"His secret weapons were an unquenchable curiosity and continuing hands-on experimentation at the bench with his beautiful frog embryos and oocytes". A thoughtful tribute to the life of Sir John Gurdon by Edward M. De Robertis that we really recommend everyone to read. doi.org/10.1016/j.cd...

Interested in development? Cave fish? Enteric nervous system? Pretty pictures? Please join us next Friday! We are looking forward to the talk! 🤩

#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...

Check out the latest work from our lab, led by Daniel Lin and Lara Elcavage: www.biorxiv.org/content/10.1... (1/3)

I love to see the endoplasmic reticulum (ER, cyan) hitchhiking over microtubules (MTs, orange). Also the membrane dynamics are lovely. It's been a while, but here we are for a late #fluorescencefriday with some #microscopy #scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬

Some good news during these difficult times. Please check out our new preprint. We built a new tool to probe the origins of high oocyte aneuploidy rates at advanced female reproductive ages. This NIH funded work was led by a fantastic postdoc in the lab, Jiyeon Leem. www.biorxiv.org/content/10.1...

This study presents an in vitro analysis of centriole and cilium formation during early mouse embryonic development, using 3D models to mimic implantation, tissue patterning, and axis elongation. @chribue.bsky.social @isabellavoelkl.bsky.social www.life-science-alliance.org/content/9/1/...

The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor. The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2. www.leadingedgesymposium.org/apply/

The FPbase spectra viewer just had it's biggest software refactor in 6 years. It *should* be largely invisible to the end user (hopefully just faster and less buggy). Please let me know if you find any issues as you use it! www.fpbase.org/spectra/

#xenopus 🐸❤️

Check out this useful #DevBio #preprint reading list on the Node. Also, the #CellBio edition just dropped on preLights, this month curated by Matthew Davies, @sristi.bsky.social & @vibhasingh.bsky.social #preList ⬇️ prelights.biologists.com/prelists/oct...

My new ImageJ / Fiji toolkit is out 🔥! The goal is to make image handling & visualization easy, with an intuitive interface! Install it on Fiji with the "Image Viewer" update site #microscopy #ImageJ #FluorescenceFriday #microscopyMonday imagej.net/plugins/imag...

We built a targeted protein degradation–based system to mimic reproductive age-related aneuploidy in young eggs - revealing how chromosome errors associated with female infertility arise with age. 🧬✨ With @jiyeonleem.bsky.social and our team at Yale MCDB. Read: www.nature.com/articles/s43...

CIN levels matter! We used CiMKi mice to induce and monitor skin tumors across five CIN levels in combination with DMBA/TPA treatment. Low → more tumors but no effect on onset or growth Moderate → more tumors earlier onset and larger growth High → fewer tumors but earlier and earlier growth (2/5)

Help: "maturating ESC colonies" or "maturing ESC colonies" AI: "Maturing" is the common, general term, while "maturating" is a less common and more formal/technical synonym, particularly used in scientific contexts. Both describe the process of reaching full development or completion.

Thank you @sacnas.bsky.social for granting us the space for our professional development workshop! #NDiSTEM2025 #latinxdb We connected with so many amazing people in the #SACNAS community! @niasv.bsky.social @fishfena.bsky.social

🚨 🚨 Science alert on a #FluorescenceFriday; check my latest paper published in @genetics-gsa.bsky.social where I integrated comparative tissue-specific transcriptomics and speciation genomics to discover two novel craniofacial genes behind pupfish extreme jaw development! tinyurl.com/craniofacial...

🚨Our collaboration with @centriolelab.bsky.social & @gautamdey.bsky.social is out today in @cp-cell.bsky.social We show that #Expansion #Microscopy is a broad-spectrum modality for Euks, enabling 3D phenotypic maps rooted to phylogeny. #ProtistsOnSky #SciComm #SciSky www.cell.com/cell/fulltex...

in Cleveland OH 4 my 24th @sacnas.bsky.social conference! Society 4 Advancement of Chicanos & Native Americans in Science has #LatinxInSTEM #NativeInSTEM mission & is open 2 all. My #NDiSTEM2025 session on #Postdoc Fundamentals w/Stanford is today! Find funding: www.minoritypostdoc.org/resources

The ECM is no longer in the back seat when it comes to development. Check out our special issue "Dynamics of the extracellular matrix in development, cell physiology and disease" with 8 selected articles to learn more: A 🧵 www.sciencedirect.com/special-issu...

📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for PhD students www.crg.eu/en/content/t... Postdocs gimm.pt/jobs/postdoc... Other calls to open, also for an experienced lab manager. Get in touch!

Really excited to see this out in the open: www.life-science-alliance.org/content/9/1/...! @isabellavoelkl.bsky.social explored and compared different in vitro developmental model systems to study ciliogenesis.

Plum, A. M., & Serra, M. (2025). Dynamical systems of fate and form in development. Seminars in cell & developmental biology, 172, 103620. #EpithelialMechanicsReview buff.ly/P7qEJPJ

🗞️🗞️New publication in @Nature! 🗞️🗞️ A study led by #ICREA researcher Iñaki Ruiz-Trillo (@multicellgenome.bsky.social) and Elena Casacuberta from @ibe-barcelona.bsky.social explains their research on the origin of multicellularity 🦠 www.nature.com/articles/d41...

