(1) New preprint from our lab! HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis. Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death. 👉 doi.org/10.1101/2025... #ferroptosis #heme #ironmetabolism #preprint

New research presents a data common named the "Neurolipid Atlas" - a useful resource prepopulated with isogenic iPS cell-derived lipidomics data for different brain conditions ( #Alzheimers, #Parkinsons, #ALS, #FTD) www.nature.com/articles/s42...

🔬 Exciting news for the ferroptosis community! FerrOZtosis 2.0 symposium is happening this 19th September 2025 at The Florey, Melbourne. 📅 Abstract deadline: August 15 📍 Details & registration: lnkd.in/dn7imCzd

Lithium Chloride Inhibits Iron Dysregulation and Ferroptosis in Induced Pluripotent Stem Cells with ApoE4/E4 from a sporadic Alzheimer's disease patient #NeuroDegeneration 🧪🧠 https://www.biorxiv.org/content/10.1101/2025.08.28.672956v1

www.nature.com/articles/s41... Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy

Wow

FYI - We've extended abstract submission deadline to June 8. Submit soon to be considered for a short talk. Come join us at the first FASEB #Ferroptosis meeting! It's going to be awwwwesome! 🤩 events.faseb.org/event/11797f...

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia. Brief Skytorial! 1/9

Congratulations James! From basic discovery to drugging it in such a short time! Amazing work out of #MolecularTherapeutics @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social!!!

rdcu.be/emFqP Excellent review of our current understanding of ferroptosis in the brain and some of the challenges of studying it

"Despite 80% sequence identity with cytosolic human H-chain ferritin, ferrous ion oxidation at the catalytic diiron ferroxidase center of mitochondrial ferritin proceeds via a distinct mechanism" www.nature.com/articles/s41...

Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...

Our new exciting work on ferroptosis initiation in lysosomes. New molecule killing persister cancer cells. www.nature.com/articles/s41... #ferroptosis #cancer #metastasis

Here is our latest paper in @ACSBiol on compounds that restore activity to the R152H GPX4 variant, found in patients with SSMD. Congrats to Hengrui, Farhad and Russ on a great collaboration! @columbia #ferroptosis pubs.acs.org/doi/full/10....

Our team (hsph.harvard.edu/research/ube...) is excited to have contributed to the intranodal in vivo testing of the remarkable new compound, Fentomycin-1. Congrats to team Rodriguez et al. for the implications of this work in targeting ferroptosis in cancer. Check it out here!

Fantastic new study from Raphael Rodriguez' lab shows that induced proximity concepts can be used to induce Ferroptosis! Inducing proximity of lysosomal iron and lipids induces lipid peroxidation! What a cool concept! Have a look at our News/Views with @olzmannlab.bsky.social shorturl.at/cbc8D

Reminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome! 📅 Abstract deadline: June 1, 2025. shorturl.at/QA6T1

Join for the first FASEB Ferroptosis conference in the US this July! This stellar speaker line up brings together almost all leaders in the field!

Thank you to @brentstockwell.bsky.social of @columbiauniversity.bsky.social for visiting #MolecularTherapeutics at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social and presenting a tour-de-force through the ferroptosis field!

Palmitoylation regulates ferroptosis and anti-tumor immunity ->Nature | More info from EcoSearch

Interesting study that attempts to explain how NAC rescues from direct GPX4 covalent binding inhibitors. Was always a bit of a mystery and it looks to me like there might be more to it. www.cell.com/cell-chemica...

What do cells undergoing #ferroptosis #celldeath release? Read all about it in our atlas on ferroptosis #secretomes out now in Cell Death and Differentiation #CDDpress Great collaboration with @cecad.bsky.social @frezzalab.bsky.social @kreuzaler.bsky.social @almutschulze.bsky.social rdcu.be/ejp9C

Have you heard of ferroptosis? 💥 This is the iron-driven, propagating form of cell death! Our Membrane Dynamics Department (@office-garcia.bsky.social) has developed an optical tool to trigger and control it. 🔗Find out more: www.biophys.mpg.de/2857694/shining-a-new-light-on-ferroptosis?c=2011019

☕Fan et al. report a role for PRMT5 in regulating GPX4 stability and #ferroptosis sensitivity through arginine methylation, which may be targeted to inhibit #tumor development. rdcu.be/ejc3M bit.ly/4iyxJMj

PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation ->Nature | More info from EcoSearch

ALDH7A1 helps guard cells against ferroptosis by producing membrane NADH, boosting FSP1's antioxidant role. Explore how cells combat iron-induced death! PMID:40233740, CELL 2025, @Cell https://doi.org/10.1016/j.cell.2025.03.019 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪

Thanks David will do. Her research interest is cell death in the central nervous system with a focus on ferroptosis Pathways, neuro degeneration focusing on central nervous disease dysfunction at cell and molecular level.

Another layer of mitochondrial regulation of ferroptosis. Very interesting!

Important considerations while studying ferroptosis. A great starting point for anyone entering this field.

Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...

First good news coming from the US this year 🫣🤭 👇👇👇👇👇👇👇👇👇👇👇

Ever wondered how #mitochondria fragmentation comes about during #ferroptosis ? Read our new paper on Drp1-mediated promotion of ferroptotic #celldeath. Great @cecad.bsky.social collaboration with Ana Garcia Saez! rdcu.be/d7L66