Honored to share our new paper, Osteoarthritis as a Systemic Disease, in @natrevrheum.nature.com, out today: rdcu.be/eSXLW - thanks to Ida Haugen, @tuhinaneogi.bsky.social and @farsh-g.bsky.social for your input on gaps and opportunities.

Congratulations Priscilla Tjandra and all on our new paper: tinyurl.com/2mbhxuz7. We demonstrate a role for complement factor D secreted by fat in the early and persistent pain after knee injury. Thanks to Darren Dunlao and Jacob @ucsfmicrobiome.bsky.social for collab on eicosanoid profiling!

Sporting mine in Sydney, Australia! Learn more about the #whitesneaker campaign and resources for #worldosteoporosisday below 👇🏻

Thrilled to be speaking at the McCaig International Research Conference on #Osteoarthritis, March 11–13, 2026 in Kananaskis, Alberta 🇨🇦 Trainee abstract submissions are open until Oct 31, 2025! Learn more: mccaig.ucalgary.ca/event/intern... #McCaig2026 #BoneAndJointHealth

Love seeing the #WhiteSneakers being packed for #ASBMR2025, keep them coming! Wear them at the meeting on Saturday 06 Sept to Take Steps to Improve Bone Health. Even if you can't join us in Seattle, post a pic with your favorite pair and join the MOVEment! @asbmr.bsky.social 🦴💪🚶‍♀️🚶

The @asbmr.bsky.social Annual Meeting is less than 2 weeks away, and we're all lacing up our #whitesneakers to get ready! Wanna join the MOVEment and Take Steps to Improve Bone Health? Be sure to pack your white sneakers for #ASBMR2025 in Seattle, wear them on 06 Sept, and stay tuned for more!

We are inviting original research studies that probe the interaction between Obesity and Osteoarthritis for @oacjournal.bsky.social by May 1, 2026. Details below & happy to discuss! @jointsintheworld.bsky.social @profdavidhunter.bsky.social @larhumato.bsky.social Shannon Mihalko Henning Bliddal

Exciting new study on the role of PIEZOs in Chondrocytes! Relevance to arthritis and pain. From: @farsh-g.bsky.social & @kelseyhcollins.bsky.social arthritis-research.biomedcentral.com/articles/10....

Most studies of cartilage mechanobiology study the upregulation of chondrocyte gene expression and biosynthesis with mechanical loading. Check out our recent paper where Daniel Palmer studied the down-regulated "mechanome" with Piezo1 or TRPV4 activation. www.tandfonline.com/doi/full/10....

1) Despite the chaos, I am very pleased to present the terrific research conducted by my post-doc @clarissacoveney.bsky.social. acrjournals.onlinelibrary.wiley.com/doi/10.1002/...

It is a joy to congratulate @jessicagwagner.bsky.social, Movement Science PhD Student in UCSF PT, on a fantastic qualifying exam this morning - first one in the lab! Way to go, Jess 👏 Here is a link to Jess' recently published paper: onlinelibrary.wiley.com/doi/full/10....

Starting in 15 min! Thanks @jointsintheworld.bsky.social and CCOMP for the opportunity to share our work @farsh-g.bsky.social

New to ORS? Join our New Member Orientation on May 21 at 12 PM CST via Zoom! Learn about member benefits, networking, and hear how ORS has impacted careers. Bring your questions! 🔗 Register now: bit.ly/3XzipIA

Join us for our quarterly C-COMP journal club, featuring this exciting new paper by the team of @kelseyhcollins.bsky.social and @farsh-g.bsky.social Monday May 12th 10 am CST- ask us how to register! www.science.org/doi/full/10....

@kelseyhcollins.bsky.social and I are kicking off the USASP Annual Scientific Meeting with a trip to the iconic Bean! Excited to be in Chicago, present my work this afternoon at poster B28, and join the Pain & Aging SIG tonight! 🎉 @usasp.bsky.social

Excited to share the latest chapter of our work on fat-joint interorgan crosstalk in knee OA, featuring the role of complement factor D secreted by fat in knee pain. Link here: bit.ly/42Og5hJ Thanks to @farsh-g.bsky.social for all of your support - @thehopefulscie1.bsky.social and all coauthors!

