We’ve been talking in our lab meetings about sexual conflict and sexual dimorphism, and have some thoughts. What if animal genomes are far more sex-specific and less cosntrained than we assume? @linley-sherin.bsky.social pulled it all together here www.zoology.ubc.ca/mank-lab/pdf... 1/n

For those interested, the papers associated with my talk: pubmed.ncbi.nlm.nih.gov/39146405/ pubmed.ncbi.nlm.nih.gov/41699381/ pubmed.ncbi.nlm.nih.gov/36735790/ pubmed.ncbi.nlm.nih.gov/36050399/ pubmed.ncbi.nlm.nih.gov/41763210/ pubmed.ncbi.nlm.nih.gov/31454312/

We are hiring POSTDOC now!🚨please repost! Fully-funded 5-year position 👩🏻‍🔬👨‍🔬🧬Looking forward to your application!✉️

There has never been a better time to study functional and mechanistic biology at the organismal (!) level than now in the age of AlphaFold and CRISPR.

Aging may feel gradual… but what if it’s not? In our recent paper, we tracked fish continuously from puberty until death. This gave us a unique view of how aging unfolds across the adult lifespan. 🧵

POV you are writing a paper about plant sex chromosome evolution

I am SO THRILLED to share our first fully-lab lab paper!!!!!! Led by @hybridzones.bsky.social & @hagarsoliman.bsky.social, w/ a major assist from @pfschwarz.bsky.social!!!!!!!!!!!!! Read more below, if you're curious (you should be- it's AWESOME!!!!!!!) link: www.sciencedirect.com/science/arti...

Thrilled to share that the Scavuzzo lab was awarded the 2026 MIND prize to support our fundamental work in understanding how homeostasis is regulated by the gut’s nervous system! See more details here: pershingsquarephilanthropies.org/prize-winner...

#dros26 are you looking for a postdoc position and want to live in Paris?! Check out the opportunity below from @cecilecourret.bsky.social who has an exciting project on the Paris drive system in D. simulans 🤩

So grateful to be able to share my work on the big stage during #Dros26! Thank you to everyone who attended my talk, especially to those who asked me such insightful questions!

Quick plug for our new resource, the Drosophila Species Stock Exchange. This is a database and mailing list that documents species currently in culture and the labs holding them. If you want to know more or sign up then please get in touch. See attached for more info and please share!

So good to see familiar faces at #dros26 😊 Ching-Ho @ching-hochang.bsky.social just opened his lab in Taiwan and Rebecca @tarnopol.bsky.social is opening her lab at UCSF this summer—can’t wait to see what their labs do next!!! 🙌

The Nelson lab is presenting at #Dros26 today! Stop by Daisy's poster to learn about rDNA instability in somatic aging (680F), and Caroline's poster about the role of an mRNA binding protein in regulating germline rDNA expansion (777F)!

If you’re at #dros26 and you like transposons don’t miss Peiwei’s talk! 🔥🪰 We’re really excited about his findings!

A lot of exciting things have been happing in the @rothenberglab.bsky.social so we have been keeping really busy. A few of us are at #Dros26 to share our science. Come by one of our posters to say hi!

If you are at #Dros26 and want to see what our lab has been up to, check out @rafaelperezvicente.bsky.social’s poster on sexual dimorphism during heart development (611, Fri 2-4pm) and @qeenyra.bsky.social’s talk on the effects of confinement on cardiac progenitor migration (Cell bio, Sat 8am). 🧪🪰

Now that the cat’s out of the bag: Excited to announce I will be starting a research group as a Sandler Fellow this August at UCSF! We will study the evolution of protein toxins at the host-pathogen interface across scales of biological organization. Learn more here: www.tarnopollab.org

Our story on the evolution of colistin resistance is just out on @plosbiology.org (journals.plos.org/plosbiology/... Evolution doesn’t happen in isolation. We show that competing fungi can rewire the evolutionary trajectory of colistin resistance in P. aeruginosa. Great teamwork with the Ernst lab

Proud of Dr @tarnopol.bsky.social who received the Sandler Award for “Outstanding Drosophila Thesis” at the fly meeting #Dros26 in Chicago this evening! @genetics-gsa.bsky.social

Rebecca Tarnopol @tarnopol.bsky.social receives the 2026 Larry Sandler award for best Drosophila PhD thesis

So excited to B repping the Hanlon Lab at #Dros26 in Chicago!!! B-wildered by the B chromosomes? Come see my talk on the meiotic drive of the B chromosomes Friday morning in the Evolution I section!

Join us at the EMBO Workshop “RNA-guided genome protection” 🇨🇭 June 16–20. Transposon silencing • stem cell biology • RNA-guided immunity. Keynotes: Déborah Bourc’his + Ian MacRae. Register now + submit your abstract! meetings.embo.org/event/26-gen...

What happens if the germline goes on without (most of the) piRNAs for 45 generations? Come find out at my talk at the evolution session on Saturday at #dros26 @genetics-gsa.bsky.social 🪰🔬🔎⁉️🤔

#Dros26 community — we’d love to see you at our workshop this Friday! [1/8] Organizers: @ritamgraze.bsky.social @marbeitman.bsky.social @lydiagrmai.bsky.social @gavinrrice.bsky.social @brhopkins92.bsky.social Artyom Kopp

For a new MBE Review, Presgraves et al. argue that many features of genome evolution, content, and organization seemingly inexplicable by adaptation or nearly neutral processes are instead best accounted for by meiotic drive. 🔗 academic.oup.com/mbe/article/... #evobio #molbio

Diving into evolutionary biology! What is the origin of the most abundant class of insect transcription factors, ZAD-ZnFs? We suggest that they evolved from ancestral insulator-binding proteins that control 3D genome topology. www.science.org/doi/10.1126/...

