The year was 2200. The US had achieved universal healthcare. A woman walked into her Epic-employed doctor’s office, took her BP on an Epic-designed cuff, watched the numbers magically enter the Epic-made computer in Epic. Everything was normal. She thanked the President, who was the CEO of Epic.

Just released mori 0.1.0 on CRAN — a new R package for shared memory across processes. Parallel R no longer has to mean duplicating your dataset in every worker's RAM. opensource.posit.co/blog/2026-04... 🧵 1/3

Here is an insane piece of lore inside SQLite's source code I am researching VACUUM and I was studying their code. In VACUUM, SQLite creates a temp file prefixed with `etilqs_` Here is why:

A few months ago, any LLM that I could run on my Macbook scored 0% on an agentic coding eval I put together. This month's Qwen 3.5 and Gemma 4 releases both scored 90%. On my blog: simonpcouch.com/blog/2026-04...

"Pancreatic cancer mRNA vaccine shows lasting results in an early trial: Scientists caution that more research is needed, but nearly all of the patients who responded to the personalized vaccine are still alive six years later."

In the year 2126… Reporter: What do you think about deskilling? Claude: *thinking* Claude: I don’t see why you would do it. The SKILL.md file takes up minimal storage space—why would you delete it?

Aspired: Skill.MDPhD

Inspired: Skill.PhD

It sounds like Anthropic was right to be concerned.

Tired: Skill.MD Wired: Dr. Skill

Is no one upset about the fact that they never sold birds in the first place?

Statisticians: “Data” is plural but “dataset” (a set of multiple data) is singular. Thank you for your attention to this matter.

House full on amazing panel discussion on Clinical Reasoning in the Era of AI at CDI2 conference at UCI @kdpsingh.bsky.social

If you work with UC Health data or aspire to do so then it might be worth attending the CDI2 conference at UCI na.eventscloud.com/website/5224...

Schrodinger’s strait

Sales rep: The customer is always right. People: Wow… that’s such good advice. — AI: The customer is always right. People: This is a phenomenon unique to AI which we have dubbed “sycophancy.” We have no idea where AI got this from.

There's a third party Julia extension for Positron! It makes Julia a peer of R and Python in Positron. open-vsx.org/extension/nt...

UC Health CDI2 upcoming conference! Thriving through change: Adapting, Advancing, Achieving Stellar listening of speakers, likes of which include @kdpsingh.bsky.social! Register 👇 na.eventscloud.com/website/5224...

Tiny personal news - I am now one of the Lead Maintainers for Model Context Protocol 👋 More work ahead, so if you have any feedback about the protocol, its docs, SDKs, or anything at all - let me know!

Holy (native) Grail update: we cracked open the #Shiny temple and eight desktop apps tumbled out. #rstats, #python, native, containerized, shinylive, you name it. One #Electron shell, every runtime mode we could dream up, all from one R package. {shinyelectron}, coming soon to a desktop near you.

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Health systems may have a blind spot if they aren’t thinking about AI consumer tool usage in caring for patients. New @ai.nejm.org editorial: When physicians use generative AI without institutional engagement, systems lose visibility and safeguards. Read ⤵️ ai.nejm.org/doi/full/10....

🎉 ggauto is now on CRAN 🎉 An #RStats package that selects better chart types, and provides more accessible styling for #ggplot2 plots 📊 Blog post explaining why I made it and how it works: nrennie.rbind.io/blog/introdu... #DataViz

Watching my kid manually type in references in a middle school essay because using a reference manager isn’t allowed. That is the most cursed thing ever.

Cyberattacks have halted care and disrupted devices across U.S. clinics. In a new piece, @arpa-h.bsky.social explains why it’s funding real-world cyber protections. Proud our CHC team built CRASHCART, restoring critical systems fast when ransomware hits. Read⬇️ arpa-h.gov/news-and-eve...

Statistician: Hey, want a ride? ML researcher: Sure. *** hops in EV *** *** 5 minutes pass ** ML: What are you waiting for? Stats: Finishing up the power calculation.

We have summer internships y'all! Come work at Posit on the PyData, tidymodels, shiny, or Connect teams: grnh.se/tigz810a3us. You will have an awesome time, learn a ton, and help advance our open source and pro tools 🧰 #rstats #pydata

Neural networks that know what they don't know? 🤔 New post with Joshua Marie: fit Bayesian Neural Networks in R with {kindling} + {tidymodels} and get uncertainty estimates out of a familiar workflow. 👉 statsandr.com/blog/bayesian-neural-networks-in-tidymodels-with-kindling/ #rstats #tidymodels

New in pointblank: Generate realistic, coherent synthetic datasets directly in #Python. 🛠️📊 Need test data that actually makes sense? Pointblank’s generate_dataset() ensures that names, emails, and locations stay consistent across rows, covering 100+ countries! Learn more: posit.co/blog/buildin...

According to my pooled analysis, this joke is average [95% CI meh, 🤣]

I have a joke about multiple imputation, but it's not very good. I have a joke about multiple imputation, but it could be better. I have a joke about multiple imputation, but it's awesome. I have a joke about multiple imputation, but it's not funny. I have a joke about multiple imputation, but it's

I have a joke about missing data, but

the horror

hmm, i need a sharpie. i better buy a pack of 50 from costco so this never ever happens again

A new paper on anomaly detection: robjhyndman.com/publications... The methods are implemented in the weird #rstats package.

He's dissolving Ohio State University

These captchas just keep getting harder #rstats

Today we're releasing AI for RStudio. It's really, really good—I'd encourage you to point it at the messiest data sources you have and see what it can do. www.simonpcouch.com/blog/2026-03...

kibbles vs. petfood.frames

The recordings from Shiny in Production 2025 are now available. Talks from speakers around the world on how they use Shiny in R and Python to solve real-world data problems. Watch the sessions: youtube.com/playlist?lis...

Appreciate the years of work by Andrew Wong, Yasir Tarabichi, Pat Lyons, and colleagues around the country to understand how routinely implemented predictive AI tools perform in diverse real-world clinical settings. Here’s a quick timeline...

Tomorrow Night Bright or Catppucchin Mocha?

tibbles are fine, probably even good.

#statstab #495 Unsure Calculator Thoughts: Nifty way to incorporate your uncertainty when making some calculations and decisions. #uncertainty #calculator #unsure #chance #sensitivity filiph.github.io/unsure/

Small update on the python-on-iOS front: the unnamed notebook app now has a name -- Pyodios -- and a new trick. Swap between a local Pyodide kernel and a remote Jupyter backend mid-session. Want offline? Stay local. Want GPU? Call home. No drama either way. #Python #iosdev #wasm #Pyodide #Jupyter

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Planning my next conversation starter

I love that whatever is going to happen will happen by 2030. Good to know.

I enjoyed working with an all-star team – the great Lisa Rotenstein of UCSF and David Bates of Brigham & Womens – on this paper describing how to measure return on investment (ROI) for clinician-facing AI tools. jamanetwork.com/journals/jam...

🚨 kuzco is now on CRAN 🚨 cran.r-project.org/web/packages...