Yet another study showing beneficial effects of metformin for pain - this time in OA pain. Effects on pain are modest, but better than placebo. Effects on WOMAC scores are more impressive. Also no sex differences observed. jamanetwork.com/journals/jam...

Congratulations to @grainofscience.bsky.social on the 2025 OARSI Rising Star Award! Well deserved 👏

If you're around Palo Alto tomorrow, come hear how we gave menisci discarded from the food industry a second life to repair tracheas and eardrums @bioe-stanford.bsky.social @pennmedicine.bsky.social @pennengineering.bsky.social @upenn.edu #ENT

Obesity has a distinct impact on the progression of OA. We showed significant loss of protective synovial lining macrophages in the synovium 3 days after joint injury, with a significant restoration in normal-weight but not in obese mice @farsh-g.bsky.social ard.eular.org/article/S000...

Fascinating new article from the Basbaum Lab! Elora Midavaine et al. show that regulatory T cells can curb pain via endogenous opioid signaling - but only in female mice. #PainResearch #Neuroimmunology #Tregs #SexDifferences #Enkephalin www.science.org/doi/10.1126/...

Our Editorial is now online! Here, we discuss recent advancements and pertinent challenges in applying modern 'omics technologies to MSK tissues. This introduces our @oacjournal.bsky.social special edition. Still ~4 weeks left if you have a paper in the works! www.sciencedirect.com/science/arti...

Want to do a #postdoc? Did you know more faculty jobs go to people who postdoc in slightly different subject area? doi.org/10.1073/pnas... Are you an expert in #microbiome OR #osteoarthritis? How'd you like to join me and @kelseyhcollins.bsky.social as we figure out how the two are connected?

I could not be more excited to have our lab's first story online where we report our discovery that HDACs ~reverse~ their activity to ADD acyl groups to lysine! We found this for our favorite ketone body, BHB, but this pathway controls other lysine modifications too!🧵 www.nature.com/articles/s41...

Hey #CartilageGRS2025 trainees! Defending soon, looking for a postdoc, and/or want to live in beautiful San Francisco, CA? We're looking for motivated folks to solve complex puzzles involving systemic factors, fat, aging, the gut microbiome and MSK health. DMs open! @thehopefulscie1.bsky.social

Stop 4: Solvang (forgot to take any photos- sign of a good time) Stop 5: In N Out (aka when in Cali) #CartilageGRC

Having lots of fun at #CartilageGRC2025 - Congrats to @thehopefulscie1.bsky.social on her election as the 2027 Cartilage GRS Co-Chair and her GRS Podium Award! Her work on aging and sex differences is awesome and so we are proud to share this work at the GRC meeting. Way to go, Hope! 🥂

Thanks for highlighting! @tuhinaneogi.bsky.social @treekb.bsky.social

Cool overview of #osteoarthritis, which will be of interest to many in #neuroskyence & #PainResearch communities. Thanks to @tuhinaneogi.bsky.social, @jointsintheworld.bsky.social & others! Some figures that will doubtless appear in many talks in years to come! www.nature.com/articles/s41...

Excited for our workshop on interdisciplinary solutions to study mechanisms of musculoskeletal pain at #USASP2025 in Chicago, featuring talks from Nadeen Chahine, Hang Lin, Rachel Miller, and Allan Basbaum @usasp.bsky.social. #painresearch Would love to see you there!

The 3/14 deadline to finalize the FY2025 budget is fast approaching! ⌛ AIMBE has developed a new advocacy letter (<1 min to send) for the scientific community to urge Congress to support our federal science agencies, including NIH, NSF, FDA, ARPA-H, CDMRP, and more 👇 takeaction.io/aimbe/suppor...

