Multi-lab, Multi-enzyme Study Demonstrates the Versatility of Bacterial Microcompartment Shells as a Modular Platform for Confined Biocatalysis https://www.biorxiv.org/content/10.64898/2026.03.18.712704v1

New preprint from our group! When we first started working with affordable, continuous-culture mini-bioreactors a few years ago, we realized they offered a unique solution for CRISPRi experiments, which rely on cell growth to dilute targeted proteins. www.biorxiv.org/content/10.6...

Our work on #hornwort #pyrenoids is finally out in @science.org! 🎉 We uncovered how hornworts pack their Rubisco into pyrenoids and successfully recreated them in Arabidopsis. A key step toward engineering more efficient photosynthesis in crops @btiscience.bsky.social www.science.org/doi/10.1126/...

Cool Preprint led by @mirbachh on comparing machine learning based engineering of a synthetic C1 fixation pathway vs the classic ALE based approach. ML allowed way faster pathway establishment and when combined with the evolved background improved growth by a factor of 3.🔥🎉

Looking for a #PhDposition in #PlantScience ? Our #IMPRS @mpi-mp-potsdam.bsky.social and @unipotsdam.bsky.social is #hiring ! 📅 Apply by 10 January 2026 More info: 👉 www.mpimp-golm.mpg.de/IMPRS-PhD Please share this post to plant it in the right feed 🌱 #PlantSciJobs

Our new paper is out: we present a quantitative framework to assess how (bio)tech interventions in plant agriculture could meaningfully contribute to climate mitigation. This may be the most important paper I ever publish #SyntheticBiology #ClimateAction #Agriculture #Biochar doi.org/10.1093/plph...

Newest preprint from our lab: a new family of promising synthetic CO2 fixation cycles that may outcompete the Calvin cycle and that Vittorio Rainaldi realized to a great extent in E. coli! Up to 11 heterologous enzymes in a cascade supporting CO2 fixation & growth! www.biorxiv.org/content/10.1...

Very excited to finally share my PhD paper, about advancing #chloroplast #synbio through high-throughput plastome engineering of #Chlamydomonas. Huge thanks to the whole team! www.nature.com/articles/s41...

Please check out our improved #preprint: CRISPR/Cas9 targeted genetic screening in Physcomitrella identifies novel cell division genes Thank you, Elena Kozgunova for taking the lead. #Physcomitrella #celldivision www.biorxiv.org/content/10.1...

🔥🔥🔥 Friday Evening, Paper Out, Feierabend 🔥🔥🔥 When evolution and enzyme engineering team up, they can convince microbes to assimilate sustainable carbon substrates preparing them for a life in a circular bioeconomy. doi.org/10.1016/j.ym...

🚀 Thrilled to share our new Nature Communications article: “A blueprint for designing the next-generation of synthetic C1 microbes” We propose a framework to unlock sustainable, carbon-efficient biomanufacturing using non-canonical hosts. 🔗 www.nature.com/articles/s41... A short 🧵1/4

1/ 🚨 New preprint! We've developed a robust IDMS-based LC-MS/MS workflow for high-throughput intracellular metabolomics in diverse bacteria. www.biorxiv.org/content/10.1... #Metabolomics #MassSpec #SystemsBiology

EMBL is back on hiring faculty! Check out the multiple open positions: 3 PIs- 2 in Heidelberg incl. our Molecular Systems Biology Unit, 1 in Grenoble 1 Head of Unit (Cell Biology & Biophysics, Heidelberg). Closing deadlines in Sep! +3 more positions to come out then, stay tuned... @embl.org

Now published in Microbial Biotechnology! enviromicro-journals.onlinelibrary.wiley.com/doi/epdf/10....

#Growth-coupled #selection just got an update ! In the last years, E. coli selection strains for #central , #amino #acid and #energy metabolism intermediates were created by the community. So, we compiled them and revisit the core concepts of growth coupling. www.sciencedirect.com/science/arti...

Ethylene glycol is widely used as monomer of the plastic PET. It is therefore highly relevant as sustainable feedstock for microbial biotechnology. In our new paper in @natcomms.nature.com, we characterize efficient enzymes for ethylene glycol oxidation: www.nature.com/articles/s41...

🎉 Excited to share that I’ve received an Emerging Investigator Grant from the Novo Nordisk Foundation! I’ll start my research group in Jan 2026 to develop universal cell factories for P2X & CO₂-based biomanufacturing 🌱🔬 👉 researchleaderprogramme.com/recipients/e...

