivery of nano-formulated chemotherapeutics by transiently shaking up tumour blood vessels. The catch? You only get one shot at this ☝️ This #BMBF funded work, driven by a predominantly female team @lmumuenchen.bsky.social is available on the @biorxivpreprint.bsky.social

🔍 Chemie studieren - eine Formel für die Zukunft! Ihr kennt jemanden, der überlegt Chemie zu studieren, aber sich nicht sicher ist? Ein Chemiestudium bietet spannende Möglichkeiten. Auf www.chemie-studieren.de finden sich alle Infos rund um Studiengänge, Ausbildungen und Berufe in der Chemie.

Join our GBM Redox Meeting 2025 in Saarbrücken! We put together an exciting program covering diverse aspects of Redox Regulation in Life. Check out the Programm and register until Feb 28! redox-gbm-meeting-2025.uni-koeln.de #redox #redoxbiology #gbm @gbmev.bsky.social

For ion-specific photocurrents across membranes: just let ionophores intermingle with photolipids. A fully modular approach with easy access to large currents. Stoked that this years-long sleuthing effort led by Peter Pohl is finally out! doi.org/10.1101/2025... #photopharma #ChemBio #lipidtime

The Young Scientist Award of @gdchbiochem.bsky.social of @gdch.bsky.social is open for nominations. If you know an excellent candidate, who defended their PhD or had a publication in 2024 in the field of biochemistry (or related), consider nominating them. #chemsky #ChemBio en.gdch.de/network-s...

Congrats to our new Doctor Markus! @m-markus.bsky.social pioneered chromocontrol by ideal efficacy photoswitching (doi.org/10.1101/2024...), TRPC5 photopharma (doi.org/10.1002/anie...), & switch-based photoacoustic imaging (doi.org/10.1002/anie... & doi.org/10.26434/che...) : a tour de force summa!

Gregorio Weber is a giant in our field, and I am deeply honored to receive this award in his name. I want to acknowledge all my collaborators over the years—especially @dyerfulchymist.bsky.social—and the place that made everything possible: @hhmijanelia.bsky.social

Ein Jahr kostenfreie Mitgliedschaft bei der GBM bei Registrierung bis Ende März 2025! Become a member of the GBM now and the 1st year is for free!

The RSC Chemical Biology and Bioorganic Group is now on Bluesky and delighted to be here! We're really looking forward to keeping you all updated with the latest events and news from our community, across the UK and internationally. Spread the word to those you know, and give us a follow! #chembio

You don´t find your people? Check blueskystarterpack.com and search for your community! #organicchemistry #Chemicalbiology #MedChem #naturalproductchemistry

Misogeny and sexism is not always easy to recognise, but it's systematic and it paves the way for inequality, hate and violence. Took me painfully long to become angry enough about this. Feminism, and make it intersectional, is good for EVERYONE. #StopViolenceAgainstWomen #TagGegenGewaltAnFrauen

@thornsesholdlab.bsky.social set up a feed, that will show all posts with #ChemBio. If you are interested in the feed, click this link, click "Pin to Home" and it will be added as feed to your home screen: bsky.app/profile/did...#ChemBio.I will use this hashtag in all relevant posts.

Thanks Stephan! Feed is ordered like this: (1) prioritises recent posts hashtagged #ChemBio or #ChemicalBiology (not case sensitive) (2) then other recent posts with "chembio", "chemical biology" etc (not as hashes) (3) then the "best 5%HN" of recent #ChemSky, #realtimechem, #FluorescenceFriday etc

reposting #ChemBio @hellmichgroup.bsky.social @lipid.bsky.social TRP fans!

