New on bioRxiv! 🚨 “Pericyte and Endothelial Primary Cilia and Centrioles have Disparate Organization Across the Brain Microvasculature” This project studying #microvascular cells took an unexpected turn when we discovered that #pericytes have primary #cilia! 🔗 www.biorxiv.org/content/10.1... 🧪 🧵1/8

Thrilled to share that our work is now published in Science! ✨ We found a preference for visual objects in the mouse spatial navigation system where they dynamically refine head-direction coding. In short, objects boost our inner compass! 🧭 www.science.org/doi/10.1126/... 🧵1/

🚨CALL FOR PAPERS🚨 For our "Integrative physiological considerations of the human vasculature system" #SpecialIssue, which will showcase further insights into vascular haemodynamics and multi-organ diseases, as well as the technology used to monitor and treat cardiovascular disease. 🔗 buff.ly/HN7wlPr

🔗 Full Open Access manuscript: link.springer.com/article/10.1... 👇 Curious to hear more about #PrecapillarySphincters? Check out these threads about the subject: Characterization: x.com/SorenGrubb/s... Ultrastructure: x.com/SorenGrubb/s...

Fantastic study shedding new light on regulation of cerebral microcirculation 👇👇👇

Vittani, Lee, Wang, Hiraoka, et al. KI mouse expressing red fluorescent blood In situ SpyTag/Catcher attachment of biosensor ECS SpyCatcher to capture BBB leak doi.org/10.1101/2025... We hope this method is useful to a wide range of the biology community.

Once again, someone else says it: "Aβ accumulation affecting brain vessel function could be a very early pathology leading to neurodegenerative disease." doi.org/10.1186/s131... #cerebrovascular

Your brain functions not only as a thinking organ but also as a miniature water factory. We here calculate how much water neuronal mitochondria produce by glucose oxidation: 300-400 ml. Of that amount, 100 ml go into brain's interstitial fluid. fluidsbarrierscns.biomedcentral.com/articles/10....

Excited to share our new paper in @acta_physiol: SorCS2—involved in trafficking and synaptic signaling—is important for neurovascular coupling: doi.org/10.1111/apha... Whisker stim in Sorcs2 KO 🐭 led to ⬇️NVC, ⬇️astrocyte Ca²⁺ signals & disrupted glutamate receptor trafficking.

🇦🇺🦘Just wrapped up 6 incredible weeks of science, collaboration at the University of the Sunshine Coast. Thanks to Vicki Hinkley for such a productive partnership—I’m excited to continue this collaboration across 🇩🇰 and 🇦🇺. I’m also grateful to the USC CONNECT Programme for the funding 🙏

🦒🫀Measuring hemodynamics in awake giraffes sounds like a wild challenge 🤯. New paper by Christian Aalkjaer et al in @actaphysiologica.bsky.social 🔓: onlinelibrary.wiley.com/doi/full/10.... 🦒 While drinking🚰: ⬇️ Heart rate ➡️ Arterial blood pressure ➡️ Carotid blood flow ⬆️ CSF pressure 🧠

Come join us at the Bioinformatics Research Centre at Aarhus University. Tenure track/associate professor position available with application deadline June 1, 2025. Application details here: international.au.dk/about/profil...

Join our #PhDcourse on #openscience datasets and tools in #Neurophysiology! We'll dive into #EM, #inVivo #physiology, behavioural analysis tools, and a talk on creating animations from open data! @quorumetrix.bsky.social 📢 Free for NorDoc PhD students, but open to all! Apply now! lnkd.in/dU_fxqqu

Amazing work out by Hirase Lab 🤩

Oral Glycine supplementation (DT-109 Gly-Gly-Leu) ⏬#Atherosclerosis & lesional #Calcification in ♂️Monkeys A potential role of Glycine in GSH antioxidant & #Inflammasome in #SmoothMuscleCell #SignalTransductTargetTher 2025 www.nature.com/articles/s41...

#StainAI: A deep learning tool trained on 8,695 manually labeled cells to classify #microglia into 6 distinct morphotypes (www.nature.com/articles/s42...). A powerful step toward automated and scalable morphology analysis. #AI #neuroimmunology #cardiacarrest

#StainAI: A deep learning tool trained on 8,695 manually labeled cells to classify #microglia into 6 distinct morphotypes (www.nature.com/articles/s42...). A powerful step toward automated and scalable morphology analysis. #AI #neuroimmunology #cardiacarrest

Vascular Tone of pressurized🐭distal MCA (sham & #IschemicStroke)⏫by BKCa inhibitor Brain Arterial #EndothelialCell BKca & TRPV4 (immunofluorescence)⏫by acute (0.5~2 h) #Hypoxia or #Stroke across🐁🐀🐖🚶‍♂️ @chrstaehr.bsky.social #ActaPhysiol 2025 onlinelibrary.wiley.com/doi/10.1111/...