Proud to be a scientist today and everyday. Science belongs to everyone and is for everyone ❤️🧬 #StandUpForScience

We’ve created a new field called “chronogenetics”: controlling gene expression with the cell’s internal clock! Lara Pferdehirt & Anna Damato made living implants that sync to the body & automatically deliver biological drugs on a 24 hr cycle. www.nature.com/articles/s41...

Thank you @zsuzsajenei-lanzl.bsky.social for a wonderful talk and for spending time with us this month! Can’t wait to collaborate with you and learn more about the role of stress in OA.

Congrats to the 2025 @orssociety.bsky.social #NIRA winners!! 🥳 @cpane94.bsky.social @vgbbrito.bsky.social @robinvroman.bsky.social, Kevin Burt, Priyanka Brahmachary, Alex Brown, Carlos Cruz, Ichiro Kurakazu, Augustine Saiz, Nazgol Tavabi, Robin Vroman, and Enhao Zhang!! www.ors.org/ors-new-inve...

Save the date: C-COMP Seminar, featuring Dr. Zsuzsa Jenei-Lanzl from Goethe University Monday, February 24, 2025, 3:00 PM Central Time "The vicious circle of chronic stress, inflammation and pain in osteoarthritis"

Congrats to all the new members of the National Academy of Engineering, especially our many biomedical engineering colleagues Kyriacos Athanasiou, Sam Achilefu, Lisa Brannon-Peppas, Lydia Kavraki, and many others! www.nae.edu/331605/NAENe...

This is a huge honor for my close friend, @ucsfhealth.bsky.social partner, & @podcast co-host: @brianfeeleymd.bsky.social Although most of you know us from injury analysis on the radio, Brian is one of the few ortho surgeons in the world with this level of expertise: www.aaos.org/aaos-home/ne...

I am starting this morning by reaching outside of my science echo chamber (posting on facebook) to explain why the NIH matters and why the new indirect rate policy will be catastrophic to everyone

Another amazing talk at #ORS2025 from @carolynchlebek.bsky.social ! 👏🏼👏🏼 It was so fun to collaborate and bring #metabolomics into this well designed study centering around the effects of #obesity and weight loss on bone 🦴

Happening now!

Shuffle the cards and kick their ass. Thanks, Sonny. #ors2025

Thank you Dr. Bukata for your service on @orssociety.bsky.social. We are so lucky to have you as an advocate, champion and role model for Orthopaedic Research @ucsandiego.bsky.social #UCWomenofOrtho

Hey @orssociety.bsky.social members! Are you at #ors2025? The board needs your feedback on the strategic plan. Please visit the focus groups in person today and tomorrow, or DM me for the QR code to submit feedback online. Your voice matters!

While we figure out the BIG next steps, we all (especially those with republican senators) need to be loud as hell about opposing RFK Jr. With everything we stand to endure as scientists, an anti-science HHS Secretary is not an option. NIH-funded science benefits EVERYONE

Your #ORSOpenDoor 2025 volunteers! We are so excited to engage students and teachers in short career talks, a discussion panel, and hands on workshops - it’ll be a fun day full of #stemoutreach! 🎉🧬🦴 @orssociety.bsky.social

It is almost time for #ORSOpenDoor! Volunteers have arrived, coffee is being served, and workshops are underway 🎉 Follow along here and on Blue Sky to get all the updates today! @orssociety.bsky.social

The #BasicScience #EditorsChoice for #February is this cutting edge work from the Brunger lab! Read about how Walton et al. deployed a synthetic receptor platform that regulates cell behaviors here: https://buff.ly/3CuBkMz

Join us Saturday at 7:30pm for our annual OA RIG at #ORS2025 @larhumato.bsky.social @thehopefulscie1.bsky.social @orssociety.bsky.social

Boarding my flight to #ORS2025! 🎉✈️ Excited to be part of the RIG: Bridging Disciplines to Find Solutions for #Osteoarthritis on Saturday night! Plus, catch my work on Monday and research from the June & Collins labs and our collaborators throughout the weekend! ⬇️⬇️