First time ❤️

Please help distribute this announcement for the Ph.D. in Biology Program @stowersinstitute.bsky.social

Thrilled that our PAR-labeling tech supported new Nature findings from the Gorbunova–Seluanov team! Characterizing CIRBP in bowhead whales reveals how PARP regulation may shape longevity. Kudos to Hongrui Liu & Raymond Cai! 🔗 www.nature.com/articles/s41...

Applications are due Dec 1st. biology.indiana.edu/graduate/gen...

The @fengfishlab.bsky.social lab have found that mutation in the Ras gene can change normal cells and trigger an immune response that promotes cancer formation - all within 24 hours. This may offer new ways to detect or prevent cancer before it becomes established. edin.ac/47h6bZq

PAPER OUT ✨ What if you could use your microscope as a 3D printer? Prototype microfluidics in-house, <5$ in material costs per chip. From idea to experiment within a day. Now published in Lab-on-a-Chip (open-access): doi.org/10.1039/D5LC...

Join us for the EMBO | EMBL Symposium 'AI and biology' 🤖🧬 Explore how AI transforms biological research – from foundation models for biology to generative modelling 🧠💡 10 – 13 March 2026 EMBL Heidelberg and Virtual Submit your abstract: s.embl.org/ees26-02-bl #EESAIBio #AI

Live cell ACTIN imaging has never been easier with SPY650-FastAct_X! 1. Add the probe to the cells 2. Image 1h later SPY650 is highly suited for STED imaging. The image shows a confocal/STED comparison of the fine actin mesh in a live HeLa cell. image credits: @stephanlab.bsky.social

Our latest perspective is out in Dis Model Mech (@biologist.bsky.social)! We discuss how brain organoids highlight the impact of Huntington's disease on brain development. We suggest takling mitochondrial fitness early on a as a potential treatment strategy. doi.org/10.1242/dmm....

🤝 In 2024, the 𝗦𝗠𝗕𝗘 𝗡𝗼𝗻-𝗣𝗮𝗿𝗮𝗰𝗵𝘂𝘁𝗲 𝗦𝗰𝗶𝗲𝗻𝗰𝗲 𝗙𝘂𝗻𝗱𝗶𝗻𝗴 from @official-smbe.bsky.social went to Drs. Boris Armel Olou, Jean Legeay, Jean Evans Israel Codjia & Roël Dire Houdanon for their project strengthening African researchers in Molecular Biology & Bioinformatics. ✨ Excited about the impact so far!

Ascidians (Ciona intestinalis)🪸Our distant chordate cousins! 🌊 Simple sea squirts that reveal how vertebrate body plans evolved 🧬 A key model for notochord formation, neural induction, and cell lineage mapping 📸 Video by MBL Embryology 2019 #ModelMonday #DevBio #EvoDevo

4/ Dissolving P-bodies in mouse naïve ESCs increased ribosome occupancy of P-body–enriched RNAs, including 2C transcripts, triggering reversion to a 2C-like state. This shows that releasing RNAs from P-bodies enables their translation and drives cell fate transitions.

1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...

🌟Nominations are open for the Arthur C. Guyton Distinguished Educator Award!🌟 Recognize an educator excelling in teaching, advancing physiology, and contributing locally & globally. 📅 Deadline: January 9, 2026 🔗 https://ow.ly/WAsm50XhLz2 https://ow.ly/V3zQ50XhLyY

We are hiring an Imaging Scientis. Apply here: go.mbl.edu/AS1887

🔬 Applications are now open! Join MBL’s world-renowned Advanced Research Training Courses, where scientists from around the globe come together to explore new ideas, master cutting-edge techniques, and become part of a dynamic network. ➡️Apply today: go.mbl.edu/courses

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

I created a starter pack for Imaging Scientists that work in core facilities. I'm sure I missed lots of people since I searched for those that have "core" or "facility" in their bios, so let me know who else should be added! go.bsky.app/2bbgRQU

We first characterized the 3D morphodynamics of mouse gastruloids during elongation using our new analysis pipeline SpinePy @cryaaa.bsky.social

Really excited to present the results of a fantastic collaboration with Jesse Veenvliet @jesseveenvliet.bsky.social @mpi-cbg.de @poldresden.bsky.social 🤩 We find a unique mechanism for body axis elongation in mammals, different from other vertebrate species ➡️ www.biorxiv.org/content/10.1...

Tomorrow! Come join us for MicRoN’s Open House Symposium. Learn about the research we get to support, meet our staff and instruments. micron.hms.harvard.edu/micron-open-...

"One email at a time, one informational interview after another, I became comfortable, confident, and strategic in building my network of mentors." One mentor isn’t enough, wrote Erika Moore in this 2021 Working Life essay. https://scim.ag/49hp8fS #NationalMentoringDay

Episode 17 - perhaps my favorite yet. How do you write a forum.image.sc post that will get you the answers you need without revealing information you don't want to tell? @erinweisbart.bsky.social and I go through what the experts need to know to help you. Post your sci q's today on forum.image.sc !

For over 20 years, the mouse model organism has helped scientists uncover the biology behind human health and disease. But the mouse reference genomes still have missing pieces. The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains. 🧬💻

microfabricated stamps, fresh off the printer :)

Meet the real rainbow fish 🌈🐟 Using Cre-mediated recombination, each zebrafish cell expresses a unique fluorescent color, creating a living rainbow of developmental history 🎨✨ Image by Bret Pearson #FluorescenceFriday #Zebrafish #DevBio