ernestiu.bsky.social
@ernestiu.bsky.social
š¤ 88
š„ 229
š 4
Anything about
#cytoskeleton
and
#microscopy
pinned post!
I'm thrilled to finally share my PhD work on understanding how Ca2+ signals regulate the protruding front of the cell. Itās been an incredible journey working alongside all the collaborators.
www.biorxiv.org/content/10.1...
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A TRPV4ādependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actinābased lamellipodia protrusions...
https://www.biorxiv.org/content/10.1101/2025.03.28.646012v1
9 months ago
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ernestiu.bsky.social
about 2 months ago
www.biorxiv.org/content/10.1...
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Vimentin promotes actin assembly by stabilizing ATP-actin subunits at the barbed end
Vimentin intermediate filaments play essential roles in maintaining cell integrity and regulating numerous cellular functions. In particular, vimentin cooperates with the actin cytoskeleton in key cel...
https://www.biorxiv.org/content/10.1101/2025.11.17.688760v2
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ernestiu.bsky.social
Courtney Schroeder
2 months ago
After a long break from social media, Iām finally on Bluesky and have a preprint alert from my lab!
doi.org/10.1101/2025...
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A microexon in Arp2 alters tissue-specific Arp2/3-generated actin structures
The Arp2/3 complex nucleates essential branched actin networks in most eukaryotes. Interestingly, the subunit Arp2 encodes two splice variants that differ merely by five amino acids in the D-loop, whi...
https://doi.org/10.1101/2025.10.12.681909
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ernestiu.bsky.social
Bardin Lab
3 months ago
The PhD work of
@bboumard.bsky.social
officially out in print! Happy to share this issue with our downstairs colleagues in the BDD
@frelab.bsky.social
@robinjournot.bsky.social
www.cell.com/developmenta...
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Cell-type-specific nucleotide sharing through gap junctions impacts sensitivity to replication stress in Drosophila
Boumard et al. demonstrate gap-junction-dependent tissue-scale nucleotide sharing, which impacts cellular sensitivity to perturbation of nucleotide homeostasis and replication stress. Drosophila wing ...
https://www.cell.com/developmental-cell/abstract/S1534-5807(25)00320-X
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ernestiu.bsky.social
Hawa Racine Thiam
3 months ago
We look forward to hearing feedback from the community on our
#preprint
where we used
#NETosis
as a platform to show that chromatin decompaction inside the nucleus directly regulates cell mechanics. This work identifies long-range biophysical impacts of chromatin in mammalian cells.
add a skeleton here at some point
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ernestiu.bsky.social
Kate Cavanaugh
3 months ago
First, check out my recent bioRxiv preprint w/
@oweinerlab.bsky.social
:
www.biorxiv.org/content/10.1...
We find contractility shifts the proportion of implantation-competent embryos from young and aged females. Keep reading this for more info!
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A mechanical origin for implantation defects in embryos from aged females
Women over 35 experience a marked reduction in fertility. The origin of these fertility defects appears to reside in the implantation capacity of the embryo itself, but the mechanistic basis of this i...
https://www.biorxiv.org/content/10.1101/2025.09.29.679218v1
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ernestiu.bsky.social
Florian Schur
3 months ago
Huntingtin binds and bundles F-actin! Thrilled to team up with the Humbert (Sorbonne UniversitĆ©) and Song (KAIST) labs on this discovery. We had a blast doing cryo-ET on this unexpected complex ā and now so many new questions lie ahead!
#TeamTomo
#CryoET
#HTT
#actin
doi.org/10.1126/scia...
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ernestiu.bsky.social
Maik Bischoff
3 months ago
1/12 A very special moment for me! š My first paper as corresponding authorāa
@jcb.org
Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes.
rupress.org/jcb/article/...
#cellbio
#devbio
#science
š§µfor details
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ernestiu.bsky.social
Miranda Hunter
4 months ago
Lay(-ish) summary of our melanoma confinement paper with some behind the scenes details of how this project came about, and what weāre planning to do next (hint: PDAC š). Thanks
@nature.com
for featuring our work.
add a skeleton here at some point
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ernestiu.bsky.social
Rodrigo Fernandez-Gonzalez
5 months ago
To celebrate the summer, our ReSCU-Net paper is out
@jcb.org
!! Work led by our dungeon master
@ray-hawkins.bsky.social
, developing a novel neural network architecture and applying it to explore the role of gap junctions in embryonic wound healing in
#Drosophila
š§Ŗ.
shorturl.at/xNRKn
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ernestiu.bsky.social
Iain Cheeseman
5 months ago
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes?
www.biorxiv.org/content/10.1...