Futile reperfusion of ischemic tissue after #stroke increases the risk of death and disabilities. Spatial transcriptomics provides new insights into the vascular alterations that drive this process. #BBB #cerebrovascular #neurosky #emedsky #medsky 🧪

Changes in endothelial cell large conductance calcium-activated potassium channels (BKCa) after #hypoxia may explain the altered myogenic tone which impacts blood flow following ischemic #stroke. #ionchannels #vascularbiology #physiology #cerebrovascular #endothelium #neurosky #emedsky #medsky

#SpatialTranscriptomics #Proteomics acute stage of #IschemicStroke (🐭tMCAO 24h) Molecular drivers of mural cell hyperconstriction & BBB disintegration in post-stroke futile reperfusion? A dual non-neuronal role of Calcineurin? @chrstaehr.bsky.social #Stroke 2025 www.ahajournals.org/doi/10.1161/...

🚨 Publication alert!🚨 Our new study (onlinelibrary.wiley.com/doi/full/10....) in Acta Physiologica shows that #stroke/#hypoxia induces the expression of BK-Ca channels in the #cerebrovascular #endothelium across species 🧔🏻‍♂️🐭🐷🐀. These channels, absent in normoxia, regulate post-stroke arterial tone.

Hello All Scientists! We are the Microcirculatory Society and we are excited to join the community here at BlueSky! Follow us for fun updates happening in the microvascular community and the amazing science being done by our scientists! #microcirculation #science

Is this real? I published it again on Brain @brain1878.bsky.social 😆 Truly appreciate the leadership of @rrust.bsky.social on this great project (>300 refs!)🫡👇 The blood–brain barrier: a help & a hindrance #Aging #Stroke #Neurodegeneration Crossing #BBB 😎 academic.oup.com/brain/advanc...

New review from our lab in @brain1878.bsky.social We explore how molecular blood-brain barrier (BBB) changes in aging, neurodegeneration and stroke affect disease progression, delivery of therapeutics, and much more! academic.oup.com/brain/advanc...

#Pericyte #PulmonaryHypertension 1/2 A subpopulation of Higd1b+ lung capillary pericytes 👉Migrate to distal arteriole 👉Upregulate Vimentin 👉Acquire #SmoothMuscleCell identity (α-SMA, circumferential wrapping) in🐭Hypoxic PH #SciArt Ke Yuan lab @embojournal.org 2025 www.embopress.org/doi/full/10....

This is a groundbreaking study for pericyte fans. We discovered the unique pericyte marker Higd1b which only labels pericytes without any off-target effect from other mural cells.

New paper led by @silvia-anderle.bsky.social Lifestyle matters for genetic Alzheimer’s disease risk: APOE4 reduces neurovascular function most in an already-stressed system,  when neurons are active and mice do less exercise. I'll tell you all about it! 🧪 #neuroscience #alzheimers rdcu.be/d74uh

🚨We are hiring!🚨 We have postdoctoral positions available! If you're passionate about studying cardiac regeneration and development, join our team in vibrant and beautiful Montreal! Please help spread the word 🫶 For more details see here research.chusj.org/RECHERCHE/fi...

Amazing organotypic effects of PDGFRβ+ #Pericyte Paracrine #Orangogenesis Pericytic BDNF/HGF KO🐭P1➡️ ⬇️Lung #Angiogenesis #Alveologenesis P21 No🧠effect Pericytic Nodal KO➡️ ⬇️Brain #Angiogenesis Disrupted #BBB Astrogliosis No🫁effect @ralfhadams.bsky.social 2025 www.researchsquare.com/article/rs-5...

Alert for Cardiovascular Grant writers, a must-archived 620-page paper😆 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association Table 29 At-a-Glance Summary✌️ #Circulation 2025 @ahajournals.bsky.social www.ahajournals.org/doi/10.1161/...

SM22α+ #SmoothMuscleCell ATF3 KO🐭➡️ #AorticAneurysm #AorticRupture by AngII or #Aging ATF3 physically sequestrates MDM2 (E3 ligase for p21) ATF3 deficiency➡️ ⏬p21 protein stability ⏫ds DNA breaks ⏫Micronuclei ⏫cGAS-STING in SMCs #AortaEd Clin Transl Med 2024 onlinelibrary.wiley.com/doi/10.1002/...

