Excited to share that a part of my PhD work is online now on BioRxiv! www.biorxiv.org/content/10.6... We developed a genome editing approach to target the JAK2 V617F mutation and demonstrate its potential to alleviate MPN hallmarks in primary patient cells. Thread 👇

A big advance, folks, for off-the-shelf, universal, engineered (base-edited) T cells achieving complete response vs incurable leukemia in several patients www.nejm.org/doi/full/10....

ONLINE FIRST ALERT! Molecular #Plasticity Results in #Oncofetal #Reprogramming and Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia aacrjournals.org/bloodcancerd... @aacrjournals.bsky.social #childhoodcancer #epigenetics #precisiononcology

#ScientistSpotlight: This week we’re introducing Verena Körber, one of the newest Group Leaders at the MRC WIMM. @rdm.ox.ac.uk @medsci.ox.ac.uk @ox.ac.uk

NEW: Oxford scientists have identified how rare populations of abnormal cells drive the formation and persistence of fistulas - painful, tunnel-like tracts that develop in around 30% of people with Crohn’s disease. Crohn’s disease affects around 1 in every 650 people.

Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.

Not from Tron or a psychedelic wallpaper. This exquisite pic reveals chromatin at base-pair resolution, captured by #ListerFellow James Davies and collaborators🤩 "For the first time, we can see how the genome's control switches are physically arranged inside cells." @jojdavies.bsky.social

NEW @cancerresearchuk.org-funded study, led by @bethpsaila.bsky.social & @l-cmurphy.bsky.social, reveals an unexpected and powerful new function for platelets with profound implications for cancer diagnosis and prenatal screening 🧪 @rdm.ox.ac.uk | @medsci.ox.ac.uk | @ox.ac.uk Learn more 👇

Huge thanks to @cancerresearchuk.org for funding and sparking the key collabs, co-authors @imm.ox.ac.uk @ox.ac.uk @ludwigcancer.bsky.social @edinburghuni.bsky.social and all who provided feedback along the way @Grc @ash.hematology.org @isehsociety.bsky.social @sarahhross.bsky.social

'[...]analysis of platelets can potentially improve screening tests, including for cancer.' @bethpsaila.bsky.social comments on newly published research findings that could transform approaches to the early detection and prevention of #Cancer. www.oxcode.ox.ac.uk/news/platele...

Thrilled that our paper is in print @science.org!! *Platelets sequester cell free DNA, including free fetal and tumour-derived DNA* Tweetorial from @l-cmurphy.bsky.social below. Check out the news feature science.org/content/arti... and terrific editorial from Dennis Lo #platelets_in_the_limelight

Check out our latest publication in @science.org, showing that platelets are a source of tumour DNA!

🚨 New paper alert! 🚨 I’m thrilled and proud to share that our latest work has just been published in @science.org! 🎉 🧽 📖 Read our paper here: doi.org/10.1126/sci... 🎬 Watch a summary: youtu.be/MttCA3GGWEM 🧵 Or keep reading for the key points! 🔑 1/19

NEW: Researchers at the MRC WIMM and @dkfz.bsky.social have developed a new method to analyse how our tissues evolve as we age, called SCIFER 🧬 🧪 Read more 👇 @rdm.ox.ac.uk | @medsci.ox.ac.uk | @ox.ac.uk

WIMM Day 2025 brought our researchers together to share discoveries, swap ideas & celebrate success — from gene editing to immunotherapy to public engagement. Catch the recap + award winners here:

We're hiring at Oxford! Join our team working on cutting-edge research in haematology & myeloproliferative neoplasms (MPNs). 🔬 Apply here: my.corehr.com/pls/uoxrecru... 🔍 Learn about our research: imm.ox.ac.uk/research/res... #AcademicJobs #Haematology #MPN #Oxford