Leveraging spectroscopic and structural approaches we obtained new insights into the role of #ferredoxins in N2 fixation. Just published in Chemistry – A European Journal: doi.org/10.1002/chem...! Great work by Holly Addison. Fantastic collaboration with Antonio Pierik on the EPR characterization.

www.sciencenews.dk/en/designed-... Piece from ScienceNews.dk on our glyoxylate and glycolate sensor strains

📢 We are proud and delighted that our Microbes for Climate (M4C) Cluster of Excellence has been selected for the 2025 Excellence Strategy! 🌟Together with @unimarburg.bsky.social, we look forward to exciting #microbe research – stay tuned! @unimarburg.bsky.social @maxplanck.de‬ @synmikro.bsky.social

🎉Doppelerfolg für die #UniMarburg in der Exzellenzstrategie! 🎉 Zwei Cluster zu Klimawandel und menschlicher Wahrnehmung sichern sich Förderung. Marburg beweist Forschungsstärke und Innovationskraft.🚀 @proloewe.bsky.social @synmikro.bsky.social @maxplanck.de @jlugiessen.bsky.social @tuda.bsky.social

Really impressive work from Ari and the team - going from an idea all the way to a functional pathway using the latest synbio tools! The CORE cycle is another carbon fixing route that could be used as an alternative to photorespiration in plants. Interested to see where this goes next! 🌱📈

Groundbreaking work just dropped🔥. @ari-satanowski.bsky.social and Daniel Marchal engineered new-to-nature CO2 reduction at ambient conditions via ATP-driven cycles for CO2->formate in vivo. All kinds of fancy experiments in here and a real seminal contribution to the field👏. Check it out!

Excited to share a main project from my PhD, out now in @naturecomms.bsky.social! 📝 We've designed and brought to life the “CORE cycle” – a new-to-nature pathway that provides a novel route for biological CO2 capture 🦠🌱 nature.com/articles/s41... Take a look! Thread below... 🧵

An energy-efficient pathway for aerobic production of formate from CO2, the CORE cycle. Could become part of a novel CO2-fixing photorespiration bypass design. Congrats @ari-satanowski.bsky.social

As well as CO2 Rubisco reacts with O2: plants evolved photorespiration to deal with the consequences. It works, but synthetic biology can do better! 🔄 We used metabolic modeling to compare alternative pathways to boost crop yields 🌱 🧵 #ScienceAdvancesResearch www.science.org/doi/10.1126/...

"We show that carbon-fixing APs are the most promising candidates to replace native photorespiration in major crop species." Alternatives to photorespiration: A system-level analysis reveals mechanisms of enhanced plant productivity | Science Advances www.science.org/doi/10.1126/...

📢 Preprint alert! In this study we provide new genomic insights into #CupriavidusNecator for #C1Biomanufacturing: - Genome assemblies for more strains - Species definition refined - Traits & methylation systems explored Great job by @magnusgj.bsky.social and team www.biorxiv.org/content/10.1...

🚨Check out this amwesome new CRISPR tool for highly efficient genome engineering in C. necator led by @dellavallesimo.bsky.social and @eorsi.bsky.social 🔥🔥🔥

We are announcing about 30 PhD positions in the @fwf-at.bsky.social Cluster of Excellence Circular Bioengineering www.circularbioengineering.at/jobs 9 projects open in Progamme 2 (Self-Sustainable Microbial Systems) in 4 Austrian Universities

Check out Sebastians crazy effort to engineer E. coli to grow on formate via the synthetic Serine-Threonine-Cycle. In contrast to the rGlyp the STC works even at ambient CO2!🔥

Check out this amazing work on engineering, characterizing and using six novel glyoxylate sensor strains led by @eorsi.bsky.social and @helenasm.bsky.social 🔥🎊🥳 Read Helenas nice post below to get the full picture.

Computation-aided designs enable developing auxotrophic #metabolic #sensors for wide-range glyoxylate and glycolate detection—spearheaded by Enrico Orsi w/a choral assembly of cool collaborators @naturecomms.bsky.social #SynBio #OpenAccess www.nature.com/articles/s41...

# MicroSky: Engineered archaea for sustainable bisabolene production! Researchers modified Methanosarcina acetivorans to produce α-bisabolene from one-carbon substrates—an eco-friendly alternative to plant-derived or synthetic methods doi.org/10.1111/1751...

Synthetic Carbon fixation just got a boost 🚀: Synthetic Biology outperformed Nature in a Living Bacterium. Check out the new work from @BDronsella @erblabs together with @NicoC_MicSynBio @MIB_WUR #synbio, #formatebioeconomy

Please also check out the great News and Views article accompanying our story 🔥https://www.nature.com/articles/s41564-025-01943-7

Super excited to see my main PhD project finally out in @naturemicrobiol.bsky.social www.nature.com/articles/s41.... We show for the first time that a synthetic and engineered pathway can indeed exceed nature at one-carbon fixation.

Preprint alert🚨Systematic #engineering of synthetic serine cycles in #Pseudomonas putida uncovers emergent topologies for #methanol assimilation · @biorxivpreprint.bsky.social led by Òscar Puiggené #SynBio #Methylotrophy #CircularEconomy www.biorxiv.org/content/10.1...

What limits rubisco function? Is it the chemical mechanism? Evolution? In this paper, @prywes.bsky.social et. al explore this question by assaying >99% of single amino acid mutants in Form II rubisco (1/7) doi.org/10.1038/s415...

We have an open professorship in #synbio / biological engineering in Heidelberg! jobs.zeit.de/jobs/full-pr... Check it out!

It's a good week for rubisco enthusiasts - very cool preprint from Ron Milo lab www.biorxiv.org/content/10.1... impressive screening of +250 genes spanning available diversity of rubisco, this then used to predict activities of 68,000 known sequences revealing role of phylogeny and habitat