#New in #OAC This study by Xiao et al. demonstrates that YAP plays a critical role in subchondral bone remodeling and targeting the YAP-Hhip axis through regulation of Hh-Gli1 signaling in Gli1+ osteogenic progenitors could inhibit OA progression! 🐭 www.sciencedirect.com/science/arti...

🌟 Four other conditions that should be considered in the differential diagnoses of early-stage symptomatic knee #osteoarthritis (EsSKOA) 1️⃣ Patellofemoral pain 2️⃣ Meniscus injuries 3️⃣ Collateral ligament injuries 4️⃣ Inflammatory arthritis Read free at lnkd.in/gvKY77uB

Excited to be part of this guest editorial team: if you are looking for a home for your research on pain mechanisms in osteoarthritis, submit away 😃 #PainResearch

New from #OrACORe in @oacjournal.bsky.social: Longitudinal associations between bilateral vs unilateral knee osteoarthritis and physical performance. Contrary to our hypothesis we did not find associations between bilateral disease & worsening physical function www.sciencedirect.com/science/arti...

Participants whose daily activity best matched patterns of high evening activity or very high morning activity had the least risk of developing #slowgaitspeed 🚶‍♂️ 🗞️ Read more from Tore et al. oarsijournal.com/article/S1063-…

NEW in this month's issue 🔥 September's Editors Choice by Akkaya et al. found that diets rich in ultra-processed foods are linked to worse knee #osteoarthritis outcomes especially in women 🍔🍦🍟🍩 👀 Read about this large (n=4403) study for free at: www.oarsijournal.com/article/S106...

#BasicScience #EditorsChoice This work by Liao et al. investigated the effects of Tamoxifen in multiple mouse models to better understand its role on bone and cartilage metabolism and endochondral ossification. 🐭 📖Read more: www.oarsijournal.com/article/S106...

🌟 #New in #OAC 🌟 Curious to know how Piezo1 deletion protects against TMJOA? Read this new work by Wang et al. sciencedirect.com/science/arti...

📢 Call for Papers OAC is excited to announce a Special Issue on Pain Mechanisms in Osteoarthritis. www.sciencedirect.com/special-issu... Submission Deadline: May 15th, 2026

#New #Basic #Science in #OAC How does sex influence the development of #PTOA using a mouse model of mechanical #ACL injury? 📑Check out this work: www.sciencedirect.com/science/arti...

Higher fat to muscle ratio (FMR) associated with higher #osteoarthritis incidence 👀 👇 🔢 Data from a large prospective cohort study from the UK Biobank dataset (n=328,549) Read further in this month's issue from Lou et al.: www.oarsijournal.com/article/S106...

Curious to know how to use #AI in #OAC? 🧐 elsevier.com/about/polici...

🔥 How can pharmacists help deliver high-value knee OA care? 📖 Explore the #Capabilities, #Opportunities, and #Motivations of Australian pharmacists in this new study: oarsijournal.com/article/S1063-…"

🎙️ New #jointaction podcast on all things #methotrexate Joint David Hunter with guests Robin Christensen, BSc, MSc, PhD Anna Døssing to learn more 👇 Podcast link: www.jointaction.info/podcast/epis... Editorial link: pubmed.ncbi.nlm.nih.gov/40222629/

New this month! 🦴 Calcium pyrophosphate deposition disease (CPPD) is associated with increased risk of fractures (Fig. 1 below 👇 ) www.oarsijournal.com/action/showP...

#August #EditorsChoice #BasicScience This work by Zapata-Linares et al. uses a dynamic mouse model to assess the positive correlation between OA and increased bone marrow adiposity. 📖 more: www.sciencedirect.com/science/arti...

🏃‍♂️‍August's Editor's Choice is on #Taichi ✅ Several benefits associated with #Taichi in this 28 study systematic review that included 1676 OA participants 👀 Read more from Zhao et al. at www.oarsijournal.com/article/S106...

