🧠 Focused ultrasound changes emotional processing 🔊 In a new study published in Neuron today, we stimulated the human amygdala using transcranial ultrasound stimulation (TUS) and show it plays a causal role in detecting and resolving emotional ambiguity.

Full thread above, but in summary: When we imagine we re-activate brain regions used during perception, an idea called "sensory reinstatement". However, our results suggest this overlap is actually in transmodal association networks, not sensory areas. Perception culminates in transmodal networks

New preprint out! We show that the exposome and attention-related brain networks jointly predict attention problems in early adolescence—highlighting how environment and brain function have shared and unique associations with reported attention problems. medrxiv.org/cgi/content/...

The recording of Mel Goodale's talk at the MIT Consciousness Club is now available here: www.youtube.com/watch?v=kThw....

Extremely cool. We haven’t known very much about how localized neuromodulator signaling is. This data — made possible by new molecular sensor tools — is revealing that it’s quite local, just a few cell-widths in extent. #neuroscience 🧪

Wait… localized norepinephrine transients in the awake visual cortex?! Who would have guessed this neuromodulatory signal is that spatially precise, right where visual processing is happening. Brain state control just got a lot more local. @ruedigersarah.bsky.social www.nature.com/articles/s41...

Transcranial temporal interference stimulation effectively modulates prefrontal circuits to alleviate chronic pain.

What makes brains (un)conscious? We provide new answers—and a universal mammalian blueprint for information processing—in a cross-species study of humans, macaques, marmosets & mice. Exploring convergent breakdown of integration in: www.nature.com/articles/s41... Led by @loopyluppi.bsky.social

I don't think people fully appreciate how apocalyptic things are for US science. I haven't had any new funding since 2024, but I'm still ok since typical grants are for three years. This means next year I will be completely out of funding and will have to fire everyone in the lab. It's not great.

Do you censor high motion frames in fMRI? In two preprints by @twktan.bsky.social @mandymejia.bsky.social, we find that we may be censoring too much! doi.org/10.64898/202... arxiv.org/html/2603.07... Strict censoring leads to worse personalized TMS targets than no censoring, even with high motion!

Our latest work, on modeling the human brain responses to sight, sound and language at scale:

Superb resource to study human brain development, out in @nature.com 🧪🧠 An atlas showing how patterns of functional connectivity between brain regions change from birth to old age “Functional hierarchy of the human neocortex across the lifespan” www.nature.com/articles/s41...

🎉 Excited to share our publication in PNAS! 🎉 What happens when our stream of consciousness turns towards the body? Our fMRI study of 536 individuals finds that 'body-wandering' is associated with patterns of brain connectivity, physiology, affect, and mental health: www.pnas.org/doi/full/10....

"We are watching two disciplines trade their worst habits. Neuroscience is mistaking benchmarked prediction for understanding, and machine learning is mistaking mechanistic language for mechanism. ..."

Cannabidiol blocks ketamine-induced hyperlocomotion by reversing ketamine-mediated dysfunction of glycine receptors in the ventral tegmental area.

Thrilled to share our new paper, which shows that the relative timing of cholinergic and dopamine release dynamically gates whether dopamine acts as an RPE for in vivo plasticity and reinforcement learning. www.nature.com/articles/s41...

✨ SHINY NEW PAPER ✨ Evidence of locus coeruleus-noradrenaline (LC-NA) hyperactivity in older adults using behavioral, pupil and EEG data @maramather.bsky.social www.sciencedirect.com/science/arti...

You have 10 minutes of task fMRI to map functional brain regions in an individual. Three decisions matter: How do you localize regions? Which tasks do you include? How do you arrange tasks in your experiment? Here, we tackle all three! Preprint👇 www.biorxiv.org/content/10.6...

Very pleased to share that our study “Noradrenaline causes a spread of association in the hippocampal cognitive map” is out in @natcomms.nature.com (my final PhD paper, only 3.5 years post PhD! 🙃) Find the paper here: www.nature.com/articles/s41...

Neuromodulatory neurons are extremely susceptible to stress. I argue that their fragility is an inherent weak point, the breaking of which directly leads to Alzheimer’s Disease. I discuss this idea and its implications in a recently published perspective piece: dx.doi.org/10.1002/alz....

Accelerating the development of impactful new psychiatric therapies requires addressing critical challenges and capitalizing on opportunities across the identification, interpretation, and clinical implementation of brain-behavior associations derived from modern neuroimaging techniques.

The Mammalian Architecture of Information Integration🧠🧬 For #BrainAwarenessWeek, excited to share our latest work about #Neuroscience of #Consciousness in @nathumbehav.nature.com www.nature.com/articles/s41... 🧵👇

Organization of neuropeptide systems in the human brain | doi.org/10.1038/s415... Neuropeptides are functionally diverse signaling molecules in the brain and body. @cebric.bsky.social curates an atlas of neuropeptide receptors and relates it to brain function @natneuro.nature.com 🧩 🧠 ⤵️

I ❤️ @ohbmofficial.bsky.social 🧠https://apertureneuro.org/article/154736-what-the-organization-for-human-brain-mapping-community-is-doing-right @ohbmtrainees.bsky.social

Are you interested in detecting brain changes in individuals with higher precision over shorter intervals? Check out our new paper in Nature Communications. With Randy Buckner, @jingnandu.bsky.social, and others. Link - doi.org/10.1038/s414...

Remarkable study from Christoph Thaiss and colleagues demonstrating a lifespan impact of a microbiome-vagal-CNS pathway dysfunction of gut interoception www.nature.com/articles/s41...

