Frequentists mogged by priormaxxing

Statistics aka Likelihoodmaxxing

In Jan 2029 a trifecta should pass a large bill package that overturns somewhere between 20 and 50 Roberts Court decisions of the last three decades. We can roll back what they did to legalize political bribery, enable fraud, empower white collar criminals, destroy the govt, etc.

Russell Vought’s OMB published a rule today attacking peer review, which came along with a Murdoch NY Post article favorable to the rule- and attacking peer review. Which all makes the timing of yesterday’s Murdoch WSJ article attacking peer review seem much more suspicious!

Move over, GLM-HMM—there’s a new hidden Markov model in town. In our new preprint, we introduce the DDM-HMM: a model that jointly infers latent decision states from reaction times and choices. Using 24-hour behavioral data from rats, we found that evidence accumulation changes with time of day!

And finally it was published! Massive thanks to my coauthors, the editor and reviewers, and the institutions that supported our research. journals.plos.org/plosone/arti...

Congratulations to #FlatironCCN director @eerosim.bsky.social#FlatironCCNon his election to the National Academy of Sciences! https://bit.ly/42AEUhl #science #neuroscience

Super excited to (finally!) show our work on identifying cell types! Now in press www.nature.com/articles/s41.... We show how to identify cell types from ephys recordings *without* optotagging. This opens the study of not just individual cell types, but the interacting neural circuit during behavior

There seems to be a broad perception across psychology and neuroscience that work shouldn't be "too technical" in order to reach the broadest possible audience. While I think we should strive for accessibility, I feel that this attitude can also be self-defeating: why are we dumbing down?

Some reports say over 500 schools, 55 libraries, & 25 universities hit. You can debate the numbers, but hitting Sharif University & Beheshti is like hitting MIT & Stanford. I keep wondering: How would the scientific community respond differently if it was those universities? What’s the difference?

The Orange Cat Brain Atlas is here. 🧠🐈 Today, we published the first comprehensive cellular map of the orange cat brain. The new atlas reveals a single, specialized neuron responsible for behaviors like staring at walls, knocking objects off tables, and the 3am "zoomies."

Cosyne invited me to give a long tutorial (4 hours!) on methods to quantify differences high-d neural recordings across animals, brain regions, deep neural nets, etc. The recording is up on youtube. I hope it inspires more research on this fundamental topic! www.youtube.com/watch?v=n44x...

ArviZ 1.0 is out! We have refactored it to be more modular, flexible & lightweight. For an overview of the changes, check the migration guide. python.arviz.org/en/stable/us...

Checkout the notebook of this epic neuroscience dataset now on @dandiarchive.org and analyzed with pynapple!

So happy to announce my first published paper: Neuropixels reveal laminar microcircuit organization in monkey V1 in vivo www.pnas.org/doi/epdf/10....

I am a pro-AI guy who often gets pigeonholed as an anti-AI guy. I am pro developing and using AI for things AI is good at. I am anti developing and using AI for things that will bring on another AI winter, a mild economic collapse, and make us all look like schmucks in ~5 years.

As a proud Minnesotan, I second this

nearly a thousand entries

Gary Larson: In my cartoon I invented Cow Tools as a cautionary tale Cows: At long last, we have created the Cow Tools from classic newspaper comic Cow Tools

Walz: "What's happening in MN defies belief. News reports simply don't do justice to the level of chaos & disruption & trauma the federal govt is raining down... This long ago stopped being a matter of immigration enforcement. Instead, it's a campaign of organized brutality against the people of MN"

I really want ppl w/o Minneapolis connections to understand You might've heard that Mpls public schools went hybrid bc so many families are in hiding. Well, a coworker just told me that today, during his kid's hybrid class, a kid's apt building was raided onscreen *Everyone has stories like this*

The woman killed by ICE was Renee Nicole Good, a 37-year old who was the mother of a 4-year old child whose father already died a few years ago. The Star Tribune talked to her mother. www.startribune.com/she-was-an-a...

BBC is reporting that the same ICE officer who murdered Renee Good was involved in another violent incident in June.

NOW: Crowd continues to grow in Minneapolis at a vigil where a federal agent shot and killed Renee Good this morning. “SAY HER NAME!” “RENEE GOOD!”

If you knew Renee Nicole Good - the 37 year old killed by ICE in Minneapolis today - please text me at 202-510-1268. You can remain anonymous

A meta-analysis of studies using Tolman’s sunburst maze suggests poor replicability and little evidence for shortcutting. Ouch! Definitely relevant reading for anyone interested in cognitive maps! 👇

Given the popularity and centrality of neuronal calcium imaging to systems and cellular neuroscience, it is shockingly under-modelled. Makes me nervous about the conclusions from those studies. At least the fMRI BOLD interpretation gets routinely debated...

New paper drop! 🧠💊 Our new paper out in Molecular Psychiatry shows that the serotonin 1B receptor is important for the neural and antidepressant/anxiolytic behavioral responses to psilocybin in mice. www.nature.com/articles/s41...

