Thomas B. Poulsen (@tbpoulsen.bsky.social)

Here is a very interesting new paper from the Baker and Chudasama groups at University College London. A clever example of leveraging reversible disulfide rebridging chemistry to achieve selective lysine modification (via proximity) of antibody-fragments. pubs.rsc.org/en/content/a...

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Formation of mono- and dual-labelled antibody fragment conjugates via reversible site-selective disulfide modification and proximity induced lysine reactivity Many protein bioconjugation strategies focus on the modification of lysine residues owing to the nucleophilicity of their amine side-chain, the generally high abundance of lysine residues on a protein... https://pubs.rsc.org/en/content/articlelanding/2025/sc/d4sc06500j