After 9 months of major revisions, 2 out of 3 reviewers were stilll not satisfied, and the editor decided to reject our manuscript. It's been a whole year since we first submitted our paper to a journal, and I am back to timepoint zero 😭😭

Someone in the news departments of @nature.com or @science.org needs to take a look at this--its a huge scandal from the scientific supplier that has become a monopoly

We're getting the new Fairy Tail manga miniseries one week sooner!

SLX4IP acts as a genome-wide brake on BLM helicase activity to preserve replication fork stability under stress – both globally and at ALT telomeres Stephanie Panier @spanier55.bsky.social, Kavi Mehta @k4v1.bsky.social and coworkers link.springer.com/article/10.1...

🎯

#Vegan #Burger, with a patty made out of lentils. Contains also vegan cheese, tomatoes, onions, cucumber pickles, ketchup, hummus and tahini. Really really good.

Okay so why was I the only one in the theater tonight who gasped when Ryan Gosling ran a centrifuge with two tubes in the whole thing, sitting right next to each other? Sorry was I the only scientist in the film society theater tonight??

We go live!!! Join us Munich July5-7th to hear exciting research on #Replication by leaders in the field AND !! registration is FREE 🥳 (but mandatory) - we hope to see many in Munich 🍺 @helmholtzmunich.bsky.social @replifate.bsky.social @epicrossborders.bsky.social replifate.eu/event/meetin...

Dear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt

Real-Time Segmentation and Classification of Birdsong Syllables for Learning Experiments https://www.biorxiv.org/content/10.64898/2025.12.19.695629v1

Mech Arena link.plrm.zone/sdlgo/ki0l4

It was great to be part of this collaboration, I always admired Prof Maya Schuldiner's and Dr Ofir Klein's work. lnkd.in/dfabHSkx For the original papers developing the fluorescent scFvs technology in yeast: lnkd.in/d_KZ8WMK lnkd.in/dxt9MD6d

DNA replication initiation timing is important for maintaining genome integrity | Journal of Bacteriology journals.asm.org/doi/10.1128/...

Such a nice review for one of our latest research works!

We look forward to the community's feedback!

The BLS did exactly what it's supposed to do: provide accurate, nonpartisan data. When the numbers showed Trump's "economic boom" was actually a bust (33k jobs vs claimed 291k), he fired the messenger. After all, when it rains too much, true leaders fire the meteorologists.

I don't like the person I become when designing primers

I am very excited to share our latest work where we describe a new method to profile genome-wide chromatin transitions over time in single cells. Great collaborative effort with the van Oudenaarden group @hubrechtinstitute.bsky.social @oncodeinstitute.bsky.social www.nature.com/articles/s41....

RIF1 orchestrates a multi-step restoration of post-replicative H3K9me3 https://www.biorxiv.org/content/10.1101/2025.07.14.664777v1

🎤 Apply to speak @our TALENT FORUM by July 31! Showcase YOUR research in Epigenetics & NucleicAcids @www.helmholtz-munich.de & connect with leading scientists 🧳Travel+accommodation covered if selected! 📝 Info+how to apply: lnkd.in/drkRvz7N #postdoc #career #groupleader #HelmholtzMunich #research

Great week for #manga readers! #WildStrawberry ch45 #Yattara ch18 #DramaQueen ch23 #Centuria ch56 #Dandadan ch198 #Chainsawman ch206 #Bugego ch10 #MärchenCrown ch11 #TheGodofTime ch5 #AsurasVerdict ch14 Especially the last one was so good! Here are a few artworks.

A Multimodal Adaptive Optical Microscope For In Vivo Imaging from Molecules to Organisms https://www.biorxiv.org/content/10.1101/2025.06.02.657494v1

#spoileralert #WildStrawberrt #Manga with itdld best double spread. Too sad this is getting axed ;(

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

#spoileralert #dandadan #manga nailed it this time, one of its coolest #artworks! Remember, this is a weekly #manga!

www.nature.com/articles/s41... POPtag is officially my new favourite named tag! BTW, nice work!

