Curious about how brain and body communicate, or how circuit states are regulated over seconds to hours? Read our paper about neuropeptide systems and how they contribute to neural architecture and function #neuroskyence #compneuro #neuroscience

🧠 Check out this preprint by our postdoc Selin Kenet from her previous work with Thomas Misgeld on neuromyelitis optica! They show that complement-mediated injury directly affects myelin and oligodendrocytes, suggesting that demyelination is not just downstream of astrocyte loss. 🧠

In our latest edition of “This paper changed my life,” @talialerner.bsky.social shares how Stephen Lammel and Rob Malenka’s 2011 Neuron paper on dopamine neuron diversity taught her how to go about challenging widely held assumptions in the field. www.thetransmitter.org/this-paper-c...

Check out our latest research drop! We show BLA dopamine signaling encodes the emotional weight of sensory transitions, but not the associative strength or value of stimuli. These signals dynamically rescale when the learning context changes: "this matters most!" www.biorxiv.org/content/10.1...

Have said this before in other forms, but will reiterate it here: if you're doing long-form writing of any sort, reading the words aloud into a microphone is a completely unparalleled cheat code. It's free, easy, and so effective it feels like it shouldn't be allowed. I do it in a few stages...

RIP redundancy reduction? Beautiful work by Liu & colleagues showing that neural redundancy increases with learning, as predicted by a Bayesian model: www.science.org/doi/10.1126/...

My first cover of 2026 "Spontaneous behavior is a succession of self-directed tasks" www.cell.com/neuron/fullt... #sciArt #Scicom #illustration #neuroskyence

Out now in @plos.org CB: doi.org/10.1371/jour... Neural representations of tasks change over time, even in the absence of changes in task performance. But neurons change tuning at different rates. How does a neuron's stability relate to its interactions with the population? #compneuro #neuroskyence

Redefining the central pattern generator for vertebrate locomotion — a Review by Abdeljabbar El Manira #neuroscience #neuroskyence www.nature.com/articles/s41...

Correa et al. show that tropicamide, an M4 muscarinic receptor antagonist, reverses catalepsy and motor impairments in a haloperidol-induced mouse model of #Parkinson’s disease. doi.org/10.4103/AGIN... #Neuroscience #Tropicamide #MuscarinicReceptors #AgingResearch #MedSky #neuroskyence

Very excited to post our paper led by @daburke.bsky.social www.nature.com/articles/s41... where we uncover a simple mathematical rule underlying how brains learn that a cue predicts a reward. 1/26

Excited to share our new findings on how chronic nicotine changes dopaminergic and cholinergic neural activity!

Congratulations to Olena, Andrew, and the rest of our incredible team! These exciting findings challenge neuron-centric models of fear - take a look! www.nature.com/articles/s41...

In the first systematic, multi-node recordings of spiking activity across the human basal ganglia–thalamic circuit, @dennislondon.bsky.social explains how this pathway integrates cognitive variables with ongoing action. We’d love to hear your thoughts.

Taking the #GRCBasalGanglia Oath ✋🏼 I acknowledge that the go/no-go model of the BG was useful but it is outdated and incorrect, or at least incomplete. I pledge not to use the go/no-go model as a strawman to motivate my work.

A study in Nature Neuroscience maps spontaneous and choice activity across mouse prefrontal cortex. The activity maps aligned with intrinsic connectivity rather than anatomical subregions, suggesting that connectivity, not cytoarchitecture, organizes prefrontal function. #Neuroskyence 🧪

𝗦𝗽𝗼𝗻𝘁𝗮𝗻𝗲𝗼𝘂𝘀 𝗯𝗲𝗵𝗮𝘃𝗶𝗼𝗿 𝗶𝘀 𝗮 𝘀𝘂𝗰𝗰𝗲𝘀𝘀𝗶𝗼𝗻 𝗼𝗳 𝘀𝗲𝗹𝗳-𝗱𝗶𝗿𝗲𝗰𝘁𝗲𝗱 𝘁𝗮𝘀𝗸𝘀 More hidden markov models for cool behaviors and brain data #neuroskyence doi.org/10.1016/j.ne...

I edited a special issue of Addiction Neuroscience on dopamine circuitry & heterogeneity in addiction - now complete!🧠🧪 Check out the full issue & my editorial (all open access) here: www.sciencedirect.com/special-issu...

To be clear, they're play-fighting and also: this video improved my day measurably and I wish I'd've watched it earlier. If you haven't, fix that now.

#neuroskyence #glia very needed single cell map of the murine female brain as a function of estrous cycle Worth a read!

#RewardSignals #neuroskyence

"My New Year's Resolution is to find a principled way to think about all those cell types in the brain" Why friend, you are in luck, because @rgast.bsky.social has just the perspective for you: www.sciencedirect.com/science/arti...

Excited to share latest study from the lab by an amazing RA, Dylan Flink. We solved a small (important) puzzle while in the trenches of a larger (wavy 🌊) puzzle. www.biorxiv.org/content/10.6... 🧵...

A study from the Baier Departement, published in Nature in February 2025, has now been selected for the Nature Highlights List 2025. Congratulations to all the researchers involved on this well-deserved recognition! 👉 Nature Highlights 2025: www.nature.com/articles/d41... @ishainer.bsky.social

Consumer PSA: A lot of stores will advertise an Xmas tree, but the package actually *contains* a Ymas tree. DON'T BE FOOLED.

