Sandeep Gupta
@guptalabuofa.bsky.social
๐ค 48
๐ฅ 151
๐ 17
Assistant Professor@ UofAlberta, Canada. Neurobiologist, stem cell scientist, mentor
pinned post!
first lab meeting of the Gupta lab! very fun start. We are building functional stern cell models to investigate neural disorders like autism.
30 days ago
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Vinny Costa
2 days ago
Still think brain regions donโt exist? That everything is everywhere? That cell types donโt matter and that everything is a dynamical phase portrait? Wrong. Interconnected brain modules exist at the level of fine grained transcriptomics.
www.nature.com/articles/s41...
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Whole-cortex in situ sequencing reveals input-dependent area identity - Nature
BARseq interrogates the expression of 104 cell-type marker genes in 10.3 million cells over nine mouse forebrain hemispheres to reveal the role of peripheral inputs on cortical area development.
https://www.nature.com/articles/s41586-024-07221-6
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James Briscoe
4 days ago
Development that lasts a life time. Check out the 2025 special issue of
@dev-journal.bsky.social
on Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues
journals.biologists.com/dev/issue/15...
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Volume 152 Issue 20 | Development | The Company of Biologists
https://journals.biologists.com/dev/issue/152/20
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what an ending with iNeurons by Dr. Carol Schuurmans. it was a great experience witnessing cutting-edge stem cell research in Canada. Next Vancouver!
#TMM2025
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3 days ago
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ISSCR
3 days ago
ISSCR &
Stem Cell Network
are seeking nominations to form a working group of early career scientists & senior trainees in stem cell & regenerative medicine research who will provide perspectives on global workforce development. Nominations are due 5 December. Learn more ๐
https://ow.ly/j8uY50Xnlzc
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The ISSCR and Stem Cell Network Launch Global Regenerative Medicine Workforce Development Initiative โ International Society for Stem Cell Research
The International Society for Stem Cell Research (ISSCR) and the Stem Cell Network (SCN) are pleased to partner to lead a joint initiative and a global conversation on workforce development in regenerative medicine. Through this collaboration, the organizations will examine current challenges and op
https://ow.ly/j8uY50Xnlzc
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Exciting keynote talk at
#TMM2025
by Christine Mummery on modeling arrhythmia using stem cell- derived cardioids!
3 days ago
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Gupta Lab's image of stem cell- derived neuroepithelium is displayed at
#TMM2025
. didn't win though ๐ญ congratulations to all the winners, beautiful pics of wonderful world of stem cells.
3 days ago
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great start of day 3 at
#TMM2025
with a talk by Neurona therapeutic on major advances in epilepsy treatment with stem cell- derived interneurons! things are getting excited!
3 days ago
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Alessandro Gozzi
4 days ago
Great coverage by
@thetransmissions.bsky.social
of our latest preprint: adding new evidence (and a hint of controversy ๐) to the E/I imbalance debate in autism ๐๐
www.thetransmitter.org/spectrum/ram...
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Ramping up cortical activity in early life sparks autism-like behaviors in mice
The findings add fuel to the long-running debate over how an imbalance in excitatory and inhibitory signaling contributes to the autism.
https://www.thetransmitter.org/spectrum/ramping-up-cortical-activity-in-early-life-sparks-autism-like-behaviors-in-mice/
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great day-2 morning at
#TMM2025
, listening to an amazing story from Dr. Cristina Nostro, finding roles of macrophages in hsc- derived islet cell differentiation that can revolutionize future diabetes treatments. Huge congratulations to Dr. Nostro for receiving TMM2025 Till & McCulloch prize!
4 days ago
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very interesting talk by Ross Fitzsimmons from
@ucalgary.bsky.social
on raindeer antler regeneration and lessons for regenerative biology.
5 days ago
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that was a crazy (awesome) result! seeing Melinda myelination in the organoids, what's next?
#TMM2025
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5 days ago
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excited to hear some cool science!
#TMM2025
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6 days ago
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Stem Cell Network
19 days ago
๐
#ICYMI
: New speakers announced for
#TMM2025
! Join us in Ottawa to hear from Dr. Maria Cristina Nostro, 2025 Till & McCulloch Award recipient, and Brandon Murareanu, Drew Lyall Award winner, as they share groundbreaking
#RegenerativeMedicine
research. ๐ฌ Donโt miss it. โก๏ธ
www.tillandmcculloch.ca
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Giulia Boezio
13 days ago
Thrilled to share my main postdoc work with
@jamesbriscoe.bsky.social
We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions ๐งต๐
www.biorxiv.org/content/10.1...
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Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding
The formation of neural circuits depends on the precise spatial and temporal organisation of neuronal populations during development. In the vertebrate spinal cord, progenitors are patterned into mole...
https://www.biorxiv.org/content/10.1101/2025.10.24.684328v1
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Daniel MacPhee ๐จ๐ฆ
13 days ago
And the open access article in Science
#ReproSky
๐งช
#ReproMed
#ObGynSky
www.science.org/doi/10.1126/...
