The frig in my basement has a magic gene editing drawer.

Big day for the new Cornell version of the Murph lab. Our first gel… woohooo!!!! Science Baby!!!

Very happy to see our preprint on how the mechanosensitive ion channel Piezo1 controls intercellular junction maturation by balancing cortex and membrane tension now published in @jcellsci.bsky.social Congratulations to Ahsan & team! journals.biologists.com/jcs/article/...

The “Ins and Outs and What-Abouts” of H2A.Z: A tribute to C. David Allis - Journal of Biological Chemistry www.jbc.org/article/S002...

Check out the new chalk art outside the lab at Cornell!

Please RT: Published today, a super fun collaboration w/ @fanjumeng.bsky.social and Marnie Halpern's lab to establish methods for transgene mapping in zebrafish - TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...

TransTag enables simple and efficient transgene mapping in zebrafish via tagmentation: Cell Reports Methods www.cell.com/cell-reports...

Congrats Shan. It was wonderful to participate in the graduation ceremony with you! @urochester.bsky.social

Great event. Great trainees. Thank you!

Such an awesome day! It was wonderful to host Marisa Bartolomei @marisa-bartolomei.bsky.social as the Keynote speaker our annual Genetics Day symposium.

Congrats!!

Having an awesome time at the Tri-Repro meeting @pennmedicine.bsky.social @pennepigenetics.bsky.social with my good bud @themodzlab.bsky.social

I had a hypothesis that vitamin D prevents cancer. I worked on this for > 10 years, had 3 NIH-funded grants, and published >30 papers on this topic. Based on our work and that of my esteemed colleagues, I concluded that the evidence does not support the hypothesis. RFK Jr., we are not the same.

Had a wonderful time visiting the Genetics Department at the University of Georgia. Great food! Great conversation! Great company! and Excellent weather! Thanks for the invite @gollmg.bsky.social

Congratulations to @flashes.blue for their official launch on the App Store 🎉🎉🎉 It’s an instagram alternative built on the AT protocol 🙌 all the visual scrolling with none of the Meta algorithm

Congrats Brandon! So proud of your accomplishments.

We all know the story of Henrietta Lacks, but there are countless other examples when biomedical research advanced with a little regard for morals or ethics - often at the expense of poor, disadvantaged, or minority individuals. This book has been enlightening. A good read for current scientists.

CONGRATS to all!!

Now that I have read this paper, my lab has new findings based on CUT&Tag data that challenge the traditional view of euchromatic and repressive factors. I have started doubting all previous ChIPseq-based conclusions for many targets we are interested in. Thanks for publishing the preprint

CUT&Tag Identifies Repetitive Genomic Loci that are Excluded from ChIP Assays https://www.biorxiv.org/content/10.1101/2025.02.03.636299v1

Very interesting another reason to stop doing Chip seq and do cut&tag. Looking forward to reading it

PREPRINT! Park et al. makes the case that we may be misunderstanding heterochromatin for past 30 years due to ChIP-Seq biases... 1/n

We did a thing... We purified native transcriptional complexes from Drosophila embryos, obtaining +/- stalk Pol II elongation complexes, native nucleosomes, as well as a nucleosome elongation complex. For more details please check out: doi.org/10.1101/2025...

Here’s why we need to study & fund developmental biology: to understand, prevent & treat birth defects. Infants can’t speak, so we must be their advocates

WTF!!! This is a for real disaster!! He needs to be stopped. We can’t have this anti-science lunatic leading HHS.

🤦‍♂️ shit.

Slashing the NSF budget would decimate the US's global leadership in science and technology in addition to wating funds already invested in technical innovations and scientific progress... www.eenews.net/articles/sci...

ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent Transcription Replication Conflicts in Triple Negative Breast Cancer www.biorxiv.org/content/10.1...

Reading @statnews.com Robert F. Kennedy Jr. is unfit to lead HHS Beyond his vaccine criticism, he doesn’t understand even the basic tenets of our health care financing system www.statnews.com/2025/01/31/r...

This is great news from one of my favorite trees - that was nearing extinction. Breeding programs established variably resistant backgrounds in which resistance-associated alleles could be identified, using next gen strategies. Putative targets for future engineering.

Bud stage? #Zebrafish

Here is the 2025 embryo alphabet from alligator to zebrafish. Developmental biology is stunning & leads to important discoveries for human medicine. @socdevbio.bsky.social

Improving American chestnut resistance to two invasive pathogens through genome-enabled breeding https://www.biorxiv.org/content/10.1101/2025.01.30.635736v1

Of course, RFK is part of the long standing attack on medicine by pseudo scientists and snake oil salesman.

Hand-drawn images of larval and juvenile zebrafish. Credit to @stednitz.bsky.social. #ZebrafishZunday 🧪

Reminder that @europepmc.org is a mirror of Pubmed with better search and that it indexes *all* bioRxiv preprints (as well as ResearchSquare), not just the ones funded by NIH like chauvinist Pubmed

Disruptions to the NIH impact more than just science; they will hit all Americans in our wallets. I spoke yesterday with Becky Fogel from @kutnews.bsky.social about the important role NIH-funded research plays in the economy. 🧵 1/n www.kut.org/education/20...

👇👇👇 www.npr.org/sections/sho...

2 days left to apply for the #ChooseDevelopment! Summer Research Program. Undergrads from underrepresented racial or ethnic groups, first-generation college students, veterans & students with a disability are eligible. bit.ly/3FwHqYp Deadline: February 1, 2025 #devbio

Trump is an extremely dangerous man--stupid, vindictive, fixated on payback for his enemies. This country will be lucky to survive him.

A few books that really helped me think about scientific writing, both for papers and grants.

The Society for Developmental Biology has released a statement on the Unprecedented Disruptions to Biomedical Research in the United States.

yet another strategy to tear down government through incompetence. With RFK as HHS, he could wreck the economy by breaking American healthcare and destroying biomedical research - huge job loses - while simultaneously causing the death of 10s of thousands of Americans - as he did in Samoa.

Please call your Senators and ask them to oppose RFK Jr. for Secretary of Health and Human Services because he is unqualified to lead an agency responsible for the health of Americans. Yes call all of them. Yes both R and Ds. They keep track of public response and this can sway votes /1

First good news in days: White House Rescinds Federal Assistance Freeze Memorandum

Sen Chris Murphy (D-CT) just now: “You could literally walk down the street and the first 100 people you’d find would be less dangerous as the head of HHS than Robert F Kennedy Jr. He will get people killed”

Hawaii Governor, a Doctor, Blames Kennedy for Measles Deaths in Samoa…. For good reason www.nytimes.com/2025/01/28/u...

Revelations about the role Robert F. Kennedy Jr. played in a deadly measles outbreak in Samoa keep getting worse.

ALERT: Kennedy confirmation hearing just started. CONTACT YOUR SENATORS NOW! Spread the word! actionnetwork.org/letters/tell...