Amazing work led by Vittorio Rainaldi from the lab of @nicoc-micsynmet.bsky.social on realizing the majority of the rMASP cycle for #synthetic #co2 #fixation in E. coli! #Ccr, the key carboxylase of the CETCH, THETA and HOPAC cycles finally works #invivo !

🔥🔥🔥 Friday Evening, Paper Out, Feierabend 🔥🔥🔥 When evolution and enzyme engineering team up, they can convince microbes to assimilate sustainable carbon substrates preparing them for a life in a circular bioeconomy. doi.org/10.1016/j.ym...

Please repost! Postdoc in adaptive laboratory evolution and C1 synthetic metabolism! Location: DTU Biosustain 🦠🧬🔬 Starting in 01/2026! Fell free to reach out if you have questions! efzu.fa.em2.oraclecloud.com/hcmUI/Candid...

Our perspective on C1 utilizing bioprocesses moved online, a super teamwork made it possible 👏 www.nature.com/articles/s41...

#Growth-coupled #selection just got an update ! In the last years, E. coli selection strains for #central , #amino #acid and #energy metabolism intermediates were created by the community. So, we compiled them and revisit the core concepts of growth coupling. www.sciencedirect.com/science/arti...

#ME16 This is quite subjective , but imo @helenasm.bsky.social just gave the most impressive talk of the conference so far and she is "only" in the third year of her PhD. If you are interested in synthetic pathway engineering or C1 fixation you should check out her research.

Excited to share a main project from my PhD, out now in @naturecomms.bsky.social! 📝 We've designed and brought to life the “CORE cycle” – a new-to-nature pathway that provides a novel route for biological CO2 capture 🦠🌱 nature.com/articles/s41... Take a look! Thread below... 🧵

We just #published an end-to-end work for the computer-aided design💻, construction🛠️, validation✅, characterization🔬 & application💪 of #auxotroph metabolic sensors, the work-horses of in vivo growth-coupled selection screening systems-using glycolate as test case. 🧵👇1/ www.nature.com/articles/s41...

Really happy to share that our work on constructing six glyoxylate / glycolate sensors covering a three order of magnitude concentration range is out now in Nature Communications ! 🔥 Read below to see how we developed the sensors and what they are good for 🥳. www.nature.com/articles/s41...