#New in #OAC MM-II is a dispersion of empty large liposomes which is under clinical development for knee OA. This research by Wechsler et al., aims to decipher the MM-II mechanism of action on the tissue types of the knee joint! 🔗https://sciencedirect.com/science/article/pii/S1063458425008155

#More #Basic #Science in #OAC Check out this exciting new paper showing TNFalpha receptors-1 & 2 modulate repair potential in painful disc degeneration in a human model system by @iatridislab.bsky.social 🔗https://www.sciencedirect.com/science/article/pii/S1063458425008684?via%3Dihub

🔊 CALL FOR PAPERS! Special Edition: Obesity and Osteoarthritis www.sciencedirect.com/special-issu... Deadline: 01 May 2026

#New #BasicScience Surface-modified exosomes effectively target early-stage arthritic cartilage, delivering therapeutic cargo like receptor antagonist of interleukin-1 into the deep zone of cartilage tissue. Read more: 🔗https://www.sciencedirect.com/science/article/pii/S1063458425008623

🆕 Hand #osteoarthritis in this month's issue! 👊 Bone marrow lesions and collateral ligament lesions are associated in interphalangeal joints with osteoarthritis 🆓 Read free from Terpstra et al. - t.co/OpfQPFalzO

💥new this month! Higher #FT4 (free throxine) concentrations may increase the risk of knee #osteoarthritis 📖 Read all about thyroid function and OA in this new paper by Xu et al. - oarsijournal.com/action/showPdf…

This month's #BasicScience #EditorsChoice paper demonstrates that the Maresin 1-LGR6 axis mitigates inflammation and #PTOA after transection of the #ACL in mice🐭. @lehoczky-lab.bsky.social 🔗https://sciencedirect.com/science/article/pii/S1063458425008696?via%3Dihub

🥳 July's Editors Choice is on MM-II for knee #osteoarthritis 💉 MM-II is a novel suspension of empty large multilamellar liposomes that can provide cartilage lubrication and protection 🆓 Read all about this 26 week RCT at: www.oarsijournal.com/article/S106...

More #BasicScience in #OAC Yuh et al. demonstrate that joint loading and motion do not act in isolation, but interact together in terms of their effect(s) on the tissue’s mechanical and biological responses at varying scales. 🔗Read more: sciencedirect.com/science/arti...

#New in #OAC read about a new histological analysis pipeline for quantification and visualization of morphometric and spatial changes in the tibial medial compartment in rat models of osteoarthritis. @orthobme.bsky.social 📖https://oarsijournal.com/article/S1063-4584(25)00867-2/fulltext

THIS JUST IN!!! #OAC rises in #impactfactor from 7.2 to 9! OAC is now ranked 2nd in the category of Orthopaedic Journals and 5th in the category of Rheumatology Journals! Thank you everyone for your contributions to this achievement. 🤩 @profdavidhunter.bsky.social @jointsintheworld.bsky.social

#BasicScience #EditorsChoice for #June 🤩 This work aimed to elucidate the role of Wnt signaling in the mechanoresponsiveness of healthy and osteoarthritic human cartilage. Read more: lnkd.in/eRiKjiQQ

Just out this month! How well do hyaluronic acid (HA) injections work for knee osteoarthritis (OA), and who benefits most? Read more from Cao et al. - oarsijournal.com/article/S1063-…

🚶🚶‍♂️Read all about #walking and structural changes in the osteoarthritic knee in this new study by Sara and colleagues: oarsijournal.com/article/S1063-…

🚨 NEW 🚨 🤩 This month's Editors Choice (Clinical) is about intestinal health and hand #osteoarthritis Read more from @mbinvignat.bsky.social @jeremiesellam.bsky.social - www.oarsijournal.com/article/S106...

In this #New #BasicScience in #OAC learn how EZH2 inhibits senescence-associated inflammation and attenuates intervertebral disc degeneration by regulating the cGAS/STING pathway. Read more 🔗 www.sciencedirect.com/science/arti...

