If you're at #CellBio2025, please join us tomorrow at 9AM in Room 122 for a fantastic speaker lineup at the #EndoplasmicReticulum Minisymposium! Immediately following our session will be the keynote presentations by Eva Nogales & Jennifer Lippincott-Schwartz! @ascbiology.bsky.social

Attending the #ASCB #CellBio2025 at Philadelphia? We are organizing a roundtable tomorrow at noon on strategic collaboration for high impact research. Please join us for this exciting session to learn and witness exchange of ideas. 👩‍🔬👨‍🔬🤝📝

Here deletion of Xbp1 in β-cells (Xbp1β-/-) of non-obese diabetic mice before insulitis is protective against #diabetes www.nature.com/articles/s41...

Hello Beta Cell folks, here's my final work as a postdoc with Michigan Medicine! Beta cell ERAD impairment affects proinsulin proteostasis not just by blocking degradation, but also by triggering stress that shuts down new synthesis. Happy reading!

Excited to share my first-author publication! "Recessive TMEM167A variants cause neonatal diabetes, microcephaly and epilepsy syndrome" was published on @jclinical-invest.bsky.social! #Genetics #Neonataldiabetes #Stemcells www.jci.org/articles/vie...

The #MembraneTrafficking online seminars are back this Thursday (June 26th, 5pm CEST). We'll hear from @jnuechel.bsky.social about how to find the right partner for a TANGO, and from Maohan Su about the organizational principles of the Golgi. @ishier.bsky.social @franbottanelli.bsky.social

Our first article on proinsulin proteostasis from ETSU. 😊 www.frontiersin.org/journals/mol... Testament to great efforts by undergraduate students in my lab! 🙋🏻‍♂️ #proteinfolding #diabetes #proteinaggregation #insulin #proinsulin #ERqualitycontrol #proteostasis

Proinflammatory cytokines mediate pancreatic beta-cell specific alterations to Golgi morphology via iNOS-dependent mitochondrial inhibition https://www.biorxiv.org/content/10.1101/2025.01.29.635550v1

We are hiring 😀 Postdoctoral position – Stem cells, Cancer, and Aging We study cell fate decision and lineage specification in hematopoietic stem and multipotent progenitor populations to modulate lineage output for therapeutic purpose in diseases and aging contexts.

Cardiolipin deficiency disrupts CoQ-complex III interface in steatohepatitis www.biorxiv.org/content/10.1...

Interested in #TPD? This might be for you. What concentrations of UPS inhibitors are safe to use to prove your proteasome dependent degradation mechanism? #PROTAC #TPD #degradation #Science #drugdiscovery pubs.acs.org/doi/10.1021/...

"Ribosome ubiquitylation events on specific ribosomal proteins impact translation activity." Interesting insight in RQC. www.cell.com/cell-reports...

We did a thing! Our first human islet isolation at Michigan by @cortig.bsky.social in partnership with our wonderful friends in the Alberta IsletCore @bcellorg.bsky.social. Excited for this to be the first of many to support diabetes research! 🤩

Excited to share our latest work in #CellReports highlighting a PPARγ dependent remodeling of translation machinery in adipose progenitors. Amazing collab between our lab Claudio Villanueva, Xia Yang, and @laurahulea.bsky.social ! #obesity #metabolism #translation www.cell.com/cell-reports...

How to write a good scientific review article. #PhD #scisky #medsky Open Access febs.onlinelibrary.wiley.com/doi/10.1111/...

There is an interesting story developing here (certainly for those us curious about disease heterogeneity in T1D) 👇🏼👇🏼 Lovely work Guido and team 🙌🏼

Research Article: Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis -Protein Science #proteinaggregation #misfolding #proteinfolding #proinsulin #disulfidebonds #betacells #Diabetes onlinelibrary.wiley.com/doi/full/10....