NEW: Researchers at the MRC Molecular Haematology Unit, led by @ckbrierley.bsky.social & @adammead.bsky.social, have uncovered a potential new therapeutic target in BP-MPN - a particularly aggressive type of leukaemia. 🧪🧬 Read more: @oxfordbrc.bsky.social | @rdm.ox.ac.uk | @medsci.ox.ac.uk

We are recruiting!! Ads now live for a Data Coordinator and 2 Research Assistants/biobankers to join a new @ludwigcancer.bsky.social - @imm.ox.ac.uk joint initiative to prevent progression from early- to advanced blood cancer. Joint posts with Adam Mead+others in Oxford Ludwig. Links below

For International Women's Day tomorrow, we asked some of our female scientists, including @agoriely.bsky.social & @sumanasharma.bsky.social, to reflect on why this day is so important, the barriers and biases women can face in their careers, and which women have inspired them. #IWD2025

To conclude our #RareDiseaseDay series, we spoke with @ellouka.bsky.social, a clinician scientist researching Paediatric Myelodysplastic Syndromes (MDS) and Juvenile Myelomonocytic Leukaemia (JMML). These are incredibly rare childhood cancers, with no current treatment options available. 🧪

Preprint alert: this was a wonderful collaborative project with Prof Karadimitris @imperialcollegeldn.bsky.social and many others. Thanks to all and especially @cancerresearchuk.org for the CAYP innovation award funding. All feedback welcome!

NEW: @ineosoxford.bsky.social has been awarded a £5 million Wellcome Discovery Award to develop vaccines against pathogens that cause diarrhoea - the third most common cause of death for children under five years of age. More info ⬇️

Celebrating Excellence in Medical Sciences Division 2024 Massive congratulations to our elected Academy of Medical Sciences fellows #ExcellenceInOxfordMedSci2024 medsci.ox.ac.uk/news/academy...

In our first skeet, check out a very cool postdoc opportunity, in the very cool @susanagodinho.bsky.social lab 👇

Had the best time at #ASH24 presenting with Simone Riva our work at the @imm.ox.ac.uk with Prof. Adam Mead and Prof. Jim Hughes on the construction of a novel multi-omic resource atlas for human granulopoiesis and the identification of molecular machinery underlying IMiD-induced neutropenia.

Absolutely outstanding presentation by @ellouka.bsky.social at #ASH24 about the role of dendritic cells secreting GAS6 in maintaining LSCs in juvenile myelomonocytic leukemia #jmml #HemeSky

We’re thrilled to introduce MuSpAn! For researchers in biological imaging, MuSpAn provides tools for Multiscale Spatial Analysis with advanced mathematical methods. 🌟 For more information: www.muspan.co.uk 📝 Preprint: doi.org/10.1101/2024... We hope you find it as useful as we do! (Poster below)

MuSpAn is a starting point, not the end stage! We've been working hard to finalise the behind the scenes infrastructure, but now the array of available methods will just keep expanding. In particular, our group works on method development for spatial data - new methods will keep appearing here!

Very pleased to announce that our package for Multiscale Spatial Analysis - MuSpAn - has landed! The preprint is on biorxiv now, but you can find a lot more details at www.muspan.co.uk, including documentation, worked tutorials (an ever-expanding list), install guides, and how to get the code!

MuSpAn: A Toolbox for Multiscale Spatial Analysis https://www.biorxiv.org/content/10.1101/2024.12.06.627195v1

8 days ago, ASH decided to join Bluesky. 🌤️ So far, we're enjoying fewer distractions & more meaningful connections. 💬 Engaging with our amazing #hematology and #hemeonc communities has never been easier. We created an #ASH24 feed for you & we have more feeds coming soon: bit.ly/ASH24feed #Hemesky

📣 Preprint alert! We have studied the formation of pair-wise and multi-way enhancer-promoter interactions in the #3Dgenome in a lymphoid-to-myeloid transdifferentiation system and learned interesting new things about their function in #GeneRegulation. 1/10 www.biorxiv.org/content/10.1...