Thrilled to share our new paper just published in @acsjacs.bsky.social: a modular, 11‑step total synthesis of lasalocid acid A—enabled by a new Pd‑catalyzed C-glycosylation reaction to construct C(sp³)–C(sp³) attached‑rings. Read the paper: pubs.acs.org/doi/10.1021/...

Our new paper in Helv. Chim. Acta, the Journal of the Swiss Chemical Society, founded 1917, elaborates on unorthodox reversible Michael addition for cellular uptake; with the groups of @tbpoulsen.bsky.social‬ and @oliverthornseshold.bsky.social‬. onlinelibrary.wiley.com/doi/10.1002/...

Great to see Ivan and Charlie's work on the synthesis and reactivity of vinyl sulfonimidamides out in @chemicalscience.rsc.org Here they show that reactivity either above or below that of the corresponding acrylamide can be achieved. @oxfordchemistry.bsky.social pubs.rsc.org/en/content/a...

Next up: Thomas Poulsen - diving into precision chemistry from the protein to the proteome! ⚗️ Powerful tools for covalent protein profiling. FANTASTIC work! #ChemBio #Proteomics #CSSB25

Delighted to share our newest pre-print. Here, we describe a very short synthesis (11 steps, LLS) of the polyether antibiotic lasalocid acid A. doi.org/10.26434/che...

18 days left until the #NordicRetrosynthesisChallenge begins... Is your team ready? Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com Sponsored by Carbolution Chemicals GmbH and AstraZeneca Please share! #chemsky #Chembio

45 days left until the challenge is revealed... Are you familiar with the rules? Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com! Sponsored by Carbolution Chemicals and AstraZeneca Please share ! #chemsky #Chembio

66 days left until the challenge is revealed... Get ready for the #NordicRetrosynthesisChallenge on 5th of May 2025! For more info check nordicretrosynthesischallenge.com! Sponsored by Carbolution Chemicals and AstraZeneca Please share and spread the news! #chemsky #Chembio

Do you already have a team to participate in the #NordicRetrosynthesisChallenge on 5th of May 2025? For more info check nordicretrosynthesischallenge.com! Sponsored by Carbolution Chemicals and AstraZeneca Please share and spread the news! #chemsky #Chembio

Check out the summary of the newest paper from our lab. Just out in Chemical Science #chembio #chemicalbiology

Ten simple rules for developing good reading habits during graduate school and beyond To me, the most important are: Read often, read broadly (incl. older papers and outside your field), and learn to read some papers in detail and others more superficially (and quickly)

Here is a very interesting new paper from the Baker and Chudasama groups at University College London. A clever example of leveraging reversible disulfide rebridging chemistry to achieve selective lysine modification (via proximity) of antibody-fragments. pubs.rsc.org/en/content/a...

It is great to have @aekiib.bsky.social from the group of @tbpoulsen.bsky.social as visiting PhD student in the lab. His stay in our lab allows us to exchange a lot of thoughts and technologies between the labs and learn so much from each other. #ChemBio onlinelibrary.wiley....

Now that’s a good #ChemSky thread! Can’t wait to read the final version of this preprint in some top notch journal. Congrats to all involved. Beautiful work 👌🏻

This looks like an interesting application of the oxSTEF probes developed in the Poulsen lab before. Good example of developing interesting chemistry/chemical biology and then asking the right biological questions.

Interesting ChemRxiv preprint by the group of @tbpoulsen.bsky.social with first author @esbensv.bsky.social. They used OxSTEF probes to study proteins with N-terminal cysteines in the proteome and used the method to specifically investigate difference in normoxia and hypoxia. doi.org/10.26434/che...

Great to see them apply the proteome-wide profiling method for electrophile reactivity and selectivity that we developed together with @nesvilab.bsky.social in Fragpipe in this exciting system. chemrxiv.org/engage/chemr...

Interested in covalent probes? Check out our most recent pre-print on chemoproteomic profiling of N-terminal cysteines. Nice overview/summary from lead author @esbensv.bsky.social

📯📯 Chemical Biology starter pack 📯📯 140 PIs & groups posting primary research in chemical biology. Please reskeet (?) & reply to this post if you want to be added! go.bsky.app/KLrTWoj Let's make ChemBioSky even greater again! #realtimechem #FluorescenceFriday #chemsky #chemtwitter #AgentOrange

Looking back on the Acetonitrile Olympics. You remember those, right?

Development of Oxadiazolone Activity-Based Probes Targeting FphE for Specific Detection of Staphylococcus aureus Infections https://covalentmodifiers.blogspot.com/2024/02/development-of-oxadiazolone-activity.html

Molecular Bidents with Two Electrophilic Warheads as a New Pharmacological Modality https://covalentmodifiers.blogspot.com/2024/02/molecular-bidents-with-two.html

Dear colleagues, my temporary contract here at the MPI is ending this year, and for reasons of german work regulations (Wissenschaftszeitvertragsgesetz, a german word of typical length ;-) ), it can not be extended. So I am looking for new opportunities, preferably in Germany.

Job Alert - Our team @uni-jena.de is looking for a PhD student who wants to unravel how enzymatic modifications of natural products impact microbial interactions. This is a highly interdisciplinary project with great collaborations within the CRC1127 ChemBioSys! Apply here until Feb.04: t.ly/alya1