The big questions facing psychedelic science: 1. What’s the biology of psychedelic experiences? 2. Is the experience necessary for clinical benefit? 3. How do we solve expectancy+unblinding in trials? We synthesize what we know and the big Qs in a Nature Med Review: nature.com/articles/s41...

🐭🧠 Can fUSI truly map canonical mouse resting-state networks — and how does it compare to fMRI? I’m excited to share the work of my PhD in our new preprint!👉 doi.org/10.64898/202... Go check it out — it’s time to expand your neuroimaging toolkit 🧠🚀

Despite decades of research there are still no reliable biomarkers for any of the major psychiatric diagnoses. In this now published perspective in Molecular Psychiatry we consolidate evidence from genetics, exposome and neuroimaging research on the potential reasons underlying these failures.

A social club — started by Nico Dosenbach, MD, PhD and a colleague — dubbed the "Midnight Scan Club," leveraged low-cost nighttime fMRI scans to provide unique insights into individual brain function. Read all about the history of precision self-scanning: https://bit.ly/4qeuLjR

With a +64% increase in MSCA 2025 scholarship applications, funding cut-offs reached absurd levels. (e.g. a score of 96/100 remained unfunded, got news today from a candidate I sponsored). When rating is this compressed, a lottery among top-rated proposals deserves serious consideration I think.

A recently discovered brain network that links cognition (thinking) and actions may have an important role in Parkinson’s disease and could improve its treatment, according to a study published in Nature: spklr.io/63320DMwOi #Neuroscience #Neuroskyence #Parkinsons 🧠 🧪

Excited to share a new preprint, led by the inimitable @colleenhughes.bsky.social! Individualized Mapping of Functional Brain Networks in Older Adulthood www.biorxiv.org/content/10.6... A short 🧵 1/

Individualized Mapping of Functional Brain Networks in Older Adulthood https://www.biorxiv.org/content/10.64898/2026.01.30.702883v1

Luppi et al. identify transcriptomic and connectomic controllers of information integration and its breakdown induced by anaesthesia across species

How are energy #metabolism pathways distributed across the #cortex? @alaindagher.bsky.social &co map five pathways in the human #brain, linking metabolic organization with brain structural & functional properties, as well as developmental dynamics @plosbiology.org 🧪 plos.io/4c1JVp8

How are energy #metabolism pathways distributed across the #cortex? @alaindagher.bsky.social &co map five pathways in the human #brain, linking metabolic organization with brain structural & functional properties, as well as developmental dynamics @plosbiology.org 🧪 plos.io/4c1JVp8

How does superficial white matter contribute to large-scale #brain function? @borismontreal.bsky.social &co use an approach based on 3D histology & 7-Tesla MRI to reveal associations between superficial #WhiteMatter microstructure & diverse cortical properties @plosbiology.org 🧪 plos.io/460WNIz

Now in press one of my last PhD projects! We traced the neurobiological profile of fMRI BOLD signal variability, a measure that has been related to age, behaviour, disease status, but had not yet been fully contextualised within the brain's multiscale architecture. www.nature.com/articles/s41...

We could all use some extra stress #resilience rn. But how does it work in the brain? On the surface, resilience looks like ignoring stress. Does the brain fail to respond? Or are active adaptations required? Or are resilience and susceptibility divergent paths? doi.org/10.1016/j.celrep.2025.116867

People have been looking at "AI & brains" through the lens of LLMs/transformers. But what latent diffusion? (think text-to-image/video platforms such as Midjourney). **Class conditioned latent diffusion and semantically cued hippocampus share a remarkably similar computational architecture...**

Should you go to academia or industry for research in AI or cognitive science? It's the most common question I get asked by PhD students, and I've written up some of my thoughts on the answer, as an epilogue to my research-focused series on these fields: infinitefaculty.substack.com/p/on-researc...

