✨June Issue✨| Targeting osteoarthritis where it hurts: the osteochondral junction This News & Views article discusses targeting neurovascular growth at the osteochondral junction as a therapeutic approach for osteoarthritis. @jointsintheworld.bsky.social bit.ly/4kiDfo3 #Rheumsky #Medsky

This looks like a great (free!) event for folks in the UK interested in #PainResearch #PatientEngagement www.eventbrite.co.uk/e/the-puzzle...

New powerful article up in the New York Times on cancelled and delayed grants www.nytimes.com/interactive/...

O’Brien et al. find that visual exposure to green light reduced joint pain in osteoarthritic rats independent of nociceptor activity. Analgesic endolipids were upregulated, suggesting involvement of the endocannabinoid system. Learn more in #PAIN bit.ly/3S2xpe3

Join us for our quarterly C-COMP journal club, featuring this exciting new paper by the team of @kelseyhcollins.bsky.social and @farsh-g.bsky.social Monday May 12th 10 am CST- ask us how to register! www.science.org/doi/full/10....

grants.nih.gov/grants/guide... The fun never stops....

ICYMI: New content online:

Looking forward to #OARSI2025 ? We are delighted to have the OAC and OAC Open Journal Session on April 24th at 11 am KST. Don't miss the Paper of the Year award presentation and updates from our Editors-in-Chief @profdavidhunter.bsky.social and @jointsintheworld.bsky.social !

www.science.org/doi/10.1126/... GLP1 in osteoarthritis...

Excited for our workshop on interdisciplinary solutions to study mechanisms of musculoskeletal pain at #USASP2025 in Chicago, featuring talks from Nadeen Chahine, Hang Lin, Rachel Miller, and Allan Basbaum @usasp.bsky.social. #painresearch Would love to see you there!

This is what’s at stake. My lab is full of young brilliant scientists who deserve the chance to make a difference in the world. Shutting them out is the dumbest move we can make. We need to rescue American science from these monsters.

ICYMI: New content online:

Our Editorial is now online! Here, we discuss recent advancements and pertinent challenges in applying modern 'omics technologies to MSK tissues. This introduces our @oacjournal.bsky.social special edition. Still ~4 weeks left if you have a paper in the works! www.sciencedirect.com/science/arti...

One month left until the submission deadline for this special edition of @oacjournal.bsky.social on the application of omics technologies to the field. Don’t miss out!

🚨 PhD Studentship 🚨 Interested in organoid and organ-chip models of cancer? 🧫 Join us to explore new treatments for osteosarcoma! Funded by Willberry Wonder Pony Charity, join us at @qmul.ac.uk, alongside Dr Lucia Cottone & Prof @fionafreeman.bsky.social! Details: www.theverbruggenlab.com/jobs

New study by BU’s Dr. Jean Liew finds people with lower bone mineral density in the subchondral bone of the knee are more likely to experience knee pain, suggesting that the structure of bone plays a key role in osteoarthritis pain: bit.ly/4hbzOx8

These are shocking graphs. We are being strangled by our own government. It is notable that the consistent message has been that us researchers are somehow doing a disservice to the American people, sitting on this money getting fat from the largesse. In fact, we are focused on discovery and cures.

Placebo effect influenced by active treatment category and changes over time in knee osteoarthritis trials doi.org/10.1002/acr.... Patient-reported treatment goals in psoriatic arthritis doi.org/10.1002/acr....

April 7 C-COMP seminar 1 pm CST by Dr Yvonne Lee - to attend virtually, please register!

Interested in understanding the role of stress on lipid droplet accumulation in chondrocytes??? This work by Yu et al., investigates the impact of stress-induced microtubule impairment on intracellular transport and lipid droplet (LD) accumulation in chondrocytes. 🧪 🥼 🔗https://buff.ly/oa95BpT

Just want to remind everyone today that the DoD just slashed a huge mechanism for cancer research funding: now this science won’t get done. Cuts below with other sources linked in the comment www.fightcancer.org/sites/defaul...

