#New in #OAC Work from Chen et al. found that treadmill #exercise offers protective effects when initiated early after OA onset but may worsen outcomes if delayed.🏃🏃‍♂️🏃‍♀️ 🔗 oarsijournal.com/article/S106...

How does Estrogen receptor-α loss accelerate cartilage degradation? 🧐 #New in #OAC this month! Read more: www.oarsijournal.com/article/S106...

#OAC #Dec TMJ condylar cartilage exhibits a distinct hyaline microstructure compared to knee cartilage, characterized by higher cell density, smaller cells, and enlarged cell lacunae filled with GAGs, contributing to a load-responsive mechanical behavior. 🔗 www.sciencedirect.com/science/arti...

Where does OA pain really come from? 🤔 December's Editor's Choice (Clinical) suggests it's NOT just the cartilage Targeting entheses might be next frontier for symptom relief Read more from Ziegeler et al: www.oarsijournal.com/article/S106...

#New in #OAC Xiao et al. investigates the role of CX3CR1⁺ macrophages and microglia in local inflammation and pain using transgenic mouse models and surgically induced disc herniation model. 🔗 sciencedirect.com/science/arti...

New in #OAC Alimy et al. identified subchondral bone endotypes with distinct clinical and cellular characteristics as a basis for developing novel OA therapies. 🔗 www.oarsijournal.com/article/S106...

This collaborative work from Farhat et al. seeks to learn about the brain-joint connection and reveals a CB1 dependent hypothalamic connection to the lateral meniscus that prevents its mineralization and subsequent articular cartilage damage. 🔗 www.oarsijournal.com/article/S106...

🆕 Editor's Choice! This month's featured paper is on plasma #lipoprotein and #osteoarthritis risk Lipoprotein subclasses play diverse roles in health and disease there is so much more to learn about its impact on knee #osteoarthritis Read more from Li et al - www.oarsijournal.com/article/S106...

LAST DAY TO SUBMIT!☺️

How did Zhou et al. monitor the temporal profiling of lipid mediators in the synovium and tibial plateau during joint inflammation🧐? Learn out this work in this month's #EditorsChoice paper for #Basic #Science. 🔗 www.sciencedirect.com/science/arti...

One week left to submit your #Cover #Art for the #OAC cover art competition. We look forward to seeing all of the creative designs. 🤩

👋 Are you a young researcher interested in editorial roles? If that is you, OAC is currently seeking Editorial Fellows for 2026! Fellows will be mentored by our Editors-in-chief David Hunter @jointsintheworld.bsky.social and our team of Deputy Editors. form.jotform.com/242315596999...

#New research highlights the key role of the NGF/TrkA pathway in chronic #OA pain. Through gene expression analysis, specific genes and pathways linked to OA progression were found, offering insights for targeted therapies against OA pain. #PainResearch 📖: www.sciencedirect.com/science/arti...

Think of transplanting stem cells like sending an athlete onto the field—without training, they'll struggle. Ai et al. created a "warm-up" system that mechanically pre-trains MSCs for the tough environment of the knee! 🔗https://www.sciencedirect.com/science/article/pii/S1063458425010659?via%3Dihub

Great summary of our latest work - a real Team Science effort! 👥 🐭

Link to paper published in @oacjournal.bsky.social here: pubmed.ncbi.nlm.nih.gov/40712915/

October's #EditorsChoice is on #guthealth 📈 Higher relative abundance of hashtag#alistipessenegalensis and alterations in tryptophan metabolites like indoleacrylic acid are associated with hand hashtag#osteoarthritis ✋ Access full-text and all their awesome figures here: lnkd.in/gPU3RNv7

#New in #OAC ! The sphingolipid sphingomyelin 34:1 is upregulated in the synovial fluid of those with OA. Work from @phar.cam.ac.uk shows that SM34:1 causes inflammatory pain in mice, inducing neuronal hyperexcitability. @psalmotoxin.bsky.social @interlukein.bsky.social @mayadannawi.bsky.social

Are you a creative scientist?🧐 #OAC is looking for a new cover design! Submit your Osteoarthritis and Cartilage based cover designs by November 10th, 2025🤩 forms.gle/5qVWiHrHk2G9...