George Mashour "Consciousness and the Dying Brain" at the MIT Consciousness Club. #neuroscience

Consciousness is personal. Awake story listening fMRI shows that default mode network dynamics diverge across individuals, supporting personal experience, while auditory & attention networks stay aligned, underpinning shared experience. #Neuroscience #Consciousness www.nature.com/articles/s42...

𝗪𝗵𝗮𝘁 𝗶𝘀 𝗻𝗼𝗶𝘀𝗲 𝗶𝗻 𝘁𝗵𝗲 𝗯𝗿𝗮𝗶𝗻? Almost always we average responses thus equating response variability with noise. Well, we shouldn't because variability is also signal, not noise to be entirely discarded. #neuroskyence doi.org/10.1016/j.ne...

When a brain researcher solved a logistical problem by going rogue, the idea proved remarkably infectious. By @lyrebard.bsky.social #neuroskyence www.thetransmitter.org/brain-imagin...

Now online in @biologicalpsych.bsky.social CNNI - our paper showing that reliance on habitual responding in transdiagnostic compulsivity may be underpinned by uncertainty about learned environmental structure 📃 www.sciencedirect.com/science/arti...

New theory of psychedelic mechanisms just dropped: "Learning as the unifying mechanism of psychedelic action." journals.sagepub.com/doi/full/10....

More than 200 published studies and at least seven ongoing clinical trials rely on potentially faulty brain network maps, according to a study published yesterday. By @avaskham.bsky.social #neuroskyence www.thetransmitter.org/brain-imagin...

Really thorough breakdown to methodological limitations of lesion network mapping! www.nature.com/articles/s41...

We have reached a situation where (1) the time/resources spent by people applying for grant X often outweighs (2) the time/resources awarded. For these grants, society loses net time/resources. www.nature.com/articles/d41...

Gonadal and sex chromosomal contributions to sex differences in mammalian brain organization www.biorxiv.org/content/10.6... - really nice work from Armin Raznahan @bogglerapture.bsky.social and colleagues

Please spread the word🔊My lab is looking to hire two international postdocs. If you want to do comp neuro, combine machine learning and awesome math to understand neural circuit activity, then come work with us! Bonn is such a cool place for neuroscience now, you don't want to miss out.

Why are gliomas overwhelmingly found in the action-mode network (AMN)? Could its function be contributing or is it that its function lines up with gene expression & receptor patterns? Either way, it raises the possibility of using inhibitory neuromod of the AMN to treat gliomas. #cancerneuroscience

🧠⚡️💊New @nature.com publication ! Mimicking opioid analgesia in cortical pain circuits We built a brain-behavior framework to decode spontaneous chronic pain in mice—and to biologically mimic morphine with a synthetic opioid gene therapy nature.com/articles/s41... @pennmedicine.bsky.social

After 5 years of data collection, our WARN-D machine learning competition to forecast depression onset is now LIVE! We hope many of you will participate—we have incredibly rich data. If you share a single thing of my lab this year, please make it this competition. eiko-fried.com/warn-d-machi...

Job alert 🚨 Fully funded PhD position available in our Maastricht lab! Are you interested in the relationship between memory and prediction, and have a track record of neuroimaging/decoding? Please apply! #NeuroJobs www.academictransfer.com/nl/jobs/3576...

This paper had a pretty shocking headline result (40% of voxels!), so I dug into it, and I think it is wrong. Essentially: they compare two noisy measures and find that about 40% of voxels have different sign between the two. I think this is just noise!

Delighted to see this incredible work by the superb @joelleba.bsky.social + a stellar team out as a preprint. Joelle provides a compelling set of results showing that canonical white matter tracts that traverse the cortical hierarchy are linked to cognitive diversity. Congrats Joelle!!!

This is your brain on Ritalin. Got your attention? Stimulant medications like Ritalin (methylphenidate) do, but not in the way you might think. They don't act directly on the brain’s attention systems! Find out what's really happening in @cellpress.bsky.social. doi.org/10.1016/j.ce...