Cellular #Senescence & Compromised #TightJunction in #SubmandibularGland in🐭Natural #Aging (18-mo) or D-galactose (for 8 wk) Interestingly, SA β-Gal activity was only evident in aged SMG, not parotid or sublingual glands. #AgingCell 2025 onlinelibrary.wiley.com/doi/full/10....

In the PARAMEDIC-3 trial involving adults with out-of-hospital cardiac arrest, an intraosseous-first strategy for vascular access did not result in a higher incidence of 30-day survival than an intravenous-first strategy. Full trial results: nej.md/48uYv4A #MedSky #CardioSky

For #FluorescenceFriday, microtubules (magenta) are shown with tau in a primary hippocampal neuron 🔬 #Neuroscience #Microscopy

"It's much more fun when your hypothesis is wrong - I have learned much more from being wrong than from being right. Don't sweep contrary findings under your intellectual rug." - 10 lessons learned by Barry Levin 👇 pmc.ncbi.nlm.nih.gov/articles/PMC...

Check out our new publication "Control of neurovascular coupling by ATP-sensitive potassium channels" A 🧵 1 journals.sagepub.com/doi/10.1177/...

Get your cerebral blood flow and metabolism abstracts in for Brain and BrainPET 2025 in Seoul! Deadline Feb 1st!! I’m so excited! www.brain2025.org

💉 Should calcium be used to treat #hyperkalemia? Our new systematic review in #Resuscitation (🔓 www.sciencedirect.com/science/arti...) found no evidence supporting calcium for hyperkalemia management. @ercresus.bsky.social #ILCOR

Our new FASEBJ paper. We looked into mTOR Ser1261 phosphorylation in human and mouse muscle, proposed by Diane Fingar's lab to be first an Akt and then AMPK site regulating mTORC1 and 2 activity. Clearly AMPK site but impact on mTORC unclear in our hands faseb.onlinelibrary.wiley.com/doi/10.1096/...

Bladder tissue regeneration using acellular synthetic PRS scaffold + instillation of conditioned medium from #MesenchymalStemCell & CD34+ HSPC vs blank media ⏫Smooth muscularization ⏫Size of regenerated blood vessel ⏫Innervation ⏫Urodynamics #AdvTher 2024 onlinelibrary.wiley.com/doi/10.1002/...

#SpatialTranscriptomics #Cartana in situ sequencing +snRNAseq 🐭Kidney development e15.5/18.5 P3 #SciArt A Critical Milestone KSTAT/Kidney Spatial Transcriptome Analysis Tool➡️ Single-cell mapping of regulon & enriched pathway biorRxiv 2024 @ondinecleaver.bsky.social www.biorxiv.org/content/10.1...

🧠 Our new study in Cephalalgia (journals.sagepub.com/doi/10.1177/...) explores genetic variants in FHM1-3 genes using @ukbiobank.bsky.social data. A genotype-first approach revealed that these 🧬variants ⬆️ #migraine risk—and surprisingly, a link to ⬇️ #epilepsy was discovered. Here’s what we found🧵

Beautiful #Immunity cover 🤩 Congratulations to Alessandro Matera (now an amazing postdoc in our lab 🙏) for his PhD thesis 🧪 tour de force! 🥳 @ale-matera.bsky.social, Anne-Claire Compagnion, Rosa Paolicelli & all authors for fascinating insights into #microglia biology www.cell.com/immunity/ful...

Very cool work!

Interesting how genetics keeps offering insights on lipids' effects on atherosclerosis🧬 ApoB-raising variants increase vascular risk by varying levels of magnitude per unit change in ApoB-particle number 👉TLR-particles 4x more than LDL 👉Lp(a)-particles 6x more than LDL 🧵1/5

Histopathology of👤Aortic wall remodeling Acute type A #AorticDissection N=5 <24 h postAD N=3 1~14 d N=4 0.5~3 mo #FalseLumen Granulation 0➡️761➡️423 µm Adventitial Fibrotic Collar Thickening 175➡️415➡️1078 µm Neovascularization #AortaEd Aorta (Stamford) 2024 www.thieme-connect.de/products/ejo...

🚨 Breaking #Physiology news: Spinal arteries dilate in response to #noradrenaline! Our new study (www.thespinejournalonline.com/article/S152... ) shows increased spinal cord blood flow in-vivo via β-adrenergic receptor–mediated vasodilation, as spinal arteries lack α1-adrenergic receptors.

New study on the pathogenic role of hypoxia in #BloodBrainBarrier disruption, with implications for vascular dementia #cerebrovascular academic.oup.com/braincomms/a...