The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.

Rising Star at #KSCHIRT: Dr. Catie Profaci (@cprofaci.bsky.social), postdoc in the Patapoutian Lab (@ardemp.bskyverified.social), delivered a standout talk on PIEZO1 mechanosensation in the choroid plexus. Grateful for her visit to Kentucky—excited to follow the work of a true star on the rise!

In-cell architecture of the mitochondrial respiratory chain

β-hydroxybutyrate facilitates mitochondrial-derived vesicle biogenesis and improves mitochondrial functions: Molecular Cell www.cell.com/molecular-ce...

Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant. Thread below: (1/11)

Very happy to share the first PhD work by Hannah de Bruin, showing that traumatic brain injury is not linked to higher fibrillar amyloid and tau per se, but to altered patterns of tau deposition preferentially in TBI vulnerable regions doi.org/10.1093/brai... @rikossenkoppele.bsky.social

new preprint! www.biorxiv.org/content/10.1... a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!) first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social

A recent preprint from the Haass lab shows that the efficacy of TREM2 agonists in microglia is contingent upon TREM2 expression levels. Cells with elevated TREM2 expression exhibit reduced responsiveness to agonist treatment. doi.org/10.1101/2024...

Simic et al. engineered T cells with synthetic receptors to target brain-localized antigens, activating circuits to kill cancer cells specifically in the brain. Could this precision pave the way for T cell therapies in neurodegenerative diseases? doi.org/10.1126/scie...

Glögl et al. used AI-driven protein design (RFdiffusion) to create selective antagonists for TNFR1, a pro-inflammatory TNF receptor, without targeting the anti-inflammatory TNFR2. This shows the potential of AI tools in therapeutic protein design. doi.org/10.1126/scie...

Congratulations to Lance Johnson on his excellent talk at the CSHL Neurodegenerative Disease conference on his ApoE switch mice. In my (biased) opinion, it sparked some of the most interesting questions of the meeting!

Zhuang et al. show that aging alters iron handling and ferroptosis. Aged cells resist ferroptosis due to reduced iron levels, while young cells rely on iron to maintain stemness. This raises interesting questions about aging and iron regulation in other cell types. doi.org/10.1038/s415...

New paper shows ketones regulate proteostasis. As stated in the paper, “Ketone bodies are janitors of damaged proteins, chaperoning away molecular waste so organisms can operate at peak molecular fitness.” www.cell.com/cell-chemica...

First, in rats (PMID: 22654062); then, in primates (PMID: 27830790); and now in humans (again) nature.com/articles/s41... This is precisely why we need animal research! Huge congratulations to the authors on this impressive work!

#Neuroinflammation Who knew? BTK - it’s not just for #Bcells - check out this study for Brutin’s tyrosine kinase in #microglia and #multiplesclerosis #neuroskyence #immunosky