Exciting new study on the role of PIEZOs in Chondrocytes! Relevance to arthritis and pain. From: @farsh-g.bsky.social & @kelseyhcollins.bsky.social arthritis-research.biomedcentral.com/articles/10....

Congrats to Amanda Cimino and team on her latest paper in @JCRnEDITORS - she developed new synthetic chronogenetic gene circuits that allow controlled drug delivery at precise times day using various elements of the circadian clock! doi.org/10.1016/j.jc...

Huge congrats to Dr. Amanda Cimino for an outstanding presentation and defense - her committee said it was time for a "PhD+" degree. Amazing work!

Chronotherapy in Rheumatoid Arthritis Treatment: Tantalizing but Understudied www.medscape.com/viewarticle/...

We don’t always know what questions will change the world. But public science has a way of answering them anyway. Federal science funding isn’t just lines in a budget. It’s a vote for progress, for possibility. www.nytimes.com/2025/05/16/s...

Most studies of cartilage mechanobiology study the upregulation of chondrocyte gene expression and biosynthesis with mechanical loading. Check out our recent paper where Daniel Palmer studied the down-regulated "mechanome" with Piezo1 or TRPV4 activation. www.tandfonline.com/doi/full/10....

Your research on Ion Channel Regulation might be the next watershed discovery! Join FASEB for the latest findings at #ICRSRC with keynote speaker @farsh-g.bsky.social and organizers @roseedixon.bsky.social and Jonathan Silva. Submit your abstract by June 8 and save your space now! buff.ly/A3wmAbp

Congrats to Amanda Cimino for her latest paper creating a chronogenetic gene circuit that automatically delivers anti-inflammatory biologic drugs in response to inflammation or circadian signal! jbioleng.biomedcentral.com/articles/10....

Lots of celebrations this month in the Guilak Lab! Congrats to Xinyi Melissa Li and Katelyn Lipa for passing their qualifying exams with flying colors!

🚨 Big updates! ✅ Successfully defended my PhD thesis: “Multiscale Modeling of Chondrocyte Mechanobiology: Insights into Degeneration and Regeneration” ✅ Joined the lab of @farsh-g.bsky.social at WashU St Louis as a Rita Levi-Montalcini Postdoc Fellow in regenerative medicine! Grateful & excited !

Please widely share these 3 new advocacy letter templates with your colleagues. @lolauic.bsky.social @orssociety.bsky.social @bmes-cmbe.bsky.social @aapmhq.bsky.social @acadrad.bsky.social @ceschmidt2024.bsky.social @settonlab.bsky.social @tejaladesai.bsky.social @farsh-g.bsky.social

Join us for our quarterly C-COMP journal club, featuring this exciting new paper by the team of @kelseyhcollins.bsky.social and @farsh-g.bsky.social Monday May 12th 10 am CST- ask us how to register! www.science.org/doi/full/10....

Congrats to Sophie Paradi on a fantastic Master's thesis and defense! Amazing work and collaboration with Erica Ely and many others in the Guilak Lab

Ion channel research can have major consequences for cancer and cardiovascular disease treatments. Join FASEB at #ICRSRC for the latest findings with keynote speaker @farsh-g.bsky.social and organizer @roseedixon.bsky.social. Check out the full program and save your space: buff.ly/d213NE1

Congrats ‪@kelseyhcollins.bsky.social‬ on another tour de force, shedding further light into the relationship between obesity and OA! The more we learn, the more complex it gets... Fantastic collaboration with the June lab and WashU Rheumatology!

put me in, coach...

Join us today for our AOC Thought Leaders Webinar: Managing the Research Enterprise — for anyone navigating the evolving landscape of academic orthopaedics. April 24 | 4:00 PM ET Register Here: lnkd.in/eTrzEem6 Joint the AOC at myaocconnect.com!

Congrats Dr. Jackie Garcia on an amazing dissertation on defense "Characterizing PIEZO1 Mechanotransduction in Articular Chondrocytes"!

Excited for our most recent publication mapping macrophage populations in the synovium with knee injury and obesity! Great work by @nharasymowicz.bsky.social and team!

The 3/14 deadline to finalize the FY2025 budget is fast approaching! ⌛ AIMBE has developed a new advocacy letter (<1 min to send) for the scientific community to urge Congress to support our federal science agencies, including NIH, NSF, FDA, ARPA-H, CDMRP, and more 👇 takeaction.io/aimbe/suppor...

Engineered stem cells automatically deliver arthritis drugs at prescribed times of day apnews.com/press-releas... www.nature.com/articles/s41...

We’ve created a new field called “chronogenetics”: controlling gene expression with the cell’s internal clock! Lara Pferdehirt & Anna Damato made living implants that sync to the body & automatically deliver biological drugs on a 24 hr cycle. www.nature.com/articles/s41...

On #RareDiseaseDay, we are excited to publish Zainab Harissa's paper showing that rare, dysplasia-causing mutations in the ion channel TRPV4 alter the response of chondrocytes to mechanical loading. journals.physiology.org/doi/abs/10.1...

Check out the latest insights on what controls pericellular matrix properties (measured by atomic force microscopy) as it is degraded in OA. fantastic collaboration with Marina Danalache. Congrats to Jule Nieuwstraten for leading this study!

Congrats to all the new members of the National Academy of Engineering, especially our many biomedical engineering colleagues Kyriacos Athanasiou, Sam Achilefu, Lisa Brannon-Peppas, Lydia Kavraki, and many others! www.nae.edu/331605/NAENe...

Please widely share our statement and advocacy letter template with your colleagues. @lolauic.bsky.social @orssociety.bsky.social @termisam.bsky.social @bmes-cmbe.bsky.social @aapmhq.bsky.social @ceschmidt2024.bsky.social @settonlab.bsky.social @tejaladesai.bsky.social @farsh-g.bsky.social

Congrats to Gabi Marushack and @alisavadipour.bsky.social & team for our latest @Guilak_Lab paper showing that polyunsaturated fatty acids alter cell membrane properties & inhibit chondrocyte #mechanotransduction by #Piezo1 and #TRPV4. faseb.onlinelibrary.wiley.com/doi/10.1096/...

Huge congrats on an amazing dissertation and defense, Dr. Erica Ely! It's #Piezo month at @Guilak_lab