🎉New positions!🎉 Postdoc and Research technician openings in our lab @yale for computational psychiatry research. Technician position a great stepping stone to grad school. More info: rutledgelab.org/positions Work w/big data from our smartphone apps and large clinical samples happinessquest.app

Last weekend I received the Troland Research Award from the @nationalacademies.org. I’m so grateful to the communities who made this work possible. It's strange to receive this award at a time when much of the work being recognized is not eligible for federal funding. My remarks 👇 and a 🧵>>

📣🔥 Early bird registration now open for 2026 Computational Psychiatry Conference cpconf.org at Yale July 14-16. Late-breaking abstracts now open (deadline: May 8) Trainee pre-conference (July 13) registration open (free!) See you in New Haven! #CPConf2026

Prediction without understanding sustained astronomy through a thousand years of epicycles, writes @tonyzador.bsky.social. AI is now offering neuroscience the same deal. #neuroskyence www.thetransmitter.org/machine-lear...

Did you know that this is the first year the Society for Neuroeconomics conference will be in California? Seize the day, left coasters! Decide to come talk about decisions with us... and keynote speaker, the brilliant Carlos Brody! neuroeconomics.org/2026-meeting/

New Annual Review with @nathanieldaw.bsky.social: “Planning in the Brain: It's Not What You Think It Is.” We argue that the brain's 'planning' machinery is mostly used for learning from simulated experience, and that thinking prospectively at decision time is just one special case of this process.

To accompany my textbook (Computational Foundations of Cognitive Neuroscience) and the class I taught this semester, I'm open-sourcing my lectures slides: gershmanlab.com/lectures.html I'll continue to update these as I improve them.

📣🔥 Early bird registration now open for 2026 Computational Psychiatry Conference cpconf.org at Yale July 14-16. Late-breaking abstracts now open (deadline: May 8) Trainee pre-conference (July 13) registration open (free!) See you in New Haven! #CPConf2026

Want a dataset to test ideas on neural basis of decision making or how areas interact as we make choices? Check out our data published today @rudebecklab.bsky.social. >16,000 single neurons from 22 anatomically confirmed areas in macaques performing a decision task. www.nature.com/articles/s41...

🧵 I gave Claude two things: a short paper (doi.org/10.1073/pnas...) and a raw behavioural dataset with 3 lines of variable descriptions. Then I asked it to fit three computational RL models described only by equations in the manuscript. No code, no toolbox, no guidance on the fitting procedure. 1/3

🧠 Focused ultrasound changes emotional processing 🔊 In a new study published in Neuron today, we stimulated the human amygdala using transcranial ultrasound stimulation (TUS) and show it plays a causal role in detecting and resolving emotional ambiguity.

🥁🎉The Psychosis Collective proudly presents our first preprint 𝐂𝐥𝐨𝐳𝐚𝐩𝐢𝐧𝐞 𝐬𝐮𝐩𝐩𝐫𝐞𝐬𝐬𝐞𝐬 𝐚𝐮𝐭𝐨𝐢𝐦𝐦𝐮𝐧𝐢𝐭𝐲 𝐝𝐫𝐢𝐯𝐢𝐧𝐠 𝐩𝐬𝐲𝐜𝐡𝐨𝐬𝐢𝐬-𝐥𝐢𝐤𝐞 𝐛𝐞𝐡𝐚𝐯𝐢𝐨𝐮𝐫 𝐢𝐧 𝐦𝐢𝐜𝐞 𝘈 𝘥𝘪𝘴𝘤𝘰𝘷𝘦𝘳𝘺 𝘫𝘰𝘶𝘳𝘯𝘦𝘺 𝘪𝘯 𝘵𝘩𝘳𝘦𝘦 𝘢𝘤𝘵𝘴 starring Le He & Harriet Feldman www.biorxiv.org/content/10.6... We wanted to understand how antipsychotics work. Thread🧵

Excited to share our new paper proposing a new computational model accounting for the dynamic interaction btw drug #craving and #decision-making, led by Kaustubh Kulkarni, MD/PhD rdcu.be/fab6B #AddictionScience #Neuroscience #ComputationalPsychiatry #BehavioralScience

Thrilled to share our new paper, which shows that the relative timing of cholinergic and dopamine release dynamically gates whether dopamine acts as an RPE for in vivo plasticity and reinforcement learning. www.nature.com/articles/s41...

