📡🧵 Excited to release an updated version of our preprint: Zebrahub-Multiome: Uncovering Gene Regulatory Network Dynamics During Zebrafish Embryogenesis 🧪🧬🖥️🐠 doi.org/10.1101/2024... A tour-de-force by @yangjoonkim with an unexpected discovery!

We’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells. www.nature.com/articles/s41...

Pregnancy loss is common in humans, and chromosomal abnormalities are the leading cause. Using genetic data from ~140,000 IVF embryos, we show that maternal variation in meiosis genes influences recombination and aneuploidy risk. First authors: @saracarioscia.bsky.social & @aabiddanda.github.io

Our photoswitchable HaloTag is out in Angewandte Chemie @angewandtechemie.bsky.social ! We now also show that this system can be used to control emitter density in SMLM. Congrats to Franzi, Bego, and our amazing collaborators. Check it out: onlinelibrary.wiley.com/doi/full/10....

Great thread about one of my very favorite cellular structures! Also home to one of our labs favorite proteins, Canoe/Afadin

A very curious paper from the De Robertis lab shows how Cerberus - a growth factor that inhibits Wnt signalling, and IGF - a growth factor that activates MAPK signalling, can synergistically induce a new head (aka ectopic archencephalic differentiation) in Xenopus embryos. doi.org/10.1016/j.cd...

MEIOC facilitates meiotic entry in the mammalian female germ line This Research Highlight showcases work by Esther G. Ushuhuda, Maria M. Mikedis (@mariamikedis.bsky.social) and colleagues: journals.biologists.com/dev/article/...

With support from the NIH, the Center for Economic Justice and Action is leading the FRESH Study to better understand how nutrition/basic needs shape the long-term health of young adults. Researchers hope findings will support investment in basic needs for college students: https://bit.ly/4shF5tv

#FluorescenceFriday Proud of our the last paper @cellcommlab.bsky.social & 1st one of @jboixcampos.bsky.social We continue to study #CellMigration & how cells decide where to go: ↖️↗️⬇️? (movie of the actin #cytoskeleton) Full www.science.org/doi/10.1126/... @focalplane.bsky.social @science.org 🧪🔬

Work by the 4D Nucleome Consortium, led by Job Dekker, PhD, reveals a systematic map of the structure and function of the human: direc.to/ooab #genome @jobdekker.bsky.social @hhmi-science.bsky.social @nature.com @marionicodemi.bsky.social @creminslab.bsky.social @gladstoneinst.bsky.social

This week's #MicroscopyMonday shows colorful #zebrafish oocytes surrounded by support cells in white, resembling Andy Warhol's flowers. 🌼 (@michaydiez.bsky.social, Gerton Lab) #SciSky

Please apply (or encourage your grad students to apply) to our awesome funded summer program by January 15th!

Stack: Simulating cellular conditions via prompt engineering, without the need for fine-tuning arcinstitute.org/news/foundat...

Organoid technology is one of the most significant advancements deriving from developmental biology. Yet, many aspects of the biology of organoid itself remain elusive, one of which is the role of mesenchymal stem cells. This review: doi.org/10.1016/j.cd... by Wang et al discusses this in detail.

Axolotl can regrow lost limbs, matching their body size. How? Our new theory-experiment paper in @pnas.org proposes how oppositely oriented morphogen gradients scaling with animal size promote proportional growth. Great collaboration with @tatianasg.bsky.social @cmcb-tud.bsky.social

ECM as a cell-cycle brake. Led by Liyuan Sui (Dahmann lab), we show that the ECM gates Yorkie nuclear entry to halt proliferation at final size via G2 arrest in the Drosophila wing disc. Programmed ECM degradation later enables re-entry + proper adult wing size. Link 👇 #Mechanobiology #ECM

Join us to study developmental cell biology with a focus on cell migration and morphogenesis. More info about our research: www.bischofflab.com Job posting and application details: focalplane.biologists.com/cell-biology... #Science #CellBio #DevBio #AcademicJobs #PhDJobs #PhDPosition #Drosophila

Now final version out: Our manuscript connecting histone modifications with metabolism: How H4K16 acylations regulate inter +intranucleosomal interactions and confer resilience to metabolic challenges in vivo. Thanks to the team+ @sandrani.bsky.social Enjoy 👇👇 www.cell.com/molecular-ce...

We often think of our genes as the script of our fate. But genes are not the whole story. www.quantamagazine.org/how-metaboli...

Journal of Cell Science @jcellsci.bsky.social is recruiting an enthusiastic and motivated Reviews Editor. An exciting opportunity for a talented scientific editor to make a contribution to an important journal in the field of #cellbiology. Deadline 2 Feb. More at: www.biologists.com/about-us/wor...

Early for #FluorescenceFriday: make more glowing #zebrafish to observe how beautiful #devbio is! (dorsal view of a zebrafish embryo, drl:mCherry (magenta) and mixl1(EFM):mCerulean; pic credit Harrison Wells) @cudevbio.bsky.social #AlwaysBeCloning

We're #hiring! Our group in the Cell Bio Dept at Hopkins is looking for a Research Technologist to join us and study #neuralcrest #cellmigration during #devbiol! Looking to build up your lab experience? Check it out! @socdevbio.bsky.social @ascbiology.bsky.social jobs.jhu.edu/job/Baltimor...

Go @mikepiacentino.bsky.social !!!!

Online Now! Human pluripotent stem cell-derived innate and adaptive immune cells for cancer immunotherapy #stemcells

The Undergraduate Community at Evolution program provides travel funding, mentoring, and a presentation opportunity at #Evol2026. More info & testimonials from previous participants are available on our website. Please share with undergrads in your lab! www.evolutionsociety.org/content/educ...