#New this month in #OAC . Translocator protein 18 kDa (TSPO) plays an important role in #OA occurrence and development. Emapunil targeting TSPO improves OA by modulating #macrophage polarization and #inflammation through the CD14/TLR4/LY96 pathway. 🔗 www.sciencedirect.com/science/arti...

#New in #OAC This study by Xiao et al. demonstrates that YAP plays a critical role in subchondral bone remodeling and targeting the YAP-Hhip axis through regulation of Hh-Gli1 signaling in Gli1+ osteogenic progenitors could inhibit OA progression! 🐭 www.sciencedirect.com/science/arti...

🌟 Four other conditions that should be considered in the differential diagnoses of early-stage symptomatic knee #osteoarthritis (EsSKOA) 1️⃣ Patellofemoral pain 2️⃣ Meniscus injuries 3️⃣ Collateral ligament injuries 4️⃣ Inflammatory arthritis Read free at lnkd.in/gvKY77uB

Excited to be part of this guest editorial team: if you are looking for a home for your research on pain mechanisms in osteoarthritis, submit away 😃 #PainResearch

New from #OrACORe in @oacjournal.bsky.social: Longitudinal associations between bilateral vs unilateral knee osteoarthritis and physical performance. Contrary to our hypothesis we did not find associations between bilateral disease & worsening physical function www.sciencedirect.com/science/arti...

Participants whose daily activity best matched patterns of high evening activity or very high morning activity had the least risk of developing #slowgaitspeed 🚶‍♂️ 🗞️ Read more from Tore et al. oarsijournal.com/article/S1063-…

NEW in this month's issue 🔥 September's Editors Choice by Akkaya et al. found that diets rich in ultra-processed foods are linked to worse knee #osteoarthritis outcomes especially in women 🍔🍦🍟🍩 👀 Read about this large (n=4403) study for free at: www.oarsijournal.com/article/S106...

#BasicScience #EditorsChoice This work by Liao et al. investigated the effects of Tamoxifen in multiple mouse models to better understand its role on bone and cartilage metabolism and endochondral ossification. 🐭 📖Read more: www.oarsijournal.com/article/S106...

🌟 #New in #OAC 🌟 Curious to know how Piezo1 deletion protects against TMJOA? Read this new work by Wang et al. sciencedirect.com/science/arti...

📢 Call for Papers OAC is excited to announce a Special Issue on Pain Mechanisms in Osteoarthritis. www.sciencedirect.com/special-issu... Submission Deadline: May 15th, 2026

#New #Basic #Science in #OAC How does sex influence the development of #PTOA using a mouse model of mechanical #ACL injury? 📑Check out this work: www.sciencedirect.com/science/arti...

Higher fat to muscle ratio (FMR) associated with higher #osteoarthritis incidence 👀 👇 🔢 Data from a large prospective cohort study from the UK Biobank dataset (n=328,549) Read further in this month's issue from Lou et al.: www.oarsijournal.com/article/S106...

Curious to know how to use #AI in #OAC? 🧐 elsevier.com/about/polici...

🔥 How can pharmacists help deliver high-value knee OA care? 📖 Explore the #Capabilities, #Opportunities, and #Motivations of Australian pharmacists in this new study: oarsijournal.com/article/S1063-…"

🎙️ New #jointaction podcast on all things #methotrexate Joint David Hunter with guests Robin Christensen, BSc, MSc, PhD Anna Døssing to learn more 👇 Podcast link: www.jointaction.info/podcast/epis... Editorial link: pubmed.ncbi.nlm.nih.gov/40222629/

New this month! 🦴 Calcium pyrophosphate deposition disease (CPPD) is associated with increased risk of fractures (Fig. 1 below 👇 ) www.oarsijournal.com/action/showP...