Nature News on the tantalising possibility of the first documented sex-ratio distorter in humans. www.nature.com/articles/d41...

So excited to share this manuscript led by the inimitable Cara Brand, who discovered that Topoisomerase II evolution causes hybrid female lethality in Drosophila. Congrats to Cara, @nickbr0wn.bsky.social, Anirban, and @buszczaklab.bsky.social! www.biorxiv.org/content/10.6...

Adaptive evolution of Topoisomerase II triggers reproductive isolation in Drosophila https://www.biorxiv.org/content/10.64898/2026.02.20.707007v1

Very honored to receive this award from GSA! I have immense gratitude for my advisor @nkwhiteman.bsky.social, labmates, collaborators, mentees, and the fly community, who in many ways potentiated my graduate research. Looking forward to sharing my work at my favorite meeting in my favorite city!

Our paper is now out in Nature: “Ancient co-option of LTR retrotransposons as yeast centromeres” www.nature.com/articles/s41... A short thread on how retrotransposons helped give rise to yeast point centromeres. 1/14

We’re excited to announce @tarnopol.bsky.social as the recipient of the 2026 Larry Sandler Award! 🎉 She’ll present the Larry Sandler Memorial Lecture during the #Dros26 opening session on March 4—she'll share how her research explores how protein toxins evolve to shape host–parasite interactions.

🔬 Recruiting a Postdoc!!!! I’m looking for a motivated postdoc to join my lab and work on characterizing the role of a heterochromatin protein involved in a sex-ratio meiotic drive system in Drosophila. If you know someone who might be interested, please share widely!

my first termite queen extracted from a mature colony in the field 🤩 thanks @tatsuyainagaki.bsky.social

How does the piRNA pathway solve the self vs. non-self problem? 🧬 Since piRNAs come from single-stranded RNA, how does the cell choose the right ones? For years, "piRNA clusters" were seen as THE privileged source. But are they really special and earmarked for biogenesis? (1/19)

The demystification of piRNA clusters if you wonder how cells generate piRNAs specifically against transposons & you are looking for a weekend read check out @86dominik.bsky.social's opus magna (or Dominik's great thread) a shared project with the one and only Rippei Hayashi, lab alumnus & friend

If Bad Bunny can cover the history of Puerto Rico, colonialism, transatlantic slavery, hemispheric consciousness, as well as contemporary life and politics in under 14 minutes, you can do your 15- or 20-minute conference presentation with time to spare.

Another announcement! 📣 Our work on hybrid incompatibility in cohesin protection in 🐭oocytes is published!! Congrats Warif El Yakoubi and Eddie Pan!!🎉 We found hybrids with cohesion errors in two distinct genus. www.science.org/doi/10.1126/...

Holy shit: it's an RFP for the NSF Postdoctoral Research Fellowship in Biology (PRFB). Hello old friend www.nsf.gov/funding/oppo...

New preprint from the lab! We identify the ZnF protein Mulberry as a condensation-dependent structural regulator of genome topology that organizes “multi-way regulatory hubs” in early Drosophila embryos. www.biorxiv.org/content/10.6...

Very excited to share the work by Alice Gadau. We found that D. suzukii (the invasive pest that loves ripe fruit) doesn’t hate CO₂, while classic lab flies avoid it. That tiny sensory shift helps explain a big ecological transition. journals.plos.org/plosgenetics...

Greetings! I decided to make a YouTube video of my AlphaFold workshop that I've given a few times in the past year. Caveats aside, people seem to find this useful for thinking about how to model protein interactions and how to interpret various AF outputs 1/2 www.youtube.com/watch?v=u63o...

ANTSR seems to be the ancient master sex determining gene in Hymenoptera (as suggested by Pan et al. 2024)! So rad that a lncRNA is doing this! www.biorxiv.org/content/10.6...

Intrigued by a long-standing conundrum in small RNA biology—how nuclear Argonaute proteins silence transposons when they *need* target transcription for their own recruitment—we studied the piRNA pathway. And found a hidden RNA-decay axis from Piwi to the RNA exosome.

So excited to finally share my recent work on sex differences in crossing over using mice from diverse genetic backgrounds! www.biorxiv.org/content/10.6...

We won the @trogersresearch.bsky.social TBEP door decoration contest … by a landslide … @willowp.bsky.social @qeenyra.bsky.social Ji @anamcarmo.bsky.social @negberry.bsky.social Veronica & Rafa.

@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/

Fly Friends: The Larry Sandler Award recognizes the PhD student with the most amazing these using Drosophila as a model. Just three days left to nominate someone. For more info on the process and the link to nominations, see: genetics-gsa.org/drosophila-2...

Have you ever wondered how new DNA methylation patterns are established? Paradigm shift ahead! We discovered a new mode of DNA methylation targeting in plants that relies on transcription factors and sequence motifs rather than chromatin modifications to regulate the methylome. rdcu.be/eQ6L5 1/8

Phages are full of genes of unknown function that are likely adaptive in specific conditions. New preprint: Phage TnSeq identifies essential genes rapidly and knocks all non-essentials. We would like to send a pool of phiKZ mutants to anyone wanting it! Reach out tinyurl.com/bdcfrejh