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Global inhibition of deadenylation stabilizes the transcriptome in mitotic cells
In the presence of cell division errors, mammalian cells can pause in mitosis for tens of hours with little to no transcription, while still requiring continued translation for viability. These unique...
https://www.biorxiv.org/content/10.1101/2025.07.22.666109v1
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ernestiu.bsky.social
Patrick Oakes
6 months ago
Congratulations to
@stefanosala89.bsky.social
, with help from
@shreya-c.bsky.social
al⬠on the optogenetic experiments, for the awesome story! Read the full preprint here:
www.biorxiv.org/content/10.1...
and thanks for listening!
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LIM Domain Proteins link molecular and global tension by recognizing strained actin in adhesions
Mechanotransduction is fundamental to cell signaling and depends on force-sensitive adhesion proteins. How these proteins differentiate and integrate their responses to tension remains an open questio...
https://www.biorxiv.org/content/10.1101/2025.07.16.665189v1
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ernestiu.bsky.social
Alt NIH Bluesky š§Ŗ
6 months ago
Yes the NIH people were out in front on this āUsing the rescission process, which requires only a simple majority in the Senate, the Republican majorities in the Senate and House can vote to return the unspent funds. That will avoid impoundment and lop billions off the NIH budgetā April
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The NIH budget is on a fast track to disaster
An NIH insider explains what Republicans are likely to do next, and what we can do
https://donmoynihan.substack.com/p/the-nih-budget-is-on-a-fast-track
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ernestiu.bsky.social
Jeremy Logue
6 months ago
Happy to share our new pre-print, "Targeting Cholesterol-Dependent Piezo1 Activation Impairs Amoeboid Migration in Melanoma Cells," led by our fabulous research technician, Sylvia Kuang.
www.biorxiv.org/content/10.1...
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https://www.biorxiv.org/content/10.1101/2025.07.11.664494v1
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ernestiu.bsky.social
Journal of Cell Biology
6 months ago
In new study from Muziyue Wu et al.
@oweinerlab.bsky.social
, in vivo biochemistry sheds new light on how the WAVE complex templates the characteristic shape of lamellipodial protrusions.
rupress.org/jcb/article/...
#Cytoskeleton
#Actin
#Migration
#Motility
#Biophysics
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ernestiu.bsky.social
Christophe š¬ L
7 months ago
Intermediate filaments join microtubules in the self-repair club! Great work with in vitro vimentin filaments from
@cecileleduc.bsky.social
@romet-jegou-lab.bsky.social
et al. in
@pnas.org
:
doi.org/10.1073/pnas...
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Continuous self-repair protects vimentin intermediate filaments from fragmentation | PNAS
Intermediate filaments are key regulators of cell mechanics. Vimentin, a type of intermediate filament expressed in mesenchymal cells and involved ...
https://doi.org/10.1073/pnas.2417660122
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ernestiu.bsky.social
Makinen lab - Lymphatic Biology and Pathology
10 months ago
If youāre curious about why lymphatic endothelial cells have their jigsaw puzzle-like shape, check out our paper @Nature
rdcu.be/eejhZ
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Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium
Nature - Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result...
https://rdcu.be/eejhZ
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ernestiu.bsky.social
Harvard T.H. Chan School of Public Health
8 months ago
With nearly all of Harvard Chan Schoolās direct federal grants terminated, we are relying on philanthropy to power our research and support our educational programs. Every gift, regardless of size, advances our vision of health, dignity, and justice for every human. Support our work:
hsph.me/whygive
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ernestiu.bsky.social
Rodrigo Fernandez-Gonzalez
8 months ago
Interested in Developmental Mechanics??? We are organizing a mechanobiology workshop in Baeza, Spain, October 21-23, 2025. Come join us (and please help us spread the word)!!!
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ernestiu.bsky.social
Sergio Cruz-León
9 months ago
Excited to share our preprint on the molecular architecture of heterochromatin in human cells š§¬š¬w/
@jpkreysing.bsky.social
,
@johannesbetz.bsky.social
,
@marinalusic.bsky.social
, TuroÅovĆ” lab,
@hummerlab.bsky.social
@becklab.bsky.social
@mpibp.bsky.social
š Preprint here
tinyurl.com/3a74uanv
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ernestiu.bsky.social
Jennifer Landino
9 months ago
I'm so pleased the final version of this research is published! We found that epithelial cells neighoring the cytokinetic furrow regulate the speed and sucess of cell division, while maintaining barrier function and cell packing geometry. Many thanks to the co-authors who contributed! šø
#xenopus
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Neighbor cells restrain furrowing during Xenopus epithelial cytokinesis
Xenopus epithelial cells mechanosensitively reinforce connections to neighbor cells during cytokinesis. Here, Landino etĀ al. show that actomyosin arrays assembled in neighbor cells restrain cytokineti...
https://www.cell.com/developmental-cell/fulltext/S1534-5807(25)00157-1?dgcid=raven_jbs_aip_email
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ernestiu.bsky.social
Henne lab
9 months ago
Important to celebrate trainee victories: excited to have Holly Merta's
@hollymerta.bsky.social
paper out! We use TurboID sub-organelle proteomics to map the ER network. We find calmin/CLMN, an ER-to-actin tether regulating focal adhesions & cell motility.
www.sciencedirect.com/science/arti...