#August #EditorsChoice #BasicScience This work by Zapata-Linares et al. uses a dynamic mouse model to assess the positive correlation between OA and increased bone marrow adiposity. 📖 more: www.sciencedirect.com/science/arti...

🏃‍♂️‍August's Editor's Choice is on #Taichi ✅ Several benefits associated with #Taichi in this 28 study systematic review that included 1676 OA participants 👀 Read more from Zhao et al. at www.oarsijournal.com/article/S106...

#New in #OAC MM-II is a dispersion of empty large liposomes which is under clinical development for knee OA. This research by Wechsler et al., aims to decipher the MM-II mechanism of action on the tissue types of the knee joint! 🔗https://sciencedirect.com/science/article/pii/S1063458425008155

#More #Basic #Science in #OAC Check out this exciting new paper showing TNFalpha receptors-1 & 2 modulate repair potential in painful disc degeneration in a human model system by @iatridislab.bsky.social 🔗https://www.sciencedirect.com/science/article/pii/S1063458425008684?via%3Dihub

🔊 CALL FOR PAPERS! Special Edition: Obesity and Osteoarthritis www.sciencedirect.com/special-issu... Deadline: 01 May 2026

#New #BasicScience Surface-modified exosomes effectively target early-stage arthritic cartilage, delivering therapeutic cargo like receptor antagonist of interleukin-1 into the deep zone of cartilage tissue. Read more: 🔗https://www.sciencedirect.com/science/article/pii/S1063458425008623

🆕 Hand #osteoarthritis in this month's issue! 👊 Bone marrow lesions and collateral ligament lesions are associated in interphalangeal joints with osteoarthritis 🆓 Read free from Terpstra et al. - t.co/OpfQPFalzO

💥new this month! Higher #FT4 (free throxine) concentrations may increase the risk of knee #osteoarthritis 📖 Read all about thyroid function and OA in this new paper by Xu et al. - oarsijournal.com/action/showPdf…

This month's #BasicScience #EditorsChoice paper demonstrates that the Maresin 1-LGR6 axis mitigates inflammation and #PTOA after transection of the #ACL in mice🐭. @lehoczky-lab.bsky.social 🔗https://sciencedirect.com/science/article/pii/S1063458425008696?via%3Dihub

🥳 July's Editors Choice is on MM-II for knee #osteoarthritis 💉 MM-II is a novel suspension of empty large multilamellar liposomes that can provide cartilage lubrication and protection 🆓 Read all about this 26 week RCT at: www.oarsijournal.com/article/S106...

More #BasicScience in #OAC Yuh et al. demonstrate that joint loading and motion do not act in isolation, but interact together in terms of their effect(s) on the tissue’s mechanical and biological responses at varying scales. 🔗Read more: sciencedirect.com/science/arti...

#New in #OAC read about a new histological analysis pipeline for quantification and visualization of morphometric and spatial changes in the tibial medial compartment in rat models of osteoarthritis. @orthobme.bsky.social 📖https://oarsijournal.com/article/S1063-4584(25)00867-2/fulltext

THIS JUST IN!!! #OAC rises in #impactfactor from 7.2 to 9! OAC is now ranked 2nd in the category of Orthopaedic Journals and 5th in the category of Rheumatology Journals! Thank you everyone for your contributions to this achievement. 🤩 @profdavidhunter.bsky.social @jointsintheworld.bsky.social

#BasicScience #EditorsChoice for #June 🤩 This work aimed to elucidate the role of Wnt signaling in the mechanoresponsiveness of healthy and osteoarthritic human cartilage. Read more: lnkd.in/eRiKjiQQ

Just out this month! How well do hyaluronic acid (HA) injections work for knee osteoarthritis (OA), and who benefits most? Read more from Cao et al. - oarsijournal.com/article/S1063-…