This was a gift from a colleague, and it looks breathtaking. Done within one day (1000 pieces, around 12-15 hours)

A rather remarkable retraction for a paper where apparently no authors contributed! I guess these #papermill authors were a bit too honest... #fraud @elsevierconnect.bsky.social doi.org/10.1016/j.ij...

CST complex blocks end resection by BLM-DNA2 or EXO1, therefore promoting non-homologous endjoining and inhibiting repair templated DNA repair. www.science.org/doi/10.1126/...

Delighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...

Grab a pint & dive into science! 🍻 Pint of Science is back in Munich: 🗓️ May 19–21, 2025 🕢 19:30–22:00 #HelmholtzMunich researchers share big ideas – from AI to antibodies. 🎟️ Info & tickets: t1p.de/lvpuv #pint25 #pint25de

Spoiler alert! #Dandadan #manga #194 does not disappoint this Monday too! Back2back peak chapters!

Excited to share our latest from my postdoc at @mskcancercenter.bsky.social in the Sfeir Lab, in collaboration with the Simon Powell Lab! We uncovered a novel genome repair mechanism in human cells: RNA-templated DNA double-strand break repair (RT-DSBR). (1/5)

I used to have nightmares about getting a pet and forgetting to feed it. I have not had a single one of those dreams since getting Heater because there is not a chance in Hell she will let me forget breakfast.

I just woke up from a nightmare where I was giving a guest lecture to an undergrad cell biology class and none of them knew the central dogma or what DNA or RNA were. I spent an hour teaching that instead. They didn’t understand why they needed to know about DNA for cell biology. 🫠😫😱

What governs where DNA replication begins in human cells? Here, we show that origins of replication in human DNA are epigenetically specified and that crucially, this epigenetic mark is required for both DNA replication and cell proliferation! @narjournal.bsky.social academic.oup.com/nar/article/...

Fluorescence recovery in the Super-Resolution regime reveals subcompartments of 53BP1 foci https://www.biorxiv.org/content/10.1101/2025.05.07.652606v1

Ever wondered how cancer cells “decide” to spread? When high-grade breast cancer cells get crowded, they shrink and become more mobile, turning a non-invasive tumour into a threat. Scientists have identified the molecular switch behind the change. buff.ly/8JIDzDF

www.biorxiv.org/content/10.1... Cool work!

🚨 new preprint from the lab. Combining modeling, new Hi-C data in yeast and data analysis, our study offers new insights into the spatial and dynamic organization of chromatin during replication in eukaryotes. Check the tweetorial below ⬇️ www.biorxiv.org/content/10.1...

#StellarFriends #manga latest issue was really peak!

New preprint! We have discovered that the splicing factor Sex lethal (Sxl - well known for its role in sex determination) binds to chromatin and regulates tRNA synthesis in neurons by interacting with RNA Pol III! Highlighting Sxl as a novel modulator of neuronal homeostasis. tinyurl.com/s44s2z95

Another one is done, this was very nice, but tough. #jigsaw

“But you know what the oddest thing was? No one seemed shocked or surprised. Not even me. Yes, I was scared, but really, I just had the most profound sense of déjà vu.” X-Men ‘97 - 1x08

New #manga, The War of the Adults. Very interesting orwelian concept

RFK HHS

Alpha-BET: Functional labeling of envelope glycoproteins with single domain antibodies for in-virus single molecule imaging by Sergio Padilla-Parra and team: www.biorxiv.org/content/10.1...

There are very fancy microscopes, but most are overpriced commodities in an un-competitive industry that sells you 100 features you don't want for every one you do. And, unless you're a cell biologist or mouse-ologist, no one makes a microscope for the experiment you want to do.

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

Unexpected Molecular Mechanism of Orc6-Based Meier-Gorlin Syndrome: Insights from a Humanized Drosophila Model https://www.biorxiv.org/content/10.1101/2025.03.31.646466v1