🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in ‪@natgenet.nature.com‬ 🧬! shorturl.at/94s5S We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n Illustration: Hratch Arbach 🧵👇

As we’re coming towards the end of #ASH2024 I’d like to express my gratitude for the great science, company and feedback! @antoniorromera.bsky.social @alexrampotas.bsky.social @bethpsaila.bsky.social

Terrific talk from the brilliant @antoniorromera.bsky.social this morning on how cells tolerate whole genome duplication and implications for cancer evolution. Check it out on the virtual platform if you missed it!

and also not to be missed - Ros Cooper and Dan Royston's oral abstract 'mapping the human bone marrow in MPNs using Spatial Transcriptomics'

Finally - thanks to a collaborative effort from the NCRI MPN subgroup across the UK - we are super excited to share a poster presenting 'real-world' efficacy and safety data of momelotinib for patients with myelofibrosis and anaemia

(3) Camelia Benlabiod presents her work from her PhD with Caroline Marty & Isabelle Plo @ Gustave Roussy on dissecting the cell-of-origin of mutCALR driven MPNs, and how del52 and ins5 elicit different signalling responses

(2) @alexrampotas.bsky.social from Pule/Roddie Labs @uclofficial.bsky.social presenting joint work (co-led by Zoe Wong from my group)-1st-in-class CAR-T against mutCALR MPNs & evaluation in the relevant human tissue environment using @abattacks.bsky.social bone marrow organoids model

Do swing by to hear: (1) @antoniorromera.bsky.social present his fascinating work on how megakaryocytes tolerate whole genome duplication, implications for genome integrity & cancer evolution

November 18 is the International Day of LGBQTIA+ People in STEM! Today more than ever we want to stress the importance of communities, building connections, and raising each other up. Let's keep leaving our mark for the betterment of us all! 🏳️‍⚧️🏳️‍🌈 #QueerinSTEM prideinstem.org/lgbtstemday/