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Spatial proteomics of ER tubules reveals CLMN, an ER-actin tether at focal adhesions that promotes cell migration
The endoplasmic reticulum (ER) is structurally and functionally diverse, yet how its functions are organized within morphological subdomains is incompā¦
https://www.sciencedirect.com/science/article/pii/S2211124725002736
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ernestiu.bsky.social
9 months ago
Excited to share our latest work on how Ca²⺠regulates actin in cell protrusionsānow available as a preprint on bioRxiv! š Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators!
www.biorxiv.org/content/10.1...
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A TRPV4ādependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actinābased lamellipodia protrusions...
https://www.biorxiv.org/content/10.1101/2025.03.28.646012v1
0
16
9
I'm thrilled to finally share my PhD work on understanding how Ca2+ signals regulate the protruding front of the cell. Itās been an incredible journey working alongside all the collaborators.
www.biorxiv.org/content/10.1...
loading . . .
A TRPV4ādependent calcium signaling axis governs lamellipodial actin architecture to promote cell migration
Cell migration is crucial for development and tissue homeostasis, while its dysregulation leads to severe pathologies. Cell migration is driven by the extension of actinābased lamellipodia protrusions...
https://www.biorxiv.org/content/10.1101/2025.03.28.646012v1
9 months ago
1
20
9
www.science.org/doi/10.1126/...
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Uphold US-Canada science
A partnership can be demanding, and as with any couple, can have good days and bad. The United StatesāCanada relationship is most definitely having a bad one. Itās difficult to fully comprehend all th...
https://www.science.org/doi/10.1126/science.adx2966
10 months ago
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ernestiu.bsky.social
Journal of Cell Science
10 months ago
The Editors-in-Chief of the 5
@biologists.bsky.social
journals have written a joint Editorial, discussing the enormous challenges currently facing researchers in the US and how members of the community can support them through this difficult time.
journals.biologists.com/jcs/issue/13...
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ernestiu.bsky.social
Ankita Jha
10 months ago
As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community!
#cellmigration
www.biorxiv.org/content/10.1...
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CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration
Cells under high confinement form highly polarized hydrostatic pressure-driven, stable leader blebs that enable efficient migration in low adhesion, environments. Here we investigated the basis of the...
https://www.biorxiv.org/content/10.1101/2024.12.31.630838v1
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ernestiu.bsky.social
Nature Cell Biology
10 months ago
š°Interested in reading more about the study? Here is the N&Vs article written by Nicoletta I. Petridou. šš¾https://rdcu.be/ecb3M
bit.ly/4bojVlz
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Flow, sense and divide - Nature Cell Biology
In each cell division during early embryogenesis, daughter cells acquire half the size of the mother cell. A study now reports that cytoplasmic flows sensing the cell boundaries allow daughter cells t...
https://bit.ly/4bojVlz
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ernestiu.bsky.social
Katja Rƶper
10 months ago
Very cool preprint by my colleague Kate McDole and her postdoc Katie Goodwin
@cellbiol-mrclmb.bsky.social
using beautiful imaging and quantitative methods to understand the wondrous migrations of primordial germ cells in mouse embryos
doi.org/10.1101/2025...
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ernestiu.bsky.social
11 months ago
Deeply saddened by the passing of Prof. Mike Sheetz, a true leader in Mechanobiology. His groundbreaking work on Kinesin, membrane organization, and mechanotransduction has left an indelible mark. A tremendous loss to science.
#Mechanobiology
#Science
#LaskerAward
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ernestiu.bsky.social
Benoit Ladoux
12 months ago
Happy to share our new publication in
@naturephysics.bsky.social
on life and death of eliminated cells! Great collaboration between our CAM team and Doostmohammadi's. Special congrats
@lakshmib02.bsky.social
and Siavash Monfared! š
www.nature.com/articles/s41...
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ernestiu.bsky.social
Debo (Debosmita Sardar)
about 1 year ago
I get a lot of questions on the
#NIH
#K99
#postdoc
to faculty transition award. Decided to pen my thoughts and experiences towards receiving the K99/R00 - hoping it would be helpful for the community. Please find article link at -
debosardarlab.org/blog
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ernestiu.bsky.social
bioRxiv Cell Biology
about 1 year ago
Cofilin promotes actin turnover and flexibility to drive coordinated cell movements in vivo
https://www.biorxiv.org/content/10.1101/2024.12.17.628979v1
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ernestiu.bsky.social
Torsten Wittmann
about 1 year ago
Highlighting our recent paper on how we think doublecortin (green) contributes to growth cone biomechanics in developing neurons for
#FluorescenceFriday
www.cell.com/current-biol...
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