This meeting is going to be awesome! Sign up for great science on an epically beautiful campus nestled among towering redwoods with views of the Pacific Ocean 🌲🌊

Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de

Our study illustrates how a single TE family can sculpt the regulatory architecture underlying a complex developmental cascade. It adds to a growing number of studies supporting Barbara McCintock’s prescient vision of TEs as “controlling elements” 💕 Hope you enjoy our preprint!

I am very excited to kick off our 2026 @enhancedgenomics.bsky.social seminar series ‘The 3D Regulatory Genome’ with @sedonamurphy.bsky.social’s talk “Can chromatin organization store memories?”. 📅 08 Jan 2026 (tomorrow!) ⏰ 4 pm GMT Please join us: us02web.zoom.us/webinar/regi...

Genomics #postdocs: applications are open for our Next Wave of Faculty in Genomics Symposium (due Jan 15)!. Come share your science in Santa Cruz, home of redwoods, ocean views, and the world’s most unbothered mascot:🐌🌲🌊. Link: genomics.ucsc.edu/calendar_eve... @baskinengineering.bsky.social

The 2026 Santa Cruz Developmental Biology Meeting website is LIVE!!! Go see the incredible list of scientists who will be speaking at the meeting next summer! (...and check the site early next year for info on registration and abstract submission.) scdb2026.sites.ucsc.edu

Please apply for the @cshlxeno course: Cell & Developmental Biology of Xenopus: Gene Discovery & Disease April 7 - 21, 2026 Application Deadline: January 16. youtu.be/T6wu7XYOP3E?...

Another fascinating - and totally serendipitous - example of how human biological sex isn't always binary, despite executive orders that it is. In this case an XX/XY mosaic individual was a fertile female. Other XX/XY mosaics can be phenotypically male.

This went under the radar but answers a fundamental question in Epigenetics... From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How? Outstanding work from Mathieu Boulard and colleagues www.biorxiv.org/content/10.6...

Join us for the AI Applications in Biology Symposium at @biohub.org! A full day of talks on ML for structural biology, imaging, single-molecule & multimodal/omics data 🗓️ Feb. 20, 2026 (1 day before BPS) 📍San Francisco 🔗 shorturl.at/uQerL Attend in-person or virtual. Submit abstracts by Jan. 20!

Apparently, 🐟 cells are not at all different from herds of 🦓! Great use of #inTRACKtive on very different types of data. Thanks Niko, for trying it out and getting it working already 'during’ my talk 😮

🔬 🖥️ Applications are open for the CSHL course Quantitative Imaging: From Acquisition to Analysis (April 6–21, 2026)! An intensive, hands-on course covering advanced fluorescence microscopy and quantitative image analysis using open-source tools. 🗓️ Apply online by Jan 30, 2026

Interested in the MBL Physiology Course in Woods Hole and want to learn more before you apply? Join myself and Cliff at our Virtual Open House TOMORROW 2–3 PM ET. You will hear what the course experience is like and get all your questions answered. Register/Join: princeton.zoom.us/j/97673682905

So many students don’t understand the importance of having letters of recommendation from professors who actually know them. Please put in the effort! Go to office hours! Send your CV! Don’t ask for letters if professors can’t identify you in a lineup or if you didn’t do well in the class. 🫠

When RNA Degradation 🤝 meets 🤝 Protein Degradation! tinyurl.com/E3TDMD In a collaboration of @bartellab.bsky.social and Schulman lab, we show that, in target-directed microRNA degradation (TDMD), 2-RNA-factors recruit an E3 ligase and induce the degradation of not only a protein but also RNA (1/5).

🫀 How do we recreate organs in labs to study diseases? Discover organoids research at Institut Pasteur 📅 Jan 26, 2026 | 9:20AM-6PM 📍 Paris | Free, registration required Register: www.eventbrite.fr/e/translatio... #Organoid #TranslationalResearch

The authors did such a great job making this spatial transcriptomics data of ovulating mouse ovaries available: www.pnas.org/doi/10.1073/... So I vibe coded a web browser app to interactively explore its spatiotemporal gene expression trends: jef.works/CellCarto-Ov... Hope it's useful!

Congrats Simon Han & @brugmannlab.bsky.social on your publication @cincyresearch.bsky.social A dual role for GLI3 signaling in neural crest development journals.biologists.com/dev/article/...

☕Shen, @zgelashvili.bsky.social and Niethammer developed an inner #NuclearMembrane tension sensor and demonstrated that ER–nuclear membrane contiguity acts as a mechanical buffer. bit.ly/3MZM6PF

AI learns from chromatin data to uncover gene interactions www.nature.com/articles/d41...

FULL SCREEN! Isn’t this the most beautiful creature you’ve ever seen? My first ever truly pelagic amphipod, from the genus Themisto. Look at that eye!! #marineplankton 🦑

Happy to share that my postdoc work with @jobdekker.bsky.social is out! rdcu.be/eWHD2 We characterize interphase chromatin folding programs with distinct modes of mitotic inheritance and identify the chromosome-intrinsic capacity to form a microcompartment of active CREs during mitotic exit.

Our final #preprint list of 2025 is now up on FocalPlane! In this post, we focus on recent (and recently updated) preprints in bioimage analysis. Let us know if you have any recommendations of preprints that we have missed. focalplane.biologists.com/2025/12/29/m...

Helping this mood is our latest now out in its final form! @irfankathiriya.bsky.social leading the teams with me. Thanks to the editors and reviewers (incl. @wythelab.bsky.social)for a pleasant and productive journey. More to come when the full issue is out. www.nature.com/articles/s44...

#DBfeature Wish our authors and readers a Happy Holiday & a fruitful 2026!🥳🥳🥳