Very happy to see this last thesis paper in press @natcomms.nature.com! We combine intracranial EEG with multimodal MRI to study how interregional similarity in neurophysiology relates to different network scales ⚡ 🧠 Full story 👇 www.nature.com/articles/s41...

I can’t believe someone who won the prestigious FIFA Peace Prize would do this

New job alert 💫 We’re hiring a 3-year postdoc for the NEPTUNE project to study the causal mechanisms of paranoia and social learning. Work with us on experimental psychopharmacology (THC), social cognition, and psychosis 🧑‍🔬 Apply here: lnkd.in/gQqnNvjR](my.corehr.com/pls/kclrecru...) Please RT :)

netneurotools: a trainee-oriented approach to network neuroscience | doi.org/10.1101/2025... Our lab’s internal toolkit for accomplishing everyday tasks in brain imaging ⤵️

𝗖𝗮𝗻 𝘄𝗲 𝘀𝘁𝘂𝗱𝘆 𝗯𝗿𝗮𝗶𝗻 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝘄𝗶𝘁𝗵 𝗳𝗠𝗥𝗜? We employed Switching Linear Dynamical Systems to investigate the dynamics of resting-state networks They are dynamic, not static! Work with Xiaoyu Zhao with lots of new methods. Thread. #neuroskyence www.biorxiv.org/content/10.6...

fMRI signals “up,” but neural metabolism might be going “down.” In our @natneuro.nature.com paper, we demonstrate that about 40% of voxels with robust BOLD responses exhibit opposite oxygen metabolism, revealing two distinct hemodynamic modes. rdcu.be/eUPO8 funds @erc.europa.eu #neuroskyence 🧵:

🚨new work with the dream team @danakarca.bsky.social @loopyluppi.bsky.social @fatemehhadaeghi.bsky.social @stuartoldham.bsky.social @duncanastle.bsky.social We use game theory and show the brain is not optimally wired for communication and there’s more to its story: www.biorxiv.org/content/10.6...

Patterns of brain-wide associations reflect socioeconomics https://www.biorxiv.org/content/10.64898/2025.12.10.693206v1

Just provisionally accepted -- preprint updated | The dual interpretation of edge time series: Time-varying connectivity versus statistical interaction | www.biorxiv.org/content/10.1...

1/4 Thrilled to be sharing new work published today in Nature describing the third wave of results from the PGC Cross-Disorder Group. This reflects a massive group effort to examine shared and unique genetic signal across >1 million cases for 14 psychiatric disorders. www.nature.com/articles/s41...

🧠 Excited to share our latest preprint: Automated Brain Mapping with AI Experts!🤖 www.biorxiv.org/content/10.6... Ever wanted to summarise the cognitive/systems neuroscience literature beyond MRI and PET? Ever wished we could do the same for macaque 🐒 and mouse 🐭 ? Read on! 🧵👇

**How distributed is the brain-wide network that is recruited for cognition?** That goes to the top of the list! #neuroskyence doi.org/10.1038/s415...

We used rabies virus 👾 to map how #psilocybin modifies long-range circuits 🧠, revealing network-specific reorganization that we didn’t expect. The full study is now online at Cell. @cp-cell.bsky.social Paper 👉 www.cell.com/cell/fulltex... Thread for a synopsis 👉 bsky.app/profile/alex...

Curious why we sometimes see minds where there are none? 🧠 Join us to uncover the foundations of attributed agency. Fully funded PhD for next year as part of DRIVE-Health, working with me, Adam Hampshire & @stefansarkadi.bsky.social Deadline: 12/1/26 Reach out for an informal chat!

Excited to see this paper out in Biological Psychiatry! It highlights that emotional pain and fear represent distinct PTSD dimensions, leading us closer to identifying PTSD subtypes with dissociable biological underpinnings. Congrats on leading the charge on this cool study @zivbenzion.bsky.social

Hot dog, this looks great www.biorxiv.org/content/10.1...