Our latest work looking at the neuroanatomical basis of impulsivity in youth is out now in Molecular Psychiatry!

🚨 New preprint alert! 🚨 Transdiagnostic latent factor models of psychopathology are widely assumed to improve brain-behaviour associations. So we decided to test this directly and found that they don't. A short 🧵 Link: www.biorxiv.org/content/10.6... 1/10

Excited to share our latest paper in which we discuss merging theory-and data- driven computational psychiatry in a large transdiagnostic cohort study (N=2400) www.biologicalpsychiatrycnni.org/article/S245... Christopher Pittenger, Godfrey Pearlson @annierhcheng.bsky.social @sobp-org.bsky.social

Yesterday we said goodbye to our beloved kitty Coco. We miss her terribly but I am glad I was able to immortalize her in Figures 1 and 2 of my 2021 Synthese paper. Hopefully she will meet Fodor's Greycat in kitty heaven.

Important call for action on the integration of research programs across species. Meaningful progress in the brain sciences will require cross-field collaborations and research that spans human and non-human animal models.

Me getting to know a new dataset...

My new chapter of Better Code, Better Science on AI-assisted coding is now complete! It's been completely revised in an attempt to futureproof it. Comments welcome. bettercodebetterscience.github.io/book/ai-codi...

If you work at the intersection of computational neuroscience and machine learning, consider applying for this postdoc position (January 2027 start date): academicpositions.harvard.edu/postings/15868 An opportunity to work with a great group of people across Harvard, MIT, and UC Berkeley.

Mental health is shaping survival after heart disease—yet we rarely treat it that way. A new meta-analysis of 22 million people links PTSD, anxiety, depression & insomnia with higher risk of acute coronary syndrome. jamanetwork.com/journals/jam...

🌟 Job alert! We are looking for a postdoc to join a multidisciplinary research team working on the Individually Measured Phenotypes to Advance Computational Translation at Yale (IMPACT-Y) study. postdocs.yale.edu/posts/2026-0...

The postdoctoral associate will lead and contribute to the analysis of behavioral task data using computational modeling approaches, working closely with me, @robbrutledge.bsky.social, and with IMPACT-Y leadership, Drs. @yiplab.bsky.social, Chris Pittenger and Godfrey Pearlson.

Neuro friends: Any one ever try tract-tracing studies in the insula or cingulate (in rats or mice) and find a connection there? It keeps showing up in resting-state studies and outside of pIC to pACC inhibitory projections here (pubmed.ncbi.nlm.nih.gov/37605272/), I can't find much else!

Looking for a postdoc in #computationalpsychiatry? Apply here to join an interdisciplinary team and work with a large longitudinal transdiagnostic dataset postdocs.yale.edu/posts/2026-0... @RobbRutledge @xiaosigu @DrChrisPitt @PearlsonGodfrey @ACNPorg @YaleMed

🔥🔥SAVE THE DATE!!🔥🔥 Join us at Yale for the 2026 Computational Psychiatry Conference July 14-16, 2026 www.cpconf.org @xiaosigu.bsky.social @yiplab.bsky.social @shirleybwang.bsky.social @alpowers7.bsky.social See you in New Haven!

Awesome work here from @ariellekeller.bsky.social er.bsky.social linking the exposome to the developing functional connectome—check it out!! www.biorxiv.org/content/10.1... 1/2

Happy New Preprint Friday!* Thrilled to share new results in collab with Sarah Lichenstein & @yiplab.bsky.social showing our brain's functional connections reflect the environments we grow up in! tinyurl.com/exposomeConnectivity #neuroskyence #PsychSciSky #DevPsy #cognition *can this be a thing??

Amazing opportunity to work at the intersection of complex clinical psychiatry and advanced neuroimaging research!!!

Been thinking for a few years about what I call the *replication ceiling*: the maximum replicability of an effect given constraints in data in which replication takes place (power, measurement error, sampling variability, etc). This leads to a maximum theoretical replicability which can be achieved.

Take a look at our paper! Led by @francimandi.bsky.social in the Lake lab: "Longitudinal, simultaneous wide-field fluorescent Ca2+ imaging and fMRI in awake mice" !!!! www.biorxiv.org/content/10.1...

Really interesting, brief ideas paper. Clearly relevant to treatment research-- the mechanism by which you leave an illness state is unlikely to just be the opposite of the mechanism by which you entered it (can see how this might apply to e.g. SSRIs in depression).

Check out the latest work from this superstar team to learn how you can go from big data to small data with transfer learning to advance precision psychiatry! 🧠

Anybody else worried that because of the long standing Republican war on SNAP people are going to experience painful hunger. Lets do something. @nanopharmnc.bsky.social and i are going to donate to some local nc food banks. Join us! Gonna match up to $500.

