Recently out: “Uniform dynamics of cohesin-mediated loop extrusion in living human cells”. In this study led by brilliant former PhD student Thomas Sabaté we use live cell microscopy and polymer simulations to characterize how DNA loops and TADs form in human cells by cohesin-driven extrusion. (1/4)

🚨🔬A great opportunity to work with high-end microscopy in an exciting scientific environment. Please re-post 🙏 @goetheuni.bsky.social @scale-cluster-ffm.bsky.social 👇🏻

We are kicking off #SMLMS2025 and are happy to welcome you all in Bonn! @smlm-symposium.bsky.social www.smlms.org

✈️ Off to #MAF25 in Montreal! The journey just started and I couldn’t be more excited to meet so many brilliant colleagues and friends in such a beautiful city. Looking forward to a week full of science, discussions, and inspiration. 🇨🇦✨

🚨 New Preprint! Ex-dSTORM resolves fine details of the molecular architecture of CCPs, the 8-nm periodicity of microtubules, and the docking site of synaptic vesicles at the presynapse of hippocampal neurons. ▶️ www.biorxiv.org/content/10.1...

😱😱😱

The summary of my third advanced ERC grant cordis.europa.eu/article/id/4...

Neue Wirkstoffe gegen Alzheimer – Prof. Dr. Steffen Pockes, Pharmazeut an der Uni Regensburg, erhält renommierte Heisenberg-Professur der @dfg.de Pockes forscht an innovativen Therapieansätzen für neurodegenerative Erkrankungen, insbesondere der Alzheimer-Krankheit. tinyurl.com/2s3r8zbv

Exciting Single-Molecule Mini Symposium and C-Trap Launch event at @uniregensburg.bsky.social! If you're nearby, don't miss it! 🧬🧑‍🏫🎉 @caliskanlab.bsky.social @curiousdina.bsky.social @beliulab.bsky.social

Thanks to the Fonds der Chemischen Industrie we can cover the accommodation costs of all participants giving a talk at youngSMLMS! And thanks to the Bonner Graduiertenzentrum youngSMLMS participation will also be free! 👉 Don’t miss the abstract submission deadline - it's this *Friday 4th of July*.

Now: 🏆 Poster prizes just awarded to the top 4 posters - congratulations to all winners! 🎉 With so much excellent science on display, it was a very tough call for the poster committee. #CSSB25 #PosterPrize #ScienceInAction

And now: Morten Meldal - for me, THE highlight of the conference! 🧪 Host, organizer, and pioneer of click chemistry, he’s now taking the stage for an inspirational talk. A true icon shaping the future of chemical biology! #ClickChemistry @isbuc.bsky.social #CSSB25

Next up: The last flashtalk from Céline Delaitre - presenting her work on fluorescent ligands for angiotensin II AT1 receptors! 🧪 A cutting-edge chemical biology tool to visualize and modulate signaling dynamics. #ChemicalBiology #GPCR #CSSB25

Next up: Jin Zhang - illuminating the biochemical activity architecture of the cell! 🧬 She’s pioneering spatiotemporal biosensors and super-resolution imaging tools to track kinase, phosphatase, GPCR & second messenger activity in living cells. #CellBiology #SuperResolution #CSSB25

Next up: Sonja Schmid @scisonja.bsky.social - presenting the broad-range dynamics of biomolecules uncovered by DyeCycling🌟! She’s using innovative single-molecule fluorescence & nanopore techniques to peer into protein dynamics. Fascinating! #SingleMolecule #ProteinDynamics #CSSB25

Last speaker of this session is Nikos Hatzakis @hatzakislab.bsky.social - spotlighting his breakthroughs in 4D single-particle microscopy and machine‑learning analysis to decode enzyme function and cell biology one molecule at a time.🔬🧑‍💻 What a fantastic talk! #SingleMolecule #Biophysics #ML #CSSB25

Next up: Ben Schuler - exploring how intrinsically disordered proteins behave in the crowded, dynamic environment of living cells. 🧬 Combining single-molecule spectroscopy with cellular complexity to decode protein folding and function in real time. #ProteinDynamics #SingleMolecule #CSSB25

Up next: Keynote talk by Markus Sauer @sauer-lab.bsky.social - pushing the limits of live-cell imaging! He’s speaking about new strategies to achieve molecular resolution with super-resolution microscopy - in living cells! A breakthrough moment for the field! 🔬🍋 #Microscopy #SuperResolution #CSSB25

Next up: Flashtalk by Mette Malle - unveiling strategies for programmable RNA loading into extracellular vesicles! 🧫 A powerful platform for targeted delivery and functional RNA transport. #RNA #ExtracellularVesicles #SyntheticBiology #CSSB25

Next up: Christian Olsen — presenting on sulfur fluoride exchange (SuFEx) chemistry to target epigenetic regulators! 🔬 A powerful approach to probe and modulate chromatin biology with covalent precision. #ChemicalBiology #Epigenetics #CSSB25

Next up: Thomas Poulsen - diving into precision chemistry from the protein to the proteome! ⚗️ Powerful tools for covalent protein profiling. FANTASTIC work! #ChemBio #Proteomics #CSSB25

Next up: Helma Wennemers - exploring the chemistry of the extracellular matrix! 🧬 Her work on collagen-targeting peptides reveals new ways to image, modulate, and understand ECM biology with precision. #PeptideChemistry #Collagen #ChemicalBiology #CSSB25

Next up: Keynote talk by Ikuhiko Nakase — pioneering strategies for intracellular delivery! 🚀 From cell-penetrating peptides to exosomes and boron-based cancer therapies, his work is transforming how we get molecules where they need to go. Truly exciting! #DrugDelivery #Nanobiotech #CSSB25