🚨 We are recruiting a full-time Research Programmer to push forward several exciting machine learning projects in the lab! Work on computational behavior and joint neural/behavior models. Start date flexible, can be a pre-grad-school position or longer term. recruiting2.ultipro.com/SCR1003TSRI/...

Are manifolds real? Are latent circuits real? Tatiana @engeltatiana.bsky.social uses one, infers the other, and says yes to both. Also, how timescales are different and the same across the entire brain... braininspired.co/podcast/226/

My baby #JuliaLang package got an award! DifferentiationInterface.jl just received a national prize for open-source research software and I couldn't be prouder. We started this from a vague dream with @adrianhill.de, and reached 1000 dependents and 100k downloads last month. Research != just papers.

Awesome to see the French government recognize our work on open-source software! @ouvrirlascience.bsky.social

Simulation-based inference has really become a commonly used tool for parameter inference across many fields and applications. We (finally...) got together to write a tutorial introduction and guide to (hopefully) help users get started and navigate the different methods and diagnostics!

Check out cool new work from the DePaq lab!

check out the @okaysteve.bsky.social lab’s posters (for both neuron and glia enthusiasts) at #SfN2025 on Saturday PM! especially say hello to @siriacoello.bsky.social who is applying to grad school this cycle✨

🚨🚨🚨NEW PAPER ALERT🚨🚨🚨 We present StateSpaceDynamics.jl, an open-source Julia package for fitting probabilistic state-space models (SSMs)—including non-conjugate models like Poisson LDS and switching variants (SLDS). Python has had existing packages that have given this functionality...

Boulder friends: if you’re into animal behavior or vision, come to The Language of Light: Bioluminescence in the Deep Sea with Sönke Johnsen (Duke)! Fri Nov 14, 4-5:30 pm, Benson Earth Sciences Auditorium, Room 180. Reception 5:30-6:30 at the Earth Sciences & Map Library Free and open to all!

Super excited to share the first part of my thesis work! Perhaps how you might be able to both recognize someone’s voice *and* understand what they’re saying, we find that both social identity and vocalization category can be decoded from gerbil auditory cortex activity👂🧠 tinyurl.com/4fba6wk4

On November 7th, DON'T MISS @bostonu.bsky.social's Dr. Rebecca Suthard when she JOINS #MSNSeminars. Hosted by Drs. Brian Kipp, Chloe Lopez-Lee and Rimjhim Tomar, Dr. Suthard will present “A hippocampal astrocytic sequence emerges during learning and memory". @mountsinainyc.bsky.social

I’m recruiting a postdoctoral researcher on a fully funded 2-year contract. The topic is developing and implementing new parallel graph algorithms, with applications to data-driven transportation and logistics. Details and application procedure below ⬇️ Reach out if you have any questions!

JuliaCon Local Paris starts tomorrow 🤩 Which part of our amazing program are you most excited about? #JuliaLang @juliacon.bsky.social @julialang.org

🚨PREPRINT ALERT🚨 "A State–Dependent Drift Diffusion Model Reveals Mice Actively Explore A Speed–Accuracy Continuum During Decision-Making" is now available on biorxiv! Check it out below 👇 www.biorxiv.org/content/10.1... In this work we find that mice are not just static mindless decision makers.

They would've found something to weaponize regardless. One of the most admirable things about science is its commitment to self-criticism. The fact that bad actors may capitalize on our legitimate concerns should never stop us from being honest and reflective about what we do.

In our latest edition of “This paper changed my life,” @liddelowsa.bsky.social explains how two papers from Ben Barres’ lab completely changed the way the field studies astrocytes and enabled everything discovered in glia research since. #neuroskyence www.thetransmitter.org/this-paper-c...

DOGE/Musk preferentially cancelled grants and contracts to recipients in counties that voted for Harris in 2024. Among cancellations with election data available, 92.9% and 86.1% cancelled grants and contracts went to Harris counties, representing 96.6% and 92.4% of total dollar amounts.

our "untangling the mind" tour has begun! #NationalGeographic come explore the foundations of thoughts, emotions, and memories - all the things that make you, you - through the lens of modern neuroscience 🧠 by learning and working together, we have the power to make an era of discovery flourish🔬

Excited to share our latest story! We found disentangled memory representations in the hippocampus that generalized across time and environments, despite the seemingly random drift and remapping of single cells. This code enabled the transfer of prior knowledge to solve new tasks

in our new lab work, we find that: natural forgetting & induced amnesia share common impaired neural dynamics this work was funded by multiple #NIH grants that supported students, postdocs, & the science, all with the goal of healing disorders of memory & the brain www.cell.com/cell-reports...

Coverage of our recent locust paper in @science.org by DW www.dw.com/en/scientist...

Get in dorks, we're going protesting! STAND UP FOR SCIENCE WITH US ON MARCH 7TH, 2025 WASHINGTON DC AND EVERY STATE CAPITOL Because science is for everyone! Find us at www.standupforscience2025.org #standupforscience2025 #scienceforall #sciencenotsilence