Excited to share this review in @biologicalpsych.bsky.social on using transfer learning to leverage large MRI datasets & enhance precision psychiatry!! www.biologicalpsychiatryjournal.com/article/S000... Fun collab with rockstars @diawang.bsky.social @bttyeo.bsky.social @avramholmes.bsky.social

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Interested in the maternal brain and addiction? @yiplab.bsky.social and I are hiring a postdoc to work on our study examining psychosocial and neural markers of stress during the perinatal period in moms receiving treatment for OUD. See link for more details: postdocs.yale.edu/posts/2025-1...

New paper in Imaging Neuroscience by Sam Laxer, Ravi S. Menon, et al: A non-invasive approach to awake mouse fMRI compatible with multi-modal techniques doi.org/10.1162/IMAG...

Interested in the mechanisms shaping the extraordinary complexity of the connectome? Then check out our new preprint, lead by Francis Normand with a stellar team, showing how geometry constrains connectome architecture: biorxiv.org/content/10.1... Full thread here: tinyurl.com/sfv3yf73

New paper from @annierhcheng.bsky.social using data from IMAGEN and ABCD she identifies distinct signatures of impulsivity and negative affect in youth that uniquely overlap with a neuromarker of risky alcohol use #development #equifinality #abcd #connectome www.nature.com/articles/s41...

The Biological Psychiatry family of journals is now officially on Bluesky! Follow us for the latest research in psychiatric neuroscience, cognitive neuroimaging, and global open science from our three leading journals.

A fresh, new @npp-journal.bsky.social paper from @yiplab.bsky.social & @lester-rodriguez.bsky.social is out now 👇

Massive congrats to @lester-rodriguez.bsky.social for his 1st (of many!) 1st authored paper!!! Identification and external replication of a neuromarker of subjective drug effects to acute methamphetamine (vs placebo)!!! nature.com/articles/s41... @npp-journal.bsky.social

I'm thrilled that my lab at NYU is now supported by an NIH MIRA grant! I'm looking to hire 1-2 senior lab members (outstanding postdoc candidates or experienced staff scientists) with expertise in computational or statistical methods in human genetics or genomics. Please share!

As chair of the @acnporg.bsky.social Global Outreach Committee, I am happy to answer any questions about the Global Scholarship! Please share with your networks! Excellent opportunity to attend what might be the best science meeting in this space!

Excited to share our latest preprint looking at the neuroanatomical basis of impulsivity in youth! 🧠

FYI, if you want to be prepared to apply for the next ABCD Study data release, prepare for these new NIST security requirements 🧠: @ohbmofficial.bsky.social abcdstudy.org/scientists/d...

Computational Phenotyping of Effort-Based Decision Making in Unmedicated Adults with Remitted Depression www.sciencedirect.com/science/arti...

Present your great work at #CPConf25 and join us in Tübingen - poster abstract submission now open!

📣 Attn researchers interested in movie fcMRI x reliability! Glad to have been part of this work led by @halleeshearer.bsky.social & @vanderlab.bsky.social

Thrilled to kick 2025 off w/ this amazing tour de force led by @elvisha.bsky.social. Grateful to have been involved in this work highlighting the importance of considering #intersectionality in #neuroimaging @natureneuro.bsky.social

🌈 “Every person has a gender, and it influences who we are.” My research explores how gender maps onto the brain in meaningful ways. To hear more, check out @northwellhealth.bsky.social podcast, 20-Minute Health Talk: www.northwell.edu/news/insight...

Don't miss these @pact-lab.bsky.social posters tonight from @ryanntansey.bsky.social & @anadeutsch.bsky.social 🤩

A friendly reminder that symposium submissions for the computational psychiatry conferences are closing in 3 weeks #cpconf2025 👇🏼👇🏼👇🏼

Resting up for #acnp @npp-journal.bsky.social Hard to know who to tag in this new space… @philcorlett.bsky.social @kangjoonsoo.bsky.social @harpaz-rotem.bsky.social @mpwpaulus.bsky.social IF YOU ARE GOING TO ACNP and want to connect let me know 😊

“Cognitive flexibility as the shifting of brain network flows by flexible neural representations”, a solo paper by yours truly, making the case that brain activity flow shifts are essential to mental flexibility (and quite interesting too!) Open access: www.sciencedirect.com/science/arti...

We recently launched a YouTube channel where we will be posting brief video explainers on HiTOP-related topics: www.youtube.com/@HiTOP_system The first video is on the limitations of the DSM that motivated the development of the HiTOP framework: https//youtu.be/4K...

Our recent work looking at adverse life events and resting-state functional connectivity in the ABCD study now available online www.nature.com/articles/s41... Key findings: 1/2

📢 Really excited to announce our new research project exploring young people's (16-25 years) experiences of racism and discrimination and their health. Two peer researcher roles up for grabs!! Salary: £15k (3 days a week) Deadline 20th December. raceequalityfoundation.org.uk/health-care/...

Starting a Human Neuroimaging pack, let me know if you’d like to be added! 🧠 go.bsky.app/8xs6oWw

Just absolutely all the congrats to Kaidi and Simon on this massive effort. Incredibly detailed, careful work at huge scale that helps us understand how we can do better moving forward.