out now in Science: @loganjames.bsky.social collected pairs of sounds in 16 species where we *know* which sound is more attractive (to that species) he played them to ppl on themusiclab.org, asking, in each pair, which was nicer. humans agreed w other animals doi.org/10.1126/science.aea1202

Hey friends, my new paper was just published in JAMA Psychiatry. I draw on biological species classification to sketch a new framework for psychiatric nosology. Brief summary follows below. Full text link: jamanetwork.com/journals/jam... 🧪 #PsychSciSky #MentalHealth

WTI's research facility, BrainWorks, has launched two social media channels to take a closer look at its welcoming environment, state-of-the-art tools, and community outreach. Follow along on: Instagram: www.instagram.com/brainworksyale Facebook: www.facebook.com/brainworksyale #KnowTogether

Excited to share our latest paper in which we discuss merging theory-and data- driven computational psychiatry in a large transdiagnostic cohort study (N=2400) www.biologicalpsychiatrycnni.org/article/S245... Christopher Pittenger, Godfrey Pearlson @annierhcheng.bsky.social @sobp-org.bsky.social

The biggest problem holding neuroscience back right now isn’t data or tools, thanks in large part to the BRAIN Initiative. It’s fragmentation across species. I wrote this to hopefully spark discussion around an issue that can only be solved as a community👇 www.thetransmitter.org/animal-model...

Prediction: In 10 years, “hardest problem” articles like this will shift from the challenge of ”C and perception“ to “C and emotions/mood“. The first is fascinating. The second is required to understand psychiatric functions & conditions. www.scientificamerican.com/article/what...

🌟 Job alert! We are looking for a postdoc to join a multidisciplinary research team working on the Individually Measured Phenotypes to Advance Computational Translation at Yale (IMPACT-Y) study. postdocs.yale.edu/posts/2026-0...

My perspective in @thetransmitter.bsky.social on why emotion research feels stuck and how we might move forward—by focusing on how the brain uses internal brain models to shape emotional processing across species. www.thetransmitter.org/emotion/why-...

Looking for a postdoc in #computationalpsychiatry? Apply here to join an interdisciplinary team and work with a large longitudinal transdiagnostic dataset postdocs.yale.edu/posts/2026-0... @RobbRutledge @xiaosigu @DrChrisPitt @PearlsonGodfrey @ACNPorg @YaleMed

Very happy to see this out now in @nathumbehav.nature.com - kudos to @magdadelrio.bsky.social who has led this work and nicely brought together data from two very different studies! article is here: doi.org/10.1038/s415... and PDF is here: rdcu.be/eZ27x

🎓 PhD Position (Paris) – Computational Cognitive Science, AI & Mental Health For Master’s students outside France Project on the computational bases of narrative pleasure 🧠📚🎮

There's much talk these days about what's required for "real" intelligence, such as world models and the like. One thing we know about the human evolution of it: it required/requires emotion. That may have been better appreciated in 1938 than today. archive.org/details/in.e...

With some trepidation, I'm putting this out into the world: gershmanlab.com/textbook.html It's a textbook called Computational Foundations of Cognitive Neuroscience, which I wrote for my class. My hope is that this will be a living document, continuously improved as I get feedback.

After 5 years of data collection, our WARN-D machine learning competition to forecast depression onset is now LIVE! We hope many of you will participate—we have incredibly rich data. If you share a single thing of my lab this year, please make it this competition. eiko-fried.com/warn-d-machi...

Just published my review of neuroscience in 2025, on The Spike. The 10th of these, would you believe? This year we have foundation models, breakthroughs in using light to understand the brain, a gene therapy, and more Enjoy! medium.com/the-spike/20...

Postdoctoral research position in #ComputationalPsychiatry and #EEG as part of relmed.ac.uk trial testing reinforcement learning as biomarker for antidepressant treatment response. www.ucl.ac.uk/work-at-ucl/... @uclbrainscience.bsky.social @mikebrowning.bsky.social @relmed.bsky.social

📣🔥Submit your symposium (30 Jan) and poster (12 Feb) abstracts to the 2026 Computational Psychiatry Conference www.cpconf.org Excited to announce new keynotes: @danisbassett.bsky.social Eyiyemisi Damisah @adredish.bsky.social Guillermo Horga, Frederike Petzschner. See you in New Haven! #CPConf2026

I’m happy to report that the Grand Plan for brain/mind research is in good hands at Yale with @wutsaiyale.bsky.social & co. They offered up many inspired thoughts about the impactful next steps for brain research and I left optimistic about the next steps for the field.