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Comparative analysis of human and mouse ovaries across age
The mouse is a tractable model for human ovarian biology, however its utility is limited by incomplete understanding of how transcription and signaling differ interspecifically and with age. We compar...
https://www.science.org/doi/10.1126/science.adx0659
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Tom Booth
19 days ago
A hearty Denisovan stew ripe with stories of mixing and more mixing, even with a third more โarchaicโ hominid.
www.biorxiv.org/content/10.1...
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A high-coverage genome from a 200,000-year-old Denisovan
Denisovans, an extinct sister group of Neandertals who lived in Eastern Eurasia during the Middle and Late Pleistocene, are known only from a handful of skeletal remains and limited genetic data, incl...
http://www.biorxiv.org/content/10.1101/2025.10.20.683404v1
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James Briscoe
30 days ago
The
@crick.ac.uk
is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov
www.crick.ac.uk/careers-stud...
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Early career group leaders
We appoint researchers from across biology and biomedicine to set up their first groups at the Crick.
https://www.crick.ac.uk/careers-study/faculty/early-career-group-leaders
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Ewan Birney
30 days ago
I am hiring! - looking for a Staff Scientist to co-run my research group with me. Staff Scientist is a senior professional scientist role at EMBL. Please forward to people you might know who could be interested!
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
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Staff Scientist
About EMBL-EBI EMBLโs European Bioinformatics Institute is a data powerhouse, utilised on a global scale to advance scientific discovery through bioinformatics and solutions to some of the worldโs mos...
https://embl.wd103.myworkdayjobs.com/en-US/EMBL/job/Staff-Scientist_JR2425
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first lab meeting of the Gupta lab! very fun start. We are building functional stern cell models to investigate neural disorders like autism.
30 days ago
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Pedro Beltrao
about 1 month ago
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (
@julianvangerwen.bsky.social
+ others) try to prioritize those most critical to the cell
www.biorxiv.org/content/10.1...
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The functional landscape of the human ubiquitinome
Protein ubiquitination regulates cell biology through diverse avenues, from quality control-linked protein degradation to signaling functions such as modulating protein-protein interactions and enzyme...
https://www.biorxiv.org/content/10.1101/2025.10.08.681129v1
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Mohammad Zubairi
about 1 month ago
At a time when there is so much discourse and rhetoric against disability, some thoughts here from a few months ago:
www.thespec.com/opinion/cont...
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Valuing disability and difference in society
Those sitting at the decision-making and policy tables are far removed from the day-to-day experience of children, youth and their families.
https://www.thespec.com/opinion/contributors/valuing-disability-and-difference-in-society/article_9487b3ab-adc3-5407-984d-d99834e11db7.html
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Megan Ranney MD MPH
about 1 month ago
I know the news is tough right now. So take a moment and soak in the gorgeousness & promise of the science that led to this yearโs Nobel Prize in Medicine & Physiology. WOW.
www.nytimes.com/2025/10/06/h...
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Nobel Prize in Physiology or Medicine Is Awarded for Work on Immune Systems
https://www.nytimes.com/2025/10/06/health/nobel-prize-medicine-physiology.html?smid=nytcore-ios-share&referringSource=articleShare
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Edda Schulz
about 1 month ago
โ ๏ธ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xistโkey for X-chromosome inactivation. ๐ We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
๐ Bluetorial
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Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwรคmmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
https://www.nature.com/articles/s41594-025-01686-3
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Nora Newcombe
about 1 month ago
Dense longitudinal neuroimaging reveals individual brain change trajectories: Trends in Cognitive Sciences
www.cell.com/trends/cogni...
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Dense longitudinal neuroimaging reveals individual brain change trajectories
Longitudinal measurements of brain structure and function are critical for understanding how humans change over time. Traditional longitudinal approaches sample sparsely across large windows of time t...
https://www.cell.com/trends/cognitive-sciences/fulltext/S1364-6613%2825%2900244-X
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Andrew Iwaniuk
about 1 month ago
I am going to repost our job ad because we are not getting many applicants! Like anywhere, there are pros and cons, so if you have questions just DM or email me.
#academicjobs
#neuroskyence
#neuroethology
#academicsky
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Konstantinos Miti
about 1 month ago
Our calcium paper is out in PLOS Biology! Check it out!
#Calcium
#Embryo
#Development
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Joseph Gordon
4 months ago
www.nature.com/articles/s42...
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Identification of a resistance-exercise-specific signalling pathway that drives skeletal muscle growth - Nature Metabolism
This study demonstrates that the MKK3b/6 signalling pathway drives the skeletal muscle growth-promoting effects of resistance exercise.
https://www.nature.com/articles/s42255-025-01298-7?utm_source=nature_etoc&utm_medium=email&utm_campaign=CONR_42255_AWA1_GL_DTEC_054CI_TOC-250724&utm_content=20250724
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had a great experience attending one child every child meeting at U Calgary, where i showcased my new lab at U Alberta. Fantastic to hear from scientists working to improve children health! and the weather was beautiful!