Excited to share my postdoc work with @yttrilab.bsky.social and @ahmarilab.bsky.social where we show that the striatal indirect pathway mediates hesitation in mice (www.nature.com/articles/s41...). And I'm honored to have @ahmarilab.bsky.social introduce the findings with a musical abstract!

**How distributed is the brain-wide network that is recruited for cognition?** That goes to the top of the list! #neuroskyence doi.org/10.1038/s415...

Hunger increases exploration and risk-taking behavior, allowing an animal to forage for food despite risks Hunger-induced changes in exploration result from the modulation of dopamine signaling in the tail of the striatum via the following circuit: 1/2 www.cell.com/neuron/fullt...

Happy to see that our recent work led by @nataliafavila.bsky.social and @jcmneuro.bsky.social on amygdala interneuron function for learning and memory was selected as an Editor’s Highlight by @natcomms.nature.com Check our work an many other great articles out here: www.nature.com/collections/...

𝗗𝘆𝗻𝗮𝗺𝗶𝗰𝗮𝗹 𝗽𝗿𝗶𝗻𝗰𝗶𝗽𝗹𝗲𝘀 𝗶𝗻 𝗻𝗲𝘂𝗿𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲 Oldie but goodie. doi.org/10.1103/RevM... #neuroskyence

1/2 S1 mice display impaired extinction and abnormally sustained VTA-DA activity during US omission. Surprisingly, optogenetic excitation of VTA or IL-terminals failed to rescue the deficit. www.eneuro.org/content/12/1... #RewardSignals #neuroskyence

How do parabrachial nucleus 🧠 neurons relay threat ⚠️ information to ventral tegmental area dopamine neurons to influence long-term aversive memory 🤔 ?

I am really proud that eLife have published this paper. It is a very nice paper, but you need to also read the reviews to understand why! 1/n

New lab paper drop, this one has been a long time coming! Driven by Rob Aukema (now a postdoc with Kerry Ressler) this paper in Science Advances answered the lingering question of what role the amygdala plays in stress-induced neuroendocrine responses. www.science.org/doi/10.1126/...

So excited to see our latest paper out today in @natcomms.nature.com! Studies led by the amazing @margestelzner.bsky.social www.nature.com/articles/s41.... VTA GABA neurons have a unique role in economic decision making - they integrate reward seeking motivation and the current cost of seeking

Our paper on the counterintuitive effects of activating dopamine "reward" neurons is out now! Props to all the trainees, especially Fio Lozada-Perdomo and Yuzhen Chen who did most of the work. Yuzhen is applying for PhD programs now and you'd be lucky to get her! www.cell.com/iscience/ful...

Join us on Dec. 2 for a webinar on the major advances in basal ganglia mapping, including cross-species cellular mapping and open-access visualization tools. 📅 Dec. 2, 9-10:30am PT 📍 Online 🔗 Register: https://alleninstitute.org/events/neuroscience-cell-types-webinars/ #studyBRAIN #neuroskyence

@accumbenshelley.bsky.social re-writing the textbook on neural circuit function

1/3 New Nature Neuroscience paper on estrogen & dopamine RPEs. Female rats in high-estradiol phase (proestrus) show stronger trial-by-trial adjustment of response vigor in a RL task: they start the next trial faster after better rewards. www.nature.com/articles/s41... #RewardSignals #neuroskyence

My paper is out! Computational modeling of error patterns during reward-based learning show evidence that habit learning (value free!) supplements working memory in 7 human data sets. rdcu.be/eQjLN

Independent NeuroScience Services INSS was registered as a company on 14th November 2016, which means it's our 9th birthday today! As a birthday present we've treated ourselves to an SfN exhibitor booth for the first time ever. Come and say hello at Booth #3327

" 60 per cent of UK university libraries are considering dropping their big deals with the five major academic publisher" Many call for diamond open access. A new organisation with many partners, @ojcollective.bsky.social , is launching in January. www.researchprofessionalnews.com/rr-news-uk-v...

Delighted to see this finally out: rdcu.be/eO9oW We tested whether brief striatal dopamine release events influence the vigor of skilled movements. Despite popular belief, we did not find any evidence linking rapid dopamine dynamics to motor vigor on a moment-by-moment basis.

Genes, environment & aging all shape Parkinson’s but timing may be key. ⏳ New biomarkers like α-synuclein SAAs highlight when risk turns to disease, and why some never progress. #Parkinsons #NeuroSkyence Source: www.thelancet.com/journals/lan...

Using containers for reproducible computing russpoldrack.substack.com/p/using-cont... - the latest in my Better Code, Better Science series

Dopamine ≠ reward but turns out, also not the learning molecule we thought. If DA RPE is the emperor, this work SCREAMS it was running naked all the time. This paper got quite some attention recently. Let's simplify it a bit. A🧵with my toy model and notes: #neuroskyence #compneuro #NeuroAI

Rank- and Threat-Dependent Social Modulation of Innate Defensive Behaviors https://www.biorxiv.org/content/10.1101/2025.10.31.685719v1

Check out this #incredible work on #stability and #control during movement across #humans, #mice, and #flies. Congratulations @nidhise.bsky.social and @antoinecomite.bsky.social 👏🏽⭐

🚨Pre-print alert! 🚨https://www.biorxiv.org/content/10.1101/2025.10.17.683171v1 Our new study tackles the question: do all neurons in motor cortices (MC) encode movement & coordinate as we move? Answering this question will be key for effectively targeting motor representations in BCIs.