See national impact of federal health research cuts scienceimpacts.org

🚨 Attention NIH & NSF grantees! AAAS is hosting a rapid response webinar this Friday, 12-1 pm ET, on responding to federal research grant terminations. NIH and NSF will be case examples. Register here: aaas.zoom.us/webinar/regi...

‘Chaos and Confusion’ at the Crown Jewel of American Science www.nytimes.com/2025/03/24/h...

How does low intensity, high frequency vibration training impact musculoskeletal structure and function after volumetric muscle loss injury? Daniel B. Hoffman & coauthors present their findings in JOR: onlinelibrary.wiley.com/doi/10.1002/...

If anyone in Indiana’s 5th Congressional district has the time, please attend this town hall and ask Rep. Spartz why she supports the NIH cuts to IU… her district is chock full of IU employees who will be negatively affected! I desperately wish I could attend but will be in Portland for a meeting 😫

New pre-print form the lab, led by @rem7106.bsky.social Targeting piezo2 to alleviate osteoarthritis pain

🚨I converted the list of terminated #NIH grants (as of 3/22) into a google sheet. I added activity codes and award jurisdictions (see tabs for grant count and $ by each). Note this HHS list likely does not include all planned/completed terminations as of this date.🚨 Please use, share and distribute!

Maybe we can spread this like wild fire

Horrible news - The Adolescent Medicine Trials Networks for HIV/AIDS Interventions (ATN) funded by the NIH has just been terminated. Stopping a clinical trial mid-course like this is insane. www.nichd.nih.gov/research/sup...

The April 2025 issue of #PAIN is out now! Catch up on the latest pain research at bit.ly/4hqEKzd

#March #BasicScience #EditorsChoice Bone marrow adipose tissue is emerging as an important regulator of bone health. This study explored its involvement in regulating bone pathology in hand OA and found elevated lipolysis in fat and bone cells. Stay tuned for more BMAT and OA! buff.ly/WlIm1qK

Our program manager extraordinaire, Ayesha Ahmad, is leaving us, so we have an exciting position open to take on her role. jobs.utdallas.edu/postings/28956 In addition to this being an exciting position, you will also get to learn from Ayesha before she departs.

If you have a federal grant, I *highly* recommend going to this Friday's webinar on responding to grant terminations. Lisa Brown, former general counsel at Dept of Ed, will present along with other lawyers. Friday, March 21, 2-3 pm. More info & register here: www.linkedin.com/pulse/regist...

Chilling to see this list of terminated NIH grants. Research on Alzheimer's, HIV, rare diseases, vaccines -- gone. Cancer centers closed, training grants & fellowships terminated. Young scientists stranded. Patients waiting for treatments that'll never come. Just sad. taggs.hhs.gov/Content/Data...

Want to be next? Take your research further with up to $30K! 💡🔬 The Bethel Musculoskeletal Research Center/ORS Fellowship supports early-career scientists tackling #musculoskeletal diseases—helping them secure critical data for bigger grants. Accepting applications until April 1: bit.ly/49uDIy2

Incredible how still recently sensory nerves were seen only for sensation. Now, almost weekly, we see their major role in regulating physiology far beyond their classic function, across the whole body. Check this study on the role of sensory nerves on cancer progression!

Thanks for highlighting! @tuhinaneogi.bsky.social @treekb.bsky.social

Our Center is a great place to work! If you are looking for a lab technician position, please check out our posting!

NIH is the best investment there is. www.forbes.com/sites/michae...

Apply by March 31 for the 2025 Clinician Scholar Development Program! #Orthopaedic residents, level up your career! Join us Oct. 2-4 in Rosemont, IL, for this competitive program focused on research, leadership, & communication. Learn more and apply now: buff.ly/xVdlesC

99% of new medicines developed by the pharmaceutical industry depend on NIH research jamanetwork.com/journals/jam...

This is the US today...

Today is the day!! Absolutely in awe about what a bunch of grad students were able to pull off when they looked around and realized no one else was standing up.

TODAY IS THE DAY! 🧪☀️⬇️ Join us at the Lincoln Memorial or your local site to Stand Up for Science!