Congratulations to Dr. Nerea González-Sanchis for a successful PhD defense, the final flipper firework with beautiful structures that solve real problems. Very best wishes for the future! A big thank you to the members of the jury, Sascha Hoogendoorn, Sander Wezenberg and Jerome Lacour.

This was the 2025 edition of the traditional group dinner in the Edelweiss, newly renovated, cheese fondue, meat fondue, chocolate fondue, live jodel, alphorn and kirsch

The current #1 Bestseller of Helv. Chim. Acta, the Journal of the Swiss Chemical Society, founded 1917, is our paper with the groups of Thomas Poulsen (Aarhus, Denmark) and Oliver Thorn-Seshold (Dresden, Germany): Thank you so much for reading! onlinelibrary.wiley.com/journal/1522...

In our new review in Helv. Chim. Acta, we summarize the first decade of CPDs – cell-penetrating poly(disulfide)s - comprehensively. It was gratifying to see how useful their thiol-mediated uptake has become in practice, also in living animals. onlinelibrary.wiley.com/doi/10.1002/...

Our new paper in Angew. Chem. could make thiol-mediated uptake more generally useful for the community, at last: Grafting CPDs to SOIs rather than the original grafting-from provides the fast bioconjugation needed. Thank you, Angew. Chem. (open access): onlinelibrary.wiley.com/doi/10.1002/...

Congratulations to Dr. Felix Bayard for a successful PhD defense, covering impressive synthetic efforts to reduce the phototoxicity of mechanosensitive flipper probes: Very best wishes for the future! A big thank you to the members of the jury, Anthony Davis, Michel Rickhaus and Jerome Lacour.

Issue 40 is here! #ChemSciCovers Our front cover this week features Stefan Matile et al 🤩 'Thiol-mediated uptake of phosphorothioate liposomes, visualized with fluorescent flippers' 🔗 doi.org/10.1039/D5SC... https://bsky.app/profile/matilegroup.bsky.social#ChemSciCovers

@matilegroup.bsky.social spotlights work from @mvdelius.bsky.social and co-workers on dynamic thioorthoester chemistry for metal-scavenging networks and sulfur-rich cathodes in Li batteries. Read more: onlinelibrary.wiley.com/doi/10.1002/... #AngewandteChemieNovit

Look at these shiny flippers, so many: pubs.rsc.org/en/journals/...

In our new paper in Chem. Sci., we show that the replacement of one oxygen by one sulfur atom in phospholipids affords phosphorothioate liposomes that penetrate cells by thiol-mediated uptake in intact form and with contributions neither from fusion nor from endocytosis.

Congratulations for an intriguing PhD defence and very best wishes to Dr. Michael Cognet for a great future. A big thank you to the members of the jury, Kurt Gothelf, Nicolas Winssinger and Clement Mazet.

Our new paper in Angew. Chem. introduces an enabling method to make catalysis with externally applied electric fields compatible with organic synthesis. onlinelibrary.wiley.com/doi/10.1002/...

For a great start into the new academic year, we climbed up to the largest glacier in the Alps, a UNESCO World Heritage Site.

This invited commentary in Angew. Chem. highlights the importance of translational supramolecular chemistry, and the power of the big yellow sulfur atom in this context, despite its diabolic reputation. onlinelibrary.wiley.com/doi/10.1002/...

Our new paper in Helv. Chim. Acta, the Journal of the Swiss Chemical Society, founded 1917, elaborates on unorthodox reversible Michael addition for cellular uptake; with the groups of @tbpoulsen.bsky.social‬ and @oliverthornseshold.bsky.social‬. onlinelibrary.wiley.com/doi/10.1002/...

552 flippers and a few crabs, what a cover, please enjoy Thank you, JACS Au: pubs.acs.org/doi/10.1021/...

Thank you so much for reading: Our new paper on photocatalytic microenvironment proteomics of thiol-mediated uptake still hangs on in the top 20 of JACS Au. It aims to give a better understanding of a process that might be more important than we all expected. pubs.acs.org/doi/10.1021/...

In our new paper in JACS Au, with the Sagara group from the Institute of Science Tokyo, we introduce flippers than respond to stretching rather than compression and applicability to the materials rather than the life sciences (GOA). pubs.acs.org/doi/10.1021/...

Photocatalytic microenvironment proteomics identifies proteins in thiol-mediated uptake by covalent labeling without disturbing exchange network dynamics. We hope our new paper will help the community to better understand, explore and use this enigmatic process. pubs.acs.org/doi/10.1021/...

Violating the EDB rules, access to intrinsically disfavored products increases with increasing electric fields applied to electromicrofluidic reactors with carbon nanotubes (besides conversion going from 0 to 100%). Now new in Chem. Sci., pubs.rsc.org/en/content/a..., Diamond Open Access, RSC

Thank you very much for highlighting our paper

Congratulations to Filipe Coelho for a great PhD defense, on uptake exchange partners, integrins, PDIs, cell motility, selenenylsulfides, and more. Many thanks for all and very best wishes for a bright future. Special thanks also to jury members, specially C. Hackenberger, who came from far.

An update on dynamic covalent cascade exchange chemistry, thiol-mediated uptake and the CH-ERC AdG TIMEUP, now new in Chimia, the POA Journal of the Swiss Chemical Society. www.chimia.ch/chimia/artic...

Congratulations, Angie - Dr. Gutiérrez-López for an excellent PhD defense on “Microfluidic Electric-Field Catalysis on Carbon Nanotubes and the Origin of Anion-π Autocatalysis” A big thank you for all and best wishes for the future! Many thanks also to the jury, M. Prato, C. Mazet, J. Lacour

Hello #ChemSky, we are a research group in Geneva, Switzerland, interested in translating principles from supramolecular chemistry to address significant challenges at the interface of organic chemistry, chemical biology and materials.