Cholinergic interneuron control of GABAergic circuits targeting spiny projection neurons is disrupted in parkinsonian models https://www.biorxiv.org/content/10.64898/2026.06.17.732978v1

New preprint from the team - what's the role of frontal cortex - LPFC & MCC - in learning about progress towards goals? Data from the checking project collected by Fred Stoll. New analyses by Xiaoqi Xu. With Matteo di Volo, Manu Procyk, & skytorial from @nilskolling.bsky.social below

Check our new work! Studies led brilliantly by @louisakuper.bsky.social. We investigate the parafascicular thalamus as an interface of sensory, attention, and movement signals that guide exploration and cue-related learning.

A genetic tool targeting brain GPR75 https://www.biorxiv.org/content/10.64898/2026.05.29.728898v1

A Small-Molecule Mitochondrial Complex I Modulator Improves Behavioral and Mitochondrial Dysfunction in Schizophrenia https://www.biorxiv.org/content/10.64898/2026.05.19.726440v1

I remember the first time I learned about affordances and what the brain does with them - our learning about how we relate to things in the world. So cool! Check out the latest by @sci_toons explaining them: 🧪 🧠 youtu.be/cs3Clg5Syf8?...

Our brains don’t think in a steady stream. They rhythmically “scan” different alternatives, using attention cycles to sample and compare choices. Rhythmic sampling of multiple decision alternatives in the human brain www.nature.com/articles/s41... #neuroscience

🎉New positions!🎉 Postdoc and Research technician openings in our lab @yale for computational psychiatry research. Technician position a great stepping stone to grad school. More info: rutledgelab.org/positions Work w/big data from our smartphone apps and large clinical samples happinessquest.app

Super important!

Really pleased that this work with @dudman.bsky.social is now out in Neuron: A global dopaminergic learning rate enables adaptive foraging across many options

Free and open-source images, icons, and tools for creating scientific illustrations doi.org/10.59350/5zt... 🧪

Reward and punishment differentially shape basketball free-throw learning https://www.biorxiv.org/content/10.64898/2026.04.28.721312v1

Another PhD! Huge congratulations to Dr. @margestelzner.bsky.social!!!! She completed a fantastic dissertation defense yesterday. We are all really proud!

Are you coming up for tenure review in the next couple of years? See the @nature.com Careers team's advice for assembling a kick-ass tenure portfolio. Reporting by @scattercushion.bsky.social A step-by-step guide to nailing your tenure promotion package www.nature.com/articles/d41...

The kind of stable, sustained support that can transform a career: Our #FreemanHrabowski Scholars Program offers early career faculty up to $10M over 10 years, plus salary & benefits. Postdoc? This year's competition has a program for you, too. Applications open 11/3! bit.ly/4tFKifj

To accompany my textbook (Computational Foundations of Cognitive Neuroscience) and the class I taught this semester, I'm open-sourcing my lectures slides: gershmanlab.com/lectures.html I'll continue to update these as I improve them.

Scientific publishing needs to change. HHMI President Erin O'Shea and Bodo Stern argue that the incentives are misaligned. Researchers should be evaluated on what they choose to share, not what journals select. Proud that HHMI @hhmi-science.bsky.social is leading the way. Pre-Print: bit.ly/4sDCCsu

📢🎉@hhmi-science.bsky.social HHMI competition for the next cohorts of #HannaGray Fellows and #FreemanHrabowski Scholars opening 11/3/2026. Senior postdocs and faculty within 7 years of appointment. Up to $10M over 10 yrs, + salary & benefits. Spread the word and consider applying! bit.ly/4vhC0LA

If you need a method to infer causality from neural data, even when the signal is short, check our recent paper: Paper: joss.theoj.org/papers/10.21... Code: github.com/CMC-lab/Tran...

Want a dataset to test ideas on neural basis of decision making or how areas interact as we make choices? Check out our data published today @rudebecklab.bsky.social. >16,000 single neurons from 22 anatomically confirmed areas in macaques performing a decision task. www.nature.com/articles/s41...

The requested boost would help counter the planned sunsetting of one of the program’s long-standing funding streams, which will result in a $195 million drop in funding for fiscal year 2027. By @avaskham.bsky.social #neuroskyence www.thetransmitter.org/funding/lett...

What happens when HHMI scientists come together? Inspiring conversations, new perspectives, and a shared excitement for discovery. No matter what program they’re part of, our Investigators, Scholars, Fellows, and more join a vibrant scientific community driven by bold ideas.

How do the brain’s event representations change as we gain familiarity with an experience? Brain regions’ representations can become coarser or finer as events become familiar. Slow-timescale structure predicts memory. Excited to share this work w/ Narjes Al-Zahli & @chrisbaldassano.bsky.social!

Proud to see this fantastic work by my PhD student @anastasiakrouglova.bsky.social on multifidelity SBI out in the world!