This is cool, D2O (in place of H2O) as analgesic via TRPV1 permeation modulation

📯📯NEW Chemical Biology Feed bsky.app/profile/did:... 📯List: >200 chemical biologists (probes, OC, PC, imaging): bsky.app/profile/did:... 📯Women in ChemBio Pack: bsky.app/starter-pack... 📯General #ChemBio Pack: bsky.app/starter-pack... 📯 #Photopharma: bsky.app/profile/trac... #chemsky 🧪 🔬

attn to new #chemsky #ChemBio #realtimechem #SciSky 🧪 🔬 #photopharma community members…

📯Chemical Biology Starter Pack ＃2: Probes Aficionadas👩‍🔬 go.bsky.app/DEjVGEn as generalist ChemBio Pack ＃1 go.bsky.app/KLrTWoj is full 🚩Feed reposting #ChemBio: bsky.app/profile/trac... 🚩 #Photoswitch: bsky.app/profile/trac... 🚩 #FluorescenceFriday: bsky.app/profile/trac... #chemsky #realtimechem

📯📯Photopharmacology and Switches communities📯📯 Here is a Feed reposting #molswitch #photoswitch #photopharma bsky.app/profile/did:... #chemsky #chembio #scisky 🧪

📯 Chemical Biology starter pack No.1: now with 📯 #chembio Feed 📯 (also gets #chemicalbiology) #ChemBio feed: bsky.app/profile/did:... Pack covers 150 groups posting primary research in chemical biology: go.bsky.app/KLrTWoj 📬 Please Repost !📬 #realtimechem #FluorescenceFriday #chemsky #scisky

Trying something new: A 🧵 on a topic I find many students struggle with: "why do their 📊 look more professional than my 📊?" It's *lots* of tiny decisions that aren't the defaults in many libraries, so let's break down 1 simple graph by @jburnmurdoch.bsky.social 🔗 www.ft.com/content/73a1...

📯Photoacoustic Imaging Heterodoxy📯 Usually PA dyes are built by *first* taking high-NIR-ε fluorophores, *then* suppressing fluorescence. @m-markus.bsky.social now argues why this misses the best chemical space for PA agents. PP out soon... stay λ-tuned! #ChemBio #ChemSky #realtimechem #SciSky

Wishing the Elsevier editors who desk-accepted this all the best for their next career moves. doi.org/10.1016/j.ij...

Here is a starter pack for folks into tiny switches and machines. I am sure I missed many. Please let me know if you should be included and I will add you go.bsky.app/EwimNbK

There’s more to rainbows than the human eye can see: here’s how a rainbow extends into the infrared and ultraviolet. Photos: 1. Infrared 2. Visible (obviously) 3. Ultraviolet, and 4. A composite showing how UV is beyond the violet in a rainbow, and IR beyond the red end. 🧪 #photography

Interested in covalent probes? Check out our most recent pre-print on chemoproteomic profiling of N-terminal cysteines. Nice overview/summary from lead author @esbensv.bsky.social

This the (short, funny, sad) video we got to see on imaging women's brains at the CZI Imaging meeting as part of Nina Miolane's talk. Worth a few minutes and worth a share. www.youtube.com/watch?v=tX5u...

Attn Chemical Biology community in Germany / Switzerland / Austria: I unofficially made @gfg-chembio.bsky.social for our Gemeinsame Fachgruppe Chemische Biologie. Please follow! Hopefully, one day it can be a hub for all GFG-CB members & speakers at our Advances in Chemical Biology conference.

#WomenInSTEM 🧪👇

Introducing: Chromocontrol! our first science Bsky post for 2024 :) #ChemSky #ChemBio The most important photopharmacology work we've done in years. Ditched the photoswitch design principles we used since a decade, & started all over again. And now it will work in vivo. doi.org/10.1101/2024...

I posted it on the dying bird, but the coverage of our results about disgusting 'tar balls' made international news in the past week! If you saw it where you are, let me know or post a link below! #ozchem #chemsky theconversation.com/black-balls-...

📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

#ChemSky challenge: how do you increase thiol probe reactivity, while *also* increasing selectivity, without target-specific binding? → Use a multistep reaction cascade allowing to tune on-target & off-target rates independently, although the rxn chemistries are the same. doi.org/10.26434/che...