After a wonderful poster session, day 1 ends, but day 2 is just about to kick off! 🔬 A lot of structural biology, chemical biology, and super-resolution imaging ahead… here we go! 🚀 #CSSB25 #microscopy #chemistry

Poster session time! 🧫🧠 So many brilliant ideas, creative experiments, and passionate scientists in one room. Come chat, exchange thoughts, and get inspired — this is where the magic happens! #CSSB25 #PosterSession #ScienceInAction

Next flashtalk up: Ciara Pugh 🎤🔬 Excited to hear her latest work developing MAASTY to use at the interface of chemical biology and structural insights. Let’s see what molecular stories unfold! #CSSB25 #ChemicalBiology #StructuralBiology

Knud Jensen on stage: "Selective Chemical Modification of Proteins: His-Tag Acylation" 🧪🔗 Smart strategies to precisely modify proteins using engineered His-tags — elegant and effective! #CSSB25 #ProteinChemistry

Now speaking: Kristian Strømgaard 🧠⚗️ Chemical probes & peptide engineering to dissect membrane proteins and synaptic signaling. Bridging chemistry and neuroscience with precision tools! #CSSB25 #Neurochemistry #ChemicalBiology

Chemical solutions to structural biology kick off by #Nobel laureate Morten Meldal . So happy to organise and attend such a event Check the amazing line up of speakers isbuc.ku.dk/documents/CS...

Keynote by Don Hilvert 🧪 Mastering enzyme design and evolution — from mechanistic insights to de novo biocatalysts. A true pioneer in protein engineering! #CSSB25 #EnzymeDesign #ProteinEngineering

Now it’s my turn! Excited to share our latest on GCE & click chemistry for live-cell and super-resolution microscopy 🧬🔬 From precise labeling to functional imaging — come by, join in, and let’s talk science! #CSSB25 #ClickChemistry #Bioimaging @uniregensburg.bsky.social @uni-wuerzburg.de

Next up: Patricia Bassereau 🧫🧠 Exploring how membrane mechanics and curvature shape cellular trafficking and signaling. Physics meets biology at the membrane! #CSSB25 #MembraneBiophysics #CellMechanics

Now on stage - 2nd Keynote by Yamuna Krishnan 💡🧬 Pioneering DNA nanodevices for real-time imaging and intracellular sensing — decoding the cell from the inside out. Brilliant science! #CSSB25 #DNANanotech #ChemicalBiology

First Flash Talk at #CSSB25 by Sara Mellemgaard: Microproteins to trigger cancer cell apoptosis 💥🧬 Smart design, functional evolution, therapeutic promise. #Microproteins #Apoptosis

Next up: Nieng Yan – From Sugar Transporters to Glyco-Conjugate Ion Channels 🍬🧬 A deep dive into the structural transitions to ion channel gating. Wonderful membrane protein science! #CSSB25 #StructuralBiology #Transporters

Annette Beck-Sickinger now on stage — exploring peptide signaling and GPCR pharmacology with a focus on chemerin and its receptor system. From biased agonism to receptor trafficking, unveiling how peptides fine-tune cellular responses. #CSSB25 #GPCRs #Chemerin #PeptideScience

After Coffee Break Next up: Jörg Rademann, pioneering selective covalent inhibitors and fragment-based ligands for decoding enzyme function. Smart chemistry meets structural precision. #CSSB25 #MedicinalChemistry #FragmentBasedDesign

Now kicking off with Brian Kobilka — a legend in the field and nobel laureate — delivering the opening keynote. Straight into the heart of #GPCR biology: old lessons, new insights. A masterclass in receptor signaling begins. #CSSB25 #StructuralBiology #ChemicalBiology

The host and nobel laureate Morten Meldal opens #CSSB25 with reflections on the cultural and scientific heritage of chemistry in Copenhagen. From foundational discoveries to molecular tools that changed how we see biology - the stage is set for a spectacular meeting. The room is ready. Let’s go 🧪✨

It’s about to start! The @isbuc.bsky.social Symposium 2025 on Chemical Solutions to Structural Biology here in Copenhagen. 🇩🇰 An outstanding speaker line-up! Find the program here: isbuc.ku.dk/chemical-sol... I’ll try to cover highlights for anyone curious. #CSSB25 #chemistry #structuralbiology

Important walkthrough for newcomers in the field rdcu.be/eg58p

Please share with all your colleagues and friends! The more the merrier! 👇👇👇 more info on smlms.org!

Thrilled to start my Professorship in `Bioimaging` at @uniregensburg.bsky.social ! Looking forward to exciting science, new ideas, and great collaborations! 🏛️🎓🔬 (Still 1% suspicious it might be an elaborate April Fools’ Joke🤔) #Bioimaging #ChemicalBiology #ClickChemistry #April1

AI4AMR is a collaboration between the labs of Ivo Boneca (microbiology, Institut Pasteur, Paris), Mark Brönstrup (chemistry, Helmholtz Center for Infection Research, Braunschweig) & Christophe Zimmer (computational biology, Univ. of Würzburg and Institut Pasteur).

A few days left to apply!

An excellent review about fluorescence labeling strategies by @beliulab.bsky.social Gerti Beliu and colleagues from Würzburg University - highly recommended reading for everybody interested in fluorescence microscopy!

🆕 Our new functionalized docetaxel probe enables superior visualization of dense mitotic spindle structures during cell division by expansion microscopy! ▶️ pubs.acs.org/doi/10.1021/...

Save the date ! Frontiers in Neurophotonics Symposium 2025 in Bordeaux October 6-9 frontiersneurophotonics.org/2025-speakers/ 🧪