Exciting times for mutCALR MPNs - lovely data from the ET cohort presented in late breaking abstract at @EHA_Hematology. Rapid platelet control after just 2 doses with 89% of patients benefitting from a molecular response with INCA033989. @mpnvoice.bsky.social @mpnrf.bsky.social @mpnhv.bsky.social

Check our commentary on the amazing work by Falgas et all on developing a TIM-3 armored CAR-T therapy

🚨Very excited to see our work with Prof Claire Roddie out in @bloodjournal.bsky.social CAR-T has revolutionized treatment for B-ALL, but what’s next? We discuss innovations, challenges, and the road ahead. 🔗 ashpublications.org/blood/articl... #Leukemia #CARTcell #Hematology

We are recruiting!! Ads now live for a Data Coordinator and 2 Research Assistants/biobankers to join a new @ludwigcancer.bsky.social - @imm.ox.ac.uk joint initiative to prevent progression from early- to advanced blood cancer. Joint posts with Adam Mead+others in Oxford Ludwig. Links below

Fantastic news and very well deserved award!!! It has been amazing working together

A very nice Sunday read on the challenged CAR-T cells face in tackling myeloid malignancies by Prof Beth Psaila and Zoe Wong ashpublications.org/thehematolog...

Bye bye, bispecific? Check out our commentary on the development of a CD19/BCMA dual targeting CAR-T for non-Hodgkin Lymphoma led by Bachiller et al. Co-transduction for the win! Link below ⬇️ for free access authors.elsevier.com/a/1kIWB5QliS...

Many thanks for highlighting our work on CAR-T for Myelofibrosis! It has been a great meeting in San Diego #ASH24 ashpublications.org/ashnewsdaily...

As we’re coming towards the end of #ASH2024 I’d like to express my gratitude for the great science, company and feedback! @antoniorromera.bsky.social @alexrampotas.bsky.social @bethpsaila.bsky.social

It was great pleasure. Amazing meeting with great MPN research presented

Amazing presentation by Camelia Benlabiod (@beth_psaila / Caroline Marty lab) on the biology of calreticulin driven myelofibrosis in an immunocompetent mouse model #ASH24 #MPNsm

Looking forward to presenting our result and discussing all about CAR-T cell therapy for mutated calreticulin myelofibrosis #ASH24 Do join!

Thank you so much!!

You have been telling us why you chose #hematology and what inspires you each day. Your answers are becoming art!🎨 See it live in the Hall A lobby. #ASH24 #Hemesky

Very eloquent presentation by Antonio Romera from @bethpsaila.bsky.social lab on megakaryocyte biology and ability to take on DNA damage! Fantastic work #ASH24

Very honoured to receive the ASH-BSH abstract achievement award The result of the tremendous work by so many talented people who I had the privilege to work with Zoe Wong, Isaac Gannon, @bethpsaila.bsky.social, Claire Roddie, Martin Pule and many more #ASH24

Very pleased to present the results of a UK wide collaborative study on real world efficacy and safety of Momelotininb - >60% anaemia responses at 6 months -G1-2 peripheral neuropathy (15%) -unexpected thrombocytosis (?hepcidin dysregulation due to AVCR1 inhibition) #ASH24 @bethpsaila.bsky.social

Sunrise and moonset beyond the Coronado Bridge on a beautiful run around San Diego bay this morning

Attending #ASH24 and missing my baby boy. At least I can get him on my cup of coffee

Off to #ASH24. Books/music/movies all ready for 12h of economy flight 💪

Really proud of our physio Steph! Thank you to UK Haemophilia Society, Ben and others for this lovely recognition of her care and support! @ouhospitals.bsky.social www.ouh.nhs.uk/news/article...

Very nice review. As we have more options for myelofibrosis the choice of the right JAKi at the right time becomes ever more important

Do swing by to hear: (1) @antoniorromera.bsky.social present his fascinating work on how megakaryocytes tolerate whole genome duplication, implications for genome integrity & cancer evolution

and also not to be missed - Ros Cooper and Dan Royston's oral abstract 'mapping the human bone marrow in MPNs using Spatial Transcriptomics'

(3) Camelia Benlabiod presents her work from her PhD with Caroline Marty & Isabelle Plo @ Gustave Roussy on dissecting the cell-of-origin of mutCALR driven MPNs, and how del52 and ins5 elicit different signalling responses

(2) @alexrampotas.bsky.social from Pule/Roddie Labs @uclofficial.bsky.social presenting joint work (co-led by Zoe Wong from my group)-1st-in-class CAR-T against mutCALR MPNs & evaluation in the relevant human tissue environment using @abattacks.bsky.social bone marrow organoids model

Finally - thanks to a collaborative effort from the NCRI MPN subgroup across the UK - we are super excited to share a poster presenting 'real-world' efficacy and safety data of momelotinib for patients with myelofibrosis and anaemia

Excited for #ASH24 & thrilled that *3* brilliant folks from the team have oral presentations, travel awards and 2/3 nominated for **best of ASH**!! @imm.ox.ac.uk @ox.ac.uk @cancerresearchuk.org @ludwigcancer.bsky.social

Hello, #hematology community! ASH is now on BlueSky. We're here to share cutting-edge research and educational resources and connect global experts in blood diseases. Join us in advancing hematology together. Welcome, colleagues! #BloodSky #HemeSky #MedSky