“Open research is about more than the tightening of analytical and methodological standards. The movement also invites us to reconsider how, and by whom, knowledge is created, shared and evaluated” By @maddipow.bsky.social, @drcpennington.bsky.social, & @flavioazevedo.bsky.social #MetaSci #OpenSci

dammit Snake knock that off

“I want the NIH to be a central driver of the MAHA agenda,” Bhattacharya said. “Essentially, it's kind of the research arm of MAHA.” NIH is not an ideological toy or 'arm'. We must insist on its scientific independence, especially if its Director will not. 🚨 www.dukechronicle.com/article/duke...

"Life During Wartime" (1979) - Talking Heads - Live performance "Stop Making Sense" (1984) 🎶🎧 #coffeebreak www.youtube.com/watch?v=gn62...

This one might be even better @barrlab.bsky.social

Fascism in America will never hold. We will win. Minnesota just showed us how.

📸🎞️ Kodak TMax p3200 35mm

📸🎞️tmax P3200

The extraordinary biochemist & pharmacologist Gertrude Elion was born #OTD in 1918. Elion won the 1988 #Nobel Prize in Physiology or Medicine (w/2 others) for her pioneering "rational drug design." Her work saved countless lives...(👇 1/2) #WomenInSTEM

I just thought everyone should see this

"There is an asymmetry in the study of trust in science: instead of examining the full spectrum from extreme distrust to extreme trust, it is heavily skewed towards the distrust end." By Petar Lukić and @iriszez.bsky.social doi.org/10.1007/s111...

Independent research fellows

I am hiring a staff bioinformatician for my new lab at the University of Utah! Please consider applying if you are on the hunt: employment.utah.edu/salt-lake-ci...

Our research scientist Núria Ros-Rocher won the 1st prize @zeiss-microscopy.bsky.social microscopy contest with this beautiful choano colony www.zeiss.fr/microscopie/... 🥳 C. flexa might not yet be a genetic model, but it is now at least a calendar model, which counts for something. I think.

Benchmate🧪 has its own custom-written ELN now.

🙂

Physical chemist Ruth Benerito was born #OTD in 1916. She pioneered a key chemical process, cross-linking, which led to wrinkle-resistant cotton fabrics. It transformed the cotton industry & helped save it from competition w/synthetic fibers. #WomenInSTEM She held >50 patents. #inventor

It's hard to breathe when all you know is The struggle of stayin' above the risin' water line

Being an American feels like getting on a school bus and then your bus driver decides to do a drive by

Expect to see a lot of this classic Onion headline, from 23 years ago, over the coming weeks.

Moulton: "When we had briefings on Venezuela, we asked, 'Are you going to invade the country?' We were told no. 'Do you plan to put troops on the ground?' We were told no. 'Do you intend regime change in VZ?' We were told no. So in a sense, we have been briefed, we've just been completely lied to"

the reason they don’t bother to manufacture the consent beforehand is that everyone just sort of does it for them post-facto now

tired: everything's computer wired: fewer things will be computer

Since we’re talking about whether avatar has any cultural impact I guess my unsolicited take is…maybe it’s healthy for a movie series to do incredibly well and not also spawn the most rabid fanbases. It’s kind of old school that way - movies could do numbers and people would be normal about them

Joy to the world!

Do not extort Venezuela, do not take over Greenland. We should not become a terrorist state. #Venezuela #Greenland

Every lab protocol

Mitt Romney, “we have reached a point where any mix of solutions to our nation’s economic problems is going to involve the wealthiest Americans’ contributing more.” www.nytimes.com/2025/12/19/o...

Another powerful morning on the picket line with my family, this time at our daughter’s former school, Fairmont Elementary. West Contra Costa County teachers are incredibly important to our family and our community. They deserve a fair contract!

"The only reason I don’t have this funding is because my last name is Rodriguez,” he said. “It has nothing to do with the science." STAT on the betrayal of early-career researchers: www.statnews.com/2025/12/08/t...

Out now in the The Atlantic — IGI's Jennifer Doudna and Fyodor Urnov on this year's remarkable progress in using #CRISPR to treat rare diseases. Read here: https://ow.ly/5vJ750XFQon

“The only reason I don’t have this funding is because my last name is Rodriguez.” MOSAIC checked many of the boxes of the administration — but that didn't matter. It was terminated, and left grantees scrambling Next installment of American Science, Shattered: www.statnews.com/2025/12/08/t...

Sonic is now available in our neighborhood (portola, SF)! It's great! Consider upgrading with this link: sonic.com/referral/504...

this is the most 8:30 PM a 6:15 PM has felt in a long time

Zα and Zβ domains of ADAR1 and ZBP1 bind to G-quadruplexes with low micromolar affinity https://www.biorxiv.org/content/10.1101/2025.11.19.688355v1

Near-atomistic simulations reveal the molecular principles that control chromatin structure and phase separation https://www.biorxiv.org/content/10.1101/2025.11.17.688899v1

Alexei ❤️

☕The authors identify a chemical cocktail to generate #totipotent - like cells, which they then use to build an #embryo model. This model captures a developmental spectrum from early #embryogenesis to post-implantation events. bit.ly/4oHxUZp

My inner state always tells me that I need to take a nap.

Yesterday’s stunning double rainbow in Davis

Polycomb Repressive Complexes 1 and 2 are recruited independently to pericentromeric heterochromatin in response to hypomethylation in mouse embryonic stem cells https://www.biorxiv.org/content/10.1101/2025.11.14.688451v1

🚨| BREAKING: Epstein Itemized for Trump Biographer Some New Areas of Trump Corruption—Giving a Road Map to Investigators 1. Who funded Mar-a-Lago mortgage(s) (Epstein implies he and Russians did) 2. Hawaiian Tropic contests (implied sexual misconduct) 3. Trump Shuttle 4. Legality of His Inheritance

My quote of the day If you had to identify, in one word, the reason why the human race has not achieved, and never will achieve, its full potential, that word would be 'meetings.' Dave Barry

Ending my evening with an email to Director Bhattacharya regarding @jenna-m-norton.bsky.social 1/3

Here's a big thank you to everyone at NIH who is trying to get everything regarding grants and reviews re-started!!!

While the government was shut down, 379 NIH study section meetings (containing 24,380 grant applications) were postponed. NIH is committed to getting these reviewed, but please be patient and understanding with staff, as this is a complex and heavy lift.

Fresh dystopian hell from Samsung fridges with ads.