🧠 Resting-state fMRI is often treated as the gold standard for studying the brain’s intrinsic organization. But is it actually the best way to estimate functional architecture? We tested this directly. 🧵1/8

My first-author review ‘Determinants of individual navigation ability’ is out in Nature Reviews Psychology, co-authored with the inspiring @hugospiers.bsky.social!!!! 🎉🧠 ➡️ rdcu.be/e7KxG #Neuroscience #Navigation @nature.com @natrevpsychol.nature.com @sfn.org @fens.org @ucl.ac.uk

🎧 OHBM Podcast Neurosalience S6, Ep 9 is out now! Host Peter Bandettini and Dr. John Allen discuss the neuroscience of depression, from frontal EEG asymmetry to emerging treatments like focused ultrasound and psilocybin. Listen now!   Spotify: tinyurl.com/m58353ht YouTube: youtu.be/7hHWJ2pKSQE

𝗪𝗵𝗮𝘁'𝘀 𝘁𝗵𝗲 𝗿𝗲𝗹𝗮𝘁𝗶𝗼𝗻𝘀𝗵𝗶𝗽 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗺𝗮𝗻𝗶𝗳𝗼𝗹𝗱𝘀 𝗮𝗻𝗱 𝗿𝗲𝗰𝘂𝗿𝗿𝗲𝗻𝘁 𝗻𝗲𝘁𝘄𝗼𝗿𝗸𝘀 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻? This looks like a must read (suppl material bursting with goodies). #neuroskeyence doi.org/10.1016/j.ne...

Data-driven profiles of psychosis stages reveal distinct and overlapping clinical, cognitive, and neuroanatomical phenotypes | medRxiv www.medrxiv.org/content/10.6...

fMRI connectivity is dominated by recurring high-amplitude BOLD events (CAPs, QPPs) But what originates these events? Many think neuromodulation is the culprit. Our new work offers a simpler take: cortico-cortical dynamics alone can generate CAP-like events! doi.org/10.1371/journal.pcbi.1013995 🧵1/n

In case you missed it, I made a feed that uses a locally hosted LLM to sort through the entire Bluesky firehose to find great science. Topics span all cognitive science and neuroscience. Check it out! bsky.app/profile/did:...

Excited to share our new paper: We uncover a locus coeruleus→amygdala circuit linking β-adrenergic signaling to transcription regulation in defined amygdala cells during memory reconsolidation—+ stress or elevated noradrenergic signaling at recall can strengthen memory. www.cell.com/neuron/abstr...

Beyond delighted to see this awesome paper from superstar Audrey Luo now out. See her wonderful thread below re: two highly-replicable axes of white matter development in youth.

Peer review would be easier if we stopped treating it like combat with the authors. Results want to be free, and perfect is the enemy of good. Do the data support the conclusions? If so, that’s enough. A paper isn’t a blank slate for projecting your own ideas.

🚨 New paper alert! 🚨 We wrote a commentary in @imagingneurosci.bsky.social on a really nice recent paper from van den Bosch & Cools where they provide the first real attempt at validating REACT (molecular-enriched fMRI). Here's what they found and what we think it means 👇 doi.org/10.1162/IMAG...

The danger of superhuman AI is not what you think. This essay in @noemamag.com by @shannonvallor.bsky.social is brilliant. Well worth a read. www.noemamag.com/the-danger-o...

Inter-individual variability of neurotransmitter receptor and transporter density in the human brain | doi.org/10.1007/s004... How do neuroreceptor distributions vary across people?

🚨 New preprint: Objective Quality Assessment for Precision fMRI Precision functional mapping (PFM) enables individual-level brain network studies — but demands more, and better, data. We introduce an objective framework to determine when a dataset truly supports interpretable, replicable PFM.

The big questions facing psychedelic science: 1. What’s the biology of psychedelic experiences? 2. Is the experience necessary for clinical benefit? 3. How do we solve expectancy+unblinding in trials? We synthesize what we know and the big Qs in a Nature Med Review: nature.com/articles/s41...

🐭🧠 Can fUSI truly map canonical mouse resting-state networks — and how does it compare to fMRI? I’m excited to share the work of my PhD in our new preprint!👉 doi.org/10.64898/202... Go check it out — it’s time to expand your neuroimaging toolkit 🧠🚀

Despite decades of research there are still no reliable biomarkers for any of the major psychiatric diagnoses. In this now published perspective in Molecular Psychiatry we consolidate evidence from genetics, exposome and neuroimaging research on the potential reasons underlying these failures.

A social club — started by Nico Dosenbach, MD, PhD and a colleague — dubbed the "Midnight Scan Club," leveraged low-cost nighttime fMRI scans to provide unique insights into individual brain function. Read all about the history of precision self-scanning: https://bit.ly/4qeuLjR

With a +64% increase in MSCA 2025 scholarship applications, funding cut-offs reached absurd levels. (e.g. a score of 96/100 remained unfunded, got news today from a candidate I sponsored). When rating is this compressed, a lottery among top-rated proposals deserves serious consideration I think.

A recently discovered brain network that links cognition (thinking) and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study published in Nature: spklr.io/63320DMwOi #Neuroscience #Neuroskyence #Parkinsons 🧠 🧪

Excited to share a new preprint, led by the inimitable @colleenhughes.bsky.social! Individualized Mapping of Functional Brain Networks in Older Adulthood www.biorxiv.org/content/10.6... A short 🧵 1/

Individualized Mapping of Functional Brain Networks in Older Adulthood https://www.biorxiv.org/content/10.64898/2026.01.30.702883v1

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia across species

How are energy #metabolism pathways distributed across the #cortex? @alaindagher.bsky.social &co map five pathways in the human #brain, linking metabolic organization with brain structural & functional properties, as well as developmental dynamics @plosbiology.org 🧪 plos.io/4c1JVp8