Using independent component analysis of [18F]Flubatine PET to dissociate β2-containing nicotinic ACh receptor subtypes in the human brain, this study found that subtype-specific nicotinic receptor adaptations may inform smoking cessation therapies

Selective control of prefrontal neural timescales by parietal cortex www.nature.com/articles/s41... #neuroscience

A corticostriatal circuit updates subjective beliefs about latent task states https://www.biorxiv.org/content/10.64898/2026.03.12.711369v1

3-001, poster session 3 (Sat, Mar. 14, 13:15): @armanbehrad.bsky.social on unsupervised method to find behaviorally relevant internal states from data. We tested it w/ RNN & monkey data doing cognitive tasks & RNN trained with deep RL on a naturalistic plum tracking task.

We made a highly blue-light resistant red-fluorescent genetically encoded calcium sensor GECI) www.biorxiv.org/content/10.6... BluePrint™ 🗺️ below:

The @whyshoulditrustyou.bsky.social team asked some tough questions of NIH Director Bhattacharya. It's worth a listen: substack.com/home/post/p-... I wanted to add some additional context on Bhattacharya's responses. Sorry, long thread. 🧵1/19

The KM Lab is hiring! We're looking for both a new technician (makes a great post-bac like experience) and a post-doc. Come do fun science. Come join an amazing community. Learn more: sites.google.com/site/krookma...

It’s out!

A lifelong passion for writing helped rising star @doctheagrif.bsky.social land a book deal and publish 15 chapter books for early readers, covering topics ranging from what the cerebellum does to how a cake bakes. By @avaskham.bsky.social www.thetransmitter.org/craft-and-ca...

Check out #StoriesOfWin interviewee, Aya Osman, in her interview with The Transmitter! Great article about an incredible scientist 🧠

Very excited to get to share culmination of this large-scale project to understand spatial gene expression in schizophrenia. Really proud of the amazing team work here working out lots of roadblocks to deploy these spatial strategies and analysis methods at scale!

🔬🧠 Releasing the 1.0 version of #Suite2p and THE PAPER w/ @marius10p.bsky.social! Now with GPU acceleration. Want to use Suite2p but don’t have 100,000 neuron recordings? We show you how to get those with a standard 2p microscope #neuroscience #imaging #neuroAI www.biorxiv.org/content/10.6...

Very excited to post our paper led by @daburke.bsky.social www.nature.com/articles/s41... where we uncover a simple mathematical rule underlying how brains learn that a cue predicts a reward. 1/26

A nice highlight of @zeenarivera.bsky.social's PR with reset task! www.eneuro.org/content/13/2...

A researchers’ propensity for risky projects is passed down to their doctoral students — and stays with trainees after they leave the laboratory go.nature.com/4sHq58H

#GRCBasalGanglia co-chairs 4 life 🫶🏼

We're partnering with @anthropic.com on the development of artificial intelligence tools for massive data analysis and exploration. This collaboration will explore how AI systems could expedite analysis and day-to-day scientific workflows. 🔗 https://bit.ly/4rsghh9

@arifahamid.bsky.social kicking off Imbizo 2026 in Cape Town! Time for comp neuro epicness in Africa! @simonsfoundation.org @imbizo.bsky.social @ibroorg.bsky.social

Yesterday, we dove deep into Generalized Linear & Latent Variable models with Prof. Pillow @jpillowtime.bsky.social from Princeton Univ. Today, we shifted gears to Neuroengineering with Prof. Felix Deku, Univ. Oregon, exploring Brain-Computer Interfaces. @simonsfoundation.org @ibroorg.bsky.social

Yesterday, we had the privilege of hosting @blaiseaguera.bsky.social, CTO of Technology & Society at Google, for a special guest lecture. He unpacked the complex history of intelligence: from biological evolution to artificial systems. A mind-expanding session for everyone at #Imbizo2026! 🇿🇦🧠

We just finished a tremendous session led by the amazing Prof. Sara Solla from Northwestern Univ. She took us on a journey through the beauty of neural manifolds and beyond. Finding geometry in high-dimensional data! 📉✨ @ibroorg.bsky.social @simonsfoundation.org @sasolla.bsky.social

To make the best use of LLMs in research, turn your scientific question into a space of concrete, checkable proposals, wire up an automatic scoring loop, and let the AI iterate, writes @kenneth-harris.bsky.social. #neuroskyence www.thetransmitter.org/artificial-i...

Yesterday, we continued our deep dive into the dopaminergic system with Profs @arifahamid.bsky.social and Michael Frank. 🧠⚡️ Today, we switched gears! Dr Dorit Hockman from UCT is leading a fascinating session on gene expression in the brain. 🧬 @simonsfoundation.org @ibroorg.bsky.social #imbizo2026

Today, our Cycle 1 Academic Director, Prof Arif Hamid @arifahamid.bsky.social from Univ of Minnesota, talked about the neural basis of reinforcement learning. Then, Prof Michael Frank from Brown Univ. talked about tuning striatal dopaminergic signals. 🧠 @simonsfoundation.org @ibroorg.bsky.social

Early-Stage Corticostriatal Circuit Hyperactivity Impairs Cholinergic Function and Cognitive Flexibility in an Alzheimer's Model https://www.biorxiv.org/content/10.64898/2026.01.13.699380v1

Wanna compare dynamics across different systems? See our fast and furious method developed by us (@armanbehrad.bsky.social @mmdtaha.bsky.social, @neuroprinciplist.bsky.social) together with our wonderful collaborators! You can already use our code: github.com/CMC-lab/fast...