5 months ago
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Esther Verheyen ๐จ๐ฆ
8 months ago
Now seems like a great time to share a starter pack I made when I joined BlueSky! Let me know if you'd like to be added:
go.bsky.app/6aMSMpy
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Andrew Simmonds ๐จ๐ฆ
8 months ago
Installation and training of an Evident (Olympus) luminescence detection microscope in the
@ualberta.bsky.social
Dept. of Cell Biology.
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Kevin
10 months ago
Thread of mental health and practical resources for LGBTQ people (US-based) ๐ณ๏ธโโง๏ธ ๐ณ๏ธโ๐ Don't need these? Help someone who does by reposting this thread and donating to the organizations. Start a thread for your own country and I'll repost! 1/6
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Giles Yeo
9 months ago
I am excited to share our latest paper @Nature where we construct a hi-res spatial map of the human hypothalamus, the brain region central in appetite control. It is a collaboration between @IMS_MRL @Cambridge_Uni & @MPI_Metabolism
www.nature.com/articles/s41...
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A comprehensive spatio-cellular map of the human hypothalamus - Nature
HYPOMAP integrates single-nucleus RNA sequencing and spatial transcriptomic data to create a comprehensive spatio-cellular map of the human hypothalamus.
https://www.nature.com/articles/s41586-024-08504-8
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Rita Strack
9 months ago
"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here:
www.nature.com/articles/s41...
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Denise Belsham
10 months ago
Canadian job posting ๐คฉ๐จ๐ฆ
@infneuroendo.bsky.social
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here is one beautiful neural organoid with a shining rosette for
#fluorescentfriday
10 months ago
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Steven Sloan
10 months ago
First ๐ฆ post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental
#glial
biology to
#stem
cells and
#tumor
biology.
rdcu.be/d5ADz
A ๐งต
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Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma
Nature Cell Biology - Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with...
https://rdcu.be/d5ADz
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Science News
12 months ago
Comprehensive single-cell aging atlas of healthy mammary tissues reveals shared epigenomic and transcriptomic signatures of aging and Cancer.
#NatureAging
#Aging
#scisky
#Medsky
#News
#Cancer
Open Access
www.nature.com/articles/s43...
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Jacob (Yaqub) Hanna - ูุนููุจ ุญูุง
11 months ago
A true masterpiece .. from chick development , to careful dissection of progenitor populations identity , to signaling needed to induce them to recapitulate notochord in human pscs . (Great way to open my Christmas family retreat on the couch).
www.nature.com/articles/s41...
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Timely TGFฮฒ signalling inhibition induces notochord - Nature
Through analysis of developing chick embryos and in vitro differentiation of embryonic stem cells, a study develops a method to generate a model of the human trunk with a notochord.
https://www.nature.com/articles/s41586-024-08332-w
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Keri Martinowich
11 months ago
Reposting new preprint investigating sex-differentially expressed (DE) genes in human ventromedial hypothalamus and arcuate ๐ง . Data identifies extensive sex DE, which is linked to genetic risk for sex-biased disorders including autism, depression, and schizophrenia
www.biorxiv.org/content/10.1...
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Masseck Lab
11 months ago
๐PinkyCaMP- our christmas gift to you! ๐: We are excited to present PinkyCaMP, the first mScarlet based calcium sensor with: โจexceptional, brightness โจphototability โจand optogenetic compatability. Check out our new preprint:
www.biorxiv.org/content/10.1...
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Sergiu P. Pasca
11 months ago
Today we report in ๐พ๐๐ก๐ก ๐๐ฉ๐๐ข ๐พ๐๐ก๐ก a systematic approach to generate neural
#organoids
resembling various domains of the neural axis Neal Amin &
@kevinkelley.bsky.social
developed a multiplexed morphogen screen to generate
#organoids
that mapped to almost 2/3 of the clusters in the 1st trimester CNS
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this is really great!
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11 months ago
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Development
12 months ago
Welcome to Development's Bluesky account ๐งช Development is a leading primary research journal in developmental and stem cell biology, published by The Company of Biologists
@biologists.bsky.social
, a not-for-profit organisation, and edited by expert researchers in the
#DevBio
field.
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Development | The Company of Biologists
https://journals.biologists.com/dev
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Allen Institute
12 months ago
Calling undergrad neuroscience educators! ๐๐งฌ We're now accepting application for a 4-day workshop (July 21-24, 2025) on developing inquiry-based activities using our open
#neuroscience
data. ๐งณ Travel to Seattle, meals, and $1000 stipend included! Apply by Feb. 3:
alleninstitute.org/events/neuro...
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Here is a pic of hESC-derived neuroepithelial sheet in a dish, for the Happy
#FluorescenceFriday
12 months ago
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Very excited to see this paper out in print!! it was a wonderful collaboration to identify this unexpected role of Netrin1, which is usually known for axon guidance. Check it out!
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12 months ago
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Happy to transition from dark sky to blue sky now! looking forward to connect with fellow bluesky-ers(?) and following wonderful science!
12 months ago
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