🚨Friends, we’re happy to share that our book is available for pre-order! 🎉 We aimed to cover all the foundations of the topic in an accessible manner for a large audience. It could help set up a bachelor-level curriculum on the topic. Pre-orders are very key for the fate of books: shorturl.at/Dxbif

🔥🔥SAVE THE DATE!!🔥🔥 Join us at Yale for the 2026 Computational Psychiatry Conference July 14-16, 2026 www.cpconf.org @xiaosigu.bsky.social @yiplab.bsky.social @shirleybwang.bsky.social @alpowers7.bsky.social See you in New Haven!

Ten Simple Rules for AI-Assisted Coding in Science arxiv.org/abs/2510.22254 - our latest, led by @ericwbridgeford.bsky.social

I think almost all scientific projects should be planned carefully. And I think an app can dramatically improve that. So I wrote an app for that (free for now, if you can fund this let me know). I tested it quite a bit (>8000 users in beta so far). try it: planyourscience.com

Thrilled to share our new paper, out now in @natneuro.nature.com, uncovering how estradiol, the most potent estrogen, modulates reinforcement learning and reward prediction errors across biological levels. www.nature.com/articles/s41... #blueprint 1/7

I love this idea. This is the type of public-facing scicomm that gives a scientist a renewed and refreshed perspective on their own work. I champion scientists engaging in ways that fill their own cups here: www.nature.com/articles/s41... BUT!! fiction writing is a challenge (at least for me). /1

Thrilled to share our new preprint highlighting distinct neurocomputational mechanisms underlying how reward and punishment determine adaptive cognitive control - a massive fMRI study and collaborative team effort with the @shenhavlab.bsky.social 🧠 Link here: www.biorxiv.org/content/10.1...

Really interesting work by Bakhurin and colleagues challenging the reward prediction error hypothesis of dopamine: www.nature.com/articles/s41... I love this figure which both echoes and undermines the famous figure from Schultz et al. (1997).

In a Comment, @docqhuys.bsky.social and Michael Browning argue that the field of computational psychiatry will improve patient outcomes through its increasing focus on interventions and trials. #mentalhealthresearch #Psychiatry ➡️ nature.com/articles/s43... 🔓 rdcu.be/eKp1v 🧵(3/8)

🚨Out now in @cp-trendscognsci.bsky.social 🚨 We explore the use of cognitive theories/models with real-world data for understanding mental health. We review emerging studies and discuss challenges and opportunities of this approach. With @yaelniv.bsky.social and @eriknook.bsky.social Thread ⬇️

New preprint from the lab! 🧠 Led by Juliana Trach, w/ Sophia Ou Using fMRI, we discovered evidence for time-sensitive reward prediction errors (RPEs) in the human cerebellum. Builds on, and extends, recent work in both rodents and NHPs

🧵 New paper! We studied depression symptoms and goal-directed decisions under uncertainty @shiyiliang.bsky.social, with @evanrussek.bsky.social & @robbrutledge.bsky.social Surprisingly, we found that apathy–anhedonia was linked to enhanced goal-directed behavior. www.biorxiv.org/content/10.1...

📣 🚨 Yale Psychology has 3 searches this year! Links below: Quantitative link: apply.interfolio.com/171903 Social link: apply.interfolio.com/171989 Clinical link: apply.interfolio.com/171970

📢 Early registration prices end tomorrow 15 April! 🚨 Computational Psychiatry Conference is 14-16 July in Tübingen, Germany. www.cpconf.org Speakers inc. Phil Corlett, Charlotte Fraza, Andreas Heinz, Georgia Koppe, Jill O'Reilly, Chandra Sripada, Sophie Valk, Tor Wager

I am SO excited to share my latest #preprint with @robbrutledge.bsky.social, Chongyu Qin, Zeb Kurth-Nelson, Martin Chadwick, @summerfieldlab.bsky.social, and others from DeepMind: "Increasing happiness through conversations with artificial intelligence" arxiv.org/abs/2504.02091 A short 🧵 1/7