Beta-defensin 1 (DEFB1), is involved in inflammation, cell apoptosis and senescence. In a disk degeneration model, DEFB1 knockdown ameliorated IDD features. Targeting DEFB1 could be a promising therapeutic strategy for IDD.🧐 Read more: www.oarsijournal.com/article/S106...

New this month in #OAC for #BasicScience Learn about how the CRLF1/CLCF1 heterodimer is involved in IVDD via exacerbation of ECM degradation and nucleus pulposus cell senescence🧪 sciencedirect.com/science/arti...

🤩 Just out this month! 3.5% ➡️ The low prevalence of primary #cam morphology (PCM) in early adolescents suggests that PCM gradually develops over time #netherlands 🇳🇱 Read more from Chen et al. - lnkd.in/gjQwjgD7

🍞 Fresh in this month's issue! Arthroscopic partial meniscectomy (APM) 📉 Worsening #bonemarrowlesions and cartilage defects with APM compared to #physicaltherapy with optional delayed-APM at 2y Read more from Sabine van der Graaff et al. - doi.org/pkbf

🚨 New #EditorsChoice Infographic 🚨 Are "healthy" joints really healthy? This study found that some might have a predisposition for general cartilage deterioration highlighting the #systemic nature of hand #osteoarthritis Read more from Mathiessen et al. - doi.org/phqf

May is upon us 🪷 🌷 🌼 And with that a new #EditorsChoice #BasicScience in #OAC This month learn about mechanical stress, PIEZO1, the cGAS-STING pathway and its contribution to cartilage degradation in #OA! buff.ly/4fYDGC7

Interested in learning about the peer review process? Apply for the Peer Review Mentorship Program through OAC and OAC Open! Applicants must be a member of OARSI and have completed at least 2 years of a professional degree. If you are interested please fill out this forml by May 2nd. buff.ly/LhEqdYL

Robin Christensen present an update on behalf of biostatistics editors #OARSI2025 @oacjournal.bsky.social Refer to ten recommendations here: www.oarsijournal.com/article/S106...

Thank you for attending the #OAC and #OACO journal session today at #OARSI2025 Highlights include the announcement of our Papers of the Year, Reviewers of the Year, and the Biostatistical Methods session! @profdavidhunter.bsky.social @jointsintheworld.bsky.social

#New #BasicScience in #OAC Tao et al demonstrates that macrophages regulate nucleus pulpous cell ECM expression in intervertebral disc degeneration (IDD) through the OPN-CD44 axis! 🧪 🔗

Looking forward to #OARSI2025 ? We are delighted to have the OAC and OAC Open Journal Session on April 24th at 11 am KST. Don't miss the Paper of the Year award presentation and updates from our Editors-in-Chief @profdavidhunter.bsky.social and @jointsintheworld.bsky.social !

⏰ April's #EditorsChoice is out! Read all about ethnic differences in hip osteoarthritis in this large UK Biobank X Shanghai Changfeng cohort study 👇👇👇👇 Open access from Zheng et al - oarsijournal.com/article/S106...

🚨 April #OAC #EditorsChoice #BasicScience 🚨 This work by Kazemi et al. demonstrates how Raman arthroscopy is a transformative tool to evaluate, monitor, and treat cartilage injuries. Read more here 🔗 buff.ly/x19xlMq

One month left until the submission deadline for this special edition of @oacjournal.bsky.social on the application of omics technologies to the field. Don’t miss out!

Interested in understanding the role of stress on lipid droplet accumulation in chondrocytes??? This work by Yu et al., investigates the impact of stress-induced microtubule impairment on intracellular transport and lipid droplet (LD) accumulation in chondrocytes. 🧪 🥼 🔗https://buff.ly/oa95BpT

#More #OAC #BasicScience In this work by Shih et al., specialized pro-resolving molecule Maresin 1 (MaR1) attenuates nociceptive behaviors in mice with osteoarthritis-like pain. 🐭 Read more 📖

#New #OAC #BasicScience Can microRNA signature be used as a predictor for early OA?🤔🧬 Check